The mushroom Agaricus blazei murill elicits medicinal effects on tumor, infection, allergy, and inflammation through its modulation of innate immunity and amelioration of Th1/Th2 imbalance and inflammation

Advances in Pharmacological Sciences

Volumn 2011, Issue , 2011, Pages

  Hetland, Geir ^a   Johnson, Egil ^b,c   Lyberg, Torstein ^b   Kvalheim, Gunnar ^a  

^a OSLO UNIVERSITY HOSPITAL   (Norway)

^b ULLEVÅL UNIVERSITY HOSPITAL   (Norway)

^c UNIVERSITY OF OSLO   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

AGARICUS BLAZEI EXTRACT; ALPHA BETA INTERFERON RECEPTOR; CD11B ANTIGEN; GRANULOCYTE COLONY STIMULATING FACTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 12; INTERLEUKIN 17; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 23P19; INTERLEUKIN 6; INTERLEUKIN 8; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; MONOCYTE CHEMOTACTIC PROTEIN 1; TUMOR NECROSIS FACTOR ALPHA;

ADAPTIVE IMMUNITY; AGARICUS BLAZEI; ALLERGY; ANTIGEN EXPRESSION; ANTIINFLAMMATORY ACTIVITY; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; CELL ACTIVATION; CELL STIMULATION; CELLULAR IMMUNITY; CROHN DISEASE; CYTOKINE PRODUCTION; ENTERITIS; GENE EXPRESSION; HUMAN; INFECTION; INFLAMMATION; INNATE IMMUNITY; NONHUMAN; PHASE 1 CLINICAL TRIAL (TOPIC); PHASE 2 CLINICAL TRIAL (TOPIC); PRIORITY JOURNAL; REVIEW; SURVIVAL RATE; TH1 CELL; TH1 TH2 BALANCE; TH17 CELL; TH2 CELL; TUBERCULOSIS; TUMOR; ULCERATIVE COLITIS; UNSPECIFIED SIDE EFFECT; UPREGULATION;

EID: 81555225186     PISSN: 16876334     EISSN: 16876342     Source Type: Journal    
DOI: 10.1155/2011/157015     Document Type: Review

References (59)

