In vivo optical imaging and dynamic contrast methods for biomedical research

Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences

Volumn 369, Issue 1955, 2011, Pages 4620-4643

  Hillman, Elizabeth M C ^a,b   Amoozegar, Cyrus B ^a   Wang, Tracy ^a   McCaslin, Addason F H ^a   Bouchard, Matthew B ^a   Mansfield, James ^c   Levenson, Richard M ^d  

^a Department of Biomedical Engineering   (United States)

^b Och Spine at New York Presbyterian Hospitals   (United States)

^c Caliper Life Sciences   (United States)

^d Brighton Consulting Group   (United States)

Author keywords

Dynamic contrast; In vivo imaging; Molecular imaging; Optical imaging

Indexed keywords

IMAGING TECHNIQUES; RESEARCH; TISSUE;

BASIC RESEARCH; BIOMEDICAL RESEARCH; CONTRAST-ENHANCED; DISEASE PROGRESSION; DYNAMIC CONTRAST; DYNAMIC EVENTS; FUTURE APPLICATIONS; IN-VIVO; IN-VIVO IMAGING; MOLECULAR IMAGING; OPTICAL IMAGING; OPTICAL IMAGING METHOD; REAL TIME; REALTIME IMAGING; SINGLE CELLS; SMALL ANIMAL;

OPTICAL IMAGE STORAGE;

CONTRAST MEDIUM; HEMOGLOBIN;

ANIMAL; CHEMISTRY; DIAGNOSTIC IMAGING; FLUORESCENCE MICROSCOPY; HUMAN; LIGHT; MEDICAL RESEARCH; METABOLISM; METHODOLOGY; MOUSE; OPTICS; RADIATION SCATTERING; REPRODUCIBILITY; REVIEW; TIME; TRANSGENE; WHOLE BODY IMAGING;

ANIMALS; BIOMEDICAL RESEARCH; CONTRAST MEDIA; DIAGNOSTIC IMAGING; HEMOGLOBINS; HUMANS; LIGHT; MICE; MICROSCOPY, FLUORESCENCE; OPTICS AND PHOTONICS; REPRODUCIBILITY OF RESULTS; SCATTERING, RADIATION; TIME FACTORS; TRANSGENES; WHOLE BODY IMAGING;

EID: 82055208752     PISSN: 1364503X     EISSN: None     Source Type: Journal    
DOI: 10.1098/rsta.2011.0264     Document Type: Review

References (121)

