Acute postoperative pain management in the older patient

Aging Health

Volumn 7, Issue 6, 2011, Pages 813-828

  Hallingbye, Thor ^a   Martin, Jacob ^a   Viscomi, Christopher ^a  

^a UNIVERSITY OF VERMONT   (United States)

Author keywords

acute pain management; older adult; older patient; postoperative pain management

Indexed keywords

ANESTHETIC AGENT; CELECOXIB; DEXAMETHASONE; DROPERIDOL; DRUG METABOLITE; FENTANYL; GABAPENTIN; HYDROMORPHONE; KETAMINE; LAXATIVE; MEMANTINE; MORPHINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; NALOXONE; NARCOTIC ANALGESIC AGENT; NONSTEROID ANTIINFLAMMATORY AGENT; ONDANSETRON; OXYCODONE; OXYMORPHONE; PARACETAMOL; PREGABALIN; PROCHLORPERAZINE MALEATE; STEROID;

AGED; AGING; CARDIOVASCULAR DISEASE; CASE REPORT; CENTRAL NERVOUS SYSTEM DISEASE; CHRONIC PAIN; COGNITIVE DEFECT; CONSTIPATION; DELIRIUM; DISORIENTATION; DIZZINESS; DOSE RESPONSE; DROWSINESS; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG COST; DRUG DOSE INCREASE; DRUG DOSE REDUCTION; DRUG DOSE TITRATION; DRUG ELIMINATION; DRUG HALF LIFE; DRUG MEGADOSE; DRUG SAFETY; DRUG TOLERABILITY; DYSPHORIA; ELDERLY CARE; EXTRAPYRAMIDAL SYMPTOM; FEMALE; FIRST PASS EFFECT; FRACTURE NONUNION; GASTROINTESTINAL HEMORRHAGE; GASTROINTESTINAL SYMPTOM; GLOMERULUS FILTRATION RATE; HALLUCINATION; HUMAN; HYPERALGESIA; HYPERTENSION; INFLAMMATION; KIDNEY DISEASE; LIVER TOXICITY; LOW DRUG DOSE; LUNG EDEMA; MALE; NAUSEA; NEUROPATHIC PAIN; NOCICEPTION; OPTIMAL DRUG DOSE; PAIN; PAIN ASSESSMENT; PATIENT CONTROLLED ANALGESIA; PERIOPERATIVE COMPLICATION; PERIPHERAL NEUROPATHY; PEROPERATIVE COMPLICATION; POSTOPERATIVE NAUSEA AND VOMITING; POSTOPERATIVE PAIN; PRURITUS; RESPIRATION DEPRESSION; RESPIRATORY TRACT DISEASE; REVIEW; RISK ASSESSMENT; SEDATION; SEX DIFFERENCE; SIDE EFFECT; SINGLE DRUG DOSE; SPINAL ANESTHESIA; SPINAL CORD DISEASE; UNSPECIFIED SIDE EFFECT; URINE RETENTION; VISCERAL PAIN; VISUAL ANALOG SCALE; VOMITING; WITHDRAWAL SYNDROME;

EID: 81855187000     PISSN: 1745509X     EISSN: 17455103     Source Type: Journal    
DOI: 10.2217/ahe.11.73     Document Type: Review

References (134)

1. Fine PG. Chronic pain management in older adults. special considerations. J. Pain Symptom Manage. 38(Suppl. 2), S4-S14 (2009).
2. Gloth FM 3rd. Principles of perioperative pain management in older adults. Clin. Geriatr. Med. 17(3), 553-573, vii-viii (2001).
3. Helme RD, Gibson SJ. The epidemiology of pain in elderly people. Clin. Geriatr. Med. 17(3), 417-431, v (2001).
4. Arnstein P, Herr K. Pain in the older person. In: Bonica's Management of Pain (4th Edition).Fishman S, Ballantyne J, Rathmell J (Eds).Lippincott, Williams and Wilkins, Baltimore, MD, USA, 782-790 (2010).
