메뉴 건너뛰기




Volumn 36, Issue 25, 2011, Pages 2122-2129

High-mobility group box-1 and its receptors contribute to proinflammatory response in the acute phase of spinal cord injury in rats

Author keywords

high mobility group box 1 (HMGB 1); proinfl ammatory cytokine; receptor for advanced glycation end products (RAGE); spinal cord injury; toll like receptor (TLR)

Indexed keywords

ADVANCED GLYCATION END PRODUCT RECEPTOR; HIGH MOBILITY GROUP B1 PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA;

EID: 81855163367     PISSN: 03622436     EISSN: 15281159     Source Type: Journal    
DOI: 10.1097/BRS.0b013e318203941c     Document Type: Article
Times cited : (59)

References (51)
  • 1
    • 0026575478 scopus 로고
    • Macrophages and inflammatory damage in spinal cord injury
    • Blight AR. Macrophages and inflammatory damage in spinal cord injury. J Neurotrauma 1992; 9 ( suppl 1 ): S83-91.
    • (1992) J Neurotrauma , vol.9 , Issue.SUPPL.
    • Blight, A.R.1
  • 2
    • 0030842973 scopus 로고    scopus 로고
    • Expression of pro-inflammatory cytokine and chemokine mRNA upon experimental spinal cord injury in mouse: An in situ hybridization study
    • Bartholdi D, Schwab ME. Expression of pro-inflammatory cytokine and chemokine mRNA upon experimental spinal cord injury in mouse: An in situ hybridization study. Eur J Neurosci 1997; 9 : 1422-38.
    • (1997) Eur J Neurosci , vol.9 , pp. 1422-1438
    • Bartholdi, D.1    Schwab, M.E.2
  • 3
    • 0030636606 scopus 로고    scopus 로고
    • Traumatic spinal cord injury: A neuropathological study on the longitudinal spreading of the lesions
    • Ito T, Oyanagi K, Wakabayashi K, et al. Traumatic spinal cord injury: A neuropathological study on the longitudinal spreading of the lesions. Acta Neuropathol 1997; 93 : 13-8.
    • (1997) Acta Neuropathol , vol.93 , pp. 13-18
    • Ito, T.1    Oyanagi, K.2    Wakabayashi, K.3
  • 4
    • 0028326548 scopus 로고
    • Secondary cell death and the inflammatory reaction after dorsal hemisection of the rat spinal cord
    • Dusart I, Schwab ME. Secondary cell death and the inflammatory reaction after dorsal hemisection of the rat spinal cord. Eur J Neurosci 1994; 6 : 712-24.
    • (1994) Eur J Neurosci , vol.6 , pp. 712-724
    • Dusart, I.1    Schwab, M.E.2
  • 5
    • 0034119666 scopus 로고    scopus 로고
    • Sequential mRNA expression for immediate early genes, cytokines, and neurotrophins in spinal cord injury
    • Hayashi M, Ueyama T, Nemoto K, et al. Sequential mRNA expression for immediate early genes, cytokines, and neurotrophins in spinal cord injury. J Neurotrauma 2000; 17 : 203-18.
    • (2000) J Neurotrauma , vol.17 , pp. 203-218
    • Hayashi, M.1    Ueyama, T.2    Nemoto, K.3
  • 6
    • 33845568271 scopus 로고    scopus 로고
    • Proinflammatory cytokine synthesis in the injured mouse spinal cord: Multiphasic expression pattern and identification of the cell types involved
    • Pineau I, Lacroix S. Proinflammatory cytokine synthesis in the injured mouse spinal cord: Multiphasic expression pattern and identification of the cell types involved. J Comp Neurol 2007; 500 : 267-85.
    • (2007) J Comp Neurol , vol.500 , pp. 267-285
    • Pineau, I.1    Lacroix, S.2
  • 7
    • 0344826467 scopus 로고    scopus 로고
    • Differences in cytokine gene expression profile between acute and secondary injury in adult rat spinal cord
    • Nakamura M, Houghtling RA, MacArthur L, et al. Differences in cytokine gene expression profile between acute and secondary injury in adult rat spinal cord. Exp Neurol 2003; 184 : 313-25.
    • (2003) Exp Neurol , vol.184 , pp. 313-325
    • Nakamura, M.1    Houghtling, R.A.2    MacArthur, L.3
  • 8
    • 0028869476 scopus 로고
    • Cytokines and the nervous system II: Actions and mechanisms of action
    • Rothwell NJ, Hopkins SJ. Cytokines and the nervous system II: Actions and mechanisms of action. Trends Neurosci 1995; 18 : 130-6.
