Design and implementation of dynamic near-infrared optical tomographic imaging instrumentation for simultaneous dual-breast measurements

Applied Optics

Volumn 44, Issue 11, 2005, Pages 2140-2153

  Schmitz, Christoph H ^a,b   Klemer, David P ^e   Hardin, Rosemarie ^b,c,d   Katz, Michael S ^b,c,d   Pei, Yaling ^a   Graber, Harry L ^a,b   Levin, Mikhail B ^a,b   Levina, Rita D ^a   Franco, Nelson A ^b,c,d   Solomon, William B ^b   Barbour, Randall L ^a,b  

^a NIRx Technologies LLC   (United States)

^b SUNY DOWNSTATE MEDICAL CENTER   (United States)

^c NEW YORK STATE DEPARTMENT OF HEALTH   (United States)

^d KINGS COUNTY HOSPITAL CENTER   (United States)

^e University of Wisconsin Milwaukee   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATTENUATION; COMPUTERIZED TOMOGRAPHY; INFRARED SPECTROSCOPY; MATHEMATICAL MODELS; OPTICAL FIBERS; PATHOLOGY; PATIENT TREATMENT; TIME DIVISION MULTIPLEXING;

DIFFUSE OPTICAL TOMOGRAPHY (DOT); OPTICAL DATA; PATHOPHYSIOLOGY; SYSTEM COMPLEXITY;

MEDICAL IMAGING;

ALGORITHM; ARTICLE; BREAST; BREAST TUMOR; CLINICAL TRIAL; COMPUTER ASSISTED DIAGNOSIS; COMPUTER INTERFACE; COMPUTER PROGRAM; EQUIPMENT; EQUIPMENT DESIGN; FEMALE; HUMAN; IMAGE ENHANCEMENT; INFORMATION RETRIEVAL; INSTRUMENTATION; METHODOLOGY; NEAR INFRARED SPECTROSCOPY; OPTICAL TOMOGRAPHY; PATHOLOGY; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY; THREE DIMENSIONAL IMAGING; VALIDATION STUDY;

ALGORITHMS; BREAST; BREAST NEOPLASMS; EQUIPMENT DESIGN; EQUIPMENT FAILURE ANALYSIS; FEMALE; HUMANS; IMAGE ENHANCEMENT; IMAGE INTERPRETATION, COMPUTER-ASSISTED; IMAGING, THREE-DIMENSIONAL; INFORMATION STORAGE AND RETRIEVAL; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SOFTWARE; SPECTROSCOPY, NEAR-INFRARED; TOMOGRAPHY, OPTICAL; USER-COMPUTER INTERFACE;

EID: 20244385274     PISSN: 1559128X     EISSN: 15394522     Source Type: Journal    
DOI: 10.1364/AO.44.002140     Document Type: Article

References (21)