5. American Geriatrics Society Panel on Pharmacological Management of Persistent Pain in Older Persons. Pharmacological management of persistent pain in older persons. J. Am. Geriatr. Soc. 57(8), 1331-1346 (2009).
6. AGS Panel on Persistent Pain in Older Persons. The management of persistent pain in older persons. J. Am. Geriatr. Soc. 50(Suppl. 6), S205-S224 (2002).
7. McLean AJ, Le Couteur DG. Aging biology and geriatric clinical pharmacology. Pharmacol. Rev. 56(2), 163-184 (2004).
8. Fick DM, Cooper JW, Wade WE, Waller JL, Maclean JR, Beers MH. Updating the Beers criteria for potentially inappropriate medication use in older adults: Results of a US consensus panel of experts. Arch. Intern. Med. 163(22), 2716-2724 (2003).
9. Gallagher PF, Barry PJ, Ryan C, Hartigan I, O'Mahony D. Inappropriate prescribing in an acutely ill population of elderly patients as determined by Beers' Criteria. Age Ageing 37, 96-101 (2008).
10. Bugeja G, Kumar A, Banerjee AK. Exclusion of elderly people from clinical research: A descriptive study of published reports. BMJ 315(7115), 1059 (1997).
11. Van Spall HG, Toren A, Kiss A, Fowler RA. Eligibility criteria of randomized controlled trials published in high-impact general medical journals: A systematic sampling review. JAMA 297(11), 1233-1240 (2007).
12. Deiner S, Silverstein JH. Postoperative delirium and cognitive dysfunction. Br. J. Anaesth. 103(Suppl. 1), i41-i46 (2009).
13. Monk TG, Weldon BC, Garvan CW et al. Predictors of cognitive dysfunction after major noncardiac surgery. Anesthesiology 108(1), 18-30 (2008).
14. Bitsch M, Foss N, Kristensen B, Kehlet H. Pathogenesis of and management strategies for postoperative delirium after hip fracture: A review. Acta Orthop. Scand. 75(4), 378-389 (2004).
15. Brouquet A, Cudennec T, Benoist S et al. Impaired mobility, ASA status and administration of tramadol are risk factors for postoperative delirium in patients aged 75 years or more after major abdominal surgery. Ann. Surg. 251(4), 759-765 (2010).
16. Lewis KS, Han NH. Tramadol: A new centrally acting analgesic. Am. J. Health Syst. Pharm. 54(6), 643-652 (1997).
17. Evered L, Scott DA, Silbert B, Maruff P. Postoperative cognitive dysfunction is independent of type of surgery and anesthetic. Anesth. Analg. doi:10.1213/ ANE.0b013e318215217e (2011) (Epub ahead of print).
18. Fong HK, Sands LP, Leung JM. The role of postoperative analgesia in delirium and cognitive decline in elderly patients: A systematic review. Anesth. Analg. 102(4), 1255-1266 (2006).
19. Charette SL, Ferrell BA. Rheumatic diseases in the elderly: Assessing chronic pain. Clin. Geriatr. Med. 21(3), 563-576, vii (2005).
20. Morrison RS, Siu AL. A comparison of pain and its treatment in advanced dementia and cognitively intact patients with hip fracture. J. Pain Symptom Manage. 19(4), 240-248 (2000).
21. Folstein MF, Folstein SE, McHugh PR. Mini-mental state. A practical method for grading the cognitive state of patients for the clinician. J. Psychiatr. Res. 12, 189-198 (1975).
22. Hadjistavropoulos T, Herr K, Turk DC et al. An interdisciplinary expert consensus statement on assessment of pain in older persons. Clin. J. Pain 23(Suppl. 1), S1e43 (2007).