    • (1995) Trends Neurosci , vol.18 , pp. 130-136
    • Rothwell, N.J.1    Hopkins, S.J.2
  • 9
    • 0030221758 scopus 로고    scopus 로고
    • Cytokines in inflammatory brain lesions: Helpful and harmful
    • Merrill JE, Benveniste EN. Cytokines in inflammatory brain lesions: Helpful and harmful. Trends Neurosci 1996; 19 : 331-8.
    • (1996) Trends Neurosci , vol.19 , pp. 331-338
    • Merrill, J.E.1    Benveniste, E.N.2
  • 10
    • 0036264280 scopus 로고    scopus 로고
    • Targeting the host inflammatory response in traumatic spinal cord injury
    • Bethea JR, Dietrich WD. Targeting the host inflammatory response in traumatic spinal cord injury. Curr Opin Neurol 2002; 15 : 355-60.
    • (2002) Curr Opin Neurol , vol.15 , pp. 355-360
    • Bethea, J.R.1    Dietrich, W.D.2
  • 11
    • 74249106986 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha and its receptors contribute to apoptosis of oligodendrocytes in the spinal cord of spinal hyperostotic mouse ( twy /twy ) sustaining chronic mechanical compression
    • Inukai T, Uchida K, Nakajima H, et al. Tumor necrosis factor-alpha and its receptors contribute to apoptosis of oligodendrocytes in the spinal cord of spinal hyperostotic mouse ( twy /twy ) sustaining chronic mechanical compression. Spine 2009; 34 : 2848-57.
    • (2009) Spine , vol.34 , pp. 2848-2857
    • Inukai, T.1    Uchida, K.2    Nakajima, H.3
  • 12
    • 0034741833 scopus 로고    scopus 로고
    • HMG1 and 2: Architectural DNA-binding proteins
    • Thomas JO. HMG1 and 2: Architectural DNA-binding proteins. Biochem Soc Trans 2001; 29 : 395-401.
    • (2001) Biochem Soc Trans , vol.29 , pp. 395-401
    • Thomas, J.O.1
  • 13
    • 0036510750 scopus 로고    scopus 로고
    • HMGB1 and HMGB2 cellspecifically down-regulate the p53-and p73-dependent sequencespecific transactivation from the human Bax gene promoter
    • Stros M, Ozaki T, Bacikova A, et al. HMGB1 and HMGB2 cellspecifically down-regulate the p53-and p73-dependent sequencespecific transactivation from the human Bax gene promoter. J Biol Chem 2002; 277 : 7157-64.
    • (2002) J Biol Chem , vol.277 , pp. 7157-7164
    • Stros, M.1    Ozaki, T.2    Bacikova, A.3
  • 14
    • 1542380035 scopus 로고    scopus 로고
    • Involvement of toll-like receptors 2 and 4 in cellular activation by high mobility group box 1 protein
    • Park JS, Svetkauskaite D, He Q, et al. Involvement of toll-like receptors 2 and 4 in cellular activation by high mobility group box 1 protein. J Biol Chem 2004; 279 : 7370-7.
    • (2004) J Biol Chem , vol.279 , pp. 7370-7377
    • Park, J.S.1    Svetkauskaite, D.2    He, Q.3
  • 15
    • 17144376810 scopus 로고    scopus 로고
    • High-mobility group box 1 protein (HMGB1): Nuclear weapon in the immune arsenal
    • Lotze MT, Tracey KJ. High-mobility group box 1 protein (HMGB1): Nuclear weapon in the immune arsenal. Nat Rev Immunol 2005; 5 : 331-42.
    • (2005) Nat Rev Immunol , vol.5 , pp. 331-342
    • Lotze, M.T.1    Tracey, K.J.2
  • 16
    • 22144447819 scopus 로고    scopus 로고
    • The cytokine activity of HMGB1
    • Yang H, Wang H, Czura CJ, et al. The cytokine activity of HMGB1. J Leukoc Biol 2005; 78 : 1-8.
    • (2005) J Leukoc Biol , vol.78 , pp. 1-8
    • Yang, H.1    Wang, H.2    Czura, C.J.3
  • 17
    • 0034698830 scopus 로고    scopus 로고
    • High mobility group 1 protein (HMG-1) stimulates proinflammatory cytokine synthesis in human monocytes
    • Andersson U, Wang H, Palmblad K, et al. High mobility group 1 protein (HMG-1) stimulates proinflammatory cytokine synthesis in human monocytes. J Exp Med 2000; 192 : 565-70.
