Toll-like receptors on the fork roads between innate and adaptive immunity

Human Immunology

Volumn 72, Issue 12, 2011, Pages 1188-1193

  Abdelsadik, Ahmed ^a,b   Trad, Ahmad ^a  

^a UNIVERSITY OF KIEL   (Germany)

^b ASWAN UNIVERSITY   (Egypt)

Author keywords

Autoimmunity; Innate and adaptive immunity; TLR

Indexed keywords

TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 1; TOLL LIKE RECEPTOR 10; TOLL LIKE RECEPTOR 11; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 5; TOLL LIKE RECEPTOR 6; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 8; TOLL LIKE RECEPTOR 9;

ADAPTIVE IMMUNITY; ARTICLE; AUTOIMMUNE DISEASE; B LYMPHOCYTE; IMMUNE SYSTEM; INNATE IMMUNITY; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE;

ADAPTIVE IMMUNITY; ANIMALS; AUTOIMMUNE DISEASES; AUTOIMMUNITY; BACTERIA; BACTERIAL INFECTIONS; CYTOKINES; HUMANS; IMMUNITY, INNATE; MICE; SIGNAL TRANSDUCTION; T-LYMPHOCYTE SUBSETS; TOLL-LIKE RECEPTORS; VIRUS DISEASES; VIRUSES;

EID: 81955161919     PISSN: 01988859     EISSN: 18791166     Source Type: Journal    
DOI: 10.1016/j.humimm.2011.08.015     Document Type: Article

References (69)