23. Herr KA, Spratt K, Mobily PR, Richardson G. Pain intensity assessment in older adults: use of experimental pain to compare psychometric properties and usability of selected pain scales with younger adults. Clin. J. Pain 20(4), 207-219 (2004).
24. Pesonen A, Kauppila T, Tarkkila P, Sutela A, Niinistö L, Rosenberg PH. Evaluation of easily applicable pain measurement tools for the assessment of pain in demented patients. Acta Anaesthesiol. Scand. 53(5), 657-664 (2009).
25. Prowse M. Postoperative pain in older people: A review of the literature. J. Clin. Nurs. 16(1), 84-97 (2007).
26. Rat P, Jouve E, Pickering G et al. Validation of an acute pain-behavior scale for older persons with inability to communicate verbally: AlgoPlus. Eur. J. Pain 15(2), 198.e1-198.e10 (2011).
27. Zwakhalen SM, Hamers JP, Abu-Saad HH, Berger MP. Pain in elderly people with severe dementia: A systematic review of behavioural pain assessment tools. BMC Geriatr. 6, 3 (2006).
28. Herr K. Pain assessment strategies in older patients. J. Pain 12(3 Suppl. 1), S3-S13 (2011).
29. Rosenthal RA, Kavic SM. Assessment and management of the geriatric patient. Crit. Care Med. 32(Suppl. 4), S92-S105 (2004).
30. Aubrun F. Management of postoperative analgesia in elderly patients. Reg. Anesth. Pain Med. 30(4), 363-379 (2005).
31. Gibson SJ, Helme RD. Age-related differences in pain perception and report. Clin. Geriatr. Med. 17(3), 433-456, v-vi (2001).
32. Benedetti F, Vighetti S, Ricco C et al. Pain threshold and tolerance in Alzheimer's disease. Pain 80, 377-382 (1999).
33. Carlino E, Benedetti F, Rainero I. Pain perception and tolerance in patients with frontotemporal dementia. Pain 151(3), 783-789 (2010).
34. Izaks GJ, Westendorp RG. Ill or just old? Towards a conceptual framework of the relation between ageing and disease. BMC Geriatr. 3, 7 (2003).
35. Fillingim RB, King CD, Ribeiro-Dasilva MC, Rahim-Williams B, Riley JL 3rd. Sex, gender, and pain: A review of recent clinical and experimental findings. J. Pain 10(5), 447-485 (2009).
36. Aubrun F, Salvi N, Coriat P, Riou B. Sex- and age-related differences in morphine requirements for postoperative pain relief. Anesthesiology 103(1), 156-160 (2005).
37. Lynch EP, Lazor MA, Gellis JE, Orav J, Goldman L, Marcantonio ER. The impact of postoperative pain on the development of postoperative delirium. Anesth. Analg. 86(4), 781-785 (1998).
38. Mangoni AA, Jackson SH. Age-related changes in pharmacokinetics and pharmacodynamics: basic principles and practical applications. Br. J. Clin. Pharmacol. 57(1), 6-14 (2004).
39. Loran DB, Hyde BR, Zwischenberger JB. Perioperative management of special populations: The geriatric patient. Surg. Clin. North Am. 85(6), 1259-1266, xi (2005).
40. Christo PJ, Li S, Gibson SJ, Fine P, Hameed H. Effective treatments for pain in the older patient. Curr. Pain Headache Rep. 15(1), 22-34 (2011).
41. Turnheim K. When drug therapy gets old: Pharmacokinetics and pharmacodynamics in the elderly. Exp. Gerontol. 38(8), 843-853 (2003).
42. El Desoky ES. Pharmacokinetic- pharmacodynamic crisis in the elderly. Am. J. Ther. 14(5), 488-498 (2007).
43. Strassels SA, McNicol E, Suleman R. Pharmacotherapy of pain in older adults. Clin. Geriatr. Med. 24(2), 275-298, vi-vii (2008).