    • (2000) J Exp Med , vol.192 , pp. 565-570
    • Andersson, U.1    Wang, H.2    Palmblad, K.3
  • 18
    • 55549128746 scopus 로고    scopus 로고
    • High-mobility group box protein 1 (HMGB1): An alarmin mediating the pathogenesis of rheumatic disease
    • Pisetsky DS, Erlandsson-Harris H, Andersson U. High-mobility group box protein 1 (HMGB1): An alarmin mediating the pathogenesis of rheumatic disease. Arthritis Res Ther 2008; 10 : 209.
    • (2008) Arthritis Res Ther , vol.10 , pp. 209
    • Pisetsky, D.S.1    Erlandsson-Harris, H.2    Andersson, U.3
  • 19
    • 2942652398 scopus 로고    scopus 로고
    • Extracellular HMGB1 as a proinflammatory cytokine
    • Chen G, Ward MF, Sama AE, et al. Extracellular HMGB1 as a proinflammatory cytokine. J Interferon Cytokine Res 2004; 24 : 329-33.
    • (2004) J Interferon Cytokine Res , vol.24 , pp. 329-333
    • Chen, G.1    Ward, M.F.2    Sama, A.E.3
  • 20
    • 0032816123 scopus 로고    scopus 로고
    • Proinflammatory cytokines (tumor necrosis factor and interleukin 1) stimulate release of high mobility group protein-1 by pituicytes
    • Wang H, Vishnubhakat JM, Bloom O, et al. Proinflammatory cytokines (tumor necrosis factor and interleukin 1) stimulate release of high mobility group protein-1 by pituicytes. Surgery 1999; 126 : 389-92.
    • (1999) Surgery , vol.126 , pp. 389-392
    • Wang, H.1    Vishnubhakat, J.M.2    Bloom, O.3
  • 21
    • 33745788420 scopus 로고    scopus 로고
    • HMGB1, a novel cytokine-like mediator linking acute neuronal death and delayed neuroinflammation in the postischemic brain
    • Kim JB, Sig Choi J, Yu YM, et al. HMGB1, a novel cytokine-like mediator linking acute neuronal death and delayed neuroinflammation in the postischemic brain. J Neurosci 2006; 26 : 6413-21.
    • (2006) J Neurosci , vol.26 , pp. 6413-6421
    • Kim, J.B.1    Sig Choi, J.2    Yu, Y.M.3
  • 22
    • 0027718105 scopus 로고
    • Survey of the distribution of a newly characterized receptor for advanced glycation end products in tissues
    • Brett J, Schmidt AM, Yan SD, et al. Survey of the distribution of a newly characterized receptor for advanced glycation end products in tissues. Am J Pathol 1993; 143 : 1699-712.
    • (1993) Am J Pathol , vol.143 , pp. 1699-1712
    • Brett, J.1    Schmidt, A.M.2    Yan, S.D.3
  • 23
    • 33846460101 scopus 로고    scopus 로고
    • Receptor for advanced glycation end products activation injures primary sensory neurons via oxidative stress
    • Vincent AM, Perrone L, Sullivan KA, et al. Receptor for advanced glycation end products activation injures primary sensory neurons via oxidative stress. Endocrinology 2007; 148 : 548-58.
    • (2007) Endocrinology , vol.148 , pp. 548-558
    • Vincent, A.M.1    Perrone, L.2    Sullivan, K.A.3
  • 24
    • 8144223671 scopus 로고    scopus 로고
    • RAGE potentiates Abetainduced perturbation of neuronal function in transgenic mice
    • Arancio O, Zhang HP, Chen X, et al. RAGE potentiates Abetainduced perturbation of neuronal function in transgenic mice. EMBO J 2004; 23 : 4096-105.
    • (2004) EMBO J , vol.23 , pp. 4096-4105
    • Arancio, O.1    Zhang, H.P.2    Chen, X.3
  • 25
    • 0022189558 scopus 로고
    • Establishment of dorsal-ventral polarity in the Drosophila embryo: The induction of polarity by the Toll gene product
    • Anderson KV, Bokla L, Nüsslein-Volhard C. Establishment of dorsal-ventral polarity in the Drosophila embryo: The induction of polarity by the Toll gene product. Cell 1985; 42 : 791-8.