1. Akira S, Takeda K, Kaisho T. Toll-like receptors: critical proteins linking innate and acquired immunity. Nat Immunol;2:675-80.
2. Alexopoulou L, Holt AC, Medzhitov R, Flavell RA. Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. Nature;413:732-8.
3. Wang L, Ligoxygakis P. Pathogen recognition and signalling in the Drosophila innate immune response. Immunobiology;211:251-61.
4. Rakoff-Nahoum S, Medzhitov R. Toll-like receptors and cancer. Nat Rev Cancer;9:57-63.
5. Unni AM, Bondar T, Medzhitov R. Intrinsic sensor of oncogenic transformation induces a signal for innate immunosurveillance. Proc Natl Acad Sci U S A;105:1686-91.
6. Horng T, Bezbradica JS, Medzhitov R. NKG2D signaling is coupled to the interleukin 15 receptor signaling pathway. Nat Immunol;8:1345-52.
7. Apetoh L, Ghiringhelli F, Tesniere A, Obeid M, Ortiz C, Criollo A, et al. Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy. Nat Med;13:1050-9.
8. Blander JM, Medzhitov R. On regulation of phagosome maturation and antigen presentation. Nat Immunol;7:1029-35.
9. Hong S.C., Sant'Angelo D.B., Dittel B.N., Medzhitov R., Yoon S.T., Waterbury P.G., et al. The orientation of a T cell receptor to its MHC class II: peptide ligands. J Immunol 1997, 159:4395-4402.
10. Sant'Angelo DB, Waterbury G, Preston-Hurlburt P, Yoon ST, Medzhitov R, Hong SC, et al. The specificity and orientation of a TCR to its peptide-MHC class II ligands. Immunity;4:367-76.
11. Pasare C, Medzhitov R. Toll-like receptors: linking innate and adaptive immunity. Microbes Infect;6:1382-7.
12. Christensen SR, Shupe J, Nickerson K, Kashgarian M, Flavell RA, Shlomchik MJ. Toll-like receptor 7 and TLR9 dictate autoantibody specificity and have opposing inflammatory and regulatory roles in a murine model of lupus. Immunity;25:417-28.
13. Pasare C, Medzhitov R. Control of B-cell responses by Toll-like receptors. Nature;438:364-8.
14. Rajewsky K. Clonal selection and learning in the antibody system. Nature;381:751-8.
15. Van Dullemen HM, van Deventer SJ, Hommes DW, et al. Treatment of Crohn's disease with anti-tumor necrosis factor chimeric monoclonal antibody (cA2). Gastroenterology;109:129-35.
16. Wang PY, Munford RS. CD14-dependent internalization and metabolism of extracellular phosphatidylinositol by monocytes. J Biol Chem;274:23235-41.
17. Takeuchi O, Hoshino K, Kawai T, et al. Differential roles of TLR2 and TLR4 in recognition of Gram-negative and Gram-positive bacterial cell wall components. Immunity;11:443-51.
18. Barton GM, Medzhitov R. Toll-like receptors and their ligands. Curr Top Microbiol Immunol;270:81-92.
19. Kirschning CJ, Wesche H, Merrill Ayres T, Rothe M. Human Toll-like receptor 2 confers responsiveness to bacterial lipopolysaccharide. J Exp Med;188:2091-7.
20. Han SH, Yea SS, Jeon YJ, Yang KH, Kaminski NE. Transforming growth factor-beta 1 (TGF-beta1) promotes IL-2 mRNA expression through the up-regulation of NF-kappaB, AP-1 and NF-AT in EL4 cells. J Pharmacol Exp Ther;287:1105-12.
21. Yang R-B, Mark MR, Gurney AL, Godowski PJ. Signaling events induced by lipopolysaccharide-activated Toll-like receptor 2. J Immunol;163:639-43.
22. MacLeod H., Wetzler L.M. T cell activation by TLRs: a role for TLRs in the adaptive immune response. Sci STKE 2007, 402:pe48.
23. Liu B., Yang Y., Dai J., Medzhitov R., Freudenberg M.A., Zhang P.L., et al. TLR4 up-regulation at protein or gene level is pathogenic for lupus-like autoimmune disease. J Immuno 2006, 177:6880-6888.
24. Diebold S.S., Kaisho T., Hemmi H., Akira S., Reis e Sousa C., et al. Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA. Science 2004, 303:1529-1531.
25. Gururajan M., Jacob J., Pulendran B. Toll-like receptor expression and responsiveness of distinct murine splenic and mucosal B-cell subsets. PLoS ONE 2007, 2:e863.
26. Ha S.A., Tsuji M., Suzuki K., Meek B., Yasuda N., Kaisho T., et al. Regulation of B1 cell migration by signals through Toll-like receptors. J Exp Med 2006, 203:2541-2550.
