Disregulation in TH1 and TH2 subsets of CD4+ T cells in peripheral blood of colorectal cancer patients and involvement in cancer establishment and progression

Cancer Immunology, Immunotherapy

Volumn 42, Issue 1, 1996, Pages 1-8

  Pellegrini, Patrizia ^a   Berghella, Anna Maria ^a   Del Beato, Tiziana ^a   Cicia, Sergio ^b   Adorno, Domenico ^a   Casciani, Carlo Umberto ^a  

^a CNR   (Italy)

^b Tivoli Hospital   (Italy)

Author keywords

Colorectal cancer; Progression mechanisms; TH1 and TH2 cells

Indexed keywords

CD4 ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 6; TUMOR NECROSIS FACTOR ALPHA;

ADULT; AGED; ARTICLE; BLOOD CELL; BLOOD LEVEL; COLORECTAL CANCER; CONTROLLED STUDY; FEMALE; HELPER CELL; HUMAN; HUMAN CELL; LYMPHOCYTE SUBPOPULATION; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; T LYMPHOCYTE; TUMOR GROWTH;

ADULT; AGED; AGED, 80 AND OVER; CD4-POSITIVE T-LYMPHOCYTES; COLORECTAL NEOPLASMS; CYTOKINES; DISEASE PROGRESSION; FEMALE; HUMANS; INTERFERON TYPE II; INTERLEUKINS; LEUKOCYTES, MONONUCLEAR; LYMPHOCYTE ACTIVATION; MALE; MIDDLE AGED; PHYTOHEMAGGLUTININS; STIMULATION, CHEMICAL; TH1 CELLS; TH2 CELLS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0030024140     PISSN: 03407004     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002620050244     Document Type: Article

References (57)