    • (1985) Cell , vol.42 , pp. 791-798
    • Anderson, K.V.1    Bokla, L.2    Nüsslein-Volhard, C.3
  • 26
    • 0034589392 scopus 로고    scopus 로고
    • Immunological regulation of neuronal degeneration and regeneration in the injured spinal cord
    • Popovich PG. Immunological regulation of neuronal degeneration and regeneration in the injured spinal cord. Prog Brain Res 2000; 128 : 43-58.
    • (2000) Prog Brain Res , vol.128 , pp. 43-58
    • Popovich, P.G.1
  • 27
    • 34250182782 scopus 로고    scopus 로고
    • Toll-like receptor (TLR)-2 and TLR-4 regulate inflammation, gliosis, and myelin sparing after spinal cord injury
    • Kigerl KA, Lai W, Rivest S, et al. Toll-like receptor (TLR)-2 and TLR-4 regulate inflammation, gliosis, and myelin sparing after spinal cord injury. J Neurochem 2007; 102 : 37-50.
    • (2007) J Neurochem , vol.102 , pp. 37-50
    • Kigerl, K.A.1    Lai, W.2    Rivest, S.3
  • 28
    • 34249862830 scopus 로고    scopus 로고
    • Rescue of rat anterior horn neurons after spinal cord injury by retrograde transfection of adenovirus vector carrying brain-derived neurotrophic factor gene
    • Nakajima H, Uchida K, Kobayashi S, et al. Rescue of rat anterior horn neurons after spinal cord injury by retrograde transfection of adenovirus vector carrying brain-derived neurotrophic factor gene. J Neurotrauma 2007; 24 : 703-12.
    • (2007) J Neurotrauma , vol.24 , pp. 703-712
    • Nakajima, H.1    Uchida, K.2    Kobayashi, S.3
  • 29
    • 77649283854 scopus 로고    scopus 로고
    • Targeted retrograde gene delivery of brain-derived neurotrophic factor suppresses apoptosis of neurons and oligodendroglias after spinal cord injury in rats
    • Nakajima H, Uchida K, Yayama T, et al. Targeted retrograde gene delivery of brain-derived neurotrophic factor suppresses apoptosis of neurons and oligodendroglias after spinal cord injury in rats. Spine 2010; 35 : 497-504.
    • (2010) Spine , vol.35 , pp. 497-504
    • Nakajima, H.1    Uchida, K.2    Yayama, T.3
  • 30
    • 0038420882 scopus 로고    scopus 로고
    • Increased expression of neurotrophins and their receptors in the mechanically compressed spinal cord of the spinal hyperostotic mouse ( twy /twy )
    • Uchida K, Baba H, Maezawa Y, et al. Increased expression of neurotrophins and their receptors in the mechanically compressed spinal cord of the spinal hyperostotic mouse ( twy /twy ). Acta Neuropathol 2003; 106 : 29-36.
    • (2003) Acta Neuropathol , vol.106 , pp. 29-36
    • Uchida, K.1    Baba, H.2    Maezawa, Y.3
  • 31
    • 45549105471 scopus 로고    scopus 로고
    • Adenovirus-mediated retrograde transfer of neurotrophin-3 enhances survival of anterior horn neurons of twy /twy mice with chronic mechanical compression of the spinal cord
    • Uchida K, Nakajima H, Inukai T, et al. Adenovirus-mediated retrograde transfer of neurotrophin-3 enhances survival of anterior horn neurons of twy /twy mice with chronic mechanical compression of the spinal cord. J Neurosci Res 2008; 86 : 1789-800.
    • (2008) J Neurosci Res , vol.86 , pp. 1789-1800
    • Uchida, K.1    Nakajima, H.2    Inukai, T.3
  • 32
    • 0035316744 scopus 로고    scopus 로고
    • HMG-1 rediscovered as a cytokine
    • Yang H, Wang H, Tracey KJ. HMG-1 rediscovered as a cytokine. Shock 2001; 15 : 247-53.
    • (2001) Shock , vol.15 , pp. 247-253
    • Yang, H.1    Wang, H.2    Tracey, K.J.3
  • 33
    • 0037062934 scopus 로고    scopus 로고
    • Release of chromatin protein HMGB1 by necrotic cells triggers inflammation
    • Scaffidi P, Misteli T, Bianchi ME. Release of chromatin protein HMGB1 by necrotic cells triggers inflammation. Nature 2002; 418 : 191-5.
