Differential expression of arrestins is a predictor of breast cancer progression and survival

Breast Cancer Research and Treatment

Volumn 130, Issue 3, 2011, Pages 791-807

  Michal, Allison M ^a   Peck, Amy R ^a   Tran, Thai H ^a   Liu, Chengbao ^a   Rimm, David L ^b   Rui, Hallgeir ^a   Benovic, Jeffrey L ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Arrestin; Breast carcinoma; Immunohistochemistry; Metastasis; Survival

Indexed keywords

ARRESTIN 2; ARRESTIN 3; RETINA S ANTIGEN; UNCLASSIFIED DRUG;

ARTICLE; BREAST CANCER; BREAST CARCINOMA; BREAST EPITHELIUM; BREAST TUMOR; CANCER CELL; CANCER GRADING; CANCER GROWTH; CANCER INVASION; CANCER SURVIVAL; HUMAN; HUMAN TISSUE; IMMUNOFLUORESCENCE; INTRADUCTAL CARCINOMA; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MYOEPITHELIUM CELL; PREDICTIVE VALUE; PRIORITY JOURNAL; PROGNOSIS; QUANTITATIVE ANALYSIS; TUMOR VOLUME;

ARRESTINS; BREAST NEOPLASMS; CELL LINE, TUMOR; DISEASE PROGRESSION; EPITHELIAL CELLS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MAMMARY GLANDS, HUMAN; NEOPLASM INVASIVENESS; PROGNOSIS; SURVIVAL ANALYSIS; TUMOR MARKERS, BIOLOGICAL;

EID: 82255163335     PISSN: 01676806     EISSN: 15737217     Source Type: Journal    
DOI: 10.1007/s10549-011-1374-9     Document Type: Article

References (62)

1. American Cancer Society (2009) Breast cancer facts & figures 2009-2010. American Cancer Society Inc., Atlanta, GA
2. T Sorlie R Tibshirani J Parker T Hastie JS Marron A Nobel S Deng H Johnsen R Pesich S Geisler J Demeter CM Perou PE Lonning PO Brown AL Borresen-Dale D Botstein 2003 Repeated observation of breast tumor subtypes in independent gene expression data sets Proc Natl Acad Sci USA 100 8418 8423 10.1073/pnas.0932692100 12829800 10.1073/pnas.0932692100 1:CAS:528: DC%2BD3sXlsFGntLk%3D (Pubitemid 36842560)
3. LA Carey CM Perou CA Livasy LG Dressler D Cowan K Conway G Karaca MA Troester CK Tse S Edmiston SL Deming J Geradts MC Cheang TO Nielsen PG Moorman HS Earp RC Millikan 2006 Race, breast cancer subtypes, and survival in the Carolina Breast Cancer Study JAMA 295 2492 2502 10.1001/jama.295.21.2492 16757721 10.1001/jama.295.21.2492 1:CAS:528:DC%2BD28XlsV2rtLw%3D (Pubitemid 43854964)
4. CM Perou T Sorlie MB Eisen M van de Rijn SS Jeffrey CA Rees JR Pollack DT Ross H Johnsen LA Akslen O Fluge A Pergamenschikov C Williams SX Zhu PE Lonning AL Borresen-Dale PO Brown D Botstein 2000 Molecular portraits of human breast tumours Nature 406 747 752 10.1038/35021093 10963602 10.1038/35021093 1:CAS:528:DC%2BD3cXmt1CnsLw%3D
5. RM Neve K Chin J Fridlyand J Yeh FL Baehner T Fevr L Clark N Bayani JP Coppe F Tong T Speed PT Spellman S DeVries A Lapuk NJ Wang WL Kuo JL Stilwell D Pinkel DG Albertson FM Waldman F McCormick RB Dickson MD Johnson M Lippman S Ethier A Gazdar JW Gray 2006 A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes Cancer Cell 10 515 527 10.1016/j.ccr.2006.10.008 17157791 10.1016/j.ccr.2006.10.008 1:CAS:528:DC%2BD28XhtlCnsrbE (Pubitemid 44854747)
