Genistein inhibited proliferation and induced apoptosis in acute lymphoblastic leukemia, lymphoma and multiple myeloma cells in vitro

Leukemia and Lymphoma

Volumn 52, Issue 12, 2011, Pages 2380-2390

  Li, Wang ^a   Frame, Lynn T ^b   Hoo, Karlene A ^c   Li, Yuan ^d   D'Cunha, Nicholas ^a   Cobos, Everardo ^a  

^a TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER SCHOOL OF MEDICINE   (United States)

^b TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER   (United States)

^c Department of Electrical and Computer Engineering   (United States)

^d PEKING UNIVERSITY THIRD HOSPITAL   (China)

Author keywords

Genistein; Leukemia; Lymphoma; Multiple myeloma

Indexed keywords

CASPASE 3; CASPASE 7; CASPASE 9; CYCLIN B1; GENISTEIN; INHIBITOR OF APOPTOSIS PROTEIN 1; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NOTCH1 RECEPTOR; PROTEIN BCL 2; TRANSCRIPTION FACTOR GLI1;

ACUTE LYMPHOBLASTIC LEUKEMIA; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CELL CYCLE ARREST; CELL PROLIFERATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; LYMPHOMA; MULTIPLE MYELOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ANTINEOPLASTIC AGENTS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; GENISTEIN; HUMANS; LYMPHOMA; MULTIPLE MYELOMA; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA;

EID: 82255184042     PISSN: 10428194     EISSN: 10292403     Source Type: Journal    
DOI: 10.3109/10428194.2011.598251     Document Type: Article

References (68)