1. Ramanujam, N. 2000 Fluorescence spectroscopy in vivo. In Encyclopedia of analytical chemistry, vol. 1 (ed R. A. Meyers), pp. 20-56. Chichester, UK: John Wiley & Sons.
2. Cerussi, A. E., Berger, A. J., Bevilacqua, F., Shah, N., Jakubowski, D., Butler, J., Holcombe, R. F. & Tromberg, B. J. 2001 Sources of absorption and scattering contrast for near-infrared optical mammography. Acad. Radiol. 8, 211-218. (doi:10.1016/S1076-6332(03)80529-9) (Pubitemid 32666460)
3. Zipfel, W. R., Williams, R. M., Christie, R., Nikitin, A. Y., Hyman, B. T. & Webb, W. W. 2003 Live tissue intrinsic emission microscopy using multiphoton-excited native fluorescence and second harmonic generation. Proc. Natl Acad. Sci. USA 100, 7075-7080. (doi:10.1073/ pnas.0832308100) (Pubitemid 36706395)
4. Hillman, E. M. C. 2007 Optical brain imaging in vivo: techniques and applications from animal to man. J. Biomed. Opt. 12, 051402. (doi:10.1117/1.2789693) (Pubitemid 351313727)
5. Mahadevan-Jansen, A. & Richards-Kortum, R. R. 1996 Raman spectroscopy for the detection of cancers and precancers. J. Biomed. Opt. 1, 31-70. (doi:10.1117/12.227815) (Pubitemid 126646134)
6. Freudiger, C. W., Min, W., Holtom, G. R., Xu, B., Dantus, M. & Xie, X. S. 2011 Highly specific label-free molecular imaging with spectrally tailored excitation-stimulated Raman scattering (STE-SRS) microscopy. Nat. Photon. 5, 103-109. (doi:10.1038/nphoton.2010.294)
7. Landsman, M. L., Kwant, G., Mook, G. A. & Zijlstra, W. G. 1976 Light-absorbing properties, stability, and spectral stabilization of indocyanine green. J. Appl. Physiol. 40, 575-583.
8. Bloch, S., Lesage, F., McIntosh, L., Gandjbakhche, A., Liang, K. & Achilefu, S. 2005 Wholebody fluorescence lifetime imaging of a tumor-targeted near-infrared molecular probe in mice. J. Biomed. Opt. 10, 054003. (doi:10.1117/1.2070148) (Pubitemid 44256017)
9. Altinoglu, E. I., Russin, T. J., Kaiser, J. M., Barth, B. M., Eklund, P. C., Kester, M. & Adair, J. H. 2008 Near-infrared emitting fluorophore-doped calcium phosphate nanoparticles for in vivo imaging of human breast cancer. ACS Nano 2, 2075-2084. (doi:10.1021/nn800448r)
10. Michalet, X., Pinaud, F. F., Bentolila, L. A., Tsay, J. M., Doose, S., Li, J. J., Sundaresan, G., Wu, A. M., Gambhir, S. S. & Weiss, S. 2005 Quantum dots for live cells, in vivo imaging and diagnostics. Science 307, 538-544. (doi:10.1126/science.1104274) (Pubitemid 40165671)
11. Chalfie, M., Tu, Y., Euskirchen, G., Ward, W. W. & Prasher, D. C. 1994 Green fluorescent protein as a marker for gene expression. Science 263, 802-805. (doi:10.1126/science.8303295) (Pubitemid 24093206)
12. Ntziachristos, V., Tung, C.-H., Bremer, C. & Weissleder, R. 2002 Fluorescence molecular tomography resolves protease activity in vivo. Nat. Med. 8, 757-761. (doi:10.1038/nm729) (Pubitemid 34778731)
13. Heim, N., Garaschuk, O., Friedrich, M. W., Mank, M., Milos, R. I., Kovalchuk, Y., Konnerth, A. & Griesbeck, O. 2007 Improved calcium imaging in transgenic mice expressing a troponin C-based biosensor. Nat. Methods 4, 127-129. (doi:10.1038/nmeth1009) (Pubitemid 46454679)
14. Sha, K., Shimokawa, M., Morii, M., Kikumoto, K., Inoue, S., Kishi, K., Kitaguchi, K. & Furuya, H. 2000 Optimal dose of indocyanine-green injected from the peripheral vein in cardiac output measurement by pulse dye-densitometry. Masui 49, 172-176. (Pubitemid 30143210)
15. Dinc, U. A., Tatlipinar, S., Yenerel, M., Görgün, E. & Ciftci, F. In press. Fundus autofluorescence in acute and chronic central serous chorioretinopathy. Clin. Exp. Optom. (doi:10.1111/j.1444-0938.2011.00598.x)
16. Contag, C. H., Spilman, S. D., Contag, P. R., Oshiro, M., Eames, B., Dennery, P., Stevenson, D. K. & Benaron, D. A. 1997 Visualizing gene expression in living mammals using a bioluminescent reporter. Photochem. Photobiol. 66, 523-531. (doi:10.1111/j.1751- 1097.1997.tb03184.x) (Pubitemid 127470201)
17. Boyden, E. S., Zhang, F., Bamberg, E., Nagel, G. & Deisseroth, K. 2005 Millisecondtimescale, genetically targeted optical control of neural activity. Nat. Neurosci. 8, 1263-1268. (doi:10.1038/nn1525) (Pubitemid 43348147)
