메뉴 건너뛰기




Volumn 187, Issue 11, 2011, Pages 5756-5763

Rapamycin attenuates airway hyperreactivity, goblet cells, and IgE in experimental allergic asthma

Author keywords

[No Author keywords available]

Indexed keywords

HOUSE DUST ALLERGEN; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G1; INTERLEUKIN 13; INTERLEUKIN 4; PEPTIDOLEUKOTRIENE; RAPAMYCIN;

EID: 82755187679     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1102133     Document Type: Article
Times cited : (63)

References (46)
  • 2
    • 0034039372 scopus 로고    scopus 로고
    • Asthma in children: Prevalence, treatment, and sensitization
    • DOI 10.1034/j.1399-3038.2000.00070.x
    • Hesselmar, B., B. Aberg, B. Eriksson, and N. Aberg. 2000. Asthma in children: prevalence, treatment, and sensitization. Pediatr. Allergy Immunol. 11: 74-79. (Pubitemid 30352835)
    • (2000) Pediatric Allergy and Immunology , vol.11 , Issue.2 , pp. 74-79
    • Hesselmar, B.1    Aberg, B.2    Eriksson, B.3    Aberg, N.4
  • 3
    • 2342590065 scopus 로고    scopus 로고
    • The global burden of asthma: Executive summary of the GINA Dissemination Committee Report
    • DOI 10.1111/j.1398-9995.2004.00526.x
    • Masoli, M., D. Fabian, S. Holt, R. Beasley; Global Initiative for Asthma (GINA) Program. 2004. The global burden of asthma: executive summary of the GINA Dissemination Committee report. Allergy 59: 469-478. (Pubitemid 38580764)
    • (2004) Allergy: European Journal of Allergy and Clinical Immunology , vol.59 , Issue.5 , pp. 469-478
    • Masoli, M.1    Fabian, D.2    Holt, S.3    Beasley, R.4
  • 4
    • 67651162340 scopus 로고    scopus 로고
    • Immunobiology of asthma
    • Hamid, Q., and M. Tulic. 2009. Immunobiology of asthma. Annu. Rev. Physiol. 71: 489-507.
    • (2009) Annu. Rev. Physiol. , vol.71 , pp. 489-507
    • Hamid, Q.1    Tulic, M.2
  • 5
    • 47949119866 scopus 로고    scopus 로고
    • Pathogenesis of asthma
    • Holgate, S. T. 2008. Pathogenesis of asthma. Clin. Exp. Allergy 38: 872-897.
    • (2008) Clin. Exp. Allergy , vol.38 , pp. 872-897
    • Holgate, S.T.1
  • 6
    • 0038299000 scopus 로고    scopus 로고
    • Sirolimus: Its discovery, biological properties, and mechanism of action
    • DOI 10.1016/S0041-1345(03)00211-2
    • Sehgal, S. N. 2003. Sirolimus: its discovery, biological properties, and mechanism of action. Transplant. Proc. 35(3, Suppl.)7S-14S. (Pubitemid 36547910)
    • (2003) Transplantation Proceedings , vol.35 , Issue.3 SUPPL.
    • Sehgal, S.N.1
  • 7
    • 0016724057 scopus 로고
    • Rapamycin (AY-22,989), a new antifungal antibiotic. I. Taxonomy of the producing streptomycete and isolation of the active principle
    • Vézina, C., A. Kudelski, and S. N. Sehgal. 1975. Rapamycin (AY-22,989), a new antifungal antibiotic. I. Taxonomy of the producing streptomycete and isolation of the active principle. J. Antibiot. (Tokyo) 28: 721-726.