1. C. H. Schmitz, H. L. Graber, R. D. Levina, M. B. Levin, and R. L. Barbour, "Data integrity assessment and instrument calibration for the DYNOT imaging system," in Biomedical Topical Meetings on CD-ROM (Optical Society of America, Washington, D.C., 2004), presentation ThF28.
2. C. H. Schmitz, M. Löcker, J. M. Lasker, A. H. Hielscher, and R. L. Barbour, "Instrumentation for fast functional optical tomography," Rev. Sci. Instrum. 73, 429-439 (2002).
3. C. H. Schmitz, H. L. Graber, R. L. Levina, M. B. Levin, and R. L. Barbour, "Data integrity assessment and instrument calibration for the DYNOT imaging system," in Biomedical Topi cal Meetings on CD-ROM (Optical Society of America, Washington, D.C., 2004), presentation WF35.
4. C. H. Schmitz, Y. Pei, H. L. Graber, J. M. Lasker, A. H. Hielscher, and R. L. Barbour, "Instrumentation for real-time dynamic optical tomography," in Photon Migration, Optical Coherence Tomography, and Microscopy, S. Andersson-Engels and M. Kaschke, eds., Proc. SPIE 4431, 282-291 (2001).
5. D. P. Klemer, R. L. Barbour, C. H. Schmitz, R. L. Graber, Y. Pei, R. E. Hardin, M. S. Katz, N. A. Franco, and A. G. Smeraldi, "Multi-site near-infrared tomographic imaging of the brain," in Biomedical Topical Meetings on CD-ROM (Optical Society of America, Washington, B.C., 2004), presentation WF35.
6. A. G. Smeraldi, N. A. Franco, H. L. Graber, D. P. Klemer, R. E. Hardin, M. S. Katz, C. H. Schmitz, T. F. Panetta, and R. L. Barbour, "Evaluation of peripheral vascular disease using non-invasive dynamic optical tomography," in Biomedical Topical Meetings on CD-ROM (Optical Society of America, Washington, D.C., 2004), presentation WF36.
7. R. E. Hardin, D. P. Klemer, M. S. Katz, N. A. Franco, H. L. Graber, C. H. Schmitz, R. L. Barbour, A. G. Smeraldi, and T. F. Panetta, "Application of dynamic optical tomography for the detection of a multi-phase physiologic response to Valsalva maneuver in healthy breast tissue," in Biomedical Topical Meetings on CD-ROM (Optical Society of America, Washington, D.C., 2004), presentation WF37.
8. M. S. Katz, R. E. Hardin, N. A. Franco, A. D. Smeraldi, D. P. Klemer, C. H. Schmitz, H. L. Graber, and R. L. Barbour, "Physiological variation in vascular reactivity of breast tissue over the menstrual cycle demonstrated by optical tomography," in Biomedical Topical Meetings on CD-ROM (Optical Society of America, Washington, D.C., 2004), presentation WA5.
9. Y. Pei, H. L. Graber, and R. L. Barbour, "Influence of systematic errors in reference states on image quality and on stability of derived information for DC optical imaging," Appl. Opt. 40, 5755-5769 (2001).
10. R. L. Barbour, H. L. Graber, Y. Pei, S. Zhong, and C. H. Schmitz, "Optical tomographic imaging of dynamic features of dense-scattering media," J. Opt. Soc. Am. A 18, 3018-3036 (2001).
11. Y. Pei, H. L. Graber, Y. Xu, and R. L. Barbour, "dynaLYZE - an analysis package for time-series NIRS imaging data," in Biomedical Topical Meetings on CD-ROM (Optical Society of America, Washington, D.C., 2004), presentation FH42.
12. R. A. Nishimura and A. J. Tajik, "The Valsalva maneuver and response revisited," Mayo Clin. Proc. 61, 211-217 (1986).
13. R. K. Jain, "Normalizing tumor vasculature with antiangiogenetic therapy: a new paradigm for combination therapy," Nat. Med. 7, 987-989 (2001).
14. H. L. Graber, Y. Pei, R. L. Barbour, D. K. Johnston, Y. Zheng, and J. E. Mayhew, "Signal source separation and localization in the analysis of dynamic near infrared optical tomographic time series," in Optical Tomography and Spectroscopy of Tissue V, B. Chance, R. R. Alfano, B. J. Tromberg, M. Tamura, and E. M. Sevick-Muraca, eds. Proc. SPIE 4955, 31-51 (2003).
15. R. L. Barbour, H. L. Graber, C. H. Schmitz, F. Tarantini, G. Khoury, D. J. Naar, T. F. Panetta, T. Lewis, and Y. Pei, "Time-frequency analysis of functional optical mammographic images," in Optical Tomography and Spectroscopy of Tissue V, B. Chance, R. R. Alfano, B. J. Tromberg, M. Tamura, and E. M. Sevick-Muraca, Proc. SPIE 4955, 84-95 (2003).
16. R. L. Barbour, H. L. Graber, Y. Pei, C. H. Schmitz, Y. Xu, A. Di Martino, F. X. Castellanos, D. P. Klemer, R. E. Hardin, N. A. Franco, M. S. Katz, M. E. Zenilman, A. G. Smeraldi, and T. F. Panetta, "Functional imaging of the vascular bed by dynamic optical tomography," in Physiology, Function, and Structure from Medical Images, A. A. Amini and A. Manduca, eds., Proc. SPIE 5369, 132-149 (2004).
17. M. Cope and D. T. Delpy, "System for long-term measurement of cerebral blood and tissue oxygenation on newborn infants by near infra-red transillumination," Med. Biol. Eng. Comput. 26, 289-294 (1988).
18. D. T. Delpy, M. Cope, P. Van der Zee, S. Arridge, S. Wray, and J. Wyatt, "Estimation of optical pathlength through tissue from direct time of flight measurement," Phys. Med. Biol. 33, 1433-1442 (1988).
19. C. H. Schmitz, H. L. Graber, H. B. Luo, I. Arif, J. Hira, Y. L. Pei, A. Bluestone, S. Zhong, R. Andronica, I. Soller, N. Ramirez, S. L. S. Barbour, and R. L. Barbour, "Instrumenta tion and calibration protocol for imaging dynamic features in dense-scattering media by optical tomography," Appl. Opt. 39, 6466-6486 (2000).
20. A. Sassaroli and S. Fantini, "Comment on the modified Beer-Lambert law for scattering media," Phys. Med. Biol. 49, N255-N257 (2004).
21. An interesting implication of the main result of Ref. 20 is that even if pulsed time-resolved or frequency-domain measurements were made, the value of d still could not be experimentally determined.