18. Borràs, T., Gabelt, B. A. T., Klintworth, G. K., Peterson, J. C. & Kaufman, P. L. 2001 Non-invasive observation of repeated adenoviral GFP gene delivery to the anterior segment of the monkey eye in vivo. J. Gene Med. 3, 437-449. (doi:10.1002/jgm.210) (Pubitemid 33684780)
19. Games, D. et al. 1995 Alzheimer-type neuropathology in transgenic mice overexpressing V717F b-amyloid precursor protein. Nature 373, 523-527. (doi:10.1038/373523a0)
20. Snouwaert, J. N., Brigman, K. K., Latour, A. M., Malouf, N. N., Boucher, R. C., Smithies, O. & Koller, B. H. 1992 An animal model for cystic fibrosis made by gene targeting. Science 257, 1083-1088. (doi:10.1126/science.257.5073. 1083)
21. Kotnik, K., Popova, E., Todiras, M., Mori, M. A., Alenina, N., Seibler, J. & Bader, M. 2009 Inducible transgenic rat model for diabetes mellitus based on shRNA-mediated gene knockdown. PLoS ONE 4, e5124. (doi:10.1371/journal. pone.0005124)
22. Wilson, B. C. & Jacques, S. L. 1990 Optical reflectance and transmittance of tissues: principles and applications. IEEE J. Quantum Electron.26, 2186-2199. (doi:10.1109/3.64355)
23. Patterson, M. S., Wilson, B. C. & Wyman, D. R. 1991 The propagation of optical radiation in tissue II. Optical properties of tissues and resulting fluence distributions. Lasers Med. Sci. 6, 379-390. (doi:10.1007/BF02042460)
24. Patterson, M. S., Wilson, B. C. & Wyman, D. R. 1991 The propagation of optical radiation in tissue I. Models of radiation transport and their application. Lasers Med. Sci. 6, 155-168. (doi:10.1007/BF02032543)
25. Ishimaru, A. 1999 Wave propagation and scattering in random media. New York, NY: Wiley- IEEE Press.
26. Bouchard, M. B., Chen, B. R., Burgess, S. A. & Hillman, E. M. C. 2009 Ultra-fast multispectral optical imaging of cortical oxygenation and blood flow dynamics. Opt. Express 17, 15670-15678 (doi:10.1364/OE.17.015670)
27. Hillman, E. M. C. & Moore, A. 2007 All-optical anatomical co-registration for molecular imaging of small animals using dynamic contrast. Nat. Photon. 1, 526-530. (doi:10.1038/ nphoton.2007.146)
28. Hillman, E. M. C., Hebden, J. C., Schweiger, M., Dehghani, H., Schmidt, F. E. W., Delpy, D. T. & Arridge, S. R. 2001 Time resolved optical tomography of the human forearm. Phys. Med. Biol. 46, 1117-1130. (doi:10.1088/0031-9155/46/4/315) (Pubitemid 32366609)
29. Hillman, E. M. C. 2002 Experimental and theoretical investigations of near infrared tomographic imaging methods and clinical applications. PhD thesis, Department of Medical Physics and Bioengineering, University College London.
30. Boyde, A. 1985 Stereoscopic images in confocal (tandem scanning) microscopy. Science 230, 1270-1272. (doi:10.1126/science.4071051) (Pubitemid 16194532)
31. Webb, R. H., Hughes, G. W. & Delori, F. C. 1987 Confocal scanning laser ophthalmoscope. Appl. Opt. 26, 1492-1499. (doi:10.1364/AO.26.001492) (Pubitemid 17061416)
32. Rajadhyaksha, M., Anderson, R. R. & Webb, R. H. 1999 Video-rate confocal scanning laser microscope for imaging human tissues in vivo. Appl. Opt. 38, 2105-2115. (doi:10.1364/ AO.38.002105) (Pubitemid 129306953)
33. Denk, W., Strickler, J. H. & Webb, W. W. 1990 Two-photon laser scanning fluorescence microscopy. Science 248, 73-76. (doi:10.1126/science. 2321027)
34. Kleinfeld, D. & Denk, W. 1999 Two-photon imaging of neocortical microcirculation. In Imaging neurons: a laboratory manual (eds R. Yuste, F. Lanni & A. Konnerth), pp. 23.1-23.15. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press.
35. McCaslin, A. F. H., Chen, B. R., Radosevich, A. J., Cauli, B. & Hillman, E. M. C. 2011 In vivo 3D morphology of astrocyte-vasculature interactions in the somatosensory cortex: implications for neurovascular coupling. J. Cereb. Blood Flow Metab. 31, 795-806. (doi:10.1038/ jcbfm.2010.204)
36. van-der-Zee, P. 1992 Measurement and modelling of the optical properties of human tissue in the near infrared, p. 313. London, UK: Department of Medical Physics and Bioengineering, University College London.
37. Cheong, W. F., Prahl, S. A. & Welch, A. J. 1990 A review of the optical properties of biological tissues. IEEE J. Quantum Electron. 26, 2166-2185. (doi:10.1109/3.64354)