27. Imanishi T., Hara H., Suzuki S., Suzuki N., Akira S., Saito T. Cutting edge: TLR2 directly triggers Th1 effector functions. J Immunol 2007, 178:6715-6719.
28. Carpenter S., O'Neill L.A.J. How important are Toll-like receptors for antimicrobial responses?. Cell Microbiol 2007, 9:1891-1901.
29. Bendelac A., Medzhitov R. Adjuvants of immunity: harnessing innate immunity to promote adaptive immunity. J Exp Med 2002, 195:F19-F23.
30. Akira S. Mammalian Toll-like receptors. Curr Opin Immunol 2003, 15:5-11.
31. Gallucci S., Lolkema M., Matzinger P. Natural adjuvants: endogenous activators of dendritic cells. Nat Med 1999, 5:1249-1255.
32. Granucci F., Feau S., Angeli V., Trottein F., Ricciardi-Castagnoli P. Early IL-2 production by mouse dendritic cells is the result of microbial-induced priming. J Immunol 2003, 170:5075-5081.
33. Manickasingham S., Reis e Sousa C. Microbial and T cell-derived stimuli regulate antigen presentation by dendritic cells in vivo. J Immunol 2000, 165:5027-5034.
34. Datta S.K., Redecke V., Prilliman K.R., Takabayashi K., Corr M., Tallant T., et al. A subset of Toll-like receptor ligands induces cross-presentation by bone marrow-derived dendritic cells. J Immunol 2003, 170:4102-4110.
35. Krieg A.M., Yi A.K., Matson S., Waldschmidt T.J., Bishop G.A., Teasdale R., et al. CpG motifs in bacterial DNA trigger direct B-cell activation. Nature 1995, 374:546-549.
36. Ruprecht C.R., Lanzavecchia A. Toll-like receptor stimulation as a third signal required for activation of human naive B cells. Eur J Immunol 2006, 36:810-816.
37. Genestier L., Taillardet M., Mondiere P., Gheit H., Bella C., Defrance T. TLR agonists selectively promote terminal plasma cell differentiation of B cell subsets specialized in thymus-independent responses. J Immunol 2007, 178:7779-7786.
38. Bernasconi N.L., Traggiai E., Lanzavecchia A. Maintenance of serological memory by polyclonal activation of human memory B cells. Science 2002, 298:2199-2202.
39. Komai-Koma M., Jones L., Ogg G.S., Xu D., Liew F.Y. TLR2 is expressed on activated T cells as a costimulatory receptor. Proc Natl Acad Sci U S A 2004, 101:3029-3034.
40. Gelman A.E., Zhang J., Choi Y., Turka L.A. Toll-like receptor ligands directly promote activated CD4+ T cell survival. J Immunol 2004, 172:6065-6073.
41. Caramalho I., Lopes-Carvalho T., Ostler D., Zelenay S., Haury M., Demengeot J. Regulatory T cells selectively express Toll-like receptors and are activated by lipopolysaccharide. J Exp Med 2003, 197:403-411.
42. +CD25+T regulatory cells. J Immunol 2005, 175:8051-8059.
43. Möller G., Andersson J., Sjöberg O. Lipopolysaccharides can convert heterologous red cells into thymus-independent antigens. Cell Immunol 1972, 4:416-424.
44. Olivier A., Sainz-Perez A., Dong H., Sparwasser T., Majlessi L., Leclerc C. The adjuvant effect of TLR agonists on CD4(+) effector T cells is under the indirect control of regulatory T cells. Eur J Immunol 2011, 41:2303-2313.
45. Ouabed A., Hubert F.X., Chabannes D., Gautreau L., Heslan M., Josien R. Differential control of T regulatory cell proliferation and suppressive activity by mature plasmacytoid versus conventional spleen dendritic cells. J Immunol 2008, 180:5862-5870.
46. Acosta-Rodriguez E.V., Rivino L., Geginat J., Jarrossay D., Gattorno M., Lanzavecchia A., et al. Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cells. Nat Immunol 2007, 8:639-646.
47. Yoshimura T., Sonoda K.H., Ohguro N., Ohsugi Y., Ishibashi T., Cua D.J., et al. Involvement of Th17 cells and the effect of anti-IL-6 therapy in autoimmune uveitis. Rheumatol Oxf Engl 2009, 48:347-354.
48. Ferraccioli G., Zizzo G. The potential role of Th17 in mediating the transition from acute to chronic autoimmune inflammation: rheumatoid arthritis as a model. Discov Med 2011, 11:413-424.
49. Yamashita T., Iwakura T., Matsui K., Kawaguchi H., Obana M., Hayama A., et al. IL-6-mediated Th17 differentiation through ROR{gamma}t is essential for the initiation of experimental autoimmune myocarditis. Cardiovasc Res 2011, 91:640-648.
50. + T cells. J Immunol 2009, 182:3372-3379.
