Targeting high mobility group box 1 as a late-acting mediator of inflammation

Critical Care Medicine

Volumn 31, Issue 1 SUPPL., 2003, Pages

  Czura, Christopher J ^a   Tracey, Kevin J ^a  

^a Northwell Health   (United States)

Author keywords

Arthritis; Cytokine; Endotoxemia; HMGB1; Interleukin 1 ; Sepsis; Tumor necrosis factor

Indexed keywords

ANTIINFLAMMATORY AGENT; CELL PROTEIN; CYTOKINE; HIGH MOBILITY GROUP B1 PROTEIN; INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; NUCLEAR PROTEIN; TUMOR NECROSIS FACTOR;

CLINICAL MEDICINE; CYTOKINE PRODUCTION; GENE MAPPING; HUMAN; IMMUNE SYSTEM; INFLAMMATION; LETHALITY; MEDIATOR RELEASE; MORTALITY; PATHOLOGICAL ANATOMY; PRIORITY JOURNAL; PROTEIN TARGETING; REVIEW; SEPSIS; STRUCTURE ACTIVITY RELATION; TISSUE INJURY; UNITED STATES;

EID: 0037251218     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/00003246-200301001-00007     Document Type: Review

References (43)

1. Tracey KJ: The inflammatory reflex. Nature 2003 (In Press)
2. Tracey KJ, Fong Y, Hesse DG, et al: Anticachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia. Nature 1987; 330:662-664
3. Tracey KJ, Beutler B, Lowry SF, et al: Shock and tissue injury induced by recombinant human cachectin. Science 1986; 234: 470-474
4. Tracey KJ, Lowry SF, Fahey TJ III, et al: Cachectin/tumor necrosis factor induces lethal shock and stress hormone responses in the dog. Surg Gynecol Obstet 1987; 164: 415-422
5. Yang H, Wang H, Tracey KJ: HMG-1 rediscovered as a cytokine. Shock 2001; 15: 247-253
6. Wang H, Bloom O, Zhang M, et al: HMG-1 as a late mediator of endotoxin lethality in mice. Science 1999; 285:248-251
7. Ulloa L, Ochani M, Yang H, et al: Ethyl pyruvate prevents lethality in mice with established lethal sepsis and systemic inflammation. Proc Natl Acad Sci U S A 2002; 99: 12351-12356
8. Goodwin GH, Sanders C, Johns EW: A new group of chromatin-associated proteins with a high content of acidic and basic amino acids. Eur J Biochem 1973; 38:14-17
9. Johns EW (Ed): The HMG Chromosomal Proteins. London, Academic Press, 1982
10. Bianchi ME, Beltrame M, Paonessa G: Specific recognition of cruciform DNA by nuclear protein HMG1. Science 1989; 243: 1056-1059
11. Gariboldi M, De Gregorio L, Ferrari S, et al: Mapping of the Hmg-1 gene and of seven related sequences in the mouse. Mamm Genome 1995; 6:581-585
12. Ferrari S, Finelli P, Rocchi M, et al: The active gene that encodes human high mobility group 1 protein (HMG1) contains introns and maps to chromosome 13. Genomics 1996; 35:367-371
13. Borrmann L, Kim I, Schultheiss D, et al: Regulation of the expression of HMG1, a co-activator of the estrogen receptor. Anticancer Res 2001; 21:301-305
14. Calogero S, Grassi F, Aguzzi A, et al: The lack of chromosomal protein HMG1 does not disrupt cell growth, but causes lethal hypoglycaemia in newborn mice. Nat Genet 1999; 22:276-280
15. Bustin M, Reeves R: High-mobility-group chromosomal proteins: Architectural components that facilitate chromatin function. Prog Nucleic Acid Res Mol Biol 1996; 54: 35-100
16. Czura CJ, Wang H, Tracey KJ: Dual roles for HMGB1: DNA binding and cytokine. J Endotoxin Res 2001; 7:315-321
17. Wang H, Yang H, Czura CJ, et al: HMGB1 as a late mediator of lethal systemic inflammation. Am J Respir Crit Care Med 2001; 164(10 Pt 1):1768-73
18. Bustin M: At the crossroads of necrosis and apoptosis: Signaling to multiple cellular targets by HMGB1. Sci STKE 2002; 2002(151): PE39
19. Bustin M: Revised nomenclature for high mobility group (HMG) chromosomal proteins. Trends Biochem Sci 2001; 26:152-153
20. Wang H, Vishnubhakat JM, Bloom O, et al: Proinflammatory cytokines (tumor necrosis factor and interleukin 1) stimulate release of high mobility group protein-1 by pituicytes. Surgery 1999; 126:389-392
21. Gardella S, Andrei C, Ferrera D, et al: The nuclear protein HMGB1 is secreted by monocytes via a non-classical, vesicle-mediated secretory pathway. EMBO Rep 2002; 3:995-1001
22. Scaffidi P, Misteli T, Bianchi ME: Release of chromatin protein HMGB1 by necrotic cells triggers inflammation. Nature 2002; 418: 191-195
