Subsurface diffuse optical tomography can localize absorber and fluorescent objects but recovered image sensitivity is nonlinear with depth

Applied Optics

Volumn 46, Issue 10, 2007, Pages 1669-1678

  Kepshire, Dax S ^a   Davis, Scott C ^a   Dehghani, Hamid ^a,b   Paulsen, Keith D ^a   Pogue, Brian W ^a  

^a DARTMOUTH COLLEGE   (United States)

^b UNIVERSITY OF EXETER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

COMPUTER SIMULATION; DIFFUSERS (OPTICAL); FLUORESCENCE; IMAGE ANALYSIS; IMAGING TECHNIQUES; SENSITIVITY ANALYSIS;

FLUORESCENCE IMAGING; FLUORESCENT OBJECTS; RECOVERED IMAGE SENSITIVITY; SUBSURFACE DIFFUSE OPTICAL TOMOGRAPHY;

OPTICAL TOMOGRAPHY;

ALGORITHM; ARTICLE; BIOLOGICAL MODEL; COMPUTER ASSISTED DIAGNOSIS; COMPUTER SIMULATION; EVALUATION; FLUORESCENCE MICROSCOPY; IMAGE ENHANCEMENT; IMAGE QUALITY; INSTRUMENTATION; METHODOLOGY; NONLINEAR SYSTEM; OPTICAL TOMOGRAPHY; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY;

ALGORITHMS; COMPUTER SIMULATION; IMAGE ENHANCEMENT; IMAGE INTERPRETATION, COMPUTER-ASSISTED; MICROSCOPY, FLUORESCENCE; MODELS, BIOLOGICAL; NONLINEAR DYNAMICS; PHANTOMS, IMAGING; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TOMOGRAPHY, OPTICAL;

EID: 34247481526     PISSN: 1559128X     EISSN: 15394522     Source Type: Journal    
DOI: 10.1364/AO.46.001669     Document Type: Conference Paper

References (49)