44. Bowie MW, Slattum PW. Pharmacodynamics in older adults: A review. Am. J. Geriatr. Pharmacother. 5(3), 263-303 (2007).
45. Scott JC, Stanski DR. Decreased fentanyl and alfentanil dose requirements with age. A simultaneous pharmacokinetic and pharmacodynamic evaluation. J. Pharmacol. Exp. Ther. 240(1), 159-166 (1987).
46. Aubrun F, Monsel S, Langeron O, Coriat P, Riou B. Postoperative titration of intravenous morphine in the elderly patient. Anesthesiology 96(1), 17-23 (2002).
47. Aubrun F, Bunge D, Langeron O, Saillant G, Coriat P, Riou B. Postoperative morphine consumption in the elderly patient. Anesthesiology 99(1), 160-165 (2003).
48. Macintyre PE, Jarvis DA. Age is the best predictor of postoperative morphine requirements. Pain 64(2), 357-364 (1996).
49. Gagliese L, Jackson M, Ritvo P, Wowk A, Katz J. Age is not an impediment to effective use of patient-controlled analgesia by surgical patients. Anesthesiology 93(3), 601-610 (2000).
50. Hudcova J, McNicol E, Lau QC et al. Patient controlled analgesia versus conventional opioid analgesia for postoperative pain. Cochrane Database Syst. Rev. 18(4), CD003348 (2006).
51. Krane EJ. Patient-controlled analgesia: Proxy-controlled analgesia? Anesth. Analg. 107(1), 15-16 (2008).
52. Collucci R, Swanton R, Thomas G et al. Relative variability in bioavailability of oral controlled-release formulations of oxycodone and morphine. Am. J. Ther. 8, 231-236 (2001).
53. Narabayashi M, Saijo Y, Takenoshita S et al. Opioid rotation from oral morphine to oral oxycodone in cancer patients with intolerable adverse effects: An open-label trial. Jpn J. Clin. Oncol. 38(4), 296-304 (2008).
54. Illgen R, Pellino T, Gordon D, Butts S, Heiner J. Prospective analysis of a novel long-acting oral opioid analgesic regimen for pain control after total hip and knee arthroplasty. J. Arthroplasty 21(6), 814-820 (2006).
55. Rothwell M, Pearson D, Hunter J et al. Oral oxycodone offers equivalent analgesia to intravenous patient-controlled analgesia after total hip replacement: A randomized, single-centre, nonblinded, non-inferior study. Br. J. Anaesth. doi:10.1093/bja/aer084 (2011) (Epub ahead of print).
56. Ho H. Patient-controlled analgesia versus oral controlled-release oxycodone - are they interchangeable for acute postoperative pain after laparascopic colorectal surgeries? Oncolocgy 74(1), 61-65 (2008).
57. Blumenthal S, Min K, Marquardt M, Borgeat A. Postoperative intravenous morphine consumption, pain scores and side effects with perioperative oral controlled-release oxycodone after lumbar discectomy. Anesth. Analg. 105(1), 233-237 (2007).
58. Wheeler M, Oderda G, Ashburn M, Lipman A. Adverse events associated with postoperative analgesia: A systematic review. J. Pain. 3(3), 159-180 (2002).
59. Viscomi CM, Pearson JK. Perioperative management of the opioid tolerant patient. Advances Anesth. 27, 25-54 (2009).
60. Graham G, Scott K. Mechanism of action of paracetamol. Am. J. Ther. 12, 46-55 (2005).
61. Oscier C, Milner Q. Perioperative use of paracetamol. Anaesthesia 64, 65-72 (2009).
62. Thummel K, Slattery J, Ro H et al. Ethanol and production of the hepatotoxic metabolite of acetaminophen in healthy adults. Clin. Pharm. Ther. 67, 591-599 (2000).
63. Kuffner E, Dart R, Bogdan G, Hill R, Casper E, Darton L. Effect of maximal daily doses of acetaminophen on the liver in alcoholic patients: A randomized double-blind placebo-controlled trial. Arch. Intern. Med. 161, 2247-2252 (2001).
