MicroRNAs involved in the EGFR/PTEN/AKT pathway in gliomas

Journal of Neuro-Oncology

Volumn 106, Issue 2, 2012, Pages 217-224

  Wang, Yingyi ^a   Wang, Xiefeng ^a   Zhang, Junxia ^a,b   Sun, Guan ^c   Luo, Hui ^a   Kang, Chunsheng ^b   Pu, Peiyu ^b   Jiang, Tao ^d   Liu, Ning ^a   You, Yongping ^a  

^a NANJING MEDICAL UNIVERSITY   (China)

^b TIANJIN MEDICAL UNIVERSITY   (China)

^c NANTONG UNIVERSITY   (China)

^d CAPITAL MEDICAL UNIVERSITY   (China)

Author keywords

AKT; EGFR; Glioma; MicroRNA; PTEN

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; GEFITINIB; MICRORNA; MICRORNA 124; MICRORNA 128; MICRORNA 137; MICRORNA 21; MICRORNA 221; MICRORNA 222; MICRORNA 26A; MICRORNA 451; MICRORNA 7; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; RNA; UNCLASSIFIED DRUG;

DRUG RESPONSE; ENZYME ACTIVATION; EPIDERMAL GROWTH FACTOR RECEPTOR GENE; GENE EXPRESSION; GLIOBLASTOMA; GLIOMA; HUMAN; MUTATOR GENE; NONHUMAN; PROTEIN DEPLETION; PROTEIN FUNCTION; REVIEW; RNA TRANSCRIPTION; SIGNAL TRANSDUCTION;

ANIMALS; BRAIN NEOPLASMS; GENE EXPRESSION REGULATION, NEOPLASTIC; GLIOMA; HUMANS; MICRORNAS; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE; RECEPTOR, EPIDERMAL GROWTH FACTOR; SIGNAL TRANSDUCTION;

EID: 82955162659     PISSN: 0167594X     EISSN: 15737373     Source Type: Journal    
DOI: 10.1007/s11060-011-0679-1     Document Type: Review

References (72)