1. Kerrigan R. W., Agaricus subrufescens, a cultivated edible and medicinal mushroom, and its synonyms Mycologia 2005 97 1 12 24 (Pubitemid 40722059)
2. Huang N., Huang N., Brazilian mushroom (Gee Song Rong) Cultivation of Eigth Rare and Precious Gourmet Mushrooms 1997 Chinese Agriculture University Press 95 101
3. Wasser S. P., Weis A. L., Therapeutic effects of substances occurring in higher basidiomycetes mushrooms: a modern perspective Critical Reviews in Immunology 1999 19 1 65 96 (Pubitemid 29062102)
4. Ohno N., Furukawa M., Miura N. N., Adachi Y., Motoi M., Yadomae T., Antitumor -glucan from the cultured fruit body of Agaricus blazei Biological and Pharmaceutical Bulletin 2001 24 7 820 828 (Pubitemid 32633492)
5. Itoh H., Ito H., Amano H., Noda H., Inhibitory action of a (1→6)- -D-glucan-protein complex (F III-2-b) isolated from Agaricus blazei Murill ('Himematsutake') on Meth A fibrosarcoma-bearing mice and its antitumor mechanism Japanese Journal of Pharmacology 1994 66 2 265 271 (Pubitemid 24357109)
6. Czop J. K., Valiante N. M., Janusz M. J., Phagocytosis of particulate activators of the human alternative complement pathway through monocyte beta-glucan receptors Progress in Clinical and Biological Research 1989 297 287 296
7. Roeder A., Kirschning C. J., Rupec R. A., Schaller M., Weindl G., Korting H. C., Toll-like receptors as key mediators in innate antifungal immunity Medical Mycology 2004 42 6 485 498 (Pubitemid 40109561)
8. Gantner B. N., Simmons R. M., Canavera S. J., Akira S., Underhill D. M., Collaborative induction of inflammatory responses by dectin-1 and toll-like receptor 2 Journal of Experimental Medicine 2003 197 9 1107 1117 (Pubitemid 36570066)
9. Goodridge H. S., Wolf A. J., Underhill D. M., β-glucan recognition by the innate immune system Immunological Reviews 2009 230 1 38 50
10. Endo M., Beppu H., Akiyama H., Wakamatsu K., Ito S., Kawamoto Y., Shimpo K., Sumiya T., Koike T., Matsui T., Agaritine purified from Agaricus blazei Murrill exerts anti-tumor activity against leukemic cells Biochimica et Biophysica Acta 2010 1800 7 669 673
11. Takaku T., Kimura Y., Okuda H., Isolation of an antitumor compound from Agaricus blazei Murill and its mechanism of action Journal of Nutrition 2001 131 5 1409 1413 (Pubitemid 32422958)
12. Oh T. W., Kim Y. A., Jang W. J., Byeon J. I., Ryu C. H., Kim J. O., Ha Y. L., Semipurified fractions from the submerged-culture broth of Agaricus blazei Murill reduce blood glucose levels in streptozotocin-induced diabetic rats Journal of Agricultural and Food Chemistry 2010 58 7 4113 4119
13. Hetland G., Johnson E., Lyberg T., Bernardshaw S., Tryggestad A. M. A., Grinde B., Effects of the medicinal mushroom Agaricus blazei Murill on immunity, infection and cancer Scandinavian Journal of Immunology 2008 68 4 363 370
14. Bernardshaw S., Johnson E., Hetland G., An extract of the mushroom Agaricus blazei Murill administered orally protects against systemic Streptococcus pneumoniae infection in mice Scandinavian Journal of Immunology 2005 62 4 393 398 (Pubitemid 41565392)
15. Bernardshaw S., Hetland G., Grinde B., Johnson E., An extract of the mushroom Agaricus blazei Murill protects against lethal septicemia in a mouse model of fecal peritonitis Shock 2006 25 4 420 425
16. Ellertsen L. K., Hetland G., An extract of the medicinal mushroom Agaricus blazei Murill can protect against allergy Clinical and Molecular Allergy 2009 7, article no. 6
17. Romagnani S., The Th1/Th2 paradigm Immunology Today 1997 18 263 266 (Pubitemid 27261442)
18. Takimoto H., Kato H., Kaneko M., Kumazawa Y., Amelioration of skewed Th1/Th2 balance in tumor-bearing and asthma-induced mice by oral administration of Agaricus blazei extracts Immunopharmacology and Immunotoxicology 2008 30 4 747 760
19. Pelligrini P., Berghella A. M., Del Beato T., Disregulation in TH1 and TH2 subsets of CD4+ T cells in peripheral blood of colorectal cancer patients and involvement in cancer establishment and progession Cancer Research 1998 42 1 8
20. Lienhardt C., Azzurri A., Amedei A., Fielding K., Sillah J., Sow O. Y., Bah B., Benagiano M., Diallo A., Manetti R., Manneh K., Gustafson P., Bennett S., D'Elios M. M., McAdam K., Del Prete G., Active tuberculosis in Africa is associated with reduced Th1 and increased Th2 activity in vivo European Journal of Immunology 2002 32 6 1605 1613 (Pubitemid 34679148)
21. Ellertsen L. K., Wiker H. G., Egeberg N. T., Hetland G., Allergic sensitisation in tuberculosis and leprosy patients International Archives of Allergy and Immunology 2005 138 3 217 224 (Pubitemid 41540680)