38. Chen, C.-S. J., Elias, M., Busam, K., Rajadhyaksha, M. & Marghoob, A. A. 2005 Multimodal in vivo optical imaging, including confocal microscopy, facilitates presurgical margin mapping for clinically complex lentigo malignant melanoma. Br. J. Dermatol. 153, 1031-1036. (doi:10.1111/j.1365-2133.2005.06831. x) (Pubitemid 41540775)
39. Kobat, D., Durst, M. E., Nishimura, N.,Wong, A. W., Schaffer, C. B. & Xu, C. 2009 Deep tissue multiphoton microscopy using longer wavelength excitation. Opt. Express 17, 13 354-13 364. (doi:10.1364/OE.17.013354)
40. Kleinfeld, D., Mitra, P. P., Helmchen, F. & Denk, W. 1998 Fluctuations and stimulus-induced changes in blood flow observed in individual capillaries in layers 2 through 4 of rat neocortex. Proc. Natl Acad. Sci. USA 95, 15 741-15 746. (doi:10.1073/pnas.95.26.15741) (Pubitemid 29018770)
41. Ohki, K., Chung, S., Ch'ng, Y. H., Kara, P. & Reid, R. C. 2005 Functional imaging with cellular resolution reveals precise micro-architecture in visual cortex. Nature 433, 597-603. (doi:10.1038/nature03274) (Pubitemid 40282986)
42. Schummers, J., Yu, H. & Sur, M. 2008 Tuned responses of astrocytes and their influence on hemodynamic signals in the visual cortex. Science 320, 1638-1643. (doi:10.1126/ science.1156120) (Pubitemid 351931254)
43. Carmeliet, P. & Jain, R. K. 2000 Angiogenesis in cancer and other diseases. Nature 407, 249-257. (doi:10.1038/35025220)
44. Jain, R. 2003 Molecular regulation of vessel maturation. Nat. Med. 9, 685-693. (doi:10.1038/ nm0603-685) (Pubitemid 36749217)
45. Hellerer, T., Axäng, C., Brackmann, C., Hillertz, P., Pilon, M. & Enejder, A. 2007 Monitoring of lipid storage in Caenorhabditis elegans using coherent anti-stokes Raman scattering (CARS) microscopy. Proc. Natl Acad. Sci. USA 104, 14 658-14 663. (doi:10.1073/pnas.0703594104) (Pubitemid 350003199)
46. Freudiger, C. W., Min, W., Saar, B. G., Lu, S., Holtom, G. R., He, C., Tsai, J. C., Kang, J. X. & Xie, X. S. 2008 Label-free biomedical imaging with high sensitivity by stimulated Raman scattering microscopy. Science 322, 1857-1861. (doi:10.1126/science.1165758)
47. Huang, D. et al. 1991 Optical coherence tomography. Science 254, 1178-1181. (doi:10.1126/ science.1957169) (Pubitemid 21917444)
48. de Boer, J. F., Cense, B., Park, B. H., Pierce, M. C., Tearney, G. J. & Bouma, B. E. 2003 Improved signal-to-noise ratio in spectral-domain compared with time-domain optical coherence tomography. Opt. Lett. 8, 2067-2069. (doi:10.1364/OL.28.002067)
49. Izatt, J. A., Kulkarni, M. D., Yazdanfar, S., Barton, J. K. & Welch, A. J. 1997 In vivo bidirectional color Doppler flow imaging of picoliter blood volumes using optical coherence tomography. Opt. Lett. 22, 1439-1441. (doi:10.1364/OL.22.001439) (Pubitemid 127565229)
50. Wang, R. K. & Hurst, S. 2007 Mapping of cerebro-vascular blood perfusion in mice with skin and skull intact by optical micro-angiography at 1.3 mm wavelength. Opt. Express 15, 11 402-11 412. (doi:10.1364/OE.15.011402) (Pubitemid 47360576)
51. Vakoc, B. J. et al. 2009 Three-dimensional microscopy of the tumor microenvironment in vivo using optical frequency domain imaging. Nat. Med. 15, 1219-1223. (doi:10.1038/nm.1971)
52. Aguirre, A. D., Chen, Y., Fujimoto, J. G., Ruvinskaya, L., Devor, A. & Boas, D. A. 2006 Depthresolved imaging of functional activation in the rat cerebral cortex using optical coherence tomography. Opt. Lett. 31, 3459-3461. (doi:10.1364/OL.31.003459) (Pubitemid 46034606)
53. Chen, B. R., Bouchard, M. B., McCaslin, A. F. H., Burgess, S. A. & Hillman, E. M. C. 2011 High-speed vascular dynamics of the hemodynamic response. NeuroImage 54, 1021-1030. (doi:10.1016/j.neuroimage.2010.09.036)
54. Malonek, D. & Grinvald, A. 1996 Interactions between electrical activity and cortical microcirculation revealed by imaging spectroscopy: implications for functional brain mapping. Science 272, 551-554. (doi:10.1126/science.272.5261.551) (Pubitemid 26138199)
55. Hillman, E. M. C. & Burgess, S. A. 2009 Sub-millimeter resolution 3D optical imaging of living tissue using laminar optical tomography. Lasers Photon. Rev. 3, 159-180. (doi:10.1002/ lpor.200810031)
