Difluoromethylbenzoxazole pyrimidine thioether derivatives: A novel class of potent non-nucleoside HIV-1 reverse transcriptase inhibitors

Journal of Medicinal Chemistry

Volumn 54, Issue 23, 2011, Pages 7974-7985

  Boyer, Jérémie ^a   Arnoult, Eric ^b   Médebielle, Maurice ^a   Guillemont, Jérôme ^b   Unge, Johan ^c   Jochmans, Dirk ^d,e  

^a UNIVERSITÉ LYON 1   (France)

^b Campus de Maigremont   (France)

^c LUND UNIVERSITY   (Sweden)

^d JANSSEN RESEARCH FOUNDATION   (Belgium)

^e REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

2 [DIFLUORO (4 METHYLPYRIMIDIN 2 YLSULFONYL)METHYL]BENZOXAZOLE; 2 [DIFLUORO [(4 AMINOPYRIMIDINYL)THIO]METHYL] 4 CHLOROBENZOXAZOLE; 2 [DIFLUORO [(4 AMINOPYRIMIDINYL)THIO]METHYL] 4 METHYLBENZOXAZOLE; 2 [DIFLUORO [(4 AMINOPYRIMIDINYL)THIO]METHYL]BENZOXAZOLE; 2 [DIFLUORO [(4 CYCLOPROPYLPYRIMIDINYL)THIO]METHYL]BENZOXAZOLE; 2 [DIFLUORO [(4 ETHYLPYRIMIDINYL)THIO]METHYL]BENZOXAZOLE; 2 [DIFLUORO [(4 ISOPROPYLPYRIMIDINYL)THIO]METHYL]BENZOXAZOLE; 2 [DIFLUORO [(4 METHYLPYRIMIDINYL)THIO]METHYL] 4 CHLOROBENZOXAZOLE; 2 [DIFLUORO [(4 METHYLPYRIMIDINYL)THIO]METHYL] 4 METHYLBENZOXAZOLE; 2 [DIFLUORO [(4 METHYLPYRIMIDINYL)THIO]METHYL] 7 CHLOROBENZOXAZOLE; 2 [DIFLUORO [(4 METHYLPYRIMIDINYL)THIO]METHYL] 7 METHYLBENZOXAZOLE; 2 [DIFLUORO [[4 (ACETAMIDYL)PYRIMIDINYL]THIO]METHYL]BENZOXAZOLE; 2 [DIFLUORO [[4 (METHOXYMETHYL)PYRIMIDINYL]THIO]METHYL]BENZOXAZOLE; NONNUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR; TMC 00597201; TMC 00597203; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; DRUG CYTOTOXICITY; DRUG POTENCY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN; NUCLEOPHILICITY; STRUCTURE ACTIVITY RELATION; TRADITIONAL MEDICINE;

ANTI-HIV AGENTS; BENZOXAZOLES; CELL LINE, TUMOR; HIV REVERSE TRANSCRIPTASE; HIV-1; HUMANS; MUTATION; PYRIMIDINES; REVERSE TRANSCRIPTASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP; SULFIDES;

EID: 82555187418     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm200766b     Document Type: Article

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