    • (1975) J. Antibiot. (Tokyo) , vol.28 , pp. 721-726
    • Vézina, C.1    Kudelski, A.2    Sehgal, S.N.3
  • 8
    • 33750044112 scopus 로고    scopus 로고
    • Stress and mTORture signaling
    • DOI 10.1038/sj.onc.1209889, PII 1209889
    • Reiling, J. H., and D. M. Sabatini. 2006. Stress and mTORture signaling. Oncogene 25: 6373-6383. (Pubitemid 44582282)
    • (2006) Oncogene , vol.25 , Issue.48 , pp. 6373-6383
    • Reiling, J.H.1    Sabatini, D.M.2
  • 9
    • 70350418625 scopus 로고    scopus 로고
    • mTOR signaling at a glance
    • Laplante, M., and D. M. Sabatini. 2009. mTOR signaling at a glance. J. Cell Sci. 122: 3589-3594.
    • (2009) J. Cell Sci. , vol.122 , pp. 3589-3594
    • Laplante, M.1    Sabatini, D.M.2
  • 11
    • 77957054466 scopus 로고    scopus 로고
    • The mammalian target of rapamycin: Linking T cell differentiation, function, and metabolism
    • Powell, J. D., and G. M. Delgoffe. 2010. The mammalian target of rapamycin: linking T cell differentiation, function, and metabolism. Immunity 33: 301-311.
    • (2010) Immunity , vol.33 , pp. 301-311
    • Powell, J.D.1    Delgoffe, G.M.2
  • 12
    • 33846569938 scopus 로고    scopus 로고
    • Targeting mammalian target of rapamycin (mTOR) for health and diseases
    • DOI 10.1016/j.drudis.2006.12.008, PII S1359644606004910
    • Tsang, C. K., H. Qi, L. F. Liu, and X. F. Zheng. 2007. Targeting mammalian target of rapamycin (mTOR) for health and diseases. Drug Discov. Today 12: 112-124. (Pubitemid 46176669)
    • (2007) Drug Discovery Today , vol.12 , Issue.3-4 , pp. 112-124
    • Tsang, C.K.1    Qi, H.2    Liu, L.F.3    Zheng, X.F.S.4
  • 13
    • 34347220473 scopus 로고    scopus 로고
    • Defining the Role of mTOR in Cancer
    • DOI 10.1016/j.ccr.2007.05.008, PII S1535610807001511
    • Guertin, D. A., and D. M. Sabatini. 2007. Defining the role of mTOR in cancer. Cancer Cell 12: 9-22. (Pubitemid 47001784)
    • (2007) Cancer Cell , vol.12 , Issue.1 , pp. 9-22
    • Guertin, D.A.1    Sabatini, D.M.2
  • 14
    • 0035165578 scopus 로고    scopus 로고
    • Rapamycin in transplantation: A review of the evidence
    • DOI 10.1046/j.1523-1755.2001.00460.x
    • Saunders, R. N., M. S. Metcalfe, and M. L. Nicholson. 2001. Rapamycin in transplantation: a review of the evidence. Kidney Int. 59: 3-16. (Pubitemid 32055209)
    • (2001) Kidney International , vol.59 , Issue.1 , pp. 3-16
    • Saunders, R.N.1    Metcalfe, M.S.2    Nicholson, M.L.3
  • 15
    • 72449147738 scopus 로고    scopus 로고
    • The multifunctional role of mTOR in innate immunity: Implications for transplant immunity
    • Säemann, M. D., M. Haidinger, M. Hecking, W. H. Hörl, and T. Weichhart. 2009. The multifunctional role of mTOR in innate immunity: implications for transplant immunity. Am. J. Transplant. 9: 2655-2661.
