The specificity and orientation of a TCR to its peptide-MHC class II ligands

Immunity

Volumn 4, Issue 4, 1996, Pages 367-376

  Sant'Angelo, Derek B ^a   Waterbury, Greg ^a   Preston Hurlburt, Paula ^a   Yoon, Sangwook Tim ^a,b   Medzhitov, Ruslan ^a   Hong, Soon Cheol ^a   Janeway Jr , Charles A ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD3 ANTIGEN; SYNTHETIC PEPTIDE; T LYMPHOCYTE RECEPTOR;

ANIMAL EXPERIMENT; ARTICLE; HYBRIDOMA; IMMUNIZATION; MAJOR HISTOCOMPATIBILITY COMPLEX; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE; TRANSGENIC MOUSE;

EID: 0029932899     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-7613(00)80250-2     Document Type: Article

References (54)

1. Amit, A.G., Mariuzza, R.A., Phillips, S.E.V., and Poljak, R.J. (1986). Three-dimensional structure of an antigen-antibody complex at 2.8 Å resolution. Science 233, 747-753.
2. Ashton-Rickhardt, P.G., Bandeira, A., Delaney, J.R., Van Kaer, L., Pircher, H.P., Zinkernagel, R.M., and Tonegawa, S. (1994). Evidence for a differential avidity model of T cell selection in the thymus. Cell 76, 651-653.
3. Bentley, G.A., Boulot, G., Karjalainen, K., and Mariuzza, R. (1995). Crystal structure of the β chain of a T cell antigen receptor. Science 267, 1984-1987.
4. Berek, C., Berger, A., and Apel, M. (1991). Maturation of the immune response in germinal centers. Cell 67, 1121-1129.
5. Betz, A.G., Neuberger, M.S., and Milstein, C. (1993). Discriminating intrinsic and antigen-selected mutational hotspots in immunoglobulin V genes. Immunol. Today 14, 405-411.
6. Bjorkman, P.J., Saper, M.A., Samraoui, B., Bennett, W.S., Strominger, J.L., and Wiley, D.C. (1987). Structure of the human class I histocompatibility antigen HLA-A2. Nature 329, 506-512.
7. Both, G.W., Taylor, L., Pollard, J.W., and Steele, E.J. (1990). Distribution of mutation around rearranged heavy-chain antibody variable-region genes. Mol. Cell. Biol. 10, 5187-5196.
8. Chothia, C., Boswell, D.R., and Lesk, A.M. (1988). The outline structure of the T cell alpha beta receptor. EMBO J 7, 3745-3755.
9. Claverie, J.M., Prochnicka, C.A., and Bouguellerret, L. (1989). Implications of a Fab-like structure for the T cell receptor. Immunol. Today 10, 10-14.
10. Danska, J.S., Livingstone, A.M., Paragas, V., Ishihara, T., and Pathman, C.G. (1990). The presumptive CDR3 regions of both T cell receptor alpha and beta chains determine T cell specificity for myoglobin peptides. J. Exp. Med. 172, 27-33.
11. Davies, D.R., Padlan, E.A., and Sherriff, S. (1990). Antibody-antigen complexes. Annu. Rev. Biochem. 59, 439-473.
12. Davis, M.M., and Bjorkman, P.J. (1988). T cell antigen receptor genes and T cell recognition. Nature 334, 395-401.
13. De Magistris, M.T., Alexander, J., Coggeshall, M., Altman, A., Gaeta, F.C.A., Grey, H.M., and Sette, A. (1992). Antigen analog-major histocompatibility complexes act as antagonists of the T cell receptor. Cell 68, 625-634.
14. Dudley, E.C., Petrie, H.T., Shah, M.L., Owen, M.J. and Hayday, A.C. (1994). T cell receptor β chain gene rearrangement and selection during thymocyte development in adult mice. Immunity 1, 83-93.
15. Evavold, B.D., Sloan-Lancaster, J., Hsu, B.L., and Allen, P.M. (1993). Separation of T helper 1 clone cytolysis from proliferation and lymphokine production using analog peptides. J. Immunol. 150, 3131-3140.