64. Sinatra R, Jahr J, Reynold L, Viscusi E, Groudine S, Payen-Champenois C. Efficacy and safety of single and repeated administration of 1 gram intravenous acetaminophen injection (paracetamol) for pain management after major orthopedic surgery. Anesthesiology 102(4), 822-831 (2005).
65. Cobby T, Crighton I, Kyriakides K, Hobbs G. Rectal paracetamol has a significant morphine-sparing effect after hysterectomy. Br. J. Anaesth. 83, 253-256 (1999).
66. Atef A, Fawaz A. Intravenous paracetamol is highly effective in pain treatment after tonsillectomy in adults. Eur. Arch. Otorhinolaryngol. 265, 351-355 (2008).
67. Maund E, McDaid C, Rice S, Wright K, Jenkins B, Woolacott N. Paracetamol and selective and nonselective nonsteroidal anti-inflammatory drugs for the reduction in morphine-related side-effects after major surgery: A systematic review. Br. J. Anaesth. 106(3), 292-297 (2011).
68. Remy C, Marret E, Bonnet F. Effects of acetaminophen on morphine side-effects and consumption after major surgery: meta-analysis of randomized controlled trials. Br. J. Anaesth. 94(4), 505-513 (2005).
69. Rawlins M, Henderson D, Hijab J. Pharmacokinetics of paracetamol after intravenous and oral administration. Eur. J. Clin. Pharm. 11, 283-286 (1977).
70. Ward B, Alexander-Williams J. Paracetamol revisited: A review of the pharmacokinetics and pharmacodynamics. Acute Pain 2, 140-149 (1999).
71. Miners J, Penhall R, Robson R, Birkett D. Comparison of paracetamol metabolism in young adult and elderly males. Eur. J. Clin. Pharmacol. 35, 157-160 (1988).
72. Bannwarth B, Pehourcq F, Lagrange F et al. Single and multiple dose pharmacokinetics of acetaminophen (paracetamol) in polymedicated very old patients with rheumatic pain. J. Rheumatol. 28, 182-184 (2001).
73. Wolfe M, Lichtenstein D, Singh G. Gastrintestinal toxicity of nonsteroidal anti-inflammatory drugs. N. Engl. J. Med. 340(24), 1888-1889 (1999).
74. Laitenen J, Nuutinen L. Intravenous diclofenac coupled with PCA fentanyl for pain relief after total hip replacement. Anesthesiology 76, 194-198 (1992).
75. Alexander R, El-Moalem H, Gan T. Comparison of the morphine sparing effects of diclofenac sodium and ketorolac tromethamine after major orthopedic surgery. J. Clin. Anesth. 14, 187-192 (2002).
76. Armstrong C, Blower A. Non-steroidal anti-inflammatory drugs and life threatening complications of peptic ulceration. Gut 28, 527-532 (1987).
77. Singh G, Triadafilopoulus G. Epidemiology of NSAID-induced GI complications. J. Rheumatol. 26(26), 18-24 (1999).
78. Lanza F, Simon T, Quan H et al. Selective inhibition of cyclooxygenase-2 (COX 2) with MK 0966 is associated with less gastroduodenal damage than aspirin or ibuprofen . Ali. Pharmaco. Ther. 13, 761-767 (1999).
79. Reinhold S, Reichle A, Leiminger S et al. Renal function during rofecoxib therapy in patients with metastatic cancer: Retrospective analysis of a prospective Phase II trial. BMC Res. Notes 4(2), 1-5 (2011).
80. Bresalier R, Snadler R, Quan H et al. Cardiovascular events associated with rofecoxib in a colorectal adenoma chemoprevention trial. N. Engl. J. Med. 352, 1092-1102 (2005).
