Induction of CYP1A and CYP2-mediated arachidonic acid epoxygenation and suppression of 20-hydroxyeicosatetraenoic acid by imidazole derivatives including the aromatase Inhibitor vorozole

Drug Metabolism and Disposition

Volumn 34, Issue 8, 2006, Pages 1376-1385

  Diani Moore, Silvia ^a   Papachristou, Fotini ^a   Labitzke, Erin ^a   Rifkind, Arleen B ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 BENZYLIMIDAZOLE; 2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; 20 HYDROXYICOSATETRAENOIC ACID; ALBENDAZOLE; ANTHELMINTIC AGENT; ARACHIDONIC ACID; AROMATASE; AROMATASE INHIBITOR; CYTOCHROME P450 1A; CYTOCHROME P450 2A; ICOSATRIENOIC ACID; IMIDAZOLE DERIVATIVE; MEMBRANE LIPID; OMEPRAZOLE; PHENOBARBITAL; PROTON PUMP INHIBITOR; THROMBOXANE SYNTHASE INHIBITOR; TIABENDAZOLE; VOROZOLE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOLOGICAL ACTIVITY; CELL STRAIN HEPG2; CONTROLLED STUDY; DRUG DISTRIBUTION; DRUG METABOLISM; DRUG STRUCTURE; EMBRYO; ENANTIOMER; ENZYME ACTIVITY; ENZYME INDUCTION; ENZYME METABOLISM; HUMAN; HUMAN CELL; ISOMER; LIVER MICROSOME; MAMMAL CELL; MOUSE; NONHUMAN; OXYGENATION; PRIORITY JOURNAL; RACEMIC MIXTURE; VASOCONSTRICTION; VASODILATATION;

ANIMALS; ARACHIDONIC ACIDS; AROMATASE INHIBITORS; BENZIMIDAZOLES; CELL LINE, TUMOR; CHICK EMBRYO; CYTOCHROME P-450 ENZYME SYSTEM; ENZYME INDUCTION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; ISOENZYMES; MICE; MICROSOMES, LIVER; PHENOBARBITAL; RNA, MESSENGER; TETRACHLORODIBENZODIOXIN; TRIAZOLES;

AVES; MAMMALIA;

EID: 33746049226     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.106.009498     Document Type: Article

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