1. LA Stewart 2002 Chemotherapy in adult high-grade glioma: a systematic review and meta-analysis of individual patient data from 12 randomised trials Lancet 359 1011 1018 11937180 10.1016/S0140-6736(02)08091-1 1:CAS:528: DC%2BD38XisV2htro%3D (Pubitemid 34286538)
2. A Esquela-Kerscher FJ Slack 2006 Oncomirs-microRNAs with a role in cancer Nat Rev Cancer 6 259 269 16557279 10.1038/nrc1840 1:CAS:528: DC%2BD28XivVyqtrs%3D
3. R Garzon M Fabbri A Cimmino GA Calin CM Croce 2006 MicroRNA expression and function in cancer Trends Mol Med 12 580 587 17071139 10.1016/j.molmed.2006. 10.006 1:CAS:528:DC%2BD28Xht1CqtbjN (Pubitemid 44780201)
4. R Garzon GA Calin CM Croce 2009 MicroRNAs in cancer Annu Rev Med 60 167 179 19630570 10.1146/annurev.med.59.053006.104707 1:CAS:528:DC%2BD1MXitlynt7Y%3D
5. A Wells 1999 EGF receptor Int J Biochem Cell Biol 31 637 643 10404636 10.1016/S1357-2725(99)00015-1 1:CAS:528:DyaK1MXkt1CjsrY%3D (Pubitemid 29248872)
6. Scagliotti GV, Selvaggi G, Novello S, Hirsch FR (2004) The biology of epidermal growth factor receptor in lung cancer. Clin Cancer Res 10:4227s-4232s (Pubitemid 38812451)
7. J Li C Yen D Liaw K Podsypanina S Bose SI Wang J Puc C Miliaresis L Rodgers R McCombie SH Bigner BC Giovanella M Ittmann B Tycko H Hibshoosh MH Wigler R Parsons 1997 PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer Science 275 1943 1947 9072974 10.1126/science.275.5308.1943 1:CAS:528:DyaK2sXit1Wgtbk%3D (Pubitemid 27148818)
8. MP Myers JP Stolarov C Eng J Li SI Wang MH Wigler R Parsons NK Tonks 1997 P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase Proc Natl Acad Sci USA 94 9052 9057 9256433 10.1073/pnas.94.17.9052 1:CAS:528:DyaK2sXls1Kmurg%3D (Pubitemid 27357780)
9. T Maehama JE Dixon 1998 The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate J Biol Chem 273 13375 13378 9593664 10.1074/jbc.273.22.13375 1:CAS:528:DyaK1cXjvVejsLk%3D (Pubitemid 28268370)
10. JA Engelman J Luo LC Cantley 2006 The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism Nat Rev Genet 7 606 619 16847462 10.1038/nrg1879 1:CAS:528:DC%2BD28XmvFCnu7Y%3D (Pubitemid 44100518)
11. RC Hresko H Murata M Mueckler 2003 Phosphoinositide-dependent kinase-2 is a distinct protein kinase enriched in a novel cytoskeletal fraction associated with adipocyte plasma membranes J Biol Chem 278 21615 21622 12682057 10.1074/jbc.M302937200 1:CAS:528:DC%2BD3sXksVems7c%3D (Pubitemid 36792561)
12. AJ Ekstrand N Sugawa CD James VP Collins 1992 Amplified and rearranged epidermal growth factor receptor genes in human glioblastomas reveal deletions of sequences encoding portions of the N- and/or C-terminal tails Proc Natl Acad Sci USA 89 4309 4313 1584765 10.1073/pnas.89.10.4309 1:CAS:528: DyaK38Xkt1Wntro%3D
13. H Ohgaki P Dessen B Jourde S Horstmann T Nishikawa PL Di Patre C Burkhard D Schuler NM Probst-Hensch PC Maiorka N Baeza P Pisani Y Yonekawa MG Yasargil UM Lütolf P Kleihues 2004 Genetic pathways to glioblastoma: a population-based study Cancer Res 64 6892 6899 15466178 10.1158/0008-5472.CAN- 04-1337 1:CAS:528:DC%2BD2cXotFalsrc%3D (Pubitemid 39330996)