81. Nussmeier N, Whelton A, Brown M et al. Complications of the COX 2 inhibitors parecoxib and valdecoxib after cardiac surgery. N. Engl. J. Med. 352, 1081-1091 (2005).
82. Fitzgerald G. Coxibs and cardiovascular disease. N. Engl. J. Med. 351, 1709-1711 (2004).
83. Solomon S, McMurray J, Pfeffer M et al. Cardiovascular risk associated with celocoxib in a clinical trial for colorectal adenoma prevention. N. Engl. J. Med. 352, 1071-1080 (2005).
84. Elves M, Bayley I, Roylance P. The effect of indomethacin upon experimental fractures in the rat. Acta Orthop. Scand. 53, 35-41 (1982).
85. Dimmen S, Nordsletten L, Madsen J. Parecoxib and indomethacin delay early fracture healing. Clin. Orthop. Relat. Res. 467, 1992-1999 (2009).
86. Riew J, Long J, Rhee J et al. Time-dependent inhibitory effects of indomethacin on spinal fusion. J. Bone Joint Surg. 85A, 632-635 (2003).
87. Dimar J, Ante W, Zhang Y et al. The effects of nonsteroidal anti-inflammatory drugs on posterior spinal fusions in the rat. Spine 21, 1870-1876 (1996).
88. Glassman S, Rose S, Dimar J et al. The effect of postoperative nonsteroidal anti-inflammatory drug administration on spinal fusion. Spine 23, 834-838 (1998).
89. Pradhan B, Tatsumi R, Gallina J et al. Does the perioperative use of ketorolac really inhibit spinal fusion? Spine 33(19), 2079-2082 (2008).
90. Sucato D, Lovejoy J, Agrawal S et al. Postoperative ketorolac does not predispose to pseudoarthrosis following posterior spinal fusion and instrumentation for adolescent idiopathic scoliosis. Spine 33(10), 1119-1124 (2008).
91. Adolphson P, Abbaszadegan H, Jonsson U, Dalén N, Sjöberg HE, Kalén S. No effects of piroxicam on osteopenia and recovery after Colles' fracture. A randomized, double-blind, placebo-controlled, prospective trial. Arch. Orthop. Trauma Surg. 112(3), 127-130 (1993).
92. Rose M, Kam P. Gabapentin: Pharmacology and its use in pain management. Anaesthesia 57, 451-462 (2002).
93. Zhang J, Ho KY, Wang Y. Efficacy of pregabalin in acute postoperative pain: A meta-analysis. Br. J. Anaesth. 106(4), 454-462 (2011).
94. Tiippana E, Hamunen K, Kontinen V, Kalso E. Do surgical patients benefit from perioperative gabapentin/pregabalin? A systematic review of efficacy and safety. Anesth. Analg. 104(6), 1545-1556 (2007).
95. Bennett M, Simpson K. Gabapentin in the treatment of neuropathic pain. Palliative Med. 18, 5-11 (2004).
96. Rowbotham M, Harden N, Stacey B, Bernstein P, Magnus-Miller L. Gabapenti for the treatment of postherpetic neuralgia: A randomized controlled clinical trial. JAMA 280, 1837-1842 (1998).
97. Wiffen P, McQuay H, Edwards J, Moore R. Gabapentin for acute and chronic pain. Cochrane Database Syst. Rev. 3, CD005452 (2005).
98. Dirks J, Moiniche S, Hilsted K, Dahl J. Mechanisms of postoperative pain: clinical indications for a contribution of central sensitization. Anesthesiology 97, 1591-1596 (2002).
99. Rusy L, Hainsworth K, Nelson T et al. Gabapentim use in pediatric spinal fusion patients: A randomized, double blind, controlled trial. Anesth. Analg. 110(5), 1393-1398 (2010).
100. Menigaux C, Adam F, Guignard B, Sessler D, Chauvin M. Preoperative gabapentin decreases anxiety and improves early recovery from knee surgery. Anesth. Analg. 100, 1394-1399 (2005).
