An albumin-butyrylcholinesterase for cocaine toxicity and addiction: Catalytic and pharmacokinetic properties

Chemico-Biological Interactions

Volumn 175, Issue 1-3, 2008, Pages 83-87

  Gao, Yang ^a   LaFleur, David ^b   Shah, Rutul ^b   Zhao, Qinghai ^b   Singh, Mallika ^b   Brimijoin, Stephen ^a  

^a MAYO CLINIC   (United States)

^b Drug Development   (United States)

Author keywords

Albumin fusion protein; Butyrylcholinesterase; Cocaine hydrolase; Enzyme kinetics; Pharmacokinetics; Rats

Indexed keywords

ALBUMIN; ALBUMIN BUTYRYLCHOLINESTERASE FUSION PROTEIN; CHOLINESTERASE; COCAINE; COCAINE HYDROLASE; HYBRID PROTEIN; HYDROLASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CATALYSIS; COCAINE DEPENDENCE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG ELIMINATION; DRUG HALF LIFE; DRUG METABOLISM; DRUG STABILITY; ENZYME ACTIVITY; EXTRACELLULAR FLUID; FEMALE; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN LOCALIZATION; RAT; WISTAR RAT;

ALBUMINS; ANIMALS; BIOCATALYSIS; BUTYRYLCHOLINESTERASE; COCAINE; COCAINE-RELATED DISORDERS; FEMALE; MALE; RATS; RATS, WISTAR;

ANIMALIA; RATTUS;

EID: 50649125211     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbi.2008.04.024     Document Type: Article

References (24)