16. Evavold, B.D., Sloan-Lancaster, J., Wilson, K.J., Rothbard, J.B., and Allen, P.M. (1995). Specific T cell recognition of minimally homologous peptides: evidence for multiple endogenous ligands. Immunity 2, 655-663.
17. Fink, P.J., Matis, L.A., McElligott, D.L., Bookman, M., and Hedrick, S.M. (1986). Correlations between T cell specificity and the structure of the antigen receptor. Nature 321, 219-226.
18. Geiger, T., Soldevilla, G., and Flavell, R.A. (1993). T cells are responsive to the simian virus 40 large tumor antigen transgenically expressed in pancreatic islets. J. Immunol. 151, 7030-7037.
19. Germain, R.N. (1994). Major histocompatibility complex-dependent antigen processing and peptide presentation: providing ligands for the clonal activation of T lymphocytes. Cell 76, 287-299.
20. Ghosh, P., Amaya, M., Mellins, E., and Wiley, D.C. (1995). The structure of an intermediate in class II MHC maturation: CLIP bound to HLA-DR3. Nature 378, 457-462.
21. Hogquist, K.A., Jameson, S.C., Heath, W.R., Howard, J.L., Bevan, M.J., and Carbone, F.R. (1994). T cell receptor antagonist peptides induce positive selection. Cell 76, 17-27.
22. Hong, S.-C., Chelouche, A., Lin, R.-h., Shaywitz, D., Braunstein, N.S., Glimcher, L., and Janeway, C.A., Jr. (1992). An MHC interaction site maps to the amino-terminal half of the T cell receptor α chain variable domain. Cell 69, 1-20.
23. Jameson, S.C., and Bevan, M.J. (1995). T cell receptor antagonists and partial agonists. Immunity 2, 1-11.
24. Jameson, S.C., Hogquist, K.A., and Bevan, M.J. (1994). Specificity and flexibility in thymic selection. Nature 369, 750-752.
25. Jorgensen, J.L., Esser, U., Fazekas de St. Groth, B., Reay, P.A., and Davis, M.M. (1992). Mapping T cell receptor-peptide contacts by variant peptide immunization of single-chain transgenics. Nature 355, 224-230.
26. Katayama, C.D., Eidelman, F.J., Duncan, A., Hooshmand, F., and Hedrick, S.M. (1995). Predicted complementarity determining regions of the T cell antigen receptor determine antigen specificity. EMBO J 14, 927-938.
27. Kaye, J., Porcelli, S., Tite, J., Jones, B., and Janeway, C.A., Jr. (1983). Both a monoclonal antibody and antisera specific for determinants unique to individual cloned helper T cell lines can substitute for antigen and antigen presenting cells in the activation of T cells. J. Exp. Med. 755, 836-856.
28. Kelly, J.M., Sterry, S.J., Cose, S., Turner, S.J., Fecondo, J., Rodda, S., Fink, P.J., and Carbone, F.R. (1993). Identification of conserved T cell receptor CDR3 residues contacting known exposed peptide side chains from a major histocompatibility complex class I-bound determinant. Eur. J. Immunol. 23, 3318-3326.
29. Kuchroo, V.K., Greer, J.M., Kaul, D., Ishioka, G., Franco, A., Sette, A., Sobel, R.A., and Lees, MB. (1994). A single TCR antagonist peptide inhibits experimental allergic encephalomyelitis mediated by a diverse T cell repertoire. J. Immunol. 153, 3326-3336.
30. d restricted cloned CTL specific for a photoreactive peptide derivative. Immunity 3, 51-63.
31. Malcherek, G., Gnau, V., Jung, G., Rammensee, H.-G., and Melms, A. (1995). Supermotifs enable natural invariant chain-derived peptides to interact with many major histocompatibility complex-class II molecules. J. Exp. Med. 181, 527-536.
32. Marrack, P., Ignatowicz, L., Kappler, J.W., Boymel, J., and Freed, J.H. (1993). Comparison of peptides bound to spleen and thymus class II. J. Exp. Med. 178, 2173-2183.
33. McHeyzer-Williams, M.G., and Davis, M.M. (1995). Antigen-specific development of primary and memory T cells in vivo. Science 268, 106-111.
