In-vitro and in-vivo metabolic studies of the candidate chemopreventative pentamethylchromanol using liquid chromatography/tandem mass spectrometry

Journal of Pharmacy and Pharmacology

Volumn 61, Issue 10, 2009, Pages 1309-1318

  Gorman, Gregory S ^a   Coward, Lori ^a   Kerstner Wood, Corenna ^a   Freeman, Lea ^a   Hebert, Charles D ^a   Kapetanovic, Izet M ^b  

^a SOUTHERN RESEARCH INSTITUTE   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

CYP450; Drug metabolism; Liquid chromatography tandem mass spectrometry; Pentamethylchromanol

Indexed keywords

ANTIOXIDANT; CYTOCHROME P450; PENTAMETHYLCHROMANOL; UNCLASSIFIED DRUG; 2,2,5,7,8 PENTAMETHYL 1 HYDROXYCHROMAN; 2,2,5,7,8-PENTAMETHYL-1-HYDROXYCHROMAN; CHROMAN DERIVATIVE; ISOENZYME;

ANIMAL TISSUE; ARTICLE; BLOOD SAMPLING; CHEMOPROPHYLAXIS; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG METABOLISM; DRUG STABILITY; HUMAN; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; LIQUID CHROMATOGRAPHY; MICROSOME MEMBRANE; NONHUMAN; TANDEM MASS SPECTROMETRY; ANIMAL; COMPARATIVE STUDY; DOG; DRUG DETOXIFICATION; FEMALE; LIVER MICROSOME; MALE; METABOLISM; METHODOLOGY; PRIMATE; RAT; SPECIES DIFFERENCE; SPRAGUE DAWLEY RAT;

ANIMALS; CHROMANS; CHROMATOGRAPHY, LIQUID; DOGS; FEMALE; HUMANS; ISOENZYMES; MALE; METABOLIC DETOXICATION, DRUG; MICROSOMES, LIVER; PRIMATES; RATS; RATS, SPRAGUE-DAWLEY; SPECIES SPECIFICITY; TANDEM MASS SPECTROMETRY;

EID: 85047681307     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/jpp.61.10.0006     Document Type: Article

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