    • (2009) Am. J. Transplant. , vol.9 , pp. 2655-2661
    • Säemann, M.D.1    Haidinger, M.2    Hecking, M.3    Hörl, W.H.4    Weichhart, T.5
  • 16
    • 0038803927 scopus 로고    scopus 로고
    • Effects of cyclosporin A and a rapamycin derivative (SAR943) on chronic allergic inflammation in sensitized rats
    • DOI 10.1046/j.1365-2567.2003.01672.x
    • Eynott, P. R., M. Salmon, T. J. Huang, T. Oates, P. L. Nicklin, and K. F. Chung. 2003. Effects of cyclosporin A and a rapamycin derivative (SAR943) on chronic allergic inflammation in sensitized rats. Immunology 109: 461-467. (Pubitemid 36783273)
    • (2003) Immunology , vol.109 , Issue.3 , pp. 461-467
    • Eynott, P.R.1    Salmon, M.2    Huang, T.-J.3    Oates, T.4    Nicklin, P.L.5    Chung, K.F.6
  • 17
    • 0037438424 scopus 로고    scopus 로고
    • In vivo and in vitro effects of SAR 943, a rapamycin analogue, on airway inflammation and remodeling
    • DOI 10.1164/rccm.200205-455OC
    • Fujitani, Y., and A. Trifilieff. 2003. In vivo and in vitro effects of SAR 943, a rapamycin analogue, on airway inflammation and remodeling. Am. J. Respir. Crit. Care Med. 167: 193-198. (Pubitemid 36076079)
    • (2003) American Journal of Respiratory and Critical Care Medicine , vol.167 , Issue.2 , pp. 193-198
    • Fujitani, Y.1    Trifilieff, A.2
  • 18
    • 0031045582 scopus 로고    scopus 로고
    • The effect of anti-IL-4 monoclonal antibody, rapamycin and interferon-gamma on airway hyperreactivity to acetylcholine in mice
    • DOI 10.1111/j.1365-2222.1997.tb00696.x
    • Nagai, H., Y. Maeda, and H. Tanaka. 1997. The effect of anti-IL-4 monoclonal antibody, rapamycin and interferon-gamma on airway hyperreactivity to acetylcholine in mice. Clin. Exp. Allergy 27: 218-224. (Pubitemid 27085424)
    • (1997) Clinical and Experimental Allergy , vol.27 , Issue.2 , pp. 218-224
    • Nagai, H.1    Maeda, Y.2    Tanaka, H.3
  • 20
    • 65249114882 scopus 로고    scopus 로고
    • A protective role for C5a in the development of allergic asthma associated with altered levels of B7-H1 and B7-DC on plasmacytoid dendritic cells
    • Zhang, X., I. P. Lewkowich, G. Köhl, J. R. Clark, M. Wills-Karp, and J. Köhl. 2009. A protective role for C5a in the development of allergic asthma associated with altered levels of B7-H1 and B7-DC on plasmacytoid dendritic cells. J. Immunol. 182: 5123-5130.
    • (2009) J. Immunol. , vol.182 , pp. 5123-5130
    • Zhang, X.1    Lewkowich, I.P.2    Köhl, G.3    Clark, J.R.4    Wills-Karp, M.5    Köhl, J.6
  • 22
    • 0036295087 scopus 로고    scopus 로고
    • The murine mCLCA3 (alias gob-5) protein is located in the mucin granule membranes of intestinal, respiratory, and uterine goblet cells
    • Leverkoehne, I., and A. D. Gruber. 2002. The murine mCLCA3 (alias gob-5) protein is located in the mucin granule membranes of intestinal, respiratory, and uterine goblet cells. J. Histochem. Cytochem. 50: 829-838 (Pubitemid 34721451)
    • (2002) Journal of Histochemistry and Cytochemistry , vol.50 , Issue.6 , pp. 829-838
    • Leverkoehne, I.1    Gruber, A.D.2
  • 23
    • 0031607879 scopus 로고    scopus 로고
    • Inflammation and airway function in asthma: What you see is not necessarily what you get
    • Haley, K. J., and J. M. Drazen. 1998. Inflammation and airway function in asthma: what you see is not necessarily what you get. Am. J. Respir. Crit. Care Med. 157: 1-3.
