Randomised controlled trial of the effect of oral premedication with dexamethasone on hyperglycaemic response to abdominal hysterectomy

European Journal of Anaesthesiology

Volumn 28, Issue 3, 2011, Pages 195-201

  Eberhart, Leopold H J ^a,b   Graf, Jürgen ^a   Morin, Astrid M ^a   Stief, Thomas ^a,c   Kalder, Matthias ^b   Lattermann, Ralph ^c   Schricker, Thomas ^a  

^a Department of Anaesthesiology and Intensive Care Medicine ^*  (Germany)

^b PHILIPPS UNIVERSITY MARBURG   (Germany)

^c MCGILL UNIVERSITY   (Canada)

Author keywords

Dexamethasone; Fat metabolism; Free fatty acids; Glucocorticoids; Hyperglycaemia

Indexed keywords

CEFUROXIME; CISATRACURIUM; DESFLURANE; DEXAMETHASONE; DOLASETRON MESILATE; FATTY ACID; FENTANYL; GLUCOSE; PLACEBO; PROPOFOL; REMIFENTANIL;

ABDOMINAL HYSTERECTOMY; ADULT; ARTICLE; BLOOD SAMPLING; DOUBLE BLIND PROCEDURE; DRUG EFFECT; FATTY ACID BLOOD LEVEL; FEMALE; GENERAL ANESTHESIA; GLUCOSE BLOOD LEVEL; HUMAN; HYPERGLYCEMIA; MAJOR CLINICAL STUDY; PERIOPERATIVE PERIOD; POSTOPERATIVE NAUSEA AND VOMITING; RANDOMIZED CONTROLLED TRIAL;

ADULT; ANTIEMETICS; BLOOD GLUCOSE; DEXAMETHASONE; DOUBLE-BLIND METHOD; FATTY ACIDS, NONESTERIFIED; FEMALE; FOLLOW-UP STUDIES; GLUCOCORTICOIDS; HUMANS; HYPERGLYCEMIA; HYSTERECTOMY; MIDDLE AGED; POSTOPERATIVE NAUSEA AND VOMITING; PREMEDICATION; TIME FACTORS;

EID: 79953836196     PISSN: 02650215     EISSN: 13652346     Source Type: Journal    
DOI: 10.1097/EJA.0b013e32834296b9     Document Type: Article

References (21)

1. RichMW, Abdulhayoglu G, DiSaia PJ. Methylprednisolone as an antiemetic drug during cancer chemotherapy: A pilot study. Gynecol Oncol 1980; 9:193-198. (Pubitemid 10096915)
2. Rasmussen ML, Mathiesen O, Dierking G, et al. Multimodal analgesia with gabapentin, ketamin and dexamethasone in combination with paracetamol and ketorolac after hip arthroplasty: A preliminary study. Eur J Anaesthesiol 2010; 27:324-330.
3. Gan TJ, Meyer TA, Apfel CC, et al. Society for Ambulatory Anesthesia guidelines for the management of postoperative nausea and vomiting. Anesth Analg 2007; 105:1615-1628. (Pubitemid 350190555)
4. Holte K, Kehlet H. Perioperative single-dose glucocorticoid administration: Pathophysiologic effects and clinical implications. J Am Coll Surg 2002; 195:694-712. (Pubitemid 35285405)
5. Anderson RE, Klerdal K, Ivert T, et al. Are even impaired fasting blood glucose levels preoperatively associated with increased mortality after CABG surgery? Eur Heart J 2005; 26:1513-1518. (Pubitemid 41373492)
6. Doenst T, Wijeysundera D, Karkouti K, et al. Hyperglycemia during cardiopulmonary bypass is an independent risk factor for mortality in patients undergoing cardiac surgery. J Thorac Cardiovasc Surg 2005; 130:1144-1150.
7. Umpierrez GE, Isaacs SD, Bazargan H, et al. Hyperglycemia: An independent marker of in-hospital mortality in patients with undiagnosed diabetes. J Clin Endocrinol Metab 2002; 87:978-982. (Pubitemid 36121050)
8. Oliver MF, Opie LH. Effects of glucose and fatty acids on myocardial ischaemia and arrhythmias. Lancet 1994; 343:155-158.
9. Wilson AP, Treasure T, Sturridge MF, Gruneberg RN. A scoring method (ASEPSIS) for postoperative wound infections for use in clinical trials of antibiotic prophylaxis. Lancet 1968; 311:e313.
10. Eisenstein AB, Tiglao C. Effect of endocrine therapy on nutritional status. Am J Publ Health 1964; 54:2068-2074.
11. Perkoff GT, Parker V, McCall J, Taylor FH. Effect of cortisol on glucose metabolism in man. J Lab Clin Med 1963; 62:431-436.
12. Pasternak JJ, McGregor DG, Lanier WL. Effect of single-dose dexamethasone on blood glucose concentration in patients undergoing craniotomy. J Neurosurg Anesthesiol 2004; 16:122-125. (Pubitemid 39090032)
13. Lukins MB, Manninen PH. Hyperglycemia in patients administered dexamethasone for craniotomy. Anesth Analg 2005; 100:1129-1133. (Pubitemid 40404222)
14. Morariu AM, Loef BG, Aarts LPHJ, et al. Dexamethasone: Benefit and prejudice for patients undergoing on-pump coronary artery bypass grafting. Chest 2005; 128:2677-2687.
15. Hans P, Vanthuyne A, Dewandre PY, et al. Blood glucose concentration profile after 10 mg dexamethasone in nondiabetic and type 2 diabetic patients undergoing abdominal surgery. Br J Anaesth 2006; 97:164-170. (Pubitemid 44295700)
16. Schricker T, Carvalho G. Abdominal surgery, morbid obesity, age, dexamethasone, diabetes mellitus and glucose metabolism. Br J Anaesth 2006; 97:751-752.
17. Madan R, Bhatia A, Chakithandy S, et al. Prophylactic dexamethasone for postoperative nausea and vomiting in pediatric strabismus surgery: A dose ranging and safety evaluation study. Anesth Analg 2005; 100:1622-1626. (Pubitemid 40712710)
18. Geisser W, Schreiber M, Hofbauer H, et al. Sevoflurane versus isoflurane: Anaesthesia for lower abdominal surgery. Effects on perioperative glucose metabolism. Acta Anaesthesiol Scand 2003; 47:174-179. (Pubitemid 36349777)
19. Nazar CE, Lacassie HJ, López RA, Muñoz HR. Dexamethasone for postoperative nausea and vomiting prophylaxis: Effect on glycaemia in obese patients with impaired glucose tolerance. Eur J Anaesthesiol 2009; 26:318-321.
20. Bonadonna RC, Groop LC, Simonson DC, Defronzo RA. Free fatty acid and glucose metabolism in human aging: Evidence for operation of the Randle cycle. Am J Physiol 1994; 266:E501-E509.
21. Liedtke AJ. Lipid burden in ischemic myocardium. J Mol Cell Cardiol 1988; 20 (Suppl 2):65-74.