1. Adlercreutz H, Markkanen H, Watanabe S. Plasma concentrations of phyto-oestrogens in Japanese men. Lancet 1993;342:1209-1210. (Pubitemid 23331713)
2. Lampe JW, Nishino Y, Ray RM, et al. Plasma isof avones and f bro cystic breast conditions and breast cancer among women in Shanghai, China. Cancer Epidemiol Biomarkers Prev 2007;16: 2579-2586. (Pubitemid 351196312)
3. Mills PK, Beeson WL, Phillips RL, et al. Cohort study of diet, lifestyle, and prostate cancer in Adventist men. Cancer 1989; 64:598-604. (Pubitemid 19185206)
4. Kurahashi N, Iwasaki M, Sasazuki S, et al. Soy product and isof avone consumption in relation to prostate cancer in Japanese men. Cancer Epidemiol Biomarkers Prev 2007;16:538-545. (Pubitemid 46548658)
5. He H, Chen L, Zhai M, Chen JZ. Genistein down-regulates the constitutive activation of nuclear factor-kappaB in human multiple myeloma cells, leading to suppression of proliferation and induction of apoptosis. Phytother Res 2009;23:868-873.
6. Sanchez Y, Amran D, Fernandez C, et al. Genistein selectively potentiates arsenic trioxide-induced apoptosis in human leukemia cells via reactive oxygen species generation and activation of reactive oxygen species-inducible protein kinases (p38-MAPK, AMPK). Int J Cancer 2008;123:1205-1214.
7. Park SS, Kim YN, Jeon YK, et al. Genistein-induced apoptosis via Akt signaling pathway in anaplastic large-cell lymphoma. Cancer Chemother Pharmacol 2005;56:271-278. (Pubitemid 40941797)
8. Power KA, Saarinen NM, Chen JM, et al. Mammalian lignans enterolactone and enterodiol, alone and in combination with the isof avone genistein, do not promote the growth of MCF-7 xenografts in ovariectomized athymic nude mice. Int J Cancer 2006;118:1316-1320. (Pubitemid 43185623)
9. Mohammad RM, Al-Katib A, Aboukameel A, et al. Genistein sensitizes dif use large cell lymphoma to CHOP (cyclophos phamide, doxorubicin, vincristine, prednisone) chemotherapy. Mol Cancer T er 2003;2:1361-1368.
10. Kyle E, Neckers L, Takimoto C, et al. Genistein-induced apoptosis of prostate cancer cells is preceded by a specif c decrease in focal adhesion kinase activity. Mol Pharmacol 1997;51:193-200. (Pubitemid 27074139)
11. Kiguchi K, Constantinou AI, Huberman E. Genistein-induced cell dif erentiation and protein-linked DNA strand breakage in human melanoma cells. Cancer Commun 1990;2:271-277.
12. Finlay GJ, Holdaway KM, Baguley BC. Comparison of the effects of genistein and amsacrine on leukemia cell proliferation. Oncol Res 1994;6:33-37. (Pubitemid 24209925)
13. Suzuki K, Koike H, Matsui H, et al. Genistein, a soy isof avone, induces glutathione peroxidase in the human prostate cancer cell lines LNCaP and PC-3. Int J Cancer 2002;99:846-852. (Pubitemid 34575703)
14. Wei H, Bowen R, Cai Q, et al. Antioxidant and antipromotional effects of the soybean isof avone genistein. Proc Soc Exp Biol Med 1995;208:124-130.
15. Fryer RA, Galustian C, Dalgleish AG. Recent advances and developments in treatment strategies against pancreatic cancer. Curr Clin Pharmacol 2009;4:102-112.
16. Zhou HB, Chen JJ, Wang WX, et al. Apoptosis of human primary gastric carcinoma cells induced by genistein. World J Gastroenterol 2004;10:1822-1825.
17. Zou H, Zhan S, Cao K. Apoptotic activity of genistein on human lung adenocarcinoma SPC-A-1 cells and preliminary exploration of its mechanisms using microarray. Biomed Pharmacother 2008;62: 583-589.
18. Ye F, Wu J, Dunn T, et al. Inhibition of cyclooxygenase-2 activity in head and neck cancer cells by genistein. Cancer Lett 2004;211: 39-46. (Pubitemid 38759767)
19. Jin CY, Park C, Moon SK, et al. Genistein sensitizes human hepatocellular carcinoma cells to TRAIL-mediated apoptosis by enhancing Bid cleavage. Anticancer Drugs 2009;20:713-722.
20. Jin CY, Park C, Kim GY, et al. Genistein enhances TRAIL-induced apoptosis through inhibition of p38 MAPK signaling in human hepatocellular carcinoma Hep3B cells. Chem Biol Interact 2009; 180:143-150.
21. Hillman GG, Wang Y, Che M, et al. Progression of renal cell carcinoma is inhibited by genistein and radiation in an orthotopic model. BMC Cancer 2007;7:4.
22. Shen J, Tai YC, Zhou J, et al. Synergistic antileukemia effect of genistein and chemotherapy in mouse xenograft model and potential mechanism through MAPK signaling. Exp Hematol 2007;35:75-83.
