Structural analyses of a purine biosynthetic enzyme from Mycobacterium tuberculosis reveal a novel bound nucleotide

Journal of Biological Chemistry

Volumn 286, Issue 47, 2011, Pages 40706-40716

  Le Nours, Jérôme ^a,b   Bulloch, Esther M M ^a   Zhang, Zhening ^a,c   Greenwood, David R ^a   Middleditch, Martin J ^a   Dickson, James M J ^a   Baker, Edward N ^a  

^a UNIVERSITY OF AUCKLAND   (New Zealand)

^b MONASH UNIVERSITY   (Australia)

^c BROOKHAVEN NATIONAL LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; ANTICANCER DRUG; BIFUNCTIONAL ENZYMES; BIOSYNTHETIC ENZYMES; BIOSYNTHETIC PATHWAY; C-TERMINAL DOMAINS; COMMON FEATURES; CYCLOHYDROLASE; DIMER INTERFACE; M. TUBERCULOSIS; MASS-SPECTRAL ANALYSIS; MONOPHOSPHATES; MYCOBACTERIUM TUBERCULOSIS; N-TERMINAL DOMAINS; RIBONUCLEOTIDES; TWO DOMAINS;

BIOSYNTHESIS; NUCLEOTIDES; SPECTRUM ANALYSIS;

ENZYMES;

4 CARBOXY 5 AMINOIMIDAZOLE RIBONUCLEOTIDE; 5 AMINOIMIDAZOLE 4 CARBOXAMIDE RIBONUCLEOTIDE; 5 FORMYL DERIVATIVE; ATIC PROTEIN; CYCLOHYDROLASE; CYCLOHYDROLASE INHIBITOR; ENZYME INHIBITOR; FORMYLTRANSFERASE; NUCLEOTIDE DERIVATIVE; RIBONUCLEOTIDE; TRANSFERASE; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL NUCLEUS; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME ANALYSIS; ENZYME BINDING; ENZYME STRUCTURE; ENZYME SUBSTRATE; MASS SPECTROMETRY; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FOLDING; PURINE SYNTHESIS;

AMINOIMIDAZOLE CARBOXAMIDE; ANIMALS; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; HUMANS; HYDROXYMETHYL AND FORMYL TRANSFERASES; LIGANDS; MODELS, MOLECULAR; MULTIENZYME COMPLEXES; MYCOBACTERIUM TUBERCULOSIS; NUCLEOTIDE DEAMINASES; PROTEIN MULTIMERIZATION; PURINE NUCLEOTIDES; RIBONUCLEOTIDES;

AVES; MYCOBACTERIUM TUBERCULOSIS;

EID: 81755189021     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.291138     Document Type: Article

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