1. Abehsira-Amar O, Gilbert M, Joliym M, Theze J, Jankovic DL (1992) IL-4 plays a dominant role in the differential development of Th0 into Th1 and Th2 cells. J Immunol 148:3820
2. Alexander JP, Kudoh S, Melsop KA, Hamilton TA, Edinger MG, Tubbs RR, Sica D, Tuason L, Klein E, Budowski RM, Finke JH (1993) T-cells infiltrating renal cell carcinoma display a poor proliferative response even though they can produce interleukin 2 and express interleukin 2 receptors. Cancer Res 53:1380
3. + precursor subpopulations. J Immunol 149:2489
4. + precursor subpopulations. J Immunol 151:2895
5. Berghella AM, Pellegrini P, Piancatelli D, Maccarone D, Del Beato T, Giubilei D, Pomidori A, Adorno D, Casciani CU (1994) Progression mechanisms in colon cancer: soluble interleukin-2 (IL-2) receptor, IL-2 plus anti-CD3 proliferative response and tumor stage correlations. Cancer Immunol Immunother 38:160
6. Bloom BR, Modlin RL, Salgame P (1992) Stigma variations: observations on suppressor T cells and leprosy. Annu Rev Immunol 10:453
7. Bloom BR, Salgame P, Diamond B (1992) Revisiting and revising suppressor T cells. Immunol Today 13:131
8. + T cells. J Exp Med 178:1655
9. Chatelain R, Varkila K, Coffman RL (1992) IL-4 induces a Th2 response in Leishmania major-infected mice. J Immunol 148:1182
10. Chen L, Tourvielle B, Burns GF, Bach FH, Mathieu-Mahul D, Sasportes M, Bensussan A (1986) Interferon: a cytotoxic T lymphocyte differentiation signal. Eur J Immunol 16:767
11. Cher DJ, Mosmann TR (1987) Two types of murine helper T cell clone. II. Delayed-type hypersensitivity is mediated by TH1 clones. J Immunol 138:3688
12. + T-cell subsets in vivo. Immunol Rev 123:189
13. Doherty TM, Coffman RL (1993) Leishmania antigens presented by GM-CSF-derived macrophages protect susceptible mice against challenge with Leishmania Major. J Immunol 150:5476
14. - cells that make TH2 cytokines and help B cells. Science 260:1802
15. Gajewski TF, Fitch F (1988) Anti-proliferative effect of IFN-gamma in immune regulation. I. IFN-gamma inhibits the proliferation of TH2 but not TH1 murine helper T lymphocyte clones. J Immunol 140:4245
16. Gajewski TF, Joyce J, Fitch FW (1989) Anti-proliferative effects of IFNγ in immune regulation. III. Differential selection of TH1 and TH2 murine helper T lymphocyte clones using recombinant IL-2 and recombinant IFN γ. J Immunol 143:15
17. Gillis S, Gillis AE, Henney CS (1981) Monoclonal antibody directed against IL-2: inhibition of T lymphocyte mitogenesis and in vitro differentiation of alloreactive cytotoxic T cells. J Exp Med 154:983
18. + cytotoxic T lymphocytes in the absence of exogenous help. J Exp Med 177:1791
19. Heinzel FP, Sadick MD, Holaday BJ, Coffman RL, Locksley RM (1989) Reciprocal expression of interferon γ or interleukin 4 during the resolution or progression of murine Leishmaniasis. J Exp Med 169:59
20. + lymphocytes in-vivo during healing and progressive murine leishmaniasis. Proc Natl Acad Sci USA 88:7011
21. + T cells through IL-12 produced by listeria-induced macrophages. Science 260:547
22. Kopf M, Le Gros G, Bachmann M, Lamers MC, Bluethmann H, Köhler G (1993) Disruption of the murine IL-4 gene blocks TH2 cytokine responses. Nature 362:245
23. LeGros G, Ben-Sasson SZ, Seder R, Finkelman FD, Paul WE (1990) Generation of interleukin 4 (IL-4)-producing cells in vivo and in vitro: IL-2 and IL-4 are required for in vitro generation of IL-4-producing cells. J Exp Med 172:921
24. + T cells. J Immunol 149:949
25. Maraskovsky E, Chen WF, Shortman K (1989) IL-2 and IFN-gamma are two necessary lymphokines in the development of cytolytic T cells. J Immunol 143:1210
26. - lymphocytes. Clin Immunol Immunopathol 51:348
27. McAveney KM, Gomella LG, Lattime EC (1994) Induction of TH1-and TH2-associated cytokine mRNA in mouse bladder following intravesical growth of the murine bladder tumor MB49 and BCG immunotherapy. Cancer Immunol Immunother 39:401
28. + T cells. Immunol Rev 123:209
29. Mulé JJ, Custer MC, Travis WD, Rosenberg SA(1992) Cellular mechanisms of the antitumor activity of recombinant IL-6 in mice. J Immunol 148:2622
30. Munoz E, Zubiaga AM, Merrow M, Sauter NP, Huber BT (1990) Choleratoxin discriminates between T helper 1 and 2 cells in T cell receptor-mediated activation: role of cAMP in T cell proliferation. J Exp Med 172:95