6. T Sorlie CM Perou R Tibshirani T Aas S Geisler H Johnsen T Hastie MB Eisen M van de Rijn SS Jeffrey T Thorsen H Quist JC Matese PO Brown D Botstein P Eystein Lonning AL Borresen-Dale 2001 Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications Proc Natl Acad Sci USA 98 10869 10874 10.1073/pnas.191367098 11553815 10.1073/pnas. 191367098 1:CAS:528:DC%2BD3MXntVGmsbo%3D (Pubitemid 32878711)
7. LM Luttrell 2006 Transmembrane signaling by G protein-coupled receptors Methods Mol Biol 332 3 49 16878684 1:CAS:528:DC%2BD28Xjtleltb4%3D
8. RT Dorsam JS Gutkind 2007 G-protein-coupled receptors and cancer Nat Rev Cancer 7 79 94 17251915 10.1038/nrc2069 1:CAS:528:DC%2BD2sXotFOisw%3D%3D (Pubitemid 46164746)
9. RJ Lefkowitz 2004 Historical review: a brief history and personal retrospective of seven-transmembrane receptors Trends Pharmacol Sci 25 413 422 15276710 10.1016/j.tips.2004.06.006 1:CAS:528:DC%2BD2cXmtVaht7k%3D (Pubitemid 38981557)
10. JG Krupnick JL Benovic 1998 The role of receptor kinases and arrestins in G protein-coupled receptor regulation Annu Rev Pharmacol Toxicol 38 289 319 10.1146/annurev.pharmtox.38.1.289 9597157 10.1146/annurev.pharmtox.38.1.289 1:CAS:528:DyaK1cXivF2itb8%3D (Pubitemid 28231497)
11. CA Moore SK Milano JL Benovic 2007 Regulation of receptor trafficking by GRKs and arrestins Annu Rev Physiol 69 451 482 10.1146/annurev.physiol.69. 022405.154712 17037978 10.1146/annurev.physiol.69.022405.154712 1:CAS:528:DC%2BD2sXltVaksLs%3D (Pubitemid 46457651)
12. SM DeWire S Ahn RJ Lefkowitz SK Shenoy 2007 Beta-arrestins and cell signaling Annu Rev Physiol 69 483 510 10.1146/annurev.ph.69.013107.100021 17305471 10.1146/annurev.physiol.69.022405.154749 1:CAS:528:DC%2BD2sXltVaksLg%3D
13. J Kang Y Shi B Xiang B Qu W Su M Zhu M Zhang G Bao F Wang X Zhang R Yang F Fan X Chen G Pei L Ma 2005 A nuclear function of beta-arrestin1 in GPCR signaling: regulation of histone acetylation and gene transcription Cell 123 833 847 10.1016/j.cell.2005.09.011 16325578 10.1016/j.cell.2005.09.011 1:CAS:528:DC%2BD2MXhtlWntLjE (Pubitemid 41721030)
14. L Ge Y Ly M Hollenberg K DeFea 2003 A beta-arrestin-dependent scaffold is associated with prolonged MAPK activation in pseudopodia during protease-activated receptor-2-induced chemotaxis J Biol Chem 278 34418 34426 10.1074/jbc.M300573200 12821670 10.1074/jbc.M300573200 1:CAS:528: DC%2BD3sXmvVCqtr4%3D (Pubitemid 37553288)
15. Y Sun Z Cheng L Ma G Pei 2002 Beta-arrestin2 is critically involved in CXCR4-mediated chemotaxis, and this is mediated by its enhancement of p38 MAPK activation J Biol Chem 277 49212 49219 12370187 10.1074/jbc.M207294200 1:CAS:528:DC%2BD38XpsFaluro%3D (Pubitemid 36014350)
16. M Zoudilova P Kumar L Ge P Wang GM Bokoch KA DeFea 2007 Beta-arrestin-dependent regulation of the cofilin pathway downstream of protease-activated receptor-2 J Biol Chem 282 20634 20646 10.1074/jbc.M701391200 17500066 10.1074/jbc.M701391200 1:CAS:528:DC%2BD2sXnsFWmsrw%3D (Pubitemid 47100047)
