Pyrrolobenzodiazepine dimers: Novel sequence-selective, DNA-interactive, cross-linking agents with activity againts Gram-positive bacteria

Journal of Antimicrobial Chemotherapy

Volumn 56, Issue 3, 2005, Pages 513-518

  Hadjivassileva, Tsveta ^a   Thurston, David E ^a   Taylor, Peter W ^a  

^a UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

DNA cross linking agents; MRSA; Pyrrolobenzodiazepine dimers; Staphylococcus aureus; Vancomycin resistant enterococci

Indexed keywords

DNA; DOUBLE STRANDED DNA; DRG 16; ELB 21; GENOMIC DNA; METICILLIN; MONOMER; PYRROLO[2,1 C][1,4]BENZODIAZEPINE DERIVATIVE; SJG 136; UNCLASSIFIED DRUG; VANCOMYCIN;

ACINETOBACTER; ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIUM ISOLATE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA CROSS LINKING; DNA DENATURATION; DRUG DNA INTERACTION; DRUG MECHANISM; DRUG STRUCTURE; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; INCUBATION TIME; KLEBSIELLA; LISTERIA MONOCYTOGENES; MELTING POINT; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PROMOTER REGION; PROTEUS; PSEUDOMONAS; SENSITIVITY ANALYSIS; SEQUENCE ANALYSIS; STREPTOCOCCUS AGALACTIAE; STREPTOCOCCUS PYOGENES; STRUCTURE ANALYSIS; VANCOMYCIN RESISTANT ENTEROCOCCUS;

ANTI-BACTERIAL AGENTS; BENZODIAZEPINES; CROSS-LINKING REAGENTS; DIMERIZATION; DNA, BACTERIAL; GRAM-NEGATIVE BACTERIA; GRAM-POSITIVE BACTERIA; METHICILLIN RESISTANCE; MICROBIAL SENSITIVITY TESTS; PYRROLES; VANCOMYCIN RESISTANCE;

EID: 24644491729     PISSN: 03057453     EISSN: None     Source Type: Journal    
DOI: 10.1093/jac/dki256     Document Type: Article

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