    • (2002) Nature , vol.418 , pp. 191-195
    • Scaffidi, P.1    Misteli, T.2    Bianchi, M.E.3
  • 34
    • 0037251218 scopus 로고    scopus 로고
    • Targeting high mobility group box 1 as a late-acting mediator of inflammation
    • Czura CJ, Tracey KJ. Targeting high mobility group box 1 as a late-acting mediator of inflammation. Crit Care Med 2003; 31 ( suppl 1 ): S46-50.
    • (2003) Crit Care Med , vol.31 , Issue.SUPPL. 1
    • Czura, C.J.1    Tracey, K.J.2
  • 35
    • 0033538467 scopus 로고    scopus 로고
    • HMG-1 as a late mediator of endotoxin lethality in mice
    • Wang H, Bloom O, Zhang M, et al. HMG-1 as a late mediator of endotoxin lethality in mice. Science 1999; 285 : 248-51.
    • (1999) Science , vol.285 , pp. 248-251
    • Wang, H.1    Bloom, O.2    Zhang, M.3
  • 36
    • 0034664791 scopus 로고    scopus 로고
    • HMG-1 as a mediator of acute lung inflammation
    • Abraham E, Arcaroli J, Carmody A, et al. HMG-1 as a mediator of acute lung inflammation. J Immunol 2000; 165 : 2950-4.
    • (2000) J Immunol , vol.165 , pp. 2950-2954
    • Abraham, E.1    Arcaroli, J.2    Carmody, A.3
  • 37
    • 0035891570 scopus 로고    scopus 로고
    • HMGB1 as a late mediator of lethal systemic inflammation
    • Wang H, Yang H, Czura CJ, et al. HMGB1 as a late mediator of lethal systemic inflammation. Am J Respir Crit Care Med 2001; 164 : 1768-73.
    • (2001) Am J Respir Crit Care Med , vol.164 , pp. 1768-1773
    • Wang, H.1    Yang, H.2    Czura, C.J.3
  • 38
    • 0003111405 scopus 로고    scopus 로고
    • Interleukin-1
    • Thomson AW, ed. 3rd ed. San Diego, CA : Academic Press
    • Dinarello CA. Interleukin-1. In: Thomson AW, ed. The Cytokine Handbook. 3rd ed. San Diego, CA : Academic Press, 1998 : 35-73.
    • (1998) The Cytokine Handbook , pp. 35-73
    • Dinarello, C.A.1
  • 39
    • 0031817692 scopus 로고    scopus 로고
    • Spinal cord injury in the rat
    • Takao Y, Okajima K. Spinal cord injury in the rat. Prog Neurobiol 1998; 56 : 341-58.
    • (1998) Prog Neurobiol , vol.56 , pp. 341-358
    • Takao, Y.1    Okajima, K.2
  • 40
    • 0142137129 scopus 로고    scopus 로고
    • Monocytic cells hyperacetylate chromatin protein HMGB1 to redirect it towards secretion
    • Bonaldi T, Talamo F, Scaffidi P, et al. Monocytic cells hyperacetylate chromatin protein HMGB1 to redirect it towards secretion. EMBO J 2003; 22 : 5551-60.
    • (2003) EMBO J , vol.22 , pp. 5551-5560
    • Bonaldi, T.1    Talamo, F.2    Scaffidi, P.3
  • 41
    • 42549139329 scopus 로고    scopus 로고
    • Early release of HMGB-1 from neurons after the onset of brain ischemia
    • Qiu J, Nishimura M, Wang Y, et al. Early release of HMGB-1 from neurons after the onset of brain ischemia. J Cereb Blood Flow Metab 2008; 28 : 927-38.
    • (2008) J Cereb Blood Flow Metab , vol.28 , pp. 927-938
    • Qiu, J.1    Nishimura, M.2    Wang, Y.3
  • 42
    • 58149352350 scopus 로고    scopus 로고
    • The HMGB1 receptor RAGE mediates ischemic brain damage
    • Muhammad S, Barakat W, Stoyanov S, et al. The HMGB1 receptor RAGE mediates ischemic brain damage. J Neurosci 2008; 28 : 12023-31.
    • (2008) J Neurosci , vol.28 , pp. 12023-12031
    • Muhammad, S.1    Barakat, W.2    Stoyanov, S.3
  • 43
    • 0037038819 scopus 로고    scopus 로고
    • Receptor for advanced glycation end products: A multiligand receptor magnifying cell stress in diverse pathologic settings
    • Stern D, Yan SD, Yan SF, et al. Receptor for advanced glycation end products: A multiligand receptor magnifying cell stress in diverse pathologic settings. Adv Drug Deliv Rev 2002; 54 : 1615-25.