17. M Zoudilova J Min HL Richards D Carter T Huang KA DeFea 2010 beta-Arrestins scaffold cofilin with chronophin to direct localized actin filament severing and membrane protrusions downstream of protease-activated receptor-2 J Biol Chem 285 14318 14329 10.1074/jbc.M109.055806 20207744 10.1074/jbc.M109.055806 1:CAS:528:DC%2BC3cXlsVOiu7o%3D
18. P Wang KA DeFea 2006 Protease-activated receptor-2 simultaneously directs beta-arrestin-1-dependent inhibition and Galphaq-dependent activation of phosphatidylinositol 3-kinase Biochemistry 45 9374 9385 16878972 10.1021/bi0602617 1:CAS:528:DC%2BD28Xms1eqt7g%3D (Pubitemid 44223242)
19. FG Buchanan DL Gorden P Matta Q Shi LM Matrisian RN DuBois 2006 Role of beta-arrestin 1 in the metastatic progression of colorectal cancer Proc Natl Acad Sci USA 103 1492 1497 16432186 10.1073/pnas.0510562103 1:CAS:528: DC%2BD28Xhs1Gns7c%3D (Pubitemid 43191193)
20. V Lakshmikanthan L Zou JI Kim A Michal Z Nie NC Messias JL Benovic Y Daaka 2009 Identification of betaArrestin2 as a corepressor of androgen receptor signaling in prostate cancer Proc Natl Acad Sci USA 106 9379 9384 10.1073/pnas.0900258106 19458261 10.1073/pnas.0900258106 1:CAS:528: DC%2BD1MXot1Cgur0%3D
21. H Shankar A Michal RC Kern DS Kang VV Gurevich JL Benovic 2010 Non-visual arrestins are constitutively associated with the centrosome and regulate centrosome function J Biol Chem 285 8316 8329 10.1074/jbc.M109.062521 20056609 10.1074/jbc.M109.062521 1:CAS:528:DC%2BC3cXisl2jtr4%3D
22. SK Raghuwanshi MW Nasser X Chen RM Strieter RM Richardson 2008 Depletion of beta-arrestin-2 promotes tumor growth and angiogenesis in a murine model of lung cancer J Immunol 180 5699 5706 18390755 1:CAS:528:DC%2BD1cXkt1artbw%3D
23. L Zou R Yang J Chai G Pei 2008 Rapid xenograft tumor progression in beta-arrestin1 transgenic mice due to enhanced tumor angiogenesis FASEB J 22 355 364 10.1096/fj.07-9046com 17890288 10.1096/fj.07-9046com 1:CAS:528: DC%2BD1cXhvVSqsLg%3D (Pubitemid 351227345)
24. MJ LeBaron HR Crismon FE Utama LM Neilson AS Sultan KJ Johnson EC Andersson H Rui 2005 Ultrahigh density microarrays of solid samples Nat Methods 2 511 513 15973421 10.1038/nmeth772 1:CAS:528:DC%2BD2MXltl2ntbc%3D (Pubitemid 41131156)
25. TH Tran FE Utama J Lin N Yang AB Sjolund A Ryder KJ Johnson LM Neilson C Liu KL Brill AL Rosenberg AK Witkiewicz H Rui 2010 Prolactin inhibits BCL6 expression in breast cancer through a Stat5a-dependent mechanism Cancer Res 15 1711 1721 10.1158/0008-5472.CAN-09-2314
26. M Dolled-Filhart L Ryden M Cregger K Jirstrom M Harigopal RL Camp DL Rimm 2006 Classification of breast cancer using genetic algorithms and tissue microarrays Clin Cancer Res 12 6459 6468 10.1158/1078-0432.CCR-06-1383 17085660 10.1158/1078-0432.CCR-06-1383 1:CAS:528:DC%2BD28XhtFKitb3P (Pubitemid 44799719)
27. RL Camp GG Chung DL Rimm 2002 Automated subcellular localization and quantification of protein expression in tissue microarrays Nat Med 8 1323 1327 10.1038/nm791 12389040 10.1038/nm791 1:CAS:528:DC%2BD38XotlWlsrc%3D (Pubitemid 35373567)
