2,3,7,8-Tetrachlorodibenzo-p-dioxin induced cytochrome P450s alter the formation of reactive oxygen species in liver cells

Molecular Nutrition and Food Research

Volumn 50, Issue 4-5, 2006, Pages 378-384

  Knerr, Stefanie ^a   Schaefer, Johanna ^a   Both, Saskia ^a   Mally, Angela ^b   Dekant, Wolfgang ^b   Schrenk, Dieter ^a  

^a Rheinland Pfälzische Technische Universität Kaiserslautern Landau   (Germany)

^b UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

2,3,7,8 Tetrachlorodibenzo p dioxin; Cytochrome P450; DNA damage; Reactive oxygen species

Indexed keywords

2',7'-DICHLORODIHYDROFLUORESCEIN DIACETATE; 2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; 8 OXO 7 HYDRODEOXYGUANOSINE; 8-OXO-7-HYDRODEOXYGUANOSINE; CYTOCHROME P450; CYTOCHROME P450 1A1; DEOXYGUANOSINE; DICHLORODIHYDROFLUORESCEIN DIACETATE; DRUG DERIVATIVE; FLUORESCEIN DERIVATIVE; REACTIVE OXYGEN METABOLITE;

ANIMAL; BIOSYNTHESIS; CONFERENCE PAPER; DRUG EFFECT; ENZYME INDUCTION; ENZYMOLOGY; HUMAN; LIVER; LIVER CELL CARCINOMA; LIVER TUMOR; METABOLISM; RAT; TUMOR CELL LINE; WESTERN BLOTTING; WISTAR RAT;

ANIMALS; BLOTTING, WESTERN; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; CYTOCHROME P-450 CYP1A1; CYTOCHROME P-450 ENZYME SYSTEM; DEOXYGUANOSINE; ENZYME INDUCTION; FLUORESCEINS; HUMANS; LIVER; LIVER NEOPLASMS; RATS; RATS, WISTAR; REACTIVE OXYGEN SPECIES; TETRACHLORODIBENZODIOXIN;

EID: 33646238475     PISSN: 16134125     EISSN: 16134133     Source Type: Journal    
DOI: 10.1002/mnfr.200500183     Document Type: Conference Paper

References (22)

1. Nelson, D. R., Koymans, L., Kamataki, T., Stegeman, J. J. et al., Pharmacogenetics 1996, 6, 1-42.
2. Schmidt, J. V., Bradfield, C. A., Annu. Rev. Cell. Dev. Biol. 1996, 12, 55-89.
3. Whitlock, P., Annu. Rev. Pharmacol. Toxicol. 1999, 39, 103-125.
4. Hahn, M. E., Chem. Biol. Interact. 2002, 141, 131-160.
5. IARC (International Agency for Research on Cancer), IARC Monogr. Eval. Carcinog. Risks Hum. 1997, 69, 1-631.
6. Steenlan, K., Bertazzi, P., Baccarelli, A., Kogevinas, M., Environ. Health Perspectives 2004, 112(13), 1265-1268.
7. Park, J. Y., Shigenaga, M. K., Ames, B. N., Proc. Natl. Acad. Sci. USA 1996, 93(6), 2322-2327.
8. Kuthan, H., Ullrich, V., Eur. J. Biochem. 1982, 126, 583-588.
9. Ingelman, S. M., Johansson, I., J. Biol. Chem. 1984, 259, 6447-6458.
10. Halliwell, B., Gutteridge, J., Free Radicals in Biology and Medicine, Clarendon, Oxford 1989.
11. Wyde, M. E., Wong, V. A., Kim, A. H., Lucier, G. W., Walker, N. J., Chem. Res. Toxicol. 2001, 14, 849-855.
12. Whitlock, J. P. Jr., Chichester, C. H., Bedgood, R. M., Okino, S. et al., Drug Metab. Rev. 1997, 29(4), 1107-1127.
13. Schlezinger, J. J., White, R. D., Stegeman, J. J., Mol. Pharmacol. 1999, 56, 588-597.
14. Schrenk, D., Karger, A., Lipp, H. P., Bock, K. W., Carcinogenesis 1992, 13(3), 453-456.
15. Molecular Probes, Product Information; Reactive Oxygen Species (ROS) Detection Reagents, 2004.
16. http://www.riedlab.nci.nih.gov/publications/ 2442. 2601_DNA_Prep_TC4_High_Salt.pdf. Section of Cancer Genomics, Genetics Branch, NCI National Institutes of Health. 2004. DNA preparation from cell lines, high salt method.
17. Kennedy, S. W. Jones, S. P., Anal. Biochem. 1994, 222, 217-223.
18. Pohl, R. J., Fouts, J. R., Anal. Biochem. 1980, 107, 150-155.
19. Kociba, R. J., Keyes, D. G., Beyer, J. E., Carreon, R. M. et al., Toxicol. Appl. Pharmacol. 1978, 46, 279-303.
20. Dragan, Y. P., Xu, X. H., Goldsworthy, T. L., Campbell, H. A., Maronpot, R. R., Pitot, H. C., Carcinogenesis 1992, 13(8), 1389-1395.
21. Zeiger, M., Haag, R., Höckel, J., Schrenk, D., Schmitz, H. J., Toxicol. Sci. 2001, 63, 65-73.
22. Xu, L., Li, A. P., Kaminski, D. L., Ruh, M. F., Chem.-Biol. Interact. 2000, 124, 173-189.