56. Hillman, E. M. C., Bernus, O., Pease, E., Bouchard, M. B. & Pertsov, A. 2007 Depthresolved optical imaging of transmural electrical propagation in perfused heart. Opt. Express 15, 17 827-17 841. (doi:10.1364/OE.15.017827)
57. Moore, A., Medarova, Z., Potthast, A. & Dai, G. 2004 In vivo targeting of underglycosylated MUC-1 tumor antigen using a multimodal imaging probe. Cancer Res. 64, 1821-1827. (doi:10.1158/0008-5472.CAN-03-3230) (Pubitemid 38428707)
58. Aina, O. H., Marik, J., Gandour-Edwards, R. & Lam, K. S. 2005 Near-infrared optical imaging of ovarian cancer xenografts with novel a3-integrin binding peptide 'OA02'. Mol. Imaging 4, 439-447. (Pubitemid 43143784)
59. Gulsen, G., Birgul, O., Unlu, M. B., Shafiiha, R. & Nalcioglu, O. 2006 Combined diffuse optical tomography (DOT) and MRI system for cancer imaging in small animals. Technol. Cancer Res. Treat. 5, 351-364.
60. Hintersteiner, M. et al. 2005 In vivo detection of amyloid-beta deposits by near-infrared imaging using an oxazine-derivative probe. Nat. Biotechnol. 23, 577-583. (doi:10.1038/nbt1085) (Pubitemid 41724896)
61. Schmidt, F. E. W., Fry, M. E., Hillman, E. M. C., Hebden, J. C. & Delpy, D. T. 2000 A 32-channel time-resolved instrument for medical optical tomography. Rev. Sci. Instrum. 71, 256-265. (doi:10.1063/1.1150191)
62. Hillman, E. M. C., Boas, D. A., Dale, A. M. & Dunn, A. K. 2004 Laminar optical tomography: demonstration of millimeter-scale depth-resolved imaging in turbid media. Opt. Lett. 29, 1650-1652. (doi:10.1364/OL.29.001650)
63. Culver, J. P., Choe, R., Holboke, M. J., Zubkov, L., Durduran, T., Slemp, A., Ntziachristos, V., Chance, B. & Yodh, A. G. 2003 Three-dimensional diffuse optical tomography in the parallel plane transmission geometry: evaluation of a hybrid frequency-domain/continuous-wave clinical system for breast imaging. Med. Phys. 30, 235-247. (doi:10.1118/1.1534109) (Pubitemid 36222859)
64. Kepshire, D. S., Davis, S. C., Dehghani, H., Paulsen, K. D. & Pogue, B. W. 2007 Subsurface diffuse optical tomography can localize absorber and fluorescent objects but recovered image sensitivity is nonlinear with depth. Appl. Opt. 46, 1669-1678. (doi:10.1364/AO.46.001669) (Pubitemid 46659533)
65. Arridge, S. R. 1999 Optical tomography in medical imaging. Invers. Probl. 15, 41-93. (doi:10.1088/0266-5611/15/2/022)
66. Hebden, J. C., Gibson, A., Austin, T., Yusof, R., Everdell, N., Delpy, D. T., Arridge, S. R., Meek, J. H. & Wyatt, J. S. 2004 Imaging changes in blood volume and oxygenation in the newborn infant brain using three-dimensional optical tomography. Phys. Med. Biol. 49, 1117-1130. (doi:10.1088/0031-9155/49/ 7/003) (Pubitemid 38514779)
67. Chang, J., Graber, H. L. & Barbour, R. L. 1997 Imaging of fluorescence in highly scattering media. IEEE. Trans. Biomed. Eng. 44, 810-822. (doi:10.1109/10.623050) (Pubitemid 27357675)
68. Godavarty, A., Sevick-Muraca, E. M. & Eppstein, M. J. 2005 Three-dimensional fluorescence lifetime tomography. Med. Phys. 32, 992-1000. (doi:10.1118/1.1861160) (Pubitemid 40586784)
69. Pakalniskis, M. G. et al. 2011 Tumor angiogenesis change estimated by using diffuse optical spectroscopic tomography: demonstrated correlation in women undergoing neoadjuvant chemotherapy for invasive breast cancer? Radiology 259, 365-374. (doi:10.1148/radiol.11100699)
70. Liao, S. M., Gregg, N. M., White, B. R., Zeff, B. W., Bjerkaas, K. A., Inder, T. E. & Culver, J. P. 2010 Neonatal hemodynamic response to visual cortex activity: high-density near-infrared spectroscopy study. J. Biomed. Opt. 15, 026010. (doi:10.1117/1.3369809)
71. Zeff, B. W., White, B. R., Dehghani, H., Schlaggar, B. L. & Culver, J. P. 2007 Retinotopic mapping of adult human visual cortex with high-density diffuse optical tomography. Proc. Natl Acad. Sci. USA 104, 12 169-12 174. (doi:10.1073/pnas.0611266104) (Pubitemid 47185648)
72. Schmitz, C. H. et al. 2000 Instrumentation and calibration protocol for imaging dynamic features in dense-scattering media by optical tomography. Appl. Opt. 39, 6466-6486. (doi:10.1364/AO.39.006466)