28. RL Camp M Dolled-Filhart DL Rimm 2004 X-tile: a new bio-informatics tool for biomarker assessment and outcome-based cut-point optimization Clin Cancer Res 10 7252 7259 10.1158/1078-0432.CCR-04-0713 15534099 10.1158/1078-0432.CCR- 04-0713 1:CAS:528:DC%2BD2cXpsVKltbc%3D (Pubitemid 39487712)
29. LM McShane DG Altman W Sauerbrei SE Taube M Gion GM Clark 2005 Reporting recommendations for tumor marker prognostic studies J Clin Oncol 23 9067 9072 16172462 10.1200/JCO.2004.01.0454
30. PA Kenny GY Lee CA Myers RM Neve JR Semeiks PT Spellman K Lorenz EH Lee MH Barcellos-Hoff OW Petersen JW Gray MJ Bissell 2007 The morphologies of breast cancer cell lines in three-dimensional assays correlate with their profiles of gene expression Mol Oncol 1 84 96 10.1016/j.molonc.2007.02.004 18516279 10.1016/j.molonc.2007.02.004 1:CAS:528:DC%2BD2sXhtlOitbbO (Pubitemid 46776616)
31. T Gudjonsson MC Adriance MD Sternlicht OW Petersen MJ Bissell 2005 Myoepithelial cells: their origin and function in breast morphogenesis and neoplasia J Mammary Gland Biol Neoplasia 10 261 272 10.1007/s10911-005-9586-4 16807805 10.1007/s10911-005-9586-4
32. T Gudjonsson L Ronnov-Jessen R Villadsen F Rank MJ Bissell OW Petersen 2002 Normal and tumor-derived myoepithelial cells differ in their ability to interact with luminal breast epithelial cells for polarity and basement membrane deposition J Cell Sci 115 39 50 11801722 1:CAS:528:DC%2BD38XovVejtA%3D%3D (Pubitemid 34105527)
33. JR Sainsbury TJ Anderson DA Morgan 2000 ABC of breast diseases: breast cancer BMJ 321 745 750 10999911 10.1136/bmj.321.7263.745 1:STN:280: DC%2BD3cvpt1yqtg%3D%3D
34. G Gimpl F Fahrenholz 2001 The oxytocin receptor system: structure, function, and regulation Physiol Rev 81 629 683 11274341 1:CAS:528: DC%2BD3MXislCrsLk%3D (Pubitemid 32267075)
35. A Sapino L Macri L Tonda G Bussolati 1993 Oxytocin enhances myoepithelial cell differentiation and proliferation in the mouse mammary gland Endocrinology 133 838 842 8344220 10.1210/en.133.2.838 1:CAS:528:DyaK3sXmtFOrsrg%3D (Pubitemid 23238900)
36. K Nishimori LJ Young Q Guo Z Wang TR Insel MM Matzuk 1996 Oxytocin is required for nursing but is not essential for parturition or reproductive behavior Proc Natl Acad Sci USA 93 11699 11704 8876199 10.1073/pnas.93.21.11699 1:CAS:528:DyaK28Xmtlansrs%3D (Pubitemid 26347185)
37. KU Wagner WS Young 3rd X Liu EI Ginns M Li PA Furth L Hennighausen 1997 Oxytocin and milk removal are required for post-partum mammary-gland development Genes Funct 1 233 244 9678900 10.1046/j.1365-4624.1997.00024.x 1:CAS:528:DyaK1cXmsFWhtA%3D%3D
38. S Ahn H Wei TR Garrison RJ Lefkowitz 2004 Reciprocal regulation of angiotensin receptor-activated extracellular signal-regulated kinases by beta-arrestins 1 and 2 J Biol Chem 279 7807 7811 10.1074/jbc.C300443200 14711824 10.1074/jbc.C300443200 1:CAS:528:DC%2BD2cXhsFejtrw%3D (Pubitemid 38294665)
39. XR Ren E Reiter S Ahn J Kim W Chen RJ Lefkowitz 2005 Different G protein-coupled receptor kinases govern G protein and beta-arrestin-mediated signaling of V2 vasopressin receptor Proc Natl Acad Sci USA 102 1448 1453 10.1073/pnas.0409534102 15671180 10.1073/pnas.0409534102 1:CAS:528: DC%2BD2MXhs1Kltrs%3D (Pubitemid 40209190)
