Synthesis and biological evaluation of aryl-phospho-indole as novel HIV-1 non-nucleoside reverse transcriptase inhibitors

Journal of Medicinal Chemistry

Volumn 54, Issue 1, 2011, Pages 392-395

  Alexandre, François René ^a   Amador, Agnès ^a   Bot, Stéphanie ^a   Caillet, Catherine ^a   Convard, Thierry ^a   Jakubik, Jocelyn ^c   Musiu, Chiara ^b   Poddesu, Barbara ^b   Vargiu, Luana ^b   Liuzzi, Michel ^b   Roland, Arlène ^a   Seifer, Maria ^c   Standring, David ^c   Storer, Richard ^a   Dousson, Cyril B ^a  

^a Laboratoires Idenix   (France)

^b UNIVERSITY OF CAGLIARI   (Italy)

^c Idenix Pharmaceuticals Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 PHENYL METHYL PHOSPHINATE 2 CARBOXAMIDE; NONNUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR; RNA DIRECTED DNA POLYMERASE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CHIRAL CHROMATOGRAPHY; CONTROLLED STUDY; DRUG METABOLISM; DRUG SCREENING; DRUG SOLUBILITY; DRUG SYNTHESIS; ENANTIOMER; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; NONHUMAN; RAT; VIRUS GENE; WILD TYPE;

ANIMALS; ANTI-HIV AGENTS; CELL LINE; DOGS; DRUG RESISTANCE, VIRAL; HAPLORHINI; HEPATOCYTES; HIV REVERSE TRANSCRIPTASE; HUMANS; INDOLES; MODELS, MOLECULAR; MUTATION; PHOSPHINIC ACIDS; RATS; REVERSE TRANSCRIPTASE INHIBITORS; SOLUBILITY; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 78651077251     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm101142k     Document Type: Article

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