1. B. W. Pogue, T. McBride, U. Osterberg, and K. Paulsen, "Comparison of imaging geometries for diffuse optical tomography of tissue," Opt. Express 4, 270-286 (1999).
2. J. S. Reynolds, T. L. Troy, R. H. Mayer, A. B. Thompson, D. J. Waters, K. K. Cornell, P. W. Snyder, and E. M. Sevick-Muraca, "Imaging of spontaneous canine mammary tumors using fluorescent contrast agents," Photochem. Photobiol. 70, 87-94 (1999).
3. H. Xu, H. Dehghani, B. W. Pogue, R. F. Springett, K. D. Paulsen, and J. F. Dunn, "Near-infrared imaging in the small animal brain: optimization of fiber positions," J. Biomed. Opt. 8, 102-110 (2003).
4. J. P. Culver, T. Durduran, D. Furuya, C. Cheung, J. H. Greenberg, and A. G. Yodh, "Diffuse optical tomography of cerebral blood flow, oxygenation, and metabolism in rat during focal ischemia," J. Cereb. Blood Flow Metab. 23, 911-924 (2003).
5. Q. Zhu, S. H. Kurtzma, P. Hegde, S. Tannenbaum, M. Kane, M. Huang, N. G. Chen, B. Jagjivan, and K. Zarfos, "Utilizing optical tomography with ultrasound localization to image heterogeneous hemoglobin distribution in large breast cancers," Neoplasia 7, 263-270 (2005).
6. M. Franceschini and D. A. Boas, "Noninvasive measurement of neuronal activity with near-infrared optical imaging," Neuroimage 21, 372-386 (2004).
7. J. C. Hebden, A. Gibson, R. M. Yusof, N. Everdell, E. M. Hillman, D. T. Delpy, S. R. Arridge, T. Austin, J. H. Meek, and J. S. Wyatt, "Three-dimensional optical tomography of the premature infant brain," Phys. Med. Biol. 47, 4155-4166 (2002).
8. W. P. Stummer, U. Pichlmeier, T. Meinel, O. D. Wiestier, F. Zanella, and H.-J. Reulen, "Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: a randomised controlled multicentre phase III trial," Lancet Oncol. 7, 392-401 (2006).
9. V. Ntziachristos, A. G. Yodh, M. Schnall, and B. Chance, "Concurrent MRI and diffuse optical tomography of breast after indocyanine green enhancement," Proc. Natl. Acad. Sci. U.S.A. 97, 2767-2772 (2000).
10. B. W. Pogue, S. P. Poplack, T. O. McBride, W. A. Wells, K. S. Osterman, U. L. Osterberg, and K. D. Paulsen, "Quantitative hemoglobin tomography with diffuse near-infrared spectroscopy: pilot results in the breast," Radiology 218, 261-266 (2001).
11. V. Ntziachristos, A. G. Yodh, M. D. Schnall, and B. Chance, "MRI-guided diffuse optical spectroscopy of malignant and benign breast lesions," Neoplasia 4, 347-354 (2002).
12. A. Corlu, R. Choe, T. Durduran, K. Lee, M. Schweiger, S. R. Arridge, E. M. Hillman, and A. G. Yodh, "Diffuse optical tomography with spectral constraints and wavelength optimization," Appl. Opt. 44, 2082-2093 (2005).
13. J. C. Hebden, A. Gibson, T. Austin, R. M. Yusof, N. Everdell, D. T. Delpy, S. R. Arridge, J. H. Meek, and J. S. Wyatt, "Imaging changes in blood volume and oxygenation in the newborn infant brain using three-dimensional optical tomography," Phys. Med. Biol. 49, 1117-1130 (2004).
14. B. Chance, S. Nioka, J. Zhang, E. F. Conant, E. Hwang, S. Briest, S. Orel, M. Schall, and B. J. Czerniecki, "Breast cancer detection based on incremental biochemical and physiological properties of breast cancers: a six-year, two-site study," Acad. Radiol. 12, 925-933 (2005).
15. D. B. Jakubowski, A. E. Cerussi, F. Bevilacqua, N. Shah, D. Hsiang, J. Butler, and B. J. Tromberg, "Monitoring neoadjuvant chemotherapy in breast cancer using quantitative diffuse optical spectroscopy: a case study," J. Biomed. Opt. 9, 230-238 (2004).
16. E. M. Sevick-Muraca, J. P. Houston, and M. Gurfinkel, "Fluorescence-enhanced, near-infrared diagnostic imaging with contrast agents," Curr. Opin. Chem. Biol. 6, 642-656 (2002).
17. V. Ntziachristos, C. Bremer, and R. Weissleder, "Fluorescence imaging with near infrared light: new technological advances that enable in vivo molecular imaging," Eur. J. Radiol. 13, 195-208 (2003).
18. R. Weissleder, "Scaling down imaging: molecular mapping of cancer in mice," Nat. Rev. Cancer 2, 11-18 (2002).
19. R. Weissleder, C. H. Tung, U. Mahmood, and A. Bogdanov, Jr., "In vivo imaging of tumors with protease-activated near-infrared fluorescent probes," Nat. Biotechnol. 17, 375-378 (1999).
20. V. Ntziachristos, C. H. Tung, C. Bremer, and R. Weissleder, "Fluorescence molecular tomography resolves protease activity in vivo," Nat. Med. 8, 757-760 (2002).
21. B. W. Pogue, S. L. Gibbs, and B. Chen, "Fluorescence imaging in vivo: raster scanned point-source imaging provides more accurate quantification than broad beam geometries," Technol. Cancer Res. Treat. 3, 15-21 (2004).
22. R. B. Schulz, J. Ripoll, and V. Ntziachristos, "Experimental fluorescence tomography of tissues with noncontact measurements," IEEE Trans. Med. Imaging 23, 492-500 (2004).
23. S. V. Patwardhan, S. R. Bloch, S. Achilefu, and J. P. Culver, "Time-dependent whole-body fluorescence tomography of probe bio-distributions in mice," Opt. Express 13, 2564-2576 (2005).