40. L Ge SK Shenoy RJ Lefkowitz K DeFea 2004 Constitutive protease-activated receptor-2-mediated migration of MDA MB-231 breast cancer cells requires both beta-arrestin-1 and -2 J Biol Chem 279 55419 55424 15489220 10.1074/jbc. M410312200 1:CAS:528:DC%2BD2cXhtFeis7vN (Pubitemid 40066542)
41. KA Defea 2007 Stop that cell! beta-arrestin-dependent chemotaxis: a tale of localized actin assembly and receptor desensitization Annu Rev Physiol 69 535 560 17002593 10.1146/annurev.physiol.69.022405.154804 1:CAS:528: DC%2BD2sXltVaksLY%3D (Pubitemid 46457654)
42. F Balkwill 2004 The significance of cancer cell expression of the chemokine receptor CXCR4 Semin Cancer Biol 14 171 179 15246052 10.1016/j.semcancer.2003.10.003 1:CAS:528:DC%2BD2cXjvVemsb0%3D (Pubitemid 38586742)
43. D Bhandari J Trejo JL Benovic A Marchese 2007 Arrestin-2 interacts with the ubiquitin-protein isopeptide ligase atrophin-interacting protein 4 and mediates endosomal sorting of the chemokine receptor CXCR4 J Biol Chem 282 36971 36979 10.1074/jbc.M705085200 17947233 10.1074/jbc.M705085200 1:CAS:528:DC%2BD2sXhsVamur3J
44. AM Fong RT Premont RM Richardson YR Yu RJ Lefkowitz DD Patel 2002 Defective lymphocyte chemotaxis in beta-arrestin2- and GRK6-deficient mice Proc Natl Acad Sci USA 99 7478 7483 12032308 10.1073/pnas.112198299 1:CAS:528:DC%2BD38XktlCktbc%3D (Pubitemid 34568716)
45. P Kumar CS Lau M Mathur P Wang KA DeFea 2007 Differential effects of beta-arrestins on the internalization, desensitization and ERK1/2 activation downstream of protease activated receptor-2 Am J Physiol Cell Physiol 293 C346 C357 10.1152/ajpcell.00010.2007 17442737 10.1152/ajpcell.00010.2007 1:CAS:528:DC%2BD2sXosV2nu7g%3D (Pubitemid 47105029)
46. W Saunders 2005 Centrosomal amplification and spindle multipolarity in cancer cells Semin Cancer Biol 15 25 32 10.1016/j.semcancer.2004.09.003 15613285 10.1016/j.semcancer.2004.09.003 1:CAS:528:DC%2BD2cXhtFahs73E (Pubitemid 40018525)
47. S Doxsey W Zimmerman K Mikule 2005 Centrosome control of the cell cycle Trends Cell Biol 15 303 311 10.1016/j.tcb.2005.04.008 15953548 10.1016/j.tcb.2005.04.008 1:CAS:528:DC%2BD2MXlt1Srtrk%3D (Pubitemid 40805326)
48. JL Salisbury AB D'Assoro WL Lingle 2004 Centrosome amplification and the origin of chromosomal instability in breast cancer J Mammary Gland Biol Neoplasia 9 275 283 10.1023/B:JOMG.0000048774.27697.30 15557800 10.1023/B:JOMG.0000048774.27697.30 (Pubitemid 39545744)
49. WL Lingle K Lukasiewicz JL Salisbury 2005 Deregulation of the centrosome cycle and the origin of chromosomal instability in cancer Adv Exp Med Biol 570 393 421 18727509 10.1007/1-4020-3764-3-14 1:CAS:528:DC%2BD2sXhtleru7vL (Pubitemid 47413181)
50. AB D'Assoro SL Barrett C Folk VC Negron K Boeneman R Busby C Whitehead F Stivala WL Lingle JL Salisbury 2002 Amplified centrosomes in breast cancer: a potential indicator of tumor aggressiveness Breast Cancer Res Treat 75 25 34 12500932 10.1023/A:1016550619925