    • (1998) Am. J. Respir. Crit. Care Med. , vol.157 , pp. 1-3
    • Haley, K.J.1    Drazen, J.M.2
  • 29
    • 11844280961 scopus 로고    scopus 로고
    • Mast cells, basophils, and eosinophils acquire constitutive IL-4 and IL-13 transcripts during lineage differentiation that are sufficient for rapid cytokine production
    • Gessner, A., K. Mohrs, and M. Mohrs. 2005. Mast cells, basophils, and eosinophils acquire constitutive IL-4 and IL-13 transcripts during lineage differentiation that are sufficient for rapid cytokine production. J. Immunol. 174: 1063-1072. (Pubitemid 40094303)
    • (2005) Journal of Immunology , vol.174 , Issue.2 , pp. 1063-1072
    • Gessner, A.1    Mohrs, K.2    Mohrs, M.3
  • 30
    • 44449141488 scopus 로고    scopus 로고
    • Activation and function of the mTORC1 pathway in mast cells
    • Kim, M. S., H. S. Kuehn, D. D. Metcalfe, and A. M. Gilfillan. 2008. Activation and function of the mTORC1 pathway in mast cells. J. Immunol. 180: 4586-4595.
    • (2008) J. Immunol. , vol.180 , pp. 4586-4595
    • Kim, M.S.1    Kuehn, H.S.2    Metcalfe, D.D.3    Gilfillan, A.M.4
  • 31
    • 33747332338 scopus 로고    scopus 로고
    • Ex vivo rapamycin generates Th1/Tc1 or Th2/Tc2 Effector T cells with enhanced in vivo function and differential sensitivity to post-transplant rapamycin therapy
    • Jung, U., J. E. Foley, A. A. Erdmann, Y. Toda, T. Borenstein, J. Mariotti, and D. H. Fowler. 2006. Ex vivo rapamycin generates Th1/Tc1 or Th2/Tc2 Effector T cells with enhanced in vivo function and differential sensitivity to post-transplant rapamycin therapy. Biol. Blood Marrow Transplant. 12: 905-918.
    • (2006) Biol. Blood Marrow Transplant. , vol.12 , pp. 905-918
    • Jung, U.1    Foley, J.E.2    Erdmann, A.A.3    Toda, Y.4    Borenstein, T.5    Mariotti, J.6    Fowler, D.H.7
  • 32
    • 70049100374 scopus 로고    scopus 로고
    • Innate cells and T helper 2 cell immunity in airway inflammation
    • Barrett, N. A., and K. F. Austen. 2009. Innate cells and T helper 2 cell immunity in airway inflammation. Immunity 31: 425-437.
    • (2009) Immunity , vol.31 , pp. 425-437
    • Barrett, N.A.1    Austen, K.F.2
  • 34
    • 0036344597 scopus 로고    scopus 로고
    • Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma
    • Kuperman, D. A., X. Huang, L. L. Koth, G. H. Chang, G. M. Dolganov, Z. Zhu, J. A. Elias, D. Sheppard, and D. J. Erle. 2002. Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma. Nat. Med. 8: 885-889.
    • (2002) Nat. Med. , vol.8 , pp. 885-889
    • Kuperman, D.A.1    Huang, X.2    Koth, L.L.3    Chang, G.H.4    Dolganov, G.M.5    Zhu, Z.6    Elias, J.A.7    Sheppard, D.8    Erle, D.J.9
  • 35
    • 34247392438 scopus 로고    scopus 로고
    • Pharmacological modulation of the leukotriene pathway in allergic airway disease
    • DOI 10.1016/j.drudis.2007.03.004, PII S1359644607001043
    • Montuschi, P., A. Sala, S. E. Dahlén, and G. Folco. 2007. Pharmacological modulation of the leukotriene pathway in allergic airway disease. Drug Discov. Today 12: 404-412. (Pubitemid 46636374)
    • (2007) Drug Discovery Today , vol.12 , Issue.9-10 , pp. 404-412
    • Montuschi, P.1    Sala, A.2    Dahlen, S.-E.3    Folco, G.4
  • 38
    • 0025099697 scopus 로고
    • Distinct mechanisms of suppression of murine T cell activation by the related macrolides FK-506 and rapamycin
    • Dumont, F. J., M. J. Staruch, S. L. Koprak, M. R. Melino, and N. H. Sigal. 1990. Distinct mechanisms of suppression of murine T cell activation by the related macrolides FK-506 and rapamycin. J. Immunol. 144: 251-258. (Pubitemid 20030485)
    • (1990) Journal of Immunology , vol.144 , Issue.1 , pp. 251-258
    • Dumont, F.J.1    Staruch, M.J.2    Koprak, S.L.3    Melino, M.R.4    Sigal, N.H.5
  • 40
    • 77958151145 scopus 로고    scopus 로고
    • The S1P(1)-mTOR axis directs the reciprocal differentiation of T(H)1 and T(reg) cells
    • Liu, G., K. Yang, S. Burns, S. Shrestha, and H. Chi. 2010. The S1P(1)-mTOR axis directs the reciprocal differentiation of T(H)1 and T(reg) cells. Nat. Immunol. 11: 1047-1056.
