Specific inhibition of cyclooxygenase-2 with MK-0966 is associated with less gastroduodenal damage than either aspirin of ibuprofen

Alimentary Pharmacology and Therapeutics

Volumn 13, Issue 6, 1999, Pages 761-767

  Lanza, F L ^b   Rack, M F ^b   Simon, T J ^a   Quan, H ^a   Bolognese, J A ^a   Hoover, M E ^a   Wilson, F R ^a   Harper, S E ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; IBUPROFEN; NONSTEROID ANTIINFLAMMATORY AGENT; PROSTAGLANDIN SYNTHASE INHIBITOR; ROFECOXIB; THROMBOXANE B2; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CLINICAL TRIAL; CONSTIPATION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIARRHEA; DRUG TOLERABILITY; FEMALE; GASTROINTESTINAL TOXICITY; HEADACHE; HUMAN; HUMAN EXPERIMENT; MAJOR CLINICAL STUDY; MALE; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RHINITIS; STOMACH PAIN;

ADOLESCENT; ADULT; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ASPIRIN; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; CYCLOOXYGENASE INHIBITORS; DOUBLE-BLIND METHOD; DUODENAL ULCER; ENZYME INHIBITORS; FEMALE; HUMANS; IBUPROFEN; ISOENZYMES; LACTONES; MALE; MEMBRANE PROTEINS; MIDDLE AGED; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; STOMACH ULCER; SULFONES; THROMBOXANES;

EID: 0001175594     PISSN: 02692813     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2036.1999.00529.x     Document Type: Article

References (13)

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