Synthesis and antitumor activity of duocarmycin derivatives: Modification of segment-A of A-ring pyrrole compounds

Journal of Medicinal Chemistry

Volumn 42, Issue 15, 1999, Pages 2946-2960

  Amishiro, Nobuyoshi ^a   Okamoto, Akihiko ^a   Murakata, Chikara ^a   Tamaoki, Tatsuya ^a   Okabe, Masami ^a   Saito, Hiromitsu ^a  

^a KYOWA HAKKO KOGYO CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; ANTINEOPLASTIC ANTIBIOTIC; DU 86; DUOCARMYCIN A; DUOCARMYCIN B1; DUOCARMYCIN B2; DUOCARMYCIN DERIVATIVE; DUOCARMYCIN SA; PIBROZELESIN; PYRINDAMYCIN A; PYRINDAMYCIN B; PYRROLE DERIVATIVE; RACHELMYCIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BLOOD TOXICITY; BONE MARROW TOXICITY; CANCER CELL CULTURE; CANCER TRANSPLANTATION; CONTROLLED STUDY; HELA CELL; HUMAN; HUMAN CELL; INTRAVENOUS DRUG ADMINISTRATION; MALE; MOUSE; NONHUMAN; SARCOMA; SARCOMA CELL; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTINEOPLASTIC AGENTS; BONE MARROW CELLS; COLONY-FORMING UNITS ASSAY; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; INDOLES; INHIBITORY CONCENTRATION 50; LEUKOCYTE COUNT; MALE; MICE; NEOPLASM TRANSPLANTATION; PLATELET COUNT; PYRROLIDINONES; SARCOMA 180; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 0033614978     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm990094r     Document Type: Article

References (54)

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