Microfluidics Enables Small-Scale Tissue-Based Drug Metabolism Studies With Scarce Human Tissue

Journal of Laboratory Automation

Volumn 16, Issue 6, 2011, Pages 468-476

  van Midwoud, Paul M ^a   Merema, Marjolijn T ^a   Verpoorte, Elisabeth ^a   Groothuis, Geny M M ^a  

^a UNIVERSITY OF GRONINGEN   (Netherlands)

Author keywords

In vitro study; Interorgan interaction; On line analysis; Precision cut intestinal slices; Precision cut liver slices

Indexed keywords

7-ETHOXYCOUMARIN; 7-HYDROXYCOUMARIN; ANIMAL STUDIES; ANIMAL TISSUE; BIOLOGICAL MODELS; CELL-BASED; CONTINUOUS FLOWS; DIFFERENT SUBSTRATES; DRUG CANDIDATES; DRUG METABOLISMS; EXPERIMENTAL SYSTEM; FURTHER DEVELOPMENT; HUMAN TISSUES; IN-VITRO; IN-VITRO TESTS; IN-VIVO; INTERORGAN INTERACTION; LIVER SLICES; METABOLIC PROFILES; MICRO FLUIDIC SYSTEM; MICRO-CHAMBERS; ON-LINE ANALYSIS; ONLINE MONITORING; PRECISION CUT; PRECLINICAL STUDIES; TOXICITY PROPERTIES; WELL PLATES;

EXPERIMENTS; FLUIDIC DEVICES; MAMMALS; METABOLISM; PHYSIOLOGY; TISSUE;

MICROFLUIDICS;

2BETA HYDROXYTESTOSTERONE; 6BETA HYDROXYTESTOSTERONE; 7 ETHOXYCOUMARIN; ALANINE AMINOTRANSFERASE; ANDROSTENEDIONE; ASPARTATE AMINOTRANSFERASE; DEETHYLLIDOCAINE; DRUG METABOLITE; LACTATE DEHYDROGENASE; LIDOCAINE; TESTOSTERONE; UMBELLIFERONE; UMBELLIFERONE GLUCURONIDE; UMBELLIFERONE SULFATE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DEETHYLATION; DRUG GLUCURONIDATION; DRUG HYDROXYLATION; DRUG METABOLISM; DRUG OXIDATION; DRUG SULFATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN TISSUE; MICROFLUIDICS; ONLINE ANALYSIS; ONLINE MONITORING; PRECISION CUT LIVER SLICES; TISSUE SLICE;

AUTOMATION, LABORATORY; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG EVALUATION, PRECLINICAL; FLOW CYTOMETRY; HUMANS; LIVER; STAINING AND LABELING;

EID: 82855161342     PISSN: 22110682     EISSN: 22110690     Source Type: Journal    
DOI: 10.1016/j.jala.2011.07.003     Document Type: Article

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