34. + T cell epitopes. Eur. J. Immunol. 21, 2851-2855.
35. k. Proc. Natl. Acad. Sci. USA 89, 7380-7383.
36. Padovan, E., Casorati, G., Dellabona, P., Meyer, S., Brockhaus, M., and Lanzavecchia, A. (1993). Expression of two T cell receptor α chains: dual receptor T cells. Science 262, 422-424.
37. Percus, J.K., Percus, O.E., and Perelson, A.S. (1993). Predicting the size of the T cell receptor and antibody combining region from consideration of efficient self-nonself discrimination. Proc. Natl. Acad. Sci. USA 90, 1691-1695.
38. Pfeiffer, C., Stein, J., Southwood, S., Ketelaar, H., Sette, A., and Bottomly, K. (1995). Altered peptide ligands can control CD4 T lymphocyte differentiation in vivo. J. Exp. Med. 181, 1569-1574.
39. Rammensee, H.G., Friede, T., and Stevanovic, S. (1995). MHC ligands and peptide motifs: first listing. Immunogenetics 41, 178-228.
40. Reich, E.-P., von Grafenstein, H., Barlow, A., Swenson, K.E., Williams, K., and Janeway, C.A., Jr. (1994). Self peptides isolated from MHC glycoproteins of non-obese diabetic mice. J. Immunol. 152, 2279-2288.
41. Rötzschke, O., and Falk, K. (1994). Origin, structure and motifs of naturally processed MHC class II ligands. Curr. Biol. 6, 45-51.
42. Saito, T., and Germain, R.N. (1987). Predictable acquisition of a new MHC recognition specificity following expression of a transfected T cell receptor β chain gene. Nature 329, 256-259.
43. k. J. Immunol. 137, 2748-54.
44. Sebzda, E., Wallace, V.A., Mayer, J., Yeung, R.S.M., Mak, T.W., and Ohashi, P.S. (1994). Positive and negative thymocyte selection induced by different concentrations of a single peptide. Science 263, 1615-1618.
45. Sette, A., Southwood, S., Miller, J., and Appella, E. (1995). Binding of major histocompatibility complex class II to the invariant chain-derived peptide, CLIP, is regulated by allelic polymorphism in class II. J. Exp. Med. 181, 677-683.
46. Sha, W.C., Nelson, C.A., Newberry, R.D., Kranz, D.M., Russell, J.H., and Loh, D.Y. (1988). Selective expression of an antigen receptor on CDS-bearing T lymphocytes in transgenic mice. Nature 335, 271-276.
47. Stern, L.J., and Wiley, D.C. (1994). Antigenic peptide binding by class I and class II histocompatibility proteins. Structure 2, 245-251.
48. Stern, L.J., Brown, J.H., Jardetsky, TS, Gorga, J.C., Urban, R.G., Strominger, J.L., and Wiley, D.C. (1994). Crystal structure of the human class II MHC protein HLA-DR1 complexed with an influenza virus peptide. Nature 368, 215-221.
49. b molecule. Immunity 3, 573-582.
50. Tonegawa, S. (1983). Somatic generation of antibody diversity. Nature 303, 575-581.
51. Winoto, A., Urban, J.L., Lan, N.C., Goverman, J., Hood, L., and Hansburg, D. (1986). Predominant use of a α gene segment in mouse T cell receptors for cytochrome c. Nature 324, 679-682.
52. Yelamos, J., Klix, N.,Goyenechea, B., Lozano, F., Chui, Y.L., Gonzalez Fernandez, A., Pannell, R., Neuberger, M.S., and Milstein, C. (1995). Targeting of non-Ig sequences in place of the V segment by somatic hypermutation. Nature 376, 225-229.
53. Yoon, S.T. (1994). The rotational orientation of the T cell receptor bound to peptide:MHC. PhD Thesis, Yale University School of Medicine, New Haven, Connecticut.
54. Yoon, S.T., Dianzani, U., Bottomly, K., and Janeway, C.A., Jr. (1994). Both high and low avidity antibodies to the T cell receptor can have agonist or antagonist activity. Immunity 1, 563-569.