Identification of inhibitors of N5-carboxyaminoimidazole ribonucleotide synthetase by high-throughput screening

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 9, 2009, Pages 3317-3323

  Firestine, Steven M ^a   Paritala, Hanumantharao ^a   Mcdonnell, Jane E ^a   Thoden, James B ^b   Holden, Hazel M ^b  

^a WAYNE STATE UNIVERSITY   (United States)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

Antimicrobial agents; Drug discovery; Enzyme inhibitors; High throughput screening; N5 CAIR synthetase; Purine biosynthesis

Indexed keywords

ENZYME INHIBITOR; N 5 CARBOZYAMINOIMIDAZOLE RIBONUCLEOTIDE SYNTHETASE INHIBITOR; UNCLASSIFIED DRUG; ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; CARBOXYAMINOIMIDAZOLE RIBOTIDE; ESCHERICHIA COLI PROTEIN; LIGASE; RIBONUCLEOTIDE;

ARTICLE; DRUG DESIGN; DRUG SCREENING; DRUG STRUCTURE; ESCHERICHIA COLI; HIGH THROUGHPUT SCREENING; MICHAELIS MENTEN KINETICS; NONHUMAN; PROTEIN ANALYSIS; PURINE SYNTHESIS; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; ENZYMOLOGY; HUMAN; KINETICS; METABOLISM;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI;

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; HUMANS; KINETICS; LIGASES; MODELS, MOLECULAR; RIBONUCLEOTIDES;

EID: 65249142280     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.03.043     Document Type: Article

References (33)

1. Appelbaum P.C. Clin. Microbiol. Infect. 12 (2006) 3
2. Alekshun M.N. Expert Opin. Investig. Drugs 14 (2005) 117
3. Klevens R.M., Morrison M.A., Nadle J., Petit S., Gershman K., Ray S., Harrison L.H., Lynfield R., Dumyati G., Townes J.M., Craig A.S., Zell E.R., Fosheim G.E., McDougal L.K., Carey R.B., and Fridkin S.K. JAMA 298 (2007) 1763
4. Lode H. Clin. Microbiol. Infect. 11 (2005) 778
5. Carleton H.A., Diep B.A., Charlebois E.D., Sensabaugh G.F., and Perdreau-Remington F. J. Infect. Dis. 190 (2004) 1730
6. Naimi T.S., LeDell K.H., Como-Sabetti K., Borchardt S.M., Boxrud D.J., Etienne J., Johnson S.K., Vandenesch F., Fridkin S., O'Boyle C., Danila R.N., and Lynfield R. JAMA 290 (2003) 2976
7. Hiramatsu K. Lancet Infect. Dis. 1 (2001) 147
8. Eliopoulos G.M. Eur. J. Clin. Microbiol. Infect. Dis. 24 (2005) 826
9. Stevens D.L., Herr D., Lampiris H., Hunt J.L., Batts D.H., and Hafkin B. Clin. Infect. Dis. 34 (2002) 1481
10. Arbeit R.D., Maki D., Tally F.P., Campanaro E., and Eisenstein B.I. Clin. Infect. Dis. 38 (2004) 1673
11. Herrero I.A., Issa N.C., and Patel R. N. Engl. J. Med. 346 (2002) 867
12. Firestine S.M., Poon S.W., Mueller E.J., Stubbe J., and Davisson V.J. Biochemistry 33 (1994) 11927
13. Firestine S.M., and Davisson V.J. Biochemistry 33 (1994) 11917
14. Firestine S.M., Misialek S., Toffaletti D.L., Klem T.J., Perfect J.R., and Davisson V.J. Arch. Biochem. Biophys. 351 (1998) 123
15. Meyer E., Leonard N.J., Bhat B., Stubbe J., and Smith J.M. Biochemistry 31 (1992) 5022
16. Meyer E., Kappock T.J., Osuji C., and Stubbe J. Biochemistry 38 (1999) 3012
17. Mueller E.J., Meyer E., Rudolph J., Davisson V.J., and Stubbe J. Biochemistry 33 (1994) 2269
18. McFarland W.C., and Stocker B.A. Microb. Pathog. 3 (1987) 129
19. Polissi A., Pontiggia A., Feger G., Altieri M., Mottl H., Ferrari L., and Simon D. Infect. Immun. 66 (1998) 5620
20. Samant S., Lee H., Ghassemi M., Chen J., Cook J.L., Mankin A.S., and Neyfakh A.A. PLoS Pathog. 4 (2008) e37
21. Wang J., Mushegian A., Lory S., and Jin S. Proc. Natl. Acad. Sci. U.S.A. 93 (1996) 10434
22. Cersini A., Martino M.C., Martini I., Rossi G., and Bernardini M.L. Infect. Immun. 71 (2003) 7002
23. Kirsch D.R., and Whitney R.R. Infect. Immun. 59 (1991) 3297
24. Donovan M., Schumuke J.J., Fonzi W.A., Bonar S.L., Gheesling-Mullis K., Jacob G.S., Davisson V.J., and Dotson S.B. Infect. Immun. 69 (2001) 2542
25. Perfect J.R., Toffaletti D.L., and Rude T.H. Infect. Immun. 61 (1993) 4446
26. Baykov A.A., Evtushenko O.A., and Avaeva S.M. Anal. Biochem. 171 (1988) 266
27. Rowlands M.G., Newbatt Y.M., Prodromou C., Pearl L.H., Workman P., and Aherne W. Anal. Biochem. 327 (2004) 176
28. Shen Y., Volrath S.L., Weatherly S.C., Elich T.D., and Tong L. Mol. Cell. 16 (2004) 881
29. Liu S., Chang J.S., Herberg J.T., Horng M.M., Tomich P.K., Lin A.H., and Marotti K.R. Proc. Natl. Acad. Sci. U.S.A. 103 (2006) 15178
30. Spellberg B., Powers J.H., Brass E.P., Miller L.G., and Edwards Jr. J.E. Clin. Infect. Dis. 38 (2004) 1279
31. Rodriguez-Suarez R., Xu D., Veillette K., Davison J., Sillaots S., Kauffman S., Hu W., Bowman J., Martel N., Trosok S., Wang H., Zhang L., Huang L.Y., Li Y., Rahkhoodaee F., Ransom T., Gauvin D., Douglas C., Youngman P., Becker J., Jiang B., and Roemer T. Chem. Biol. 14 (2007) 1163
32. Thoden J.B., Firestine S., Nixon A., Benkovic S.J., and Holden H.M. Biochemistry 39 (2000) 8791
33. Marolewski A., Smith J.M., and Benkovic S.J. Biochemistry 33 (1994) 2531