Structure-based design, synthesis, evaluation, and crystal structures of transition state analogue inhibitors of inosine monophosphate cyclohydrolase

Journal of Biological Chemistry

Volumn 282, Issue 17, 2007, Pages 13033-13046

  Xu, Lan ^a   Chong, Youhoon ^a,c   Hwang, Inkyu ^a   D'Onofrio, Anthony ^b   Amore, Kristen ^b   Beardsley, G Peter ^b   Li, Chenglong ^a,d   Olson, Arthur J ^a   Boger, Dale L ^a   Wilson, Ian A ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c Konkuk University   (South Korea)

^d OHIO STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOSYNTHESIS; CRYSTAL STRUCTURE; ENZYME ACTIVITY; ENZYME INHIBITION; NUCLEOTIDES; PHOSPHATES;

ANTINEOPLASTIC INTERVENTION; MONOPHOSPHATES; PURINE BIOSYNTHESIS; TRANSITION STATE ANALOGUE INHIBITORS;

ENZYME KINETICS;

INOSINE PHOSPHATE; NUCLEOSIDE; NUCLEOSIDE MONOPHOSPHATE KINASE; PHOSPHATE; XANTHOSINE; AVIAN PROTEIN; ENZYME INHIBITOR; NUCLEOTIDE; PHOSPHORIBOSYLAMINOIMIDAZOLECARBOXAMIDE FORMYLTRANSFERASE; PURINE; PURINE DERIVATIVE; TUMOR PROTEIN;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BINDING AFFINITY; CRYSTAL STRUCTURE; CRYSTALLIZATION; CYCLIZATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME MECHANISM; ENZYME STRUCTURE; ENZYME SYNTHESIS; EVALUATION; INTERVENTION STUDY; MOLECULAR INTERACTION; PRIORITY JOURNAL; ANIMAL; BINDING SITE; BIOSYNTHESIS; BIRD; CHEMISTRY; DRUG ANTAGONISM; ENZYMOLOGY; HUMAN; METABOLISM; NEOPLASM; PROTEIN BINDING; PROTEIN TERTIARY STRUCTURE; SYNTHESIS;

ANIMALS; AVIAN PROTEINS; BINDING SITES; BIRDS; ENZYME INHIBITORS; HUMANS; NEOPLASM PROTEINS; NEOPLASMS; NUCLEOSIDES; NUCLEOTIDES; PHOSPHORIBOSYLAMINOIMIDAZOLECARBOXAMIDE FORMYLTRANSFERASE; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PURINES;

EID: 34250326342     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M607293200     Document Type: Article

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