24. E. E. Graves, J. Ripoll, R. Weissleder, and V. Ntziachristos, "A submillimeter resolution fluorescence molecular imaging system for small animal imaging," Med. Phys. 30, 901-911 (2003).
25. A. Godavarty, A. B. Thompson, R. Roy, M. Gurfinkel, M. J. Eppstein, C. Zhang, and E. M. Sevick-Muraca, "Diagnostic imaging of breast cancer using fluorescence-enhanced optical tomography: phantom studies," J. Biomed. Opt. 9, 488-496 (2004).
26. A. Godavarty, M. J. Eppstein, C. Zhang, and E. M. Sevick-Muraca, "Detection of single and multiple targets in tissue phantoms with fluorescence-enhanced optical imaging: feasibility study," Radiology 235, 148-154 (2005).
27. D. Kepshire, S. Gibbs, S. Davis, H. Dehghani, K. D. Paulsen, and B. W. Pogue, "Subsurface fluorescence imaging of Protoporphyrin DC with B-Scan mode tomography," Proc. SPIE. 6139, 61391F (2006).
28. R. B. S. Jorge Ripoll and V. Ntziaehristos, "Free-space propagation of diffuse light: theory and experiments," Phys. Rev. Lett. 91, 1-4 (2003).
29. T. O. McBride, B. W. Pogue, S. Jiang, U. L. Osterberg, and K. D. Paulsen, "Development and calibration of a parallel modulated near-infrared tomography system for hemoglobin imaging in vivo," Rev. Sci. Instrum. 72, 1817-1824 (2001).
30. H. Jiang, K. D. Paulsen, U. L. Osterberg, B. W. Pogue, and M. S. Patterson, "Optical image reconstruction using frequency-domain data: simulations and experiments," J. Opt. Soc. Am. A 13, 253-266 (1996).
31. A. H. Hielscher, A. Y. Bluestone, G. S. Abdoulaev, A. D. Hose, J. Lasker, M. Stewart, U. Netz, and J. Beuthan, "Near-infrared diffuse optical tomography," Dis. Markers 18, 313-337 (2002).
32. S. R. Arridge and M. Schweiger, "Image reconstruction in optical tomography," Philos. Trans. R. Soc. London Ser. B. 352, 717-726 (1997).
33. S. R. Arridge and J. C. Hebden, "Optical imaging in medicine: II. Modelling and reconstruction," Phys. Med. Biol. 42, 841-853 (1997).
34. J. Chang, H. L. Graber, and R. L. Barbour, "Luminescence optical tomography of dense scattering media," J. Opt. Soc. Am. A 14, 288-299 (1997).
35. D. Y. Paithankar, A. U. Chen, B. W. Pogue, M. S. Patterson, and E. M. Sevick-Muraca, "Imaging of fluorescent yield and lifetime from multiply scattered light re-emitted from tissues and other random media," Appl. Opt. 36, 2260-2272 (1997).
36. H. Jiang, "Frequency-domain fluorescence diffusion tomography: a finite-element-based algorithm and simulations," Appl. Opt. 37, 5337-5343 (1998).
37. A. B. Millstein, S. Oh, K. J. Webb, C. A. Bouman, Q. Zhang, D. A. Boas, and R. P. Millane, "Fluorescence optical diffusion tomography," Appl. Opt. 42, 3081-3093 (2003).
38. R. Roy and E. M. Sevick-Muraca, "Three-dimensional unconstrained and constrained image-reconstruction techniques applied to fluorescence, frequency-domain photon migration," Appl. Opt. 40, 2206-2215 (2001).
39. S. C. Davis, B. W. Pogue, H. Dehghani, and K. D. Paulsen, "Contrast-detail analysis characterizing diffuse optical fluorescence tomography image reconstruction," J. Biomed. Opt. 10, 1-3 (2005).
40. K. D. Paulsen and H. Jiang, "Spatially varying optical property reconstruction using a finite element diffusion equation approximation," Med. Phys. 22, 691-701 (1995).
41. M. S. Patterson and B. W. Pogue, "Mathematical model for time-resolved and frequency-domain fluorescence spectroscopy in biological tissues," Appl. Opt. 33, 1963-1974 (1994).
42. S. R. Arridge and M. Schweiger, "Photon-measurement density functions. Part 2: Finite-element-method calculations," Appl. Opt. 34, 8026-8037 (1995).
43. B. W. Pogue, T. O. McBride, J. Prewitt, U. L. Osterberg, and K. D. Paulsen, "Spatially variant regularization improves diffuse optical tomography," Appl. Opt. 38, 2950-2961 (1999).
44. H. Dehghani, B. W. Pogue, S. Jiang, B. A. Brooksby, and K. D. Paulsen, "Three-dimensional optical tomography: resolution in small-object imaging," Appl. Opt. 42, 3117-3128 (2003).
45. K. D. Paulsen, P. M. Meaney, M. J. Moskowitz, and J. M. Sullivan, Jr., "A dual mesh scheme for finite element based reconstruction algorithms," IEEE Trans. Med. Imaging 14, 504-514 (1995).
46. W. Stummer, A. Novotny, H. Stepp, C. Goetz, K. Bise, and H. J. Reulen, "Fluorescence-guided resection of glioblastoma multiforme by using 5-aminolevulinic acid-induced porphyrins: a prospective study in 52 consecutive patients," J. Neurosurg. 93, 1003-1013 (2000).
47. A. Bogaards, A. Varma, S. P. Collens, A. Lin, A. Giles, V. Yang, J. M. Bilbao, L. D. Lilge, P. J. Muller, and B. C. Wilson, "Increased brain tumor resection using fluorescence image guidance in a preclinical model," Lasers Surg. Med. 35, 181-190 (2004).
48. J. P. Culver, V. Ntziachristos, M. J. Holboke, and A. G. Yodh, "Optimization of optode arrangements for diffuse optical tomography: A singular-value analysis," Opt. Lett. 26, 701-703 (2001).
49. Q. Zhu, N. Chen, and S. H. Kurtzman, "Imaging tumor angiogenesis by use of combined near-infrared diffusive light and ultrasound," Opt. Lett. 28, 337-339 (2003).