Evaluation of the hydrolytic activity of a long-acting mutant bacterial cocaine in the presence of commonly co-administered drugs

Drug and Alcohol Dependence

Volumn 119, Issue 3, 2011, Pages 224-228

  Brim, Remy L ^a   Noon, Kathleen R ^a,b   Nichols, Joseph ^a   Narasimhan, Diwahar ^a   Woods, James H ^a   Sunahara, Roger K ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

^b MEDICAL COLLEGE OF WISCONSIN   (United States)

Author keywords

Benzodiazepines; Cocaine; Cocaine esterase; Cocaine toxicity

Indexed keywords

ALCOHOL; BACTERIAL COCAINE; CARBOXYLESTERASE; COCAINE DERIVATIVE; KETAMINE; METHAMPHETAMINE; MIDAZOLAM; MORPHINE; NALOXONE; NALTREXONE; PHENCYCLIDINE; UNCLASSIFIED DRUG;

ARTICLE; COCAINE DEPENDENCE; ENZYME ACTIVE SITE; HYDROLYSIS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MICHAELIS MENTEN KINETICS; MOLECULAR WEIGHT; PRIORITY JOURNAL; SPECTROPHOTOMETRY; TANDEM MASS SPECTROMETRY; THERMOSTABILITY;

BACTERIAL PROTEINS; CARBOXYLIC ESTER HYDROLASES; COCAINE; DIAZEPAM; DRUG EVALUATION, PRECLINICAL; DRUG INTERACTIONS; HYDROLYSIS; MASS SPECTROMETRY; MUTATION; PHARMACEUTICAL PREPARATIONS;

BACTERIA (MICROORGANISMS); PRIMATES; RODENTIA;

EID: 82555189761     PISSN: 03768716     EISSN: 18790046     Source Type: Journal    
DOI: 10.1016/j.drugalcdep.2011.06.018     Document Type: Article

References (34)

