The effects of nonsteroidal anti-inflammatory drugs on posterior spinal fusions in the rat

Spine

Volumn 21, Issue 16, 1996, Pages 1870-1876

  Dimar II, John R ^a,b   Ante, William A ^a   Zhang, Y Ping ^a   Glassman, Steven D ^a  

^a University of Louisville School of Medicine   (United States)

^b NONE   (United States)

Author keywords

heterotopic ossification; nonsteroidal anti inflammatory drugs; NSAIDs; spinal fusion

Indexed keywords

INDOMETACIN; NONSTEROID ANTIINFLAMMATORY AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; BONE DEVELOPMENT; BONE GRAFT; CONFERENCE PAPER; CONTROLLED STUDY; FRACTURE HEALING; HETEROTOPIC OSSIFICATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SPINE FUSION;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; INDOMETHACIN; INJECTIONS, SUBCUTANEOUS; LAMINECTOMY; LUMBAR VERTEBRAE; MALE; OSTEOGENESIS; RATS; RATS, SPRAGUE-DAWLEY; SURVIVAL RATE;

EID: 0029783213     PISSN: 03622436     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007632-199608150-00006     Document Type: Conference Paper

References (22)

1. Allen HL, Wase A, Bear WT. Indomethacin and aspirin: Effect of nonsteroidal antiinflammatory agents on the rate of fracture repair in the rat. Acta Orthop Scand 1980;51:595-600.
2. Elves MW, Bayley I, Roylance PJ. The effect of indomethacin upon experimental fractures in the rat. Acta Orthop Scand 1982;53:35-41.
3. Gilman AG, Goodman LS. Goodman and Gilman's The Pharmacological Basis of Therapeutics. 8th ed. New York: Pergamon Press, 1990:638-81.
4. Keller J, Bunger C, Andreassen T, Bak B, Lucht U. Bone repair inhibited by indomethacin. Effects on bone metabolism and strength of rabbit osteotomies. Acta Orthop Scand 1987; 53:379-83.
5. Keller J, Kjaersgaard-Anderson P, Bayer-Kristensen I, Melson F. Indomethacin and bone trauma. Effects on remodeling of rabbit bone. Acta Orthop Scan 1990;61:66-9.
6. Kjaersgaard-Anderson P, Ritter MA. Short-term treatment with nonsteroidal antiinflammatory medications to prevent heterotopic bone formation after total hip arthroplasty. A preliminary report. Clin Orthop 1992;279:157-92.
7. Kjaersgaard-Anderson P, Schmidt SA. Indomethacin for prevention of ectopic ossification after hip arthroplasty. Acta Orthop Scand 1986;57:12-4.
8. Kjaersgaard-Anderson P, Schmidt SA. Total hip arthroplasty. The role of antiinflammatory medications in the prevention of heterotopic ossification. Clin Orthop 1991;263: 78-86.
9. Kjaersgaard-Anderson P, Sletgard J, Gjerloff C, Lund F. Heterotopic bone formation after noncemented total hip arthroplasty. Location of ectopic bone and the influence of postoperative antiinflammatory treatment. Clin Orthop 1990;252: 156-62.
10. Lebwohl NH, Starr NK, Madsen P, Milne EL, Latta LL, Malinin TI. The inhibitory effect of ibuprofen on spinal fusion in rabbits. Presented at the Proceedings of the 8th Annual Meeting, North American Spine Society, San Diego, California, October, 1993.
11. Lindholm TS, Tornkvist H. Inhibitory effect on bone formation and calcification exerted by the antiinflammatory drug ibuprofen. An experimental study on adult rat with fracture. Scand J Rheumatol 1981;10:38-42.
12. Nilsson OS, Bauer HC, Brosjo O, Tornkvist H. Influence of indomethacin on induced heterotopic bone formation in rats. Importance of length of treatment and of age. Clin Orthop 1986;207:239-45.
13. Ritter MA, Gioe TJ. The effect of indomethacin on paraarticular ectopic ossification following total hip arthroplasty. Clin Orthop 1982;167:113-7.
14. Ro J, Langeland N, Sander J. Effect of indomethacin on collagen metabolism of rat fracture callus in vitro. Acta Orthop Scand 1978;49:323-8.
15. Ro J, Sudman E, Marton PF. Effect of indomethacin on fracture healing in rats. Acta Orthop Scand 1976;47:588-99.
16. Rothman RH, Simeone FA. The Spine. 3rd ed. Philadelphia: WB Saunders, 1992:1739-55.
17. Sodemann B, Person P-E, Nilsson OS. Prevention of periarticular heterotopic ossification following total hip arthroplasty. Clinical experience with indomethacin and ibuprofen. Arch Orthop Trauma Surg 1988;107:329-33.
18. Sodemann B, Persson P-E, Nilsson OS. Prevention of heterotopic ossification by nonsteroidal antiinflammatory drugs after total hip arthroplasty. Clin Orthop 1987;237:158-63.
19. Sudmann E, Bang G. Indomethacin-induced inhibition of haversion remodeling in rabbits. Acta Orthop Scand 1979;50: 621-7.
20. Sudmann E, Tveita T, Hald J. Lack of effect of indomethacin on ordered growth of the femur in rats. Acta Orthop Scand 1982;53:43-9.
21. Tornkvist H, Lindholm TS, Netz P, Stromberg L, Lindholm TC. Effect of ibuprofen and indomethacin on bone metabolism reflected in bone strength. Clin Orthop 1984;187: 255-9.
22. Tornkvist H, Nilsson OS, Bauer FCH, Lindholm TS. Experimentally induced heterotopic ossification in rats influenced by antiinflammatory drugs. Scand J Rheumatol 1983;12:177-80.