14. K Watanabe O Tachibana K Sata Y Yonekawa P Kleihues H Ohgaki 1996 Overexpression of the EGF receptor and p53 mutations are mutually exclusive in the evolution of primary and secondary glioblastomas Brain Pathol 6 217 223 8864278 10.1111/j.1750-3639.1996.tb00848.x 1:STN:280:DyaK2s%2FhslKlsw%3D%3D
15. N Shinojima K Tada S Shiraishi T Kamiryo M Kochi H Nakamura K Makino H Saya H Hirano J Kuratsu K Oka Y Ishimaru Y Ushio 2003 Prognostic value of epidermal growth factor receptor in patients with glioblastoma multiforme Cancer Res 63 6962 6970 14583498 1:CAS:528:DC%2BD3sXosVGnsLg%3D (Pubitemid 37322983)
16. G Karpel-Massler U Schmidt A Unterberg ME Halatsch 2009 Therapeutic inhibition of the epidermal growth factor receptor in high-grade gliomas: where do we stand? Mol Cancer Res 7 1000 1012 19584260 10.1158/1541-7786.MCR-08-0479 1:CAS:528:DC%2BD1MXos1emsbY%3D
17. HW Lo 2010 EGFR-targeted therapy in malignant glioma: novel aspects and mechanisms of drug resistance Curr Mol Pharmacol 3 37 52 20030624 1:CAS:528:DC%2BC3cXkvFGqtrc%3D
18. JN Rich DA Reardon T Peery JM Dowell JA Quinn KL Penne CJ Wikstrand LB Van Duyn JE Dancey RE McLendon JC Kao TT Stenzel BK Ahmed Rasheed SE Tourt-Uhlig JE Herndon 2nd JJ Vredenburgh JH Sampson AH Friedman DD Bigner HS Friedman 2004 Phase II trial of gefitinib in recurrent glioblastoma J Clin Oncol 22 133 142 14638850 10.1200/JCO.2004.08.110 1:CAS:528:DC%2BD2cXpsVKhsr8%3D (Pubitemid 41095125)
19. DN Louis H Ohgaki OD Wiestler WK Cavenee PC Burger A Jouvet BW Scheithauer P Kleihues 2007 The 2007 WHO classification of tumours of the central nervous system Acta Neuropathol 114 97 109 17618441 10.1007/s00401-007- 0243-4 (Pubitemid 47103521)
20. JS Smith I Tachibana SM Passe BK Huntley TJ Borell N Iturria JR O'Fallon PL Schaefer BW Scheithauer CD James JC Buckner RB Jenkins 2001 PTEN mutation, EGFR amplification, and outcome in patients with anaplastic astrocytoma and glioblastoma multiforme J Natl Cancer Inst 93 1246 1256 11504770 10.1093/jnci/93.16.1246 1:CAS:528:DC%2BD3MXms1Ortbw%3D (Pubitemid 32816199)
21. T Sano H Lin X Chen LA Langford D Koul ML Bondy KR Hess JN Myers YK Hong WK Yung PA Steck 1999 Differential expression of MMAC/PTEN in glioblastoma multiforme: relationship to localization and prognosis Cancer Res 59 1820 1824 10213484 1:CAS:528:DyaK1MXislejsb4%3D (Pubitemid 29186149)
22. LD Mayo JE Dixon DL Durden NK Tonks DB Donner 2002 PTEN protects p53 from Mdm2 and sensitizes cancer cells to chemotherapy J Biol Chem 277 5484 5489 11729185 10.1074/jbc.M108302200 1:CAS:528:DC%2BD38XhsFCjtrc%3D (Pubitemid 34968598)
23. W Wick FB Furnari U Naumann WK Cavenee M Weller 1999 PTEN gene transfer in human malignant glioma: sensitization to irradiation and CD95L-induced apoptosis Oncogene 18 3936 3943 10435616 10.1038/sj.onc.1202774 1:CAS:528:DyaK1MXkvVKksrg%3D (Pubitemid 29361331)
24. GL Gallia V Rand IM Siu CG Eberhart CD James SK Marie SM Oba-Shinjo CG Carlotti OL Caballero AJ Simpson MV Brock PP Massion BS Carson Sr GJ Riggins 2006 PIK3CA gene mutations in pediatric and adult glioblastoma multiforme Mol Cancer Res 4 709 714 17050665 10.1158/1541-7786.MCR-06-0172 1:CAS:528: DC%2BD28XhtVyqtr%2FE (Pubitemid 44683311)