101. Dirks J, Fredensborg B, Christensen D, Fomsgaard J, Flyger H, Dahl J. A randomized study of the effects of single dose gabapentin versus placebo on postoperative pain and morphine consumption after mastectomy. Anesthesiology 97, 560-564 (2002).
102. Ho K, Gan T, Habib A. Gabapentin and postoperative pain - a systematic review of randomized controlled trials. Pain 126, 91-101 (2006).
103. Guay D. Pregabalin in neuropathic pain: A more "pharmaceutically elegant" gabapentin? Am. J. Ger. Pharmaco. 3(4), 274-287 (2005).
104. Fisher K, Coderre T, Hagen N. Targeting the N methyl-d-aspartate receptor for chronic pain management: Preclinical animal studies, recent clinical experience and future research directions. J. Pain Sympt. Manage. 20, 358-373 (2000).
105. Lossignol D, Obiols-Portis M, Body J. Successful use of ketamine for intractable cancer pain. Support Care Cancer 13, 188-193 (2005).
106. Grande L, O'Donnell B, Fitzgibbon D, Terman G. Ultra-low dose ketamine and memantine treatment for pain in an opioid-tolerant oncology patient. Anesth. Analg. 107(4), 1380-1383 (2008).
107. McMartney C, Sinha A, Katz J. A qualitative systematic review of the role of N methyl d aspartate receptor antagonists in preventive analgesia. Anesth. Analg. 98, 1385-1400 (2004).
108. Bell RF, Dahl JB, Moore RA, Kalso E. Perioperative ketamine for acute postoperative pain. Cochrane Database Syst. Rev. 25(1), CD004603 (2006).
109. Kollender Y, Bickels J, Stocki D et al. Subanesthetic ketamine spares postoperative morphine and controls pain better than standard morphine does alone in orthopedic-oncological patients. Eur. J. Cancer 44, 954-962 (2008).
110. Remerand F, Le Tendre C, Baud A et al. The early and delayed analgesic effect of ketamine after total hip arthroplasty: A prospective, randomized, controlled, double-blind study. Anesth. Analg. 109, 1963-1971 (2009).
111. Petrenko A, Yamakura T, Baba H, Shimoji K. The role of N methyl d aspartate (NMDA) receptors in pain: A review. Anesth. Analg. 97, 1108-1116 (2003).
112. Tverskoy M, Oren M, Vaskovich M, Dashkovsky I, Kissin I. Ketamine enhances local anesthetic and analgesic effects of bupivacaine by peripheral mechanism: A study in postoperative patients. Neurosci. Lett. 215, 5-8 (1996).
113. Warncke T, Jorum E, Stubhaug A. Local treatment with N methyl-d-aspartate receptor antagonist ketamine, inhibit development of secondary hyperalgesia in man by peripheral action. Neurosci. Lett. 227, 1-4 (1997).
114. Parsons C, Danysz W, Quack G. Memantine is a clinically well tolerated N methyl-d-aspartate (NMDA) receptor antagonist - a review of preclinical data. Neuropharmacology 38, 735-767 (1999).
115. Eisenberg E, Kleiser A, Cortort A, Haim T, Yarnitsky D. The NMDA (N methyl-d-aspartate) receptor antagonist memantine in the treatment of post herpetic neuralgia: A double blind placebo controlled trial. Eur. J. Pain 2, 321-327 (1998).
116. Lipton S. Failure and success of NMDA receptor antagonists: molecular basis for the use of open-channel blockers like memantine in the treatment of acute and chronic neurologic insults. Am. Soc. Exp. Neuro. Ther. 1, 101-110 (2004).
117. Horlocker TT. Pain management in total joint arthroplasty: A historical review. Orthopedics 33(Suppl. 9), 14-19 (2010).