    • (2002) Adv Drug Deliv Rev , vol.54 , pp. 1615-1625
    • Stern, D.1    Yan, S.D.2    Yan, S.F.3
  • 44
    • 0036957367 scopus 로고    scopus 로고
    • HMGB1 as a cytokine and therapeutic target
    • Yang H, Wang H, Czura CJ, et al. HMGB1 as a cytokine and therapeutic target. J Endotoxin Res 2002; 8 : 469-72.
    • (2002) J Endotoxin Res , vol.8 , pp. 469-472
    • Yang, H.1    Wang, H.2    Czura, C.J.3
  • 45
    • 0032529151 scopus 로고    scopus 로고
    • Human blood-brain barrier receptors for Alzheimer's amyloid-beta 1-40. Asymmetrical binding, endocytosis, and transcytosis at the apical side of brain microvascular endothelial cell monolayer
    • Mackic JB, Stins M, McComb JG, et al. Human blood-brain barrier receptors for Alzheimer's amyloid-beta 1-40. Asymmetrical binding, endocytosis, and transcytosis at the apical side of brain microvascular endothelial cell monolayer. J Clin Invest 1998; 102 : 734-43.
    • (1998) J Clin Invest , vol.102 , pp. 734-743
    • Mackic, J.B.1    Stins, M.2    McComb, J.G.3
  • 46
    • 0037703255 scopus 로고    scopus 로고
    • RAGE mediates amyloid-beta peptide transport across the blood-brain barrier and accumulation in brain
    • Deane R, Du Yan S, Submamaryan RK, et al. RAGE mediates amyloid-beta peptide transport across the blood-brain barrier and accumulation in brain. Nat Med 2003; 9 : 907-13.
    • (2003) Nat Med , vol.9 , pp. 907-913
    • Deane, R.1    Du Yan, S.2    Submamaryan, R.K.3
  • 47
    • 0037376222 scopus 로고    scopus 로고
    • Activation of gene expression in human neutrophils by high mobility group box 1 protein
    • Park JS, Arcaroli J, Yum HK, et al. Activation of gene expression in human neutrophils by high mobility group box 1 protein. Am J Physiol Cell Physiol 2003; 284 : C870-9.
    • (2003) Am J Physiol Cell Physiol , vol.284
    • Park, J.S.1    Arcaroli, J.2    Yum, H.K.3
  • 48
    • 0034610291 scopus 로고    scopus 로고
    • The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors
    • Ozinsky A, Underhill DM, Fontenot JD, et al. The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors. Proc Natl Acad Sci U S A 2000; 97 : 13766-71.
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 13766-13771
    • Ozinsky, A.1    Underhill, D.M.2    Fontenot, J.D.3
  • 49
    • 0036019158 scopus 로고    scopus 로고
    • The clinical course of experimentalautoimmune encephalomyelitis is associated with a profound and sustained transcriptionalactivation of the genes encoding toll-like receptor 2 and CD14 in the mouse CNS
    • Zekki H, Feinstein DL, Rivest S. The clinical course of experimentalautoimmune encephalomyelitis is associated with a profound and sustained transcriptionalactivation of the genes encoding toll-like receptor 2 and CD14 in the mouse CNS. Brain Pathol 2002; 12 : 308-19.
    • (2002) Brain Pathol , vol.12 , pp. 308-319
    • Zekki, H.1    Feinstein, D.L.2    Rivest, S.3
  • 50
    • 7244226396 scopus 로고    scopus 로고
    • Toll-like receptors in rat brains injured by hypoxic-ischaemia or exposed to staphylococcalalpha-toxin
    • Ma li ska D, Laure-Kamionowska M, Ma li ski S. Toll-like receptors in rat brains injured by hypoxic-ischaemia or exposed to staphylococcalalpha-toxin. Folia Neuropathol 2004; 42 : 125-32.
    • (2004) Folia Neuropathol , vol.42 , pp. 125-132
    • Ma Li Ska, D.1    Laure-Kamionowska, M.2    Ma Li Ski, S.3
  • 51
    • 17644414137 scopus 로고    scopus 로고
    • The CNS role of Tolllike receptor 4 in innate neuroimmunity and painful neuropathy
    • Tanga FY, Nutile-McMenemy N, DeLeo JA. The CNS role of Tolllike receptor 4 in innate neuroimmunity and painful neuropathy. Proc Natl Acad Sci U S A 2005; 102 : 5856-61.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 5856-5861
    • Tanga, F.Y.1    Nutile-McMenemy, N.2    DeLeo, J.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.