25. D Kita Y Yonekawa M Weller H Ohgaki 2007 PIK3CA alterations in primary (de novo) and secondary glioblastomas Acta Neuropathol 113 295 302 17235514 10.1007/s00401-006-0186-1 1:CAS:528:DC%2BD2sXhsVersr8%3D (Pubitemid 46443564)
26. R Prevo E Deutsch O Sampson J Diplexcito K Cengel J Harper P O'Neill WG McKenna S Patel EJ Bernhard 2008 Class I PI3 kinase inhibition by the pyridinylfuranopyrimidine inhibitor PI-103 enhances tumor radiosensitivity Cancer Res 68 5915 5923 18632646 10.1158/0008-5472.CAN-08-0757 1:CAS:528:DC%2BD1cXovVCntr4%3D
27. D Opel MA Westhoff A Bender V Braun KM Debatin S Fulda 2008 Phosphatidylinositol 3-kinase inhibition broadly sensitizes glioblastoma cells to death receptor- and drug-induced apoptosis Cancer Res 68 6271 6280 18676851 10.1158/0008-5472.CAN-07-6769 1:CAS:528:DC%2BD1cXpt1WjsL4%3D
28. G Wang C Kang P Pu 2010 Increased expression of Akt2 and activity of PI3K and cell proliferation with the ascending of tumor grade of human gliomas Clin Neurol Neurosurg 112 324 327 20116920 10.1016/j.clineuro.2010.01.003
29. J Zhang L Han A Zhang Y Wang X Yue Y You P Pu C Kang 2010 AKT2 expression is associated with glioma malignant progression and required for cell survival and invasion Oncol Rep 24 65 72 20514445
30. H Jiang X Shang H Wu SC Gautam S Al-Holou C Li J Kuo L Zhang M Chopp 2009 Resveratrol downregulates PI3K/Akt/mTOR signaling pathways in human U251 glioma cells J Exp Ther Oncol 8 25 33 19827268
31. Y Ruano M Mollejo FI Camacho A Rodriguez de Lope C Fiano T Ribalta P Martinez JL Hernandez-Moneo B Melendez 2008 Identification of survival-related genes of the phosphatidylinositol 3'-kinase signaling pathway in glioblastoma multiforme Cancer 112 1575 1584 18260157 10.1002/cncr.23338 1:CAS:528: DC%2BD1cXktlKrurg%3D (Pubitemid 351441171)
32. RG Verhaak KA Hoadley E Purdom V Wang Y Qi MD Wilkerson CR Miller L Ding T Golub JP Mesirov G Alexe M Lawrence M O'Kelly P Tamayo BA Weir S Gabriel W Winckler S Gupta L Jakkula HS Feiler JG Hodgson CD James JN Sarkaria C Brennan A Kahn PT Spellman RK Wilson TP Speed JW Gray M Meyerson G Getz CM Perou DN Hayes Cancer Genome Atlas Research Network 2010 Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1 Cancer Cell 17 98 110 20129251 10.1016/j.ccr.2009.12.020 1:CAS:528:DC%2BC3cXkvFKgsL4%3D
33. AM Denli BB Tops RH Plasterk RF Ketting GJ Hannon 2004 Processing of primary microRNAs by the microprocessor complex Nature 432 231 235 15531879 10.1038/nature03049 1:CAS:528:DC%2BD2cXpsF2gtrY%3D (Pubitemid 39545854)
34. RI Gregory TP Chendrimada N Cooch R Shiekhattar 2005 Human RISC couples microRNA biogenesis and posttranscriptional gene silencing Cell 123 631 640 16271387 10.1016/j.cell.2005.10.022 1:CAS:528:DC%2BD2MXht1yktrjN (Pubitemid 41608466)
35. X Zhou X Duan J Qian F Li 2009 Abundant conserved microRNA target sites in the 5′-untranslated region and coding sequence Genetica 137 159 164 19578934 10.1007/s10709-009-9378-7 1:CAS:528:DC%2BD1MXht1Whur%2FK
36. AM Duursma M Kedde M Schrier C le Sage R Agami 2008 miR-148 targets human DNMT3b protein coding region Rna 14 872 877 18367714 10.1261/rna.972008 1:CAS:528:DC%2BD1cXls1Wrtrg%3D (Pubitemid 351574909)