1. Altamirano C., and Lockridge O. Association of tetramers of human butyrylcholinesterase is mediated by conserved aromatic residues of the carboxy terminus. Chem. Biol. Interact. 119-120 (1999) 53-60
2. Bresler M., Rosser S., Basran A., and Bruce N. Gene cloning and nucleotide sequencing and properties of a cocaine esterase from Rhodococcus sp. strain MB1. Appl. Environ. Microbiol. 66 (2000) 904-908
3. Brimijoin S., Gao Y., Anker J.J., Gliddon L.A., LaFleur D., Shah R., Zhang Q., Singh M., and Carroll M.E. A cocaine hydrolase engineered from human butyrylcholinesterase selectively blocks cocaine toxicity and reinstatement of drug seeking in rats. Neuropsychopharmacology (2008) January 16 [E pub ahead of print]
4. Brimijoin S., Shen M., and Sun H. Radiometric solvent-partitioning assay for screening cocaine hydrolases and measuring cocaine levels in milligram tissue samples. Analytical Biochemistry 309 (2002) 200-205
5. Carmona G., Jufer R., Goldberg S., Gorelick D., Greig N., Yu Q., Cone E., and Schindler C. Butyrylcholinesterase accelerates cocaine metabolism: in vitro and in vivo effects in nonhuman primates and humans. Drug Metab. Dispos. 28 (2000) 367-371
6. Chilukuri N., Parikh K., Sun W., Naik R., Tipparaju P., Doctor B.P., and Saxena A. Polyethylene glycosylation prolongs the circulatory stability of recombinant human butyrylcholinesterase. Chem. Biol. Interact. 157-158 (2005) 115-121
7. Cooper Z.D., Narasimhan D., Sunahara R.K., Mierrzejewski P., Jutkiewicz E.M., Larsen N.A., Wilson I.A., Landry D.W., and Woods J.H. Rapid and robust protection against cocaine-induced lethality in rats by the bacterial cocaine esterase. Mol. Pharmacol. 70 (2006) 1885-1891
8. Gao Y., Atanasova E., Nan S., Pancook J.D., Watkins J.D., and Brimijoin S. Gene transfer of cocaine hydrolase suppresses cardiovascular responses to cocaine in rats. Mol. Pharm. 67 (2005) 204-211
9. Gao Y., and Brimijoin S. An engineered cocaine hydrolase blunts and reverses cardiovascular responses to cocaine in rats. J. Pharmacol. Exp. Ther. 310 (2004) 1046-1052
10. Inaba T., Stewart D., and Kalow W. Metabolism of cocaine in man. Clin. Pharmacol. Ther. 23 (1978) 547-552
11. Johnson C.D., and Russell R.L. A rapid simple radiometric assay for cholinesterase, suitable for multiple determinations. Anal. Biochem. 64 (1975) 229-238
12. Ko M.C., Bowen L.D., Narasimhan D., Berlin A.A., Lukacs N.W., Sunahara R.K., Cooper Z.D., and Woods J.H. Cocaine esterase: interactions with cocaine and immune responses in mice. J. Pharmacol. Exp. Ther. 320 (2007) 926-933
13. Kronman C., Velan B., Marcus D., Ordentlich A., Reuveny S., and Shafferman A. Involvement of oligomerization, N-glycosylation and sialylation in the clearance of cholinesterases from the circulation. Biochem. J. 311 (1995) 959-967
14. Lynch T., Mattes C., Singh A., Bradley R., Brady R., and Dretchen K. Cocaine detoxification by human plasma butyrylcholinesterase. J. Appl. Pharmacol. 145 (1997) 363-371
15. Osborn B.L., Olsen H.S., Nardelli B., Murray J.H., Zhou J.X., Garcia A., Moody G., Zaritskaya L.S., and Sung C. Pharmacokinetic and pharmacodynamic studies of a human serum albumin-interferon-alpha fusion protein in cynomolgus monkeys. J. Pharmacol. Exp. Ther. 303 (2002) 540-548
16. Ostergaard D., Viby-Mogensen J., Hanel H.K., and Skovgaard L.T. Half-life of plasma cholinesterase. Acta Anaesthesiol. Scand. 32 (1988) 266-269
17. Pan Y., Gao D., Yang W., Cho H., Yang G., Tai H.H., and Zhan C.G. Computational redesign of human butyrylcholinesterase for anticocaine medication. Proc. Natl. Acad. Sci. U.S.A. 102 (2005) 16656-16661
18. Pancook J.D., Pecht G., Ader M., Lockridge M.M.O., and Watkins J.D. Application of directed evolution technology to optimize the cocaine hydrolase activity of human butyrylcholinesterase. FASEB J. 17 (2003) A565
19. Saxena A., Ashani Y., Raveh L., Stevenson D., Patel T., and Doctor B. Role of oligosaccharides in the pharmacokinetics of tissue-derived and genetically engineered cholinesterases. Mol. Pharmacol. 53 (1998) 112-122
20. Sun H., El Yazal J., Brimijoin S., and Pang Y.-P. Predicted Michaelis-Menten complexes of cocaine-butyrylcholinesterase: engineering effective butyrylcholinesterase mutants for cocaine detoxification. J. Biol. Chem. 276 (2001) 9330-9336
21. Sun H., Pang Y.P., Lockridge O., and Brimijoin S. Re-engineering butyrylcholinesterase as a cocaine hydrolase. Mol. Pharmacol. 62 (2002) 220-224
22. Sun H., Shen M.L., Pang Y.-P., Lockridge O., and Brimijoin S. Cocaine metabolism accelerated by a re-engineered human butyrylcholinesterase. JPET 302 (2002) 710-716
23. Sung C., Nardelli B., LaFleur D.W., Blatter E., Corcoran M., Olsen H.S., Birse C.E., Pickeral O.K., Zhang J., Shah D., Moody G., Gentz S., Beebe L., and Moore P.A. An IFN-beta-albumin fusion protein that displays improved pharmacokinetic and pharmacodynamic properties in nonhuman primates. J. Interferon Cytokine Res. 23 (2003) 25-36
24. Turner J.M., Larsen N.A., Basran A., Barbas III C.F., Bruce N.C., Wilson I.A., and Lerner R.A. Biochemical characterization and structural analysis of a highly proficient cocaine esterase. Biochemistry 41 (2002) 12297-12307