51. WL Lingle SL Barrett VC Negron AB D'Assoro K Boeneman W Liu CM Whitehead C Reynolds JL Salisbury 2002 Centrosome amplification drives chromosomal instability in breast tumor development Proc Natl Acad Sci USA 99 1978 1983 10.1073/pnas.032479999 11830638 10.1073/pnas.032479999 1:CAS:528: DC%2BD38XitVSrsL0%3D (Pubitemid 34169000)
52. A Molla-Herman C Boularan R Ghossoub MG Scott A Burtey M Zarka S Saunier JP Concordet S Marullo A Benmerah 2008 Targeting of beta-arrestin2 to the centrosome and primary cilium: role in cell proliferation control PLoS ONE 3 e3728 10.1371/journal.pone.0003728 19008961 10.1371/journal.pone.0003728
53. Strous GJ, Schantl JA (2001) Beta-arrestin and Mdm2, unsuspected partners in signaling from the cell surface. Sci STKE 2001(110):pe41. DOI: 10.1126/stke.2001.110.pe41
54. JT Zilfou SW Lowe 2009 Tumor suppressive functions of p53 Cold Spring Harbor Perspect Biol 1 a001883 10.1101/cshperspect.a001883 10.1101/cshperspect. a001883
55. SN Jones AR Hancock H Vogel LA Donehower A Bradley 1998 Overexpression of Mdm2 in mice reveals a p53-independent role for Mdm2 in tumorigenesis Proc Natl Acad Sci USA 95 15608 15612 9861017 10.1073/pnas.95.26.15608 1:CAS:528:DyaK1MXhvFejtQ%3D%3D (Pubitemid 29018747)
56. DA Turbin MC Cheang CD Bajdik KA Gelmon E Yorida A De Luca TO Nielsen DG Huntsman CB Gilks 2006 MDM2 protein expression is a negative prognostic marker in breast carcinoma Mod Pathol 19 69 74 10.1038/modpathol.3800484 16258514 10.1038/modpathol.3800484 1:CAS:528:DC%2BD2MXhtlSqu7%2FK (Pubitemid 43250980)
57. L Girnita SK Shenoy B Sehat R Vasilcanu A Girnita RJ Lefkowitz O Larsson 2005 β-Arrestin is crucial for ubiquitination and down-regulation of the insulin-like growth factor-1 receptor by acting as adaptor for the MDM2 E3 ligase J Biol Chem 280 24412 24419 15878855 10.1074/jbc.M501129200 1:CAS:528:DC%2BD2MXlsFyrtb0%3D (Pubitemid 40934525)
58. H Werner I Bruchim 2009 The insulin-like growth factor-I receptor as an oncogene Arch Physiol Biochem 115 58 71 10.1080/13813450902783106 19485702 10.1080/13813450902783106 1:CAS:528:DC%2BD1MXhtlCqtLjI
59. SE Dunn M Ehrlich NJ Sharp K Reiss G Solomon R Hawkins R Baserga JC Barrett 1998 A dominant negative mutant of the insulin-like growth factor-I receptor inhibits the adhesion, invasion, and metastasis of breast cancer Cancer Res 58 3353 3361 9699666 1:CAS:528:DyaK1cXltFyisr0%3D (Pubitemid 28371076)
60. J Bonneterre JP Peyrat R Beuscart A Demaille 1990 Prognostic significance of insulin-like growth factor 1 receptors in human breast cancer Cancer Res 50 6931 6935 2170011 1:STN:280:DyaK3M%2FgsVSltg%3D%3D (Pubitemid 20361093)
61. MJ Ellis S Jenkins J Hanfelt ME Redington M Taylor R Leek K Siddle A Harris 1998 Insulin-like growth factors in human breast cancer Breast Cancer Res Treat 52 175 184 10066081 10.1023/A:1006127621512 1:STN:280: DyaK1M7mtl2ltg%3D%3D (Pubitemid 29056094)
62. JL Resnik DB Reichart K Huey NJ Webster BL Seely 1998 Elevated insulin-like growth factor I receptor autophosphorylation and kinase activity in human breast cancer Cancer Res 58 1159 1164 9515800 1:CAS:528: DyaK1cXhvV2rsrs%3D (Pubitemid 28183203)