37. NP Tsai YL Lin LN Wei 2009 MicroRNA miR-346 targets the 5′-untranslated region of receptor-interacting protein 140 (RIP140) mRNA and up-regulates its protein expression Biochem J 424 411 418 19780716 10.1042/BJ20090915 1:CAS:528:DC%2BD1MXhsFCitbnO
38. SA Ciafrè S Galardi A Mangiola M Ferracin CG Liu G Sabatino M Negrini G Maira CM Croce MG Farace 2005 Extensive modulation of a set of microRNAs in primary glioblastoma Biochem Biophys Res Commun 334 1351 1358 16039986 10.1016/j.bbrc.2005.07.030 (Pubitemid 41074723)
39. F Guessous Y Zhang A Kofman A Catania Y Li D Schiff B Purow R Abounader 2010 microRNA-34a is tumor suppressive in brain tumors and glioma stem cells Cell Cycle 9 1031 1036 20190569 10.4161/cc.9.6.10987 1:CAS:528: DC%2BC3cXht12itr7I
40. L Jiang P Mao L Song J Wu J Huang C Lin J Yuan L Qu SY Cheng J Li 2010 miR-182 as a prognostic marker for glioma progression and patient survival Am J Pathol 177 29 38 20472885 10.2353/ajpath.2010.090812
41. B Kefas L Comeau N Erdle E Montgomery S Amos B Purow 2010 Pyruvate kinase M2 is a target of the tumor-suppressive microRNA-326 and regulates the survival of glioma cells Neuro Oncol 12 1102 1112 20667897 10.1093/neuonc/noq080 1:CAS:528:DC%2BC3cXhtlClu7fP
42. J Godlewski MO Nowicki A Bronisz S Williams A Otsuki G Nuovo A Raychaudhury HB Newton EA Chiocca S Lawler 2008 Targeting of the Bmi-1 oncogene/stem cell renewal factor by microRNA-128 inhibits glioma proliferation and self-renewal Cancer Res 68 9125 9130 19010882 10.1158/0008-5472.CAN-08-2629 1:CAS:528:DC%2BD1cXhtlOmt7zL
43. A Conti M Aguennouz D La Torre C Tomasello S Cardali FF Angileri F Maio A Cama A Germano G Vita F Tomasello 2009 miR-21 and 221 upregulation and miR-181b downregulation in human grade II-IV astrocytic tumors J Neurooncol 93 325 332 19159078 10.1007/s11060-009-9797-4 1:CAS:528:DC%2BD1MXmsVClsbs%3D
44. JA Chan AM Krichevsky KS Kosik 2005 MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells Cancer Res 65 6029 6033 16024602 10.1158/0008-5472.CAN-05-0137 1:CAS:528:DC%2BD2MXmt1eht7c%3D (Pubitemid 40994386)
45. X Zhou J Zhang Q Jia Y Ren Y Wang L Shi N Liu G Wang P Pu Y You C Kang 2010 Reduction of miR-21 induces glioma cell apoptosis via activating caspase 9 and 3 Oncol Rep 24 195 201 20514462 10.3892/or-00001020 1:CAS:528: DC%2BC3cXpt1ahu74%3D
46. T Papagiannakopoulos A Shapiro KS Kosik 2008 MicroRNA-21 targets a network of key tumor-suppressive pathways in glioblastoma cells Cancer Res 68 8164 8172 18829576 10.1158/0008-5472.CAN-08-1305 1:CAS:528:DC%2BD1cXhtF2msLjO
47. Y Ren X Zhou M Mei XB Yuan L Han GX Wang ZF Jia P Xu PY Pu CS Kang 2010 MicroRNA-21 inhibitor sensitizes human glioblastoma cells U251 (PTEN-mutant) and LN229 (PTEN-wild type) to taxol BMC Cancer 10 27 20113523 10.1186/1471-2407-10- 27
48. G Gabriely T Wurdinger S Kesari CC Esau J Burchard PS Linsley AM Krichevsky 2008 MicroRNA 21 promotes glioma invasion by targeting matrix metalloproteinase regulators Mol Cell Biol 28 5369 5380 18591254 10.1128/MCB.00479-08 1:CAS:528:DC%2BD1cXhtVersLrF
49. Y Chen W Liu T Chao Y Zhang X Yan Y Gong B Qiang J Yuan M Sun X Peng 2008 MicroRNA-21 down-regulates the expression of tumor suppressor PDCD4 in human glioblastoma cell T98G Cancer Lett 272 197 205 19013014 10.1016/j.canlet.2008. 06.034 1:CAS:528:DC%2BD1cXhtlyhtr%2FL
