Localization of the C-terminus of rat glutathione S-transferase A1-1: Crystal structure of mutants W21F and W21F/F220Y

Proteins: Structure, Function and Genetics

Volumn 42, Issue 2, 2001, Pages 192-200

  Adman, Elinor T ^a   Le Trong, Isolde ^a   Stenkamp, Ronald E ^a   Nieslanik, Brenda S ^a   Dietze, Eric C ^a   Tai, Guoying ^a   Ibarra, Catherine ^a   Atkins, William M ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Glutathione S transferase; Glutathione sulfonate; Helix localization; X ray structure

Indexed keywords

GLUTATHIONE TRANSFERASE;

ALPHA HELIX; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CONFERENCE PAPER; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME CONFORMATION; ENZYME KINETICS; ENZYME LOCALIZATION; HYDROGEN BOND; NONHUMAN; PRIORITY JOURNAL; RAT; X RAY CRYSTALLOGRAPHY;

EID: 0035255021     PISSN: 08873585     EISSN: None     Source Type: Journal    
DOI: 10.1002/1097-0134(20010201)42:2<192::aid-prot60>3.0.co;2-%23     Document Type: Conference Paper

References (36)

1. The glutathione S-transferase supergene family: Regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance
2. Detoxication of base propenals and other alpha, beta-unsaturated aldehyde products of radical reactions and lipid peroxidation by human glutathione transferases
3. Glutathione-associated enzymes in anticancer drug resistance
4. Overexpression of the gene encoding the multidrug resistance-associated protein results in increased ATP-dependent glutathione S-conjugate transport
5. The isoenzymes of glutathione transferase
6. X-ray crystal structures of cytosolic glutathione S-transferases: Implications for protein architecture, substrate recognition and catalytic function
7. Glutathione S-transferase class kappa: Characterization by the cloning of rat mitochondrial GST and identification of a human homologue
8. Zeta, a novel class of glutathione transferases in a range of species from plants to humans
9. Theta, a new class of glutathione transferases purified from rat and man
10. Glutathione transferases - Structure and catalytic activity
11. Structural analysis of human alpha-class glutathione transferase A1-1 in the apo-form and in complexes with ethacrynic acid and its glutathione conjugate
12. Pressure-dependent ionization of Tyr 9 in glutathione S-transferase A1-1: Contribution of the C-terminal helix to a "soft" active site
13. Rational modulation of the catalytic activity of A1-1 glutathione S-transferase: Evidence for incorporation of an on-face (pi. . .HO-Ar) hydrogen bond at tyrosine-9
14. Oscillation Data Reduction Program
15. Processing of X-ray diffraction data collected in oscillation mode
16. AMoRe: An automated package for molecular replacement
17. The CCP4 Suite: Programs for Protein Crystallography
18. Improved methods for building protein models in electron density maps and the location of errors in these models
19. Improved Fourier coefficients for maps using phases from partial structures with errors
20. Assessment of phase accuracy by cross validation: The free R value: Methods and applications
21. PRO-CHECK: A program to check the stereochemical quality of protein structures
22. Ligand effects on the fluorescence properties of tyrosine-9 in alpha 1-1 glutathione S-transferase
23. Weakly polar interactions in proteins
24. NMR structural studies of glutathione S-transferase
25. Benzoic acid derivatives induce recovery of catalytic activity in the partially inactive Met208Lys mutant of human glutathione transferase A1-1
26. Crystal structure of a murine glutathione S-transferase in complex with a glutathione conjugate of 4-hydroxynon-2-enal in one subunit and glutathione in the other: Evidence of signaling across the dimer interface
27. Human glutathione transferase A4-4 crystal structures and mutagenesis reveal the basis of high catalytic efficiency with toxic lipid peroxidation products
28. Crystal structure of a murine alpha-class glutathione S-transferase involved in cellular defense against oxidative stress
29. Structure determination and refinement of human alpha class glutathione transferase A1-1, and a comparison with the Mu and Pi class enzymes
30. The role of tyrosine-9 and the C-terminal helix in the catalytic mechanism of alpha-class glutathione S-transferases
31. Involvement of the carboxyl groups of glutathione in the catalytic mechanism of human glutathione transferase A1-1
32. Role of the C-terminal helix 9 in the stability and ligandin function of class a glutathione transferase A1-1
33. Folding and assembly of dimeric human glutathione transferase A1-1
34. MOLSCRIPT: A program to produce both detailed and schematic plots of protein structures
35. Raster3D Version 2.0: A program for photorealistic molecular graphics