23. Traganos F, Ardelt B, Halko N, et al. effects of genistein on the growth and cell cycle progression of normal human lymphocytes and human leukemic MOLT-4 and HL-60 cells. Cancer Res 1992;52: 6200-6208.
24. McCall JL, Burich RA, Mack PC. GCP, a genistein-rich compound, inhibits proliferation and induces apoptosis in lymphoma cell lines. Leuk Res 2010;34:69-76.
25. Martinez-Lorenzo MJ, Anel A, Monleon I, et al. Tyrosine phosphorylation of the p85 subunit of phosphatidylinositol 3-kinase correlates with high proliferation rates in sublines derived from the Jurkat leukemia. Int J Biochem Cell Biol 2000;32:435-445. (Pubitemid 30101624)
26. Park J, Chung SW, Kim SH, et al. Up-regulation of interleukin-4 production via NF-AT/AP-1 activation in T cells by biochanin A, a phytoestrogen and its metabolites. Toxicol Appl Pharmacol 2006;212:188-199.
27. Keshelava N, Frgala T, Krejsa J, et al. DIMSCAN: a microcomputer f uorescence-based cytotoxicity assay for preclinical testing of combination chemotherapy. Methods Mol Med 2005;110:139-153.
28. Li X, Darzynkiewicz Z. Cleavage of poly(ADP-ribose) polymerase measured in situ in individual cells: relationship to DNA fragmentation and cell cycle position during apoptosis. Exp Cell Res 2000;255: 125-132. (Pubitemid 30115295)
29. Stong RC, Korsmeyer SJ, Parkin JL, et al. Human acute leukemia cell line with the t(4;11) chromosomal rearrangement exhibits B lineage and monocytic characteristics. Blood 1985;65:21-31. (Pubitemid 15191033)
30. Foley GE, Lazarus H, Farber S, et al. Continuous culture of human lymphoblasts from peripheral blood of a child with acute leukemia. Cancer 1965;18:522-529.
31. Gabay C, Ben-Bassat H, Schlesinger M, et al. Somatic mutations and intraclonal variations in the rearranged Vkappa genes of B-non-Hodgkin's lymphoma cell lines. Eur J Haematol 1999; 63:180-191. (Pubitemid 29406735)
32. Rapoport AP, Simons-Evelyn M, Chen T, et al. Flavopiridol induces apoptosis and caspase-3 activation of a newly characterized Burkitt's lymphoma cell line containing mutant p53 genes. Blood Cells Mol Dis 2001;27:610-624. (Pubitemid 32757056)
33. Katagiri S, Yonezawa T, Kuyama J, et al. Two distinct human myeloma cell lines originating from one patient with myeloma. Int J Cancer 1985;36:241-246. (Pubitemid 15243451)
34. Nilsson K, Bennich H, Johansson SG, Ponten J. Established immunoglobulin producing myeloma (IgE) and lymphoblastoid (IgG) cell lines from an IgE myeloma patient. Clin Exp Immunol 1970;7: 477-489.
35. Carlo-Stella C, Regazzi E, Garau D, et al. effect of the protein tyrosine kinase inhibitor genistein on normal and leukaemic haemopoietic progenitor cells. Br J Haematol 1996;93:551-557. (Pubitemid 26167364)
36. Aikawa S, Hatta Y, Tanaka M, et al. Requirement of soluble factors produced by bone marrow stromal cells on the growth of novel established human myeloma cell line. Int J Oncol 2003;22: 631-637.
37. Van Riet I, Van Camp B. Te involvement of adhesion molecules in the biology of multiple myeloma. Leuk Lymphoma 1993;9:441-452. (Pubitemid 23209529)
38. Blagosklonny MV. Cell death beyond apoptosis. Leukemia 2000;14:1502-1508. (Pubitemid 30601357)
39. Duriez PJ, Shah GM. Cleavage of poly(ADP-ribose) polymerase: a sensitive parameter to study cell death. Biochem Cell Biol 1997;75: 337-349. (Pubitemid 127733184)
40. Bouchard VJ, Rouleau M, Poirier GG. PARP-1, a determinant of cell survival in response to DNA damage. Exp Hematol 2003;31: 446-454. (Pubitemid 36793950)
41. de Graaf AO, de Witte T, Jansen JH. Inhibitor of apoptosis proteins: new therapeutic targets in hematological cancer? Leukemia 2004;18:1751-1759. (Pubitemid 39530002)
42. Grzybowska-Izydorczyk O, Smolewski P. Te role of the inhibitor of apoptosis protein (IAP) family in hematological malignancies. Postepy Hig Med Dosw (Online) 2008;62:55-63.
43. Takada Y, Andreef M, Aggarwal BB. Indole-3-carbinol suppresses NF-kappaB and IkappaBalpha kinase activation, causing inhibition of expression of NF-kappaB-regulated antiapoptotic and metastatic gene products and enhancement of apoptosis in myeloid and leukemia cells. Blood 2005;106:641-649. (Pubitemid 40981262)
44. Tsujimoto Y, Finger LR, Yunis J, Nowell PC, Croce CM. Cloning of the chromosome breakpoint of neoplastic B cells with the t(14;18) chromosome translocation. Science 1984;226:1097-1099. (Pubitemid 15217831)