50. X Zhou Y Ren L Moore M Mei Y You P Xu B Wang G Wang Z Jia P Pu W Zhang C Kang 2010 Downregulation of miR-21 inhibits EGFR pathway and suppresses the growth of human glioblastoma cells independent of PTEN status Lab Invest 90 144 155 20048743 10.1038/labinvest.2009.126 1:CAS:528:DC%2BC3cXht1Kqs7s%3D
51. Y Li W Li Y Yang Y Lu C He G Hu H Liu J Chen J He H Yu 2009 MicroRNA-21 targets LRRFIP1 and contributes to VM-26 resistance in glioblastoma multiforme Brain Res 1286 13 18 19559015 10.1016/j.brainres.2009.06.053 1:CAS:528:DC%2BD1MXps1Wlsbk%3D
52. S Zhu ML Si H Wu YY Mo 2007 MicroRNA-21 targets the tumor suppressor gene tropomyosin 1 (TPM1) J Biol Chem 282 14328 14336 17363372 10.1074/jbc. M611393200 1:CAS:528:DC%2BD2sXkvVynsLk%3D (Pubitemid 47100416)
53. D Sayed M He C Hong S Gao S Rane Z Yang M Abdellatif 2010 MicroRNA-21 is a downstream effector of AKT that mediates its antiapoptotic effects via suppression of Fas ligand J Biol Chem 285 20281 20290 20404348 10.1074/jbc.M110.109207 1:CAS:528:DC%2BC3cXnsFygtLo%3D
54. T Li D Li J Sha P Sun Y Huang 2009 MicroRNA-21 directly targets MARCKS and promotes apoptosis resistance and invasion in prostate cancer cells Biochem Biophys Res Commun 383 280 285 19302977 10.1016/j.bbrc.2009.03.077 1:CAS:528:DC%2BD1MXlsVKjtrw%3D
55. K Wang PF Li 2010 Foxo3a regulates apoptosis by negatively targeting miR-21 J Biol Chem 285 16958 16966 20371612 10.1074/jbc.M109.093005 1:CAS:528:DC%2BC3cXmtlygt7c%3D
56. K Yuki A Natsume H Yokoyama Y Kondo M Ohno T Kato P Chansakul M Ito SU Kim T Wakabayashi 2009 Induction of oligodendrogenesis in glioblastoma- initiating cells by IFN-mediated activation of STAT3 signaling Cancer Lett 284 71 79 19457609 10.1016/j.canlet.2009.04.020 1:CAS:528:DC%2BD1MXhtVKlsLnL
57. D Loffler K Brocke-Heidrich G Pfeifer C Stocsits J Hackermuller AK Kretzschmar R Burger M Gramatzki C Blumert K Bauer H Cvijic AK Ullmann PF Stadler F Horn 2007 Interleukin-6 dependent survival of multiple myeloma cells involves the Stat3-mediated induction of microRNA-21 through a highly conserved enhancer Blood 110 1330 1333 17496199 10.1182/blood-2007-03-081133 (Pubitemid 47281433)
58. C Zhang C Kang Y You P Pu W Yang P Zhao G Wang A Zhang Z Jia L Han H Jiang 2009 Co-suppression of miR-221/222 cluster suppresses human glioma cell growth by targeting p27kip1 in vitro and in vivo Int J Oncol 34 1653 1660 19424584 10.3892/ijo-00000241 1:CAS:528:DC%2BD1MXmsVCiur4%3D
59. J Zhang L Han Y Ge X Zhou A Zhang C Zhang Y Zhong Y You P Pu C Kang 2010 miR-221/222 promote malignant progression of glioma through activation of the Akt pathway Int J Oncol 36 913 920 20198336 1:CAS:528:DC%2BC3cXksl2gsLo%3D
60. R Medina SK Zaidi CG Liu JL Stein AJ van Wijnen CM Croce GS Stein 2008 MicroRNAs 221 and 222 bypass quiescence and compromise cell survival Cancer Res 68 2773 2780 18413744 10.1158/0008-5472.CAN-07-6754 1:CAS:528: DC%2BD1cXks1Giur4%3D (Pubitemid 351556275)
61. H He K Jazdzewski W Li S Liyanarachchi R Nagy S Volinia GA Calin CG Liu K Franssila S Suster RT Kloos CM Croce A de la Chapelle 2005 The role of microRNA genes in papillary thyroid carcinoma Proc Natl Acad Sci USA 102 19075 19080 16365291 10.1073/pnas.0509603102 1:CAS:528:DC%2BD28XivV2htA%3D%3D (Pubitemid 43049568)