73. Nissila, I. et al. 2006 Comparison between a time-domain and a frequency-domain system for optical tomography. J. Biomed. Opt. 11, 064015. (doi:10.1117/1.2400700) (Pubitemid 46323018)
74. Srinivasan, S., Ghadyani, H. R., Pogue, B. W. & Paulsen, K. D. 2010 A coupled finite element-boundary element method for modeling diffusion equation in 3D multi-modality optical imaging. Biomed. Opt. Express 1, 398-413. (doi:10.1364/BOE.1.000398)
75. Zhang, Q. et al. 2005 Coregistered tomographic X-ray and optical breast imaging: initial results. J. Biomed. Opt. 10, 024033. (doi:10.1117/1.1899183) (Pubitemid 41046609)
76. Ntziachristos, V., Turner, G., Dunham, J., Windsor, S., Soubret, A., Ripoll, J. & Shih, H. A. 2005 Planar fluorescence imaging using normalized data. J. Biomed. Opt. 10, 064007. (doi:10.1117/1.2136148) (Pubitemid 44255960)
77. Zacharakis, G., Kambara, H., Shih, H., Ripoll, J., Grimm, J., Saeki, Y., Weissleder, R. & Ntziachristos, V. 2005 Volumetric tomography of fluorescent proteins through small animals in vivo. Proc. Natl Acad. Sci. USA 102, 18 252-18 257. (doi:10.1073/pnas.0504628102) (Pubitemid 43011213)
78. Soubret, A., Ripoll, J. & Ntziachristos, V. 2005 Accuracy of fluorescent tomography in presence of heterogeneities: study of the normalized born ratio. IEEE Trans. Med. Imaging 24, 1377-1386. (doi:10.1109/TMI.2005. 857213) (Pubitemid 41463574)
79. El Hilali, N., Rubio, N., Martinez-Villacampa, M. & Blanco, J. 2002 Combined noninvasive imaging and luminometric quantification of luciferase-labeled human prostate tumors and metastases. Lab. Invest. 82, 1563-1571. (Pubitemid 35332915)
80. Wack, S., Hajri, A., Heisel, F., Sowinska, M., Berger, C., Whelan, M., Marescaux, J. & Aprahamian, M. 2003 Feasibility, sensitivity and reliability of laser-induced fluorescence imaging of green fluorescent protein-expressing tumors in vivo. Mol. Ther. 7, 765-773. (doi:10.1016/S1525-0016(03)00102-3) (Pubitemid 36790253)
81. Liao, C.- P. et al. 2007 Mouse models of prostate adenocarcinoma with the capacity to monitor spontaneous carcinogenesis by bioluminescence or fluorescence. Cancer Res. 67, 7525-7533. (doi:10.1158/0008-5472.CAN-07-0668) (Pubitemid 47206583)
82. Kovar, J. L., Volcheck, W., Sevick-Muraca, E., Simpson, M. A. & Olive, D. M. 2009 Characterization and performance of a near-infrared 2-deoxyglucose optical imaging agent for mouse cancer models. Anal. Biochem. 384, 254-262. (doi:10.1016/j.ab.2008.09.050)
83. Ye, Y. & Chen, X. 2011 Integrin targeting for tumor optical imaging. Theranostics 1, 102-126.
84. Lee, S. J. et al. 2011 Tumor-homing photosensitizer-conjugated glycol chitosan nanoparticles for synchronous photodynamic imaging and therapy based on cellular on/off system. Biomaterials 32, 4021-4029. (doi:10.1016/j. biomaterials.2011.02.009)
85. Zhou, H. L., Luby-Phelps, K., Mickey, B. E., Habib, A. A., Mason, R. P. & Zhao, D. W. 2009 Dynamic near-infrared optical imaging of 2-deoxyglucose uptake by intracranial glioma of athymic mice. PLoS ONE 4, e8051. (doi:10.1371/journal.pone.0008051)
86. Lee, J., Pöschinger, T., Hernandez, S., Huang, J., Johung, T., Kandel, J., Yamashiro, D. J. & Hielscher, A. H. 2010 Dynamic fluorescence imaging for the detection of vascular changes in anti-angiogenic drug therapy. Paper JMA74, Biomedical Optics, OSA Technical Digest, Optical Society of America.
87. Deliolanis, N., Lasser, T., Hyde, D., Soubret, A., Ripoll, J. & Ntziachristos, V. 2007 Free-space fluorescence molecular tomography utilizing 360? geometry projections. Opt. Lett. 32, 382-384. (doi:10.1364/OL.32.000382) (Pubitemid 46354030)
88. Wang, C., Wu, C., Popescu, D. C., Zhu, J., Macklin, W. B., Miller, R. H. & Wang, Y. 2011 Longitudinal near-infrared imaging of myelination. J. Neurosci. 31, 2382-2390. (doi:10.1523/ JNEUROSCI.2698-10.2011)
89. Bouchard, M. B., MacLaurin, S. A., Dwyer, P. J., Mansfield, J., Levenson, R. & Krucker, T. 2007 Technical considerations in longitudinal multispectral small animal molecular imaging. J. Biomed. Opt. 12, 051601. (doi:10.1117/1.2799188) (Pubitemid 351309591)