51. Hansel A., Gunther C., Ingwersen J., Starke J., Schmitz M., Bachmann M., et al. Human slan (6-sulfo LacNAc) dendritic cells are inflammatory dermal dendritic cells in psoriasis and drive strong TH17/TH1 T-cell responses. J Allergy Clin Immunol 2011, 127:787-794.
52. van de Veerdonk F.L., Marijnissen R.J., Kullberg B.J., Koenen H.J., Cheng S.C., Joosten I., et al. The macrophage mannose receptor induces IL-17 in response to Candida albicans. Cell Host Microbe 2009, 5:329-340.
53. Teixeira-Coelho M., Cruz A., Carmona J., Sousa C., Ramos-Pereira D., Saraiva A.L., et al. TLR2 deficiency by compromising p19 (IL-23) expression limits Th 17 cell responses to Mycobacterium tuberculosis. Int Immunol 2010, 23:89-96.
54. Yu C.F., Peng W.M., Oldenburg J., Hoch J., Bieber T., Limmer A., et al. Human plasmacytoid dendritic cells support Th17 cell effector function in response to TLR7 ligation. J Immunol 2010, 184:1159-1167.
55. Shortman K., Liu Y.-J. Mouse and human dendritic cell subtypes. Nat Rev Immunol 2002, 2:151-161.
56. Mohammad M.K., Morran M., Slotterbeck B., Leaman D.W., Sun Y., Grafenstein H., et al. Dysregulated Toll-like receptor expression and signaling in bone marrow-derived macrophages at the onset of diabetes in the non-obese diabetic mouse. Int Immunol 2006, 18:1101-1113.
57. Creely S.J., McTernan P.G., Kusminski C.M., Fisher F.M., Da Silva N.F., Khanolkar M., et al. Lipopolysaccharide activates an innate immune system response in human adipose tissue in obesity and type 2 diabetes. Am J Physiol Endocrinol Metab 2007, 292:E740-E747.
58. Devaraj S., Jialal I., Yun J.-M., Bremer A. Demonstration of increased Toll-like receptor 2 and Toll-like receptor 4 expression in monocytes of type 1 diabetes mellitus patients with microvascular complications. Metabolism 2011, 60:256-259.
59. Devaraj S., Dasu M.R., Rockwood J., Winter W., Griffen S.C., Jialal I. Increased Toll-like receptor (TLR) 2 and TLR4 expression in monocytes from patients with type 1 diabetes: further evidence of a proinflammatory state. J Clin Endocrinol Metab 2008, 93:578-583.
60. Fallarino F., Puccetti P. Toll-like receptor 9-mediated induction of the immunosuppressive pathway of tryptophan catabolism. Eur J Immunol 2006, 36:8-11.
61. Fallarino F., Volpi C., Zelante T., Vacca C., Calvitti M., Fioretti M.C., et al. IDO mediates TLR9-driven protection from experimental autoimmune diabetes. J Immunol 2009, 183:6303-6312.
62. Alsaleh G., François A., Knapp A.-M., Schickel J.-N., Sibilia J., Pasquali J.-L., et al. Synovial fibroblasts promote immunoglobulin class switching by a mechanism involving BAFF. Eur J Immunol 2011, 41:2113-2122.
63. Roelofs MF L.J., Abdollahi-Roodsaz S., van Lieshout A.W.T., Radstake T.R.D.J., van den Berg W.B. Expression of Toll-like receptor (TLR) 2, TLR3, TLR4 and TLR7 is increased in rheumatoid arthritis synovium and regulates cytokine production by dendritic cells upon stimulation of TLR specific pathways. Arthritis Res Ther 2005, 7:70.
64. Geurts J., van den Brand B.T., Wolf A., Abdollahi-Roodsaz S., Arntz O.J., Kracht M., et al. Toll-like receptor 4 signalling is specifically TGF-beta-activated kinase 1 independent in synovial fibroblasts. Rheumatology 2011, 50:1216-1225.
65. Hennessy E.J., Parker A.E., O'Neill L.A.J. Targeting Toll-like receptors: emerging therapeutics?. Nat Rev Drug Discov 2010, 9:293-307.
66. Krieg AM, Wu T, Weeratan R, Efler SM, Love-Homan L, Yang L. Sequence motif in adenoviral DNA block immune activation by stimulatory CpG motifs. Proc Natl Acad Sci USA1998;156:4570-5.
67. Hemmi H., Kaisho T., Takeuchi O., Sato S., Sanjo H., Hoshino K., et al. Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway. Nat Immunol 2002, 3:196-200.
68. Anders H.J., Zecher D., Pawar R.D., Patole P.S. Molecular mechanisms of autoimmunity triggered by microbial infection. Arthritis Res Ther 2005, 7:215-224.
69. Xu D., Liu H., Komai-Koma M. Direct and indirect role of Toll-like receptors in T cell mediated immunity. Cell Mol Immunol 2004, 1:239-246.