    • (2010) Nat. Immunol. , vol.11 , pp. 1047-1056
    • Liu, G.1    Yang, K.2    Burns, S.3    Shrestha, S.4    Chi, H.5
  • 41
    • 20444373376 scopus 로고    scopus 로고
    • Rapamycin selectively expands CD4+CD25+FoxP3+ regulatory T cells
    • Battaglia, M., A. Stabilini, and M. G. Roncarolo. 2005. Rapamycin selectively expands CD4+CD25+FoxP3+ regulatory T cells. Blood 105: 4743-4748.
    • (2005) Blood , vol.105 , pp. 4743-4748
    • Battaglia, M.1    Stabilini, A.2    Roncarolo, M.G.3
  • 42
    • 46949088630 scopus 로고    scopus 로고
    • De novo induction of antigen-specific CD4+CD25+Foxp3+ regulatory T cells in vivo following systemic antigen administration accompanied by blockade of mTOR
    • DOI 10.1189/jlb.1207851
    • Kang, J., S. J. Huddleston, J. M. Fraser, and A. Khoruts. 2008. De novo induction of antigen-specific CD4+CD25+Foxp3+ regulatory T cells in vivo following systemic antigen administration accompanied by blockade of mTOR. J. Leukoc. Biol. 83: 1230-1239. (Pubitemid 351960355)
    • (2008) Journal of Leukocyte Biology , vol.83 , Issue.5 , pp. 1230-1239
    • Kang, J.1    Huddleston, S.J.2    Fraser, J.M.3    Khoruts, A.4
  • 44
    • 33745861719 scopus 로고    scopus 로고
    • + T cells
    • Valmori, D., V. Tosello, N. E. Souleimanian, E. Godefroy, L. Scotto, Y. Wang, and M. Ayyoub. 2006. Rapamycin-mediated enrichment of T cells with regulatory activity in stimulated CD4+ T cell cultures is not due to the selective expansion of naturally occurring regulatory T cells but to the induction of regulatory functions in conventional CD4+ T cells. J. Immunol. 177: 944-949. (Pubitemid 44036595)
    • (2006) Journal of Immunology , vol.177 , Issue.2 , pp. 944-949
    • Valmori, D.1    Tosello, V.2    Souleimanian, N.E.3    Godefroy, E.4    Scotto, L.5    Wang, Y.6    Ayyoub, M.7
  • 46
    • 34548723461 scopus 로고    scopus 로고
    • A review of anti-IgE monoclonal antibody (omalizumab) as add on therapy for severe allergic (IgE-mediated) asthma
    • D'Amato, G., A. Salzillo, A. Piccolo, M. D'Amato, and G. Liccardi. 2007. A review of anti-IgE monoclonal antibody (omalizumab) as add on therapy for severe allergic (IgE-mediated) asthma. Ther. Clin. Risk Manag. 3: 613-619. (Pubitemid 47496966)
    • (2007) Therapeutics and Clinical Risk Management , vol.3 , Issue.4 , pp. 613-619
    • D'Amato, G.1    Salzillo, A.2    Piccolo, A.3    D'Amato, M.4    Liccardi, G.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.