22. Hetland G., Lvik M., Wiker H. G., Protective effect of -glucan against Mycobacterium bovis, BCG infection in BALB/c mice Scandinavian Journal of Immunology 1998 47 6 548 553 (Pubitemid 28273364)
23. Johnson E., Frland D. T., Stre L., Bernardshaw S. V., Lyberg T., Hetland G., Effect of an extract based on the medicinal mushroom Agaricus blazei Murill on release of cytokines, chemokines and leukocyte growth factors in human blood ex vivo and in vivo Scandinavian Journal of Immunology 2009 69 3 242 250
24. Frland D. T., Johnson E., Stre L., Lyberg T., Lygren I., Hetland G., Effect of an extract based on the medicinal mushroom Agaricus blazei Murill on expression of cytokines and calprotectin in patients with ulcerative colitis and Crohn's disease Scandinavian Journal of Immunology 2011 73 1 66 75
25. Lee I. P., Kang B. H., Roh J. K., Kim J. R., Lack of carcinogenicity of lyophilized Agaricus blazei Murill in a F344 rat two year bioassay Food and Chemical Toxicology 2008 46 1 87 95 (Pubitemid 350245552)
26. Kumagai Y., Akira S., Identification and functions of pattern-recognition receptors Journal of Allergy and Clinical Immunology 2010 125 5 985 992
27. Tryggestad A. M. A., Espevik T., Frland D. T., The medical mushroom Agaricus blazei Murill activates NF- B via TLR2 Proceedings of the 13th International Congress of Immunology August 2007 Rio de Janeiro, Brazil 1193 P2.23 INI-02 Signalling pathways of innate immune receptors
28. Bernardshaw S., Lyberg T., Hetland G., Johnson E., Effect of an extract of the mushroom Agaricus blazei Murill on expression of adhesion molecules and production of reactive oxygen species in monocytes and granulocytes in human whole blood ex vivo Acta Pathologica, Microbiologica, et Immunologica Scandinavica 2007 115 6 719 725 (Pubitemid 46854989)
29. Bernardshaw S., Hetland G., Ellertsen L. K., Tryggestad A. M. A., Johnson E., An extract of the medicinal mushroom Agaricus blazei Murill differentially stimulates production of pro-inflammatory cytokines in human monocytes and human vein endothelial cells in vitro Inflammation 2005 29 46 147 153 (Pubitemid 44897912)
30. Fitzner N., Clauberg S., Essmann F., Liebmann J., Kolb-Bachofen V., Human skin endothelial cells can express all 10 TLR genes and respond to respective ligands Clinical and Vaccine Immunology 2008 15 1 138 146 (Pubitemid 351966534)
31. Ahn W. S., Kim D. J., Chae G. T., Lee J. M., Bae S. M., Sin J. I., Kim Y. W., Namkoong S. E., Lee I. P., Natural killer cell activity and quality of life were improved by consumption of a mushroom extract, Agaricus blazei Murill Kyowa, in gynecological cancer patients undergoing chemotherapy International Journal of Gynecological Cancer 2004 14 4 589 594 (Pubitemid 39062912)
32. Geddes K., Magalhes J. G., Girardin S. E., Unleashing the therapeutic potential of NOD-like receptors Nature Reviews Drug Discovery 2009 8 6 465 479
33. Benko S., Magyarics Z., Szab A., Rajnavlgyi E., Dendritic cell subtypes as primary targets of vaccines: the emerging role and cross-talk of pattern recognition receptors Biological Chemistry 2008 389 5 469 485 (Pubitemid 351874188)
34. Suzuki T., Ohno N., Saito K., Yadomae T., Activation of the complement system by (1→3)- -D-glucans having different degrees of branching and different ultrastructures Journal of Pharmacobio-Dynamics 1992 15 6 277 285
35. Chan G. C., Chan W. K., Sze D. M., The effects of beta-glucan on human immune and cancer cells Journal of Hematology amp; Oncology 2009 2 25
36. Sorimachi K., Akimoto K., Ikehara Y., Inafuku K., Okubo A., Yamazaki S., Secretion of TNF-, IL-8 and nitric oxide by macrophages activated with Agaricus blazei Murill fractions in vitro Cell Structure and Function 2001 26 2 103 108 (Pubitemid 32747234)
37. Volman J. J., Helsper J. P. F. G., Wei S., Baars J. J. P., van Griensven L. J. L. D., Sonnenberg A. S. M., Mensink R. P., Plat J., Effects of mushroom-derived -glucan-rich polysaccharide extracts on nitric oxide production by bone marrow-derived macrophages and nuclear factor- b transactivation in Caco-2 reporter cells: can effects be explained by structure? Molecular Nutrition and Food Research 2010 54 2 268 276
38. Niu Y. C., Liu J. C., Zhao X. M., Wu X. X., A low molecular weight polysaccharide isolated from Agaricus blazei suppresses tumor growth and angiogenesis in vivo Oncology Reports 2009 21 1 145 152
39. Kimura Y., Kido T., Takaku T., Sumiyoshi M., Baba K., Isolation of an anti-angiogenic substance from Agaricus blazei Murill: its antitumor and antimetastatic actions Cancer Science 2004 95 9 758 764 (Pubitemid 39335097)