1. Boehrer J.D., Moliterno D.J., Willard J.E., Hillis L.D., Lange R.A. Influence of labetalol on cocaine-induced coronary vasoconstriction in humans. Am. J. Med. 1993, 94:608-610.
2. Bresler M.M., Rosser S.J., Basran A., Bruce N.C. Gene cloning and nucleotide sequencing and properties of a cocaine esterase from Rhodococcus sp. strain MB1. Appl. Environ. Microbiol. 2000, 66:904-908.
3. Brim R.L., Nance M.R., Youngstrom D.W., Narasimhan D., Zhan C.G., Tesmer J.J., Sunahara R.K., Woods J.H. A thermally stable form of bacterial cocaine esterase: a potential therapeutic agent for treatment of cocaine abuse. Mol. Pharmacol. 2010, 77:593-600.
4. Brimijoin S., Gao Y., Anker J.J., Gliddon L.A., Lafleur D., Shah R., Zhao Q., Singh M., Carroll M.E. A cocaine hydrolase engineered from human butyrylcholinesterase selectively blocks cocaine toxicity and reinstatement of drug seeking in rats. Neuropsychopharmacology 2008, 33:2715-2725.
5. Canning J., Brooks D.E., Gerkin R.D. Identifying patients with cocaine-related chest pain at true risk for beta-blocker toxicity. Arch. Intern. Med. 2010, 170:1859. author reply 1860.
6. Collins G.T., Carey K.A., Narasimhan D., Nichols J., Berlin A.A., Lukacs N.W., Sunahara R.K., Woods J.H., Ko M.C. Amelioration of the cardiovascular effects of cocaine in rhesus monkeys by a long-acting mutant form of cocaine esterase. Neuropsychopharmacology 2011, 36:1047-1059.
7. Collins G.T., Zaks M.E., Cunningham A.R., St. Clair C., Nichols J., Narasimhan D., Ko M.-C., Sunahara R.K., Woods J.H. Effects of a long-acting mutant bacterial cocaine esterase on acute cocaine toxicity in rats. Drug Alcohol Depend. 2011, Epub ahead of print: PMID: 21481548.
8. Cooper Z.D., Narasimhan D., Sunahara R.K., Mierzejewski P., Jutkiewicz E.M., Larsen N.A., Wilson I.A., Landry D.W., Woods J.H. Rapid and robust protection against cocaine-induced lethality in rats by the bacterial cocaine esterase. Mol. Pharmacol. 2006, 70:1885-1891.
9. Couper F.J., Logan B.K. Drug and Human Performance Fact Sheets 2004, NHTSA, Washington, DC.
10. Ferrari A., Bertolotti M., Dell'Utri A., Avico U., Sternieri E. Serum time course of naltrexone and 6[beta]-naltrexol levels during long term treatment in drug addicts. Drug Alcohol Depend. 1998, 52:211-220.
11. Freye E., Levy J. Pharmacology and Abuse of Cocaine, Amphetamines, Ecstasy and Related Designer Drugs: A Comprehensive Review on their Mode of Action, Treatment of Abuse and Intoxication 2009, Springer, Dordrecht.
12. Gao D., Narasimhan D.L., Macdonald J., Brim R., Ko M.C., Landry D.W., Woods J.H., Sunahara R.K., Zhan C.G. Thermostable variants of cocaine esterase for long-time protection against cocaine toxicity. Mol. Pharmacol. 2009, 75:318-323.
13. Gao Y., Brimijoin S. An engineered cocaine hydrolase blunts and reverses cardiovascular responses to cocaine in rats. J. Pharmacol. Exp. Ther. 2004, 310:1046-1052.
14. Gao Y., LaFleur D., Shah R., Zhao Q., Singh M., Brimijoin S. An albumin-butyrylcholinesterase for cocaine toxicity and addiction: catalytic and pharmacokinetic properties. Chem. Biol. Interact. 2008, 175:83-87.
15. Gupta A.K., Greller H.A., Hoffman R.S. Beta-blockers and cocaine: still a bad idea. Arch. Intern. Med 2010, 170:1859-1860. author reply 1860.
16. Jutkiewicz E.M., Baladi M.G., Cooper Z.D., Narasimhan D., Sunahara R.K., Woods J.H. A bacterial cocaine esterase protects against cocaine-induced epileptogenic activity and lethality. Ann. Emerg. Med. 2009, 54:409-420.
17. Karch S. Karch's Pathology of Drug Abuse 2001, CRC Press, Boca Raton.
18. Ko M.C., Bowen L.D., Narasimhan D., Berlin A.A., Lukacs N.W., Sunahara R.K., Cooper Z.D., Woods J.H. Cocaine esterase: interactions with cocaine and immune responses in mice. J. Pharmacol. Exp. Ther. 2007, 320:926-933.
19. Larsen N.A., Turner J.M., Stevens J., Rosser S.J., Basran A., Lerner R.A., Bruce N.C., Wilson I.A. Crystal structure of a bacterial cocaine esterase. Nat. Struct. Biol. 2002, 9:17-21.
20. Lynch T.J., Mattes C.E., Singh A., Bradley R.M., Brady R.O., Dretchen K.L. Cocaine detoxification by human plasma butyrylcholinesterase. Toxicol. Appl. Pharmacol. 1997, 145:363-371.
21. Mattes C.E., Lynch T.J., Singh A., Bradley R.M., Kellaris P.A., Brady R.O., Dretchen K.L. Therapeutic use of butyrylcholinesterase for cocaine intoxication. Toxicol. Appl. Pharmacol. 1997, 145:372-380.
22. Midazolam Hydrochloride [Package Insert] Lake Forest 2004, Hospira Inc., IL.
23. Narasimhan D., Nance M.R., Gao D., Ko M.C., Macdonald J., Tamburi P., Yoon D., Landry D.M., Woods J.H., Zhan C.G., Tesmer J.J., Sunahara R.K. Structural analysis of thermostabilizing mutations of cocaine esterase. Protein Eng. Des. Sel. 2010, 23:537-547.
24. Narcan (R) [Package Insert]. Chadds Ford 2003, Endo Pharmaceuticals, PA.
25. Ngo H.T.T., Arnold-Reed D.E., Hansson R.C., Tait R.J., Hulse G.K. Blood naltrexone levels over time following naltrexone implant. Prog. Neuropsychopharmacol. Biol. Psychiatry 2008, 32:23-28.
26. Pan Y., Gao D., Yang W., Cho H., Yang G., Tai H.H., Zhan C.G. Computational redesign of human butyrylcholinesterase for anticocaine medication. Proc. Natl. Acad. Sci. U.S.A. 2005, 102:16656-16661.
27. Rangel C., Shu R.G., Lazar L.D., Vittinghoff E., Hsue P.Y., Marcus G.M. Beta-blockers for chest pain associated with recent cocaine use. Arch. Intern. Med. 2010, 170:874-879.
28. Sand I.C., Brody S.L., Wrenn K.D., Slovis C.M. Experience with esmolol for the treatment of cocaine-associated cardiovascular complications. Am. J. Emerg. Med. 1991, 9:161-163.
29. Schrank K. Cocaine-related emergency department presentations. Acute Cocaine Intoxication: Current Methods of Treatment 1992, National Institutes of Health, Rockville, MD. H. Sorer (Ed.).
30. Substance Abuse and Mental Health Services Administration Results from the 2009 National Survey on Drug Use and Health: Volume I. Summary of National Findings, Office of Applied Studies, NSDUH Series H-38A 2010, HHS, Rockville, MD.
31. Turner J.M., Larsen N.A., Basran A., Barbas C.F., Bruce N.C., Wilson I.A., Lerner R.A. Biochemical characterization and structural analysis of a highly proficient cocaine esterase. Biochemistry 2002, 41:12297-12307.
32. US Department of Health and Human Services S.A.M.H.S.A. Office of Applied Studies. Drug Abuse Warning Network 2003: Interim National Estimates of Drug-Related Emergency Department Visits December 2004, http://www.drugabuse.gov/infofacts/HospitalVisits.html.
33. Wood S.K., Narasimhan D., Cooper Z., Sunahara R.K., Woods J.H. Prevention and reversal by cocaine esterase of cocaine-induced cardiovascular effects in rats. Drug Alcohol Depend. 2010, 106:219-229.
34. Xue L., Ko M.C., Tong M., Yang W., Hou S., Fang L., Liu J., Zheng F., Woods J.H., Tai H.H., Zhan C.G. Design, preparation, and characterization of high-activity mutants of human butyrylcholinesterase specific for detoxification of cocaine. Mol. Pharmacol. 2011, 79:290-297.