62. Z Chun-Zhi H Lei Z An-Ling F Yan-Chao Y Xiao W Guang-Xiu J Zhi-Fan P Pei-Yu Z Qing-Yu K Chun-Sheng 2010 MicroRNA-221 and microRNA-222 regulate gastric carcinoma cell proliferation and radioresistance by targeting PTEN BMC Cancer 10 367 20618998 10.1186/1471-2407-10-367
63. CZ Zhang CS Kang PY Pu GX Wang ZF Jia AL Zhang L Han P Xu 2009 Inhibitory effect of knocking down microRNA-221 and microRNA-222 on glioma cell growth in vitro and in vivo Zhonghua Zhong Liu Za Zhi 31 721 726 20021821 1:CAS:528:DC%2BC3cXhtVOiu7o%3D
64. B Kefas J Godlewski L Comeau Y Li R Abounader M Hawkinson J Lee H Fine EA Chiocca S Lawler B Purow 2008 microRNA-7 inhibits the epidermal growth factor receptor and the Akt pathway and is down-regulated in glioblastoma Cancer Res 68 3566 3572 18483236 10.1158/0008-5472.CAN-07-6639 1:CAS:528:DC%2BD1cXlvVOit78%3D
65. H Gal G Pandi AA Kanner Z Ram G Lithwick-Yanai N Amariglio G Rechavi D Givol 2008 MIR-451 and Imatinib mesylate inhibit tumor growth of Glioblastoma stem cells Biochem Biophys Res Commun 376 86 90 18765229 10.1016/j.bbrc.2008.08. 107 1:CAS:528:DC%2BD1cXhtFyqtL3P
66. J Godlewski MO Nowicki A Bronisz G Nuovo J Palatini M De Lay J Van Brocklyn MC Ostrowski EA Chiocca SE Lawler 2010 MicroRNA-451 regulates LKB1/AMPK signaling and allows adaptation to metabolic stress in glioma cells Mol Cell 37 620 632 20227367 10.1016/j.molcel.2010.02.018 1:CAS:528:DC%2BC3cXlt1KrsL4%3D
67. Y Nan L Han A Zhang G Wang Z Jia Y Yang X Yue P Pu Y Zhong C Kang 2010 miRNA-451 plays a role as tumor suppressor in human glioma cells Brain Res 1359 14 21 20816946 10.1016/j.brainres.2010.08.074 1:CAS:528:DC%2BC3cXhtlSgt7%2FF
68. JT Huse C Brennan D Hambardzumyan B Wee J Pena SH Rouhanifard C Sohn-Lee C le Sage R Agami T Tuschl EC Holland 2009 The PTEN-regulating microRNA miR-26a is amplified in high-grade glioma and facilitates gliomagenesis in vivo Genes Dev 23 1327 1337 19487573 10.1101/gad.1777409 1:CAS:528:DC%2BD1MXntlegsbc%3D
69. Y Zhang T Chao R Li W Liu Y Chen X Yan Y Gong B Yin W Liu B Qiang J Zhao J Yuan X Peng 2009 MicroRNA-128 inhibits glioma cells proliferation by targeting transcription factor E2F3a J Mol Med 87 43 51 18810376 10.1007/s00109-008-0403- 6 1:CAS:528:DC%2BD1cXhsFSrurrO
70. J Silber DA Lim C Petritsch AI Persson AK Maunakea M Yu SR Vandenberg DG Ginzinger CD James JF Costello G Bergers WA Weiss A Alvarez-Buylla JG Hodgson 2008 miR-124 and miR-137 inhibit proliferation of glioblastoma multiforme cells and induce differentiation of brain tumor stem cells BMC Med 6 14 18577219 10.1186/1741-7015-6-14 (Pubitemid 352003733)
71. L Shi Z Cheng J Zhang R Li P Zhao Z Fu Y You 2008 hsa-miR-181a and hsa-miR-181b function as tumor suppressors in human glioma cells Brain Res 1236 185 193 18710654 10.1016/j.brainres.2008.07.085 1:CAS:528:DC%2BD1cXht1SitL%2FE
72. T Sasayama M Nishihara T Kondoh K Hosoda E Kohmura 2009 MicroRNA-10b is overexpressed in malignant glioma and associated with tumor invasive factors, uPAR and RhoC Int J Cancer 125 1407 1413 19536818 10.1002/ijc.24522 1:CAS:528:DC%2BD1MXovVels7k%3D