45. Kuo ML, Huang TS, Lin JK. Curcumin, an antioxidant and anti-tumor promoter, induces apoptosis in human leukemia cells. Biochim Biophys Acta 1996;1317:95-100.
46. Yamasaki M, Fujita S, Ishiyama E, et al. Soy-derived isof avones inhibit the growth of adult T-cell leukemia cells in vitro and in vivo. Cancer Sci 2007;98:1740-1746. (Pubitemid 47487910)
47. Spinozzi F, Pagliacci MC, Migliorati G, et al. Te natural tyrosine kinase inhibitor genistein produces cell cycle arrest and apoptosis in Jurkat T-leukemia cells. Leuk Res 1994;18:431-439. (Pubitemid 24169825)
48. Jeong MH, Jin YH, Kang EY, et al. Te modulation of radiation-induced cell death by genistein in K562 cells: activation of thymidine kinase 1. Cell Res 2004;14:295-302. (Pubitemid 43231811)
49. Pines J, Hunter T. Isolation of a human cyclin cDNA: evidence for cyclin mRNA and protein regulation in the cell cycle and for interaction with p34cdc2. Cell 1989;58:833-846. (Pubitemid 19227894)
50. Sanchez Y, Amran D, de Blas E, et al. Regulation of genistein-induced dif erentiation in human acute myeloid leukaemia cells (HL60, NB4) protein kinase modulation and reactive oxygen species generation. Biochem Pharmacol 2009;77:384-396.
51. Borgne A, Versteege I, Mahe M, et al. Analysis of cyclin B1 and CDK activity during apoptosis induced by camptothecin treatment. Oncogene 2006;25:7361-7372. (Pubitemid 44853427)
52. Huang X, Kurose A, Tanaka T, et al. Activation of ATM and histone H2AX phosphorylation induced by mitoxantrone but not by topotecan is prevented by the antioxidant N-acetyl-L-cysteine. Cancer Biol T er 2006;5:959-964.
53. Porter LA, Singh G, Lee JM. Abundance of cyclin B1 regulates gamma-radiation-induced apoptosis. Blood 2000;95:2645-2650. (Pubitemid 30210545)
54. Weng AP, Ferrando AA, Lee W, et al. Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia. Science 2004;306:269-271. (Pubitemid 39336870)
55. Jundt F, Schwarzer R, Dorken B. Notch signaling in leukemias and lymphomas. Curr Mol Med 2008;8:51-59. (Pubitemid 351516824)
56. Murata-Ohsawa M, Tohda S, Nara N. Cellular analysis of growth suppression induced by the Notch ligands, Delta-1 and Jagged-1 in two myeloid leukemia cell lines. Int J Mol Med 2004;14:223-226.
57. Tohda S, Kogoshi H, Murakami N, et al. Diverse effects of the Notch ligands Jagged1 and Delta1 on the growth and dif erentiation of primary acute myeloblastic leukemia cells. Exp Hematol 2005;33: 558-563. (Pubitemid 40592172)
58. Jundt F, Probsting KS, Anagnostopoulos I, et al. Jagged1-induced Notch signaling drives proliferation of multiple myeloma cells. Blood 2004;103:3511-3515. (Pubitemid 38525685)
59. Jundt F, Anagnostopoulos I, Forster R, et al. Activated Notch1 signaling promotes tumor cell proliferation and survival in Hodgkin and anaplastic large cell lymphoma. Blood 2002;99:3398-3403. (Pubitemid 34525322)
60. Ferrando AA. Te role of NOTCH1 signaling in T-ALL. Hematology Am Soc Hematol Educ Program 2009:353-361.
61. Berman DM, Karhadkar SS, Maitra A, et al. Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours. Nature 2003;425:846-851. (Pubitemid 37351469)
62. Tayer SP, di Magliano MP, Heiser PW, et al. Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis. Nature 2003;425:851-856. (Pubitemid 37355945)
63. Watkins DN, Berman DM, Burkholder SG, et al. Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer. Nature 2003;422:313-317. (Pubitemid 36378358)
64. Kim JE, Singh RR, Cho-Vega JH, et al. Sonic hedgehog signaling proteins and ATP-binding cassette G2 are aberrantly expressed in dif use large B-cell lymphoma. Mod Pathol 2009;22:1312-1320.
65. Kawahara T, Kawaguchi-Ihara N, Okuhashi Y, et al. Cyclopamine and quercetin suppress the growth of leukemia and lymphoma cells. Anticancer Res 2009;29:4629-4632.
66. Singh RR, Kim JE, Davuluri Y, et al. Hedgehog signaling pathway is activated in dif use large B-cell lymphoma and contributes to tumor cell survival and proliferation. Leukemia 2010;24:1025-1036.
67. Peterson G. Evaluation of the biochemical targets of genistein in tumor cells. J Nutr 1995;125:784S-789S.
68. Uckun FM, Dibirdik I, Qazi S, et al. T erapeutic nanoparticle constructs of a JAK3 tyrosine kinase inhibitor against human B-lineage ALL cells. Arzneimittelforschung 2010;60:210-217.