90. Mansfield, J. R., Gossage, K. W., Hoyt, C. C. & Levenson, R. M. 2005 Autofluorescence removal, multiplexing, and automated analysis methods for in vivo fluorescence imaging. J. Biomed. Opt. 10, 041207. (doi:10.1117/1.2032458) (Pubitemid 43328899)
91. Lin, M. Z. et al. 2009 Autofluorescent proteins with excitation in the optical window for intravital imaging in mammals. Chem. Biol. 16, 1169-1179. (doi:10.1016/j.chembiol. 2009.10.009)
92. Deliolanis, N. C., Kasmieh, R., Wurdinger, T., Tannous, B. A., Shah, K. & Ntziachristos, V. 2008 Performance of the red-shifted fluorescent proteins in deep-tissue molecular imaging applications. J. Biomed. Opt. 13, 044008. (doi:10.1117/1.2967184)
93. Deliolanis, N. C., Wurdinger, T., Pike, L., Tannous, B. A., Breakefield, X. O., Weissleder, R. & Ntziachristos, V. 2011 In vivo tomographic imaging of red-shifted fluorescent proteins. Biomed. Opt. Express 2, 887-900. (doi:10.1364/BOE.2.000887)
94. Pesnel, S., Pillon, A., Créancier, L., Guilbaud, N., Bailly, C., Kruczynski, A., Lerondel, S. & Le Pape, A. 2011 Quantitation in bioluminescence imaging by correction of tissue absorption for experimental oncology. Mol. Imaging Bio. 13, 646-652. (doi:10.1007/s11307-010-0387-9)
95. Dehghani, H., Davis, S. C., Jiang, S., Pogue, B. W., Paulsen, K. D. & Patterson, M. S. 2006 Spectrally resolved bioluminescence optical tomography. Opt. Lett. 31, 365-367. (doi:10.1364/ OL.31.000365)
96. Gurfinkel, M. et al. 2000 Pharmacokinetics of ICG and HPPH-car for the detection of normal and tumor tissue using fluorescence, near-infrared reflectance imaging: a case study. Photochem. Photobiol. 72, 94-102. (doi:10.1562/0031-8655(2000)072<0094:POIAHC>2.0.CO;2)
97. Cuccia, D. J., Bevilacqua, F., Durkin, A. J., Merritt, S., Tromberg, B. J., Gulsen, G., Yu, J. W. H. & Nalcioglu, O. 2003 In vivo quantification of optical contrast agent dynamics in rat tumors by use of diffuse optical spectroscopy with magnetic resonance imaging coregistration. Appl. Opt. 42, 2940-2950. (doi:10.1364/AO.42.002940)
98. Welsher, K., Sherlock, S. P. & Dai, H. 2011 Deep-tissue anatomical imaging of mice using carbon nanotube fluorophores in the second near-infrared window. Proc. Natl Acad. Sci. USA 108, 8943-8948. (doi:10.1073/pnas.1014501108)
99. Hell, S. W. 2009 Microscopy and its focal switch. Nat. Methods 6, 24-32. (doi:10.1038/ nmeth.1291)
100. Lee, J., Poschinger, T., Hernandez, S. L., Huang, J., Johung, T., Kandel, J., Yamashiro, D. J. & Hielscher, A. H. 2010 Monitoring of anti-angiogenic drug response with dynamic fluorescence imaging. In Proc. IEEE 36th Anual Northeast Bioengineering Conf., New York, 26-28 March 2010. (doi:10.1109/NEBC. 2010.5458158)
101. El-Desoky, A., Seifalian, A. M., Cope, M., Delpy, D. T. & Davidson, B. R. 1999 Experimental study of liver dysfunction evaluated by direct indocyanine green clearance using near infrared spectroscopy. Br. J. Surg. 86, 1005-1011. (doi:10.1046/j.1365-2168.1999.01186.x) (Pubitemid 29387064)
102. Amoozegar, C. B., McCaslin, A. F. H., Bouchard, M. B., Blaner, W. S. & Hillman, E. M. C. 2009 Non-invasive evaluation of organ function using dynamic contrast enhanced molecular imaging. In Advances in Optics for Biotechnology, Medicine and Surgery XI, Burlington, VT, 28 June-2 July 2009.
103. Kotz, K. T., Dixit, S. S., Gibbs, A. D., Orduna, J. M., Haroon, Z., Amin, K. & Faris, G. W. 2008 Inspiratory contrast for in vivo optical imaging. Opt. Express 16, 19-31. (doi:10.1364/OE.16.000019)
104. Patwardhan, S., Bloch, S., Achilefu, S. & Culver, J. 2005 Time-dependent whole-body fluorescence tomography of probe bio-distributions in mice. Opt. Express 13, 2564-2577. (doi:10.1364/OPEX.13.002564) (Pubitemid 40899217)
105. Liu, X., Wang, D., Liu, F. & Bai, J. 2010 Principal component analysis of dynamic fluorescence diffuse optical tomography images. Opt. Express 18, 6300-6314. (doi:10.1364/OE.18.006300)
106. Liu, X., Liu, F., Zhang, Y. & Bai, J. In press. Unmixing dynamic fluorescence diffuse optical tomography images with independent component analysis. IEEE Trans. Med. Imaging. (doi:10.1109/TMI.2011.2134865)