40. Fujimiya Y., Suzuki Y., Oshiman K. I., Kobori H., Moriguchi K., Nakashima H., Matumoto Y., Takahara S., Ebina T., Katakura R., Selective tumoricidal effect of soluble proteoglucan extracted from the basidiomycete, Agaricus blazei Murill, mediated via natural killer cell activation and apoptosis Cancer Immunology Immunotherapy 1998 46 3 147 159 (Pubitemid 28239880)
41. Kobayashi H., Yoshida R., Kanada Y., Fukuda Y., Yagyu T., Inagaki K., Kondo T., Kurita N., Suzuki M., Kanayama N., Terao T., Suppressing effects of daily oral supplementation of beta-glucan extracted from Agaricus blazei Murill on spontaneous and peritoneal disseminated metastasis in mouse model Journal of Cancer Research and Clinical Oncology 2005 131 8 527 538 (Pubitemid 41215308)
42. Xiaohui T., Lun Z., Wang J., Clinical observation on treatment of acute nonlymphocytic leukemia with Agaricus blazei Murill Journal of Lanzhou Medical College 1994 20 169 171
43. Murakawa K., Fukunaga K., Tanouchi M., Hosokawa M., Hossain Z., Takahashi K., Therapy of myeloma in vivo using marine phospholipid in combination with Agaricus blazei Murill as an immune respond activator Journal of Oleo Science 2007 56 4 179 188
44. Yu C. H., Kan S. F., Shu C. H., Lu T. J., Sun-Hwang L., Wang P. S., Inhibitory mechanisms of Agaricus blazei Murill on the growth of prostate cancer in vitro and in vivo Journal of Nutritional Biochemistry 2009 20 10 753 764
45. Balkwill F., Mantovani A., Cancer and inflammation: implications for pharmacology and therapeutics Clinical Pharmacology and Therapeutics 2010 87 4 401 406
46. Grinde B., Hetland G., Johnson E., Effects on gene expression and viral load of a medicinal extract from Agaricus blazei in patients with chronic hepatitis C infection International Immunopharmacology 2006 6 8 1311 1314 (Pubitemid 43868192)
47. Hsu C. H., Hwang K. C., Chiang Y. H., Chou P., The mushroom Agaricus blazei Murill extract normalizes liver function in patients with chronic hepatitis B Journal of Alternative and Complementary Medicine 2008 14 3 299 301 (Pubitemid 351519557)
48. Hsu C. H., Liao Y. L., Lin S. C., Hwang K. C., Chou P., The mushroom Agaricus blazei Murill in combination with metformin and gliclazide improves insulin resistance in type 2 diabetes: a randomized, double-blinded, and placebo-controlled clinical trial Journal of Alternative and Complementary Medicine 2007 13 1 97 102
49. Zittermann A., Effects of vitamin K on calcium and bone metabolism Current Opinion in Clinical Nutrition and Metabolic Care 2001 4 6 483 487 (Pubitemid 34755403)
50. Frland D. T., Johnson E., Tryggestad A. M. A., Lyberg T., Hetland G., An extract based on the medicinal mushroom Agaricus blazei Murill stimulates monocyte-derived dendritic cells to cytokine and chemokine production in vitro Cytokine 2010 49 3 245 250
51. Chen L., Shao H. J., Su Y. B., Coimmunization of Agaricus blazei Murill extract with hepatitis B virus core protein through DNA vaccine enhances cellular and humoral immune responses International Immunopharmacology 2004 4 3 403 409 (Pubitemid 38375973)
52. Chen L., Shao H., Extract from Agaricus blazei Murill can enhance immune responses elicited by DNA vaccine against foot-and-mouth disease Veterinary Immunology and Immunopathology 2006 109 1-2 177 182 (Pubitemid 41739687)
53. Afzali B., Lombardi G., Lechler R. I., Lord G. M., The role of T helper 17 (Th17) and regulatory T cells (Treg) in human organ transplantation and autoimmune disease Clinical and Experimental Immunology 2007 148 1 32 46 (Pubitemid 46365005)
54. Yazawa Y., Yokota M., Sugiyama K., Antitumor promoting effect of an active component of polyporus, ergosterol and related compounds on rat urinary bladder carcinogenesis in a short-term test with concanavalin A Biological and Pharmaceutical Bulletin 2000 23 11 1298 1302
55. Viola A., Improving cancer immunotherapy by preventing chemokine nitration European Journal of Cancer Supplment 2010 8 89
56. Schetter A. J., Heegaard N. H. H., Harris C. C., Inflammation and cancer: interweaving microRNA, free radical, cytokine and p53 pathways Carcinogenesis 2009 31 1 37 49
57. Hussain S. P., Harris C. C., Inflammation and cancer: an ancient link with novel potentials International Journal of Cancer 2007 121 11 2373 2380 (Pubitemid 350022405)
58. Yoshimura K., Kamoto T., Ogawa O., Matsui S., Tsuchiya N., Tada H., Murata K., Yoshimura K., Habuchi T., Fukushima M., Medical mushrooms used for biochemical failure after radical treatment for prostate cancer: an open-label study International Journal of Urology 2010 17 6 548 554
59. Jiang J., Sliva D., Novel medicinal mushroom blend suppresses growth and invasiveness of human breast cancer cells International Journal of Oncology 2010 37 6 1529 1536