118. Costantini R, Affaitati G, Fabrizio A, Giamberardino MA. Controlling pain in the post-operative setting. Int. J. Clin. Pharmacol. Ther. 49(2), 116-127 (2011).
119. Tiippana EM, Hamunen K, Kontinen VK, Kalso E. Do surgical patients benefit from perioperative gabapentin/pregabalin? A systematic review of efficacy and safety. Anesth. Analg. 104, 1545-1556 (2007).
120. Sen H, Sizlan A, Yanarates O et al. A comparison of gabapentin and ketamine in acute and chronic pain after hysterectomy. Anesth. Analg. 109, 1645-1650 (2009).
121. Clivatti J, Sakata RK, Issy AM. Review of the use of gabapentin in the control of postoperative pain. Rev. Bras. Anesthesiol. 59(1), 87-98 (2009).
122. Eberhart LH, Graf J, Morin AM et al. Randomised controlled trial of the effect of oral premedication with dexamethasone on hyperglycaemic response to abdominal hysterectomy. Eur. J. Anaesthesiol. 28(3), 195-201 (2011).
123. Cappabianca G, Rotunno C, de Luca Tupputi Schinosa L, Ranieri VM, Paparella D. Protective effects of steroids in cardiac surgery: A meta-analysis of randomized double-blind trials. J. Cardiothorac. Vasc. Anesth. 25, 156-165 (2011).
124. McKenzie PJ, Wishart HY, Gray I, Smith G. Effects of anaesthetic technique on deep venous thrombosis. A comparison of subarachnoid and general anesthesia. Br. J. Anaesth. 57, 853-857 (1985).
125. Mullaji A, Kanna R, Shetty GM, Chavda V, Singh DP. Efficacy of periarticular injection of bupivacaine, fentanyl, and methylprednisolone in total knee arthroplasty: A prospective randomized trial. J. Arthroplasty 25, 851-857 (2010).
126. Busch CA, Shore BJ, Bhandari R et al. Efficacy of periarticular multimodal drug injection in total knee arthroplasty. A randomized trial. J. Bone Joint Surg. Am. 88(5), 959-963 (2006).
127. Remerand F, Le Tendre C, Baud A et al. The early and delayed analgesic effects of ketamine after total hip arthroplasty: A prospective, randomized, controlled, double-blind study. Anesth. Analg. 109, 1963-1971 (2009).
128. Wilhelm SM, Dehoorne-Smith ML, Kale-Pradhan PB. Prevention of postoperative nausea and vomiting. Ann. Pharmacother. 41(1), 68-78 (2007).
129. Carli F, Clemente A, Asenjo JF et al. Analgesia and functional outcome after total knee arthroplasty: Periarticular infiltration vs continuous femoral nerve block. Br. J. Anaesth. 105(2), 185-195 (2010).
130. Atkinson HD, Hamid I, Gupte CM, Russell RC, Handy JM. Postoperative fall after the use of the 3-in-1 femoral nerve block for knee surgery: A report of four cases. J. Orthop. Surg. (Hong Kong) 16(3), 381-384 (2008).
131. Patel M, Schimpf MO, O'Sullivan DM, LaSala CA. The use of senna with docusate for postoperative constipation after pelvic reconstructive surgery: A randomized, double-blind, placebo-controlled trial. Am. J. Obstet. Gynecol. 202(5), 479.e1-479.e5 (2010).
132. Rapp SE. Acute pain management in patients with prior opioid consumption: A case controlled retrospective review. Pain 61, 195-201 (1995).
133. Li Q, Zhang Z, Cai Z. High dose ketorolac affects adult spine fusion: A meta-analysis of the effect of perioperative nonsteroidal anti-inflammatory drugs on spinal fusion. Spine 36, 461-468 (2011).
134. Loftus RW, Yeager MP, Clark JA et al. Intraoperative ketamine reduces perioperative opiate consumption in opiate-dependent patients with chronic pain undergoing back surgery. Anesthesiology 113(3), 639-46 (2010).