107. Partridge, S. C. et al. 2010 Association between serial dynamic contrast-enhanced MRI and dynamic 18F-FDG PET measures in patients undergoing neoadjuvant chemotherapy for locally advanced breast cancer. J. Magn. Reson. Imaging 32, 1124-1131. (doi:10.1002/jmri.22362)
108. Howard-Lech, V. L., Lee, T.-Y., Craen, R. A. & Gelb, A. W. 1999 Cerebral blood volume measurements using dynamic contrast-enhanced X-ray computed tomography: application to isoflurane anaesthetic studies. Physiol. Measur. 20, 75. (doi:10.1088/0967-3334/20/1/006) (Pubitemid 29101767)
109. Boesen, M., Kubassova, O., Cimmino, M. A., Østergaard, M., Taylor, P., Danneskiold-Samsoe, B. & Bliddal, H. In press. Dynamic contrast enhanced MRI can monitor the very early inflammatory treatment response upon intra-articular steroid injection in the knee joint: a case report with review of the literature. Arthritis. (doi:10.1155/2011/578252)
110. Ocak, I., Bernardo, M., Metzger, G., Barrett, T., Pinto, P., Albert, P. S. & Choyke, P. L. 2007 Dynamic contrast-enhanced MRI of prostate cancer at 3 T: a study of pharmacokinetic parameters. Am. J. Roentgenol. 189, W192-W201. (doi:10.2214/AJR.06.1329)
111. Roberts, H. C., Roberts, T. P. L., Lee, T.-Y. & Dillon, W. P. 2002 Dynamic, contrastenhanced CT of human brain tumors: quantitative assessment of blood volume, blood flow and microvascular permeability: report of two cases. Am. J. Neuroradiol. 23, 828-832. (Pubitemid 34525701)
112. Schmitz, C. H. et al. 2005 Design and implementation of dynamic near-infrared optical tomographic imaging instrumentation for simultaneous dual-breast measurements. Appl. Opt. 44, 2140-2153. (doi:10.1364/AO.44.002140) (Pubitemid 40567087)
113. Intes, X., Ripoll, J., Chen, Y., Nioka, S., Yodh, A. G. & Chance, B. 2003 In vivo continuouswave optical breast imaging enhanced with Indocyanine Green. Med. Phys. 30, 1039-1047. (doi:10.1118/1.1573791) (Pubitemid 36735969)
114. Liebert, A., Wabnitz, H., Steinbrink, J., Moller, M., Macdonald, R., Rinneberg, H., Villringer, A. & Obrig, H. 2005 Bed-side assessment of cerebral perfusion in stroke patients based on optical monitoring of a dye bolus by time-resolved diffuse reflectance. NeuroImage 24, 426-435. (doi:10.1016/j.neuroimage.2004.08.046) (Pubitemid 41359038)
115. Keller, E., Nadler, A., Alkadhi, H., Kollias, S. S., Yonekawa, Y. & Niederer, P. 2003 Noninvasive measurement of regional cerebral blood flow and regional cerebral blood volume by near-infrared spectroscopy and indocyanine green dye dilution. NeuroImage 20, 828-839. (doi:10.1016/S1053-8119(03)00315-X) (Pubitemid 37268107)
116. Elliott, J. T., Diop, M., Tichauer, K. M., Lee, T.-Y. & Lawrence, K. S. 2010 Quantitative measurement of cerebral blood flow in a juvenile porcine model by depth-resolved near-infrared spectroscopy. J. Biomed. Opt. 15, 037014. (doi:10.1117/1.3449579)
117. Klein, S., Staring, M., Murphy, K., Viergever, M. A. & Pluim, J. 2010 Elastix: a tool box for intensity-based medical image registration. IEEE Trans. Med. Imaging 29, 196-205. (doi:10.1109/TMI.2009.2035616)
118. Wang, F.,Wang, Y., Chan, T. H. & Chi, C. Y. 2006 Blind separation of multichannel biomedical image patterns by non-negative least-correlated component analysis. In Pattern recognition in bioinformatics. Lecture Notes in Computer Science, no. 4146, pp. 151-162. Berlin, Germany: Springer-Verlag. (Pubitemid 44576460)
119. Radosevich, A. J., Bouchard, M. B., Burgess, S. A., Chen, B. & Hillman, E. M. C. 2008 Hyperspectral in vivo two-photon microscopy of intrinsic contrast. Opt. Lett. 33, 2164-2166. (doi:10.1364/OL.33.002164)
120. Chen, L., Chan, T.-H., Choyke, P. L., Hillman, E. M. C., Bhu-jwalla, Z. M., Chi, C.-Y., Wang, G., Szabo, Z. & Wang, Y. In press. CAM-CM: a signal deconvolution tool for in vivo dynamic contrast-enhanced imaging of complex tissues. Bioinformatics. (doi:10.1093/bioinformatics/btr436)
121. Gurfinkel, M., Ke, S., Wang, W., Li, C. & Sevick-Muraca, E. M. 2005 Quantifying molecular specificity of avb3 integrin-targeted optical contrast agents with dynamic optical imaging. J. Biomed. Opt. 10, 034019. (doi:10.1117/1.1924696) (Pubitemid 41236413)