23. Andersson U, Wang H, Palmblad K, et al: HMG-1 stimulates proinflammatory cytokine synthesis in human monocytes. J Exp Med 2000; 192:565-570
24. Degryse B, Bonaldi T, Scaffidi P, et al: The high mobility group (HMG) boxes of the nuclear protein HMG1 induce chemotaxis and cytoskeleton reorganization in rat smooth muscle cells. J Cell Biol 2001; 152: 1197-1206
25. Rauvala H, Pihlaskari R: Isolation and some characteristics of an adhesive factor of brain that enhances neurite outgrowth in central neurons. J Biol Chem 1987; 262: 16625-16635
26. Datson MM, Ratner N: Expression of P30, a protein with adhesive properties, in Schwann cells and neurons of the developing and regenerating peripheral nerve. J Cell Biol 1991; 112:1229-1239
27. Parkkinen J, Raulo E, Merenmies J, et al: Amphoterin, the 30-kDa protein in a family of HMG1-type polypeptides: Enhanced expression in transformed cells, leading edge localization, and interactions with plasminogen activation. J Biol Chem 1993; 268: 19726-19738
28. Parkkinen J, Rauvala H: Interactions of plasminogen and tissue plasminogen activator (t-PA) with amphoterin: Enhancement of tPA-catalyzed plasminogen activation by amphoterin. J Biol Chem 1991; 266: 16730-16735
29. Hori O, Brett J, Slattery T, et al: The receptor for advanced glycation end products (RAGE) is a cellular binding site for amphoterin; Mediation of neurite outgrowth and co-expression of RAGE and amphoterin in the developing nervous system. J Biol Chem 1995; 274:19919-19924
30. Neeper M, Schmidt AM, Brett J, et al: Cloning and expression of a cell surface receptor for advanced glycosylation end products of proteins. J Biol Chem 1992;267: 14998-15004
31. Srikrishna G, Huttunen H, Johansson L, et al: N-glycans on the receptor for advanced glycation end products influence amphoterin binding and neurite outgrowth. J Neurochem 2002; 80:998-1008
32. Yang H, Wang HC, Bernik TR, et al: The HMGB1 B box confers cytokine activity and signals via RAGE. Shock 2001; 15(Suppl 1):27
33. Sappington PL, Yang R, Yang H, et al: HMGB1 B box increases the permeability of Caco-2 enterocytic monolayers and impairs intestinal barrier function in mice. Gastroenterology 2002; 123:790-802
34. Agnello D, Wang H, Yang H, et al: HMGB-1, a DNA-binding protein with cytokine activity, induces brain TNF and IL-6 production, and mediates anorexia and taste aversion. Cytokine 2002; 18:231-236
35. Wichmann MW, Haisken JM, Ayala A, et al: Melatonin administration following hemorrhagic shock decreases mortality from subsequent septic challenge. J Surg Res 1996; 65:109-114
36. Abraham E, Arcaroli J, Carmody A, et al: HMG-1 as a mediator of acute lung inflammation. J Immunol 2000; 165:2950-2954
37. Fink MP: Reactive oxygen species as mediators of organ dysfunction caused by sepsis, acute respiratory distress syndrome, or hemorrhagic shock: Potential benefits of resuscitation with Ringer's ethyl pyruvate solution. Curr Opin Clin Nutr Metab Care 2002; 5:167-174
38. Sims CA, Wattanasirichaigoon S, Menconi MJ, et al: Ringer's ethyl pyruvate solution ameliorates ischemia/reperfusion-induced intestinal mucosal injury in rats. Crit Care Med 2001; 29:1513-1518
39. Tawadrous ZS, Delude RL, Fink MP: Resuscitation from hemorrhagic shock with Ringer's ethyl pyruvate solution improves survival and ameliorates intestinal mucosal hyperpermeability in rats. Shock 2002; 17: 473-477
40. Yang R, Gallo DJ, Baust JJ, et al: Ethyl pyruvate modulates inflammatory gene expression in mice subjected to hemorrhagic shock. Am J Physiol Gastrointest Liver Physiol 2002; 283:G212-G221
41. Ombrellino M, Wang H, Ajemian MS, et al: Increased serum concentrations of high-mobility-group protein 1 in haemorrhagic shock. Lancet 1999; 354:1446-1447
42. Kokkola R, Sundberg E, Ulfgren A-K, et al: High mobility group box chromosomal protein 1: A novel proinflammatory mediator in synovitis. Arthritis Rheum 2002; 46: 2598-2603
43. Müller S, Scaffidi P, Degryse B, et al: The double life of HMGB1 chromatin protein: Architectural factor and extracellular signal. EMBO J 2001; 20:4337-4340