31. Murray JS, Madri J, Pasqualini T, Bottomly K (1993) Functional CD4 T cell subset interplay in an intact immune system. J Immunol 150:4270
32. Nagelkerken L, Gollob KJ, Tielemans M, Coffman RL (1993) Role of transforming growth factor-beta in the preferential induction of T helper cell of type I by staphylococcal enterotoxin B. Eur J Immunol 23:2306
33. Paul WE, Seder RA, Hu-Li J, Tanaka T, Ben-Sasson SZ (1992) IL-4 is a major determinant of T cell lymphokine-producing phenotype. In: Gregely J, Benezür M, Erdei A et al (eds) Progress in immunology. VIII. Springer Hungarica, Budapest, p 347
34. + T cell subsets producing a selective pattern of lymphokines in the pathogenesis of human chronic inflammatory and allergic diseases. Immunol Rev 123:23
35. + T cells are important for the balance between protective and pathogenic cell-mediated immunity. J Exp Med 179:589
36. Reiner SL, Waing ZE, Hatam F, Scott P, Locksley RM (1993) Common lineage of TH1 and TH2 subsets in leishmaniasis. Science 259:1457
37. + human T lymphocyte subsets. Eur J Immunol 23:61
38. + T cells producing IL-2 and IL-4. J Immunol 148:1031
39. Rott O, Cash E, Fleischer B (1993) Phosphodiesterase inhibitor pentoxifylline, a selective suppressor of T helper type 1- but not type 2-associated lymphokine production, prevents induction of experimental autoimmune encephalomyelitis in Lewis rats. Eur J Immunol 23:1745
40. Salgame P, Abrams JS, Clayberger C, Goldstein H, Convit J, Modlin RL, Bloom BR (1991) Differing lymphokine profiles of functional subsets of human CD4 and CD8 T cell clones. Science 254:279
41. Schwarz EM, Salgame P, Bloom BR (1993) Molecular regulation of human interleukin 2 and T-cell function by interleukin 4. Proc Natl Acad Sci USA 90:7734
42. Scott P (1991) IFN-gamma modulates the early development of TH1 and TH2 responses in a murine model of cutaneous leishmaniasis. J Immunol 147:3149
43. Scott P (1993) IL-12: initiation cytokine for cell-mediated immunity. Science 260:496
44. + T helper cell subsets. Curr Opin Immunol 5:391
45. + T cells from T cell receptor transgenic mice. J Exp Med 176:1091
46. Sher A, Coleman RL (1992) Regulation of immunity to parasites by T cells and T cell-derived cytokines. Annu Rev Immunol 10:385
47. Stevens TL, Bossie A, Sanders VM, Fernandez-Botram R, Coffman LR, Mosmann RT, Vitetta ES (1988) Regulation of antibody isotype secretion by subsets of antigen-specific helper T cells. Nature 334:255
48. Swain SL, Weinberg AD, English M, Huston G (1990) IL-4 directs the development of TH2-like helper effectors. J Immunol 145:3796
49. Swain SL, Bradley LM, Croft M, Tonkonogy S, Atkins G, Weinberg AD, Duncan DD, Hedrick SM, Dutton RV, Helper G (1991) Helper T-cell subsets: phenotype, function and the role of lymphokines in regulating their development. Immunol Rev 123:115
50. Takai Y, Waong GG, Clark SC, Burkoff SJ, Hermann SH (1988) B-cell stimulatory factor-2 is involved in the differentiation of cytotoxic T lymphocytes. J Immunol 140:508
51. Tanaka T, Hu-Li J, Seder RA, Fazekas de St.Groth B, Paul WE (1993) Interleukin 4 suppresses interleukin 2 and interferon γ production by naive T cells stimulated by accessory cell-dependent receptor engagement. Proc Natl Acad Sci USA 90:5914
52. Wagner H, Hardt C, Rouse BT, Roellinghoff M, Scheurich P, Pfizenmaier K (1982) Dissection of the proliferative and differentiation signals controlling murine cytotoxic T lymphocyte responses. J Exp Med 155:1876
53. Weinberg AD, English M, Swain SL (1990) Distinct regulation of lymphokine production is found in fresh versus in vitro primed murine helper T cells. J Immunol 144:1800
54. Welge T, Wolf M, Jaggle C, Luckenbach G-N (1993) Human naive T cells are preferentially stimulated by crosslinking of CD3 and CD45RA with monoclonal antibodies. Cell Immunol 148:218
55. Williams ME, Lichtman AH, Abbas KA (1990) Anti-CD3 antibody induces unresponsiveness to IL-2 in TH1 clones but not in TH2 clones. J Immunol 144:1208
56. + cytotoxic T lymphocytes. J Immunol 143:1518
57. Yoschino I, Yano T, Murata M, Ishida T, Sugimachi K, Kimura G (1992) Tumor-reactive T cells accumulate in lung cancer tissues but fail to respond due to tumor cell-derived factor. Cancer Res 52:775