Toxicogenomics and metabolomics of pentamethylchromanol (PMCol)-induced hepatotoxicity

Toxicological Sciences

Volumn 124, Issue 2, 2011, Pages 487-501

  Parman, Toufan ^a   Bunin, Deborah I ^a   Ng, Hanna H ^a   Mcdunn, Jonathan E ^b   Wulff, Jacob E ^b   Wang, Abraham ^a   Swezey, Robert ^a   Rasay, Laura ^a   Fairchild, David G ^a   Kapetanovic, Izet M ^c   Green, Carol E ^a  

^a SRI INTERNATIONAL   (United States)

^b METABOLON INC   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Gene expression; Glutathione; Hepatotoxicity; Metabolomics; Pentamethylchromanol; Toxicogenomic

Indexed keywords

6 HYDROXY 2,2,5,7,8 PENTAMETHYLCHROMAN; ALANINE AMINOTRANSFERASE; BILIRUBIN; CHOLESTEROL; CYSTEINE; CYSTINE; CYTOCHROME P450; GLUTATHIONE; METHIONINE; S ADENOSYLHOMOCYSTEINE; TRIACYLGLYCEROL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CLINICAL CHEMISTRY; DOWN REGULATION; DRUG BLOOD LEVEL; DRUG STRUCTURE; GENE EXPRESSION; LIVER TOXICITY; MALE; METABOLOMICS; MICROARRAY ANALYSIS; NONHUMAN; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TOXICOGENETICS; UPREGULATION;

ANIMALS; BIOLOGICAL MARKERS; CHROMANS; DRUG-INDUCED LIVER INJURY; GENE EXPRESSION; GENE EXPRESSION PROFILING; KIDNEY; LIVER; MALE; METABOLOMICS; MOLECULAR STRUCTURE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; ORGAN SIZE; RATS; RATS, SPRAGUE-DAWLEY; REAL-TIME POLYMERASE CHAIN REACTION; TOXICOGENETICS;

EID: 81855194820     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfr238     Document Type: Article

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