Cardiomyocyte-restricted deletion of PPARβ/δ in PPARα-null mice causes impaired mitochondrial biogenesis and defense, but no further depression of myocardial fatty acid oxidation

PPAR Research

Volumn , Issue , 2011, Pages

  Liu, Jian ^a   Wang, Peiyong ^a   He, Lan ^a   Li, Yuquan ^b   Luo, Jinwen ^a,c   Cheng, Lihong ^d   Qin, Qianhong ^d   Brako, Lawrence A ^e   Lo, Woo Kuen ^e   Lewis, William ^d   Yang, Qinglin ^a  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b SECOND MILITARY MEDICAL UNIVERSITY   (China)

^c HUNAN CHILDREN'S HOSPITAL   (China)

^d EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e MOREHOUSE SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FATTY ACID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BIOGENESIS; CONTROLLED STUDY; DEFENSE MECHANISM; FATTY ACID OXIDATION; GENE DELETION; HEART MUSCLE CELL; HEART PERFORMANCE; HEART VENTRICLE HYPERTROPHY; LIPID METABOLISM; MITOCHONDRION; MOUSE; NONHUMAN; PHENOTYPE; PROTEIN DEPLETION; PROTEIN FUNCTION;

EID: 81555220926     PISSN: 16874757     EISSN: 16874765     Source Type: Journal    
DOI: 10.1155/2011/372854     Document Type: Article

References (32)

1. Madrazo J. A., Kelly D. P., The PPAR trio: regulators of myocardial energy metabolism in health and disease Journal of Molecular and Cellular Cardiology 2008 44 6 968 975
2. Yang Q., Li Y., Roles of PPARs on regulating myocardial energy and lipid homeostasis Journal of Molecular Medicine 2007 85 7 697 706 (Pubitemid 47063523)
3. Feige J. N., Gelman L., Michalik L., Desvergne B., Wahli W., From molecular action to physiological outputs: peroxisome proliferator-activated receptors are nuclear receptors at the crossroads of key cellular functions Progress in Lipid Research 2006 45 2 120 159 (Pubitemid 43248732)
4. Djouadi F., Weinheimer C. J., Saffitz J. E., Pitchford C., Bastin J., Gonzalez F. J., Kelly D. P., A gender-related defect in lipid metabolism and glucose homeostasis in peroxisome proliferator-activated receptor -deficient mice The Journal of Clinical Investigation 1998 102 6 1083 1091 (Pubitemid 28436268)
5. Finck B. N., Han X., Courtois M., Aimond F., Nerbonne J. M., Kovacs A., Gross R. W., Kelly D. P., A critical role for PPAR -mediated lipotoxicity in the pathogenesis of diabetic cardiomyopathy: modulation by dietary fat content Proceedings of the National Academy of Sciences of the United States of America 2003 100 3 1226 1231 (Pubitemid 36183984)
6. Watanabe K., Fujii H., Takahashi T., Kodama M., Aizawa Y., Ohta Y., Ono T., Hasegawa G., Naito M., Nakajima T., Kamijo Y., Gonzalez F. J., Aoyama T., Constitutive regulation of cardiac fatty acid metabolism through peroxisome proliferator-activated receptor associated with age-dependent cardiac toxicity The Journal of Biological Chemistry 2000 275 29 22293 22299 (Pubitemid 30621813)
7. Leone T. C., Weinheimer C. J., Kelly D. P., A critical role for the peroxisome proliferator-activated receptor (PPAR ) in the cellular fasting response: the PPAR -null mouse as a model of fatty acid oxidation disorders Proceedings of the National Academy of Sciences of the United States of America 1999 96 13 7473 7478 (Pubitemid 29299686)
8. Son N. H., Yu S., Tuinei J., Arai K., Hamai H., Homma S., Shulman G. I., Abel E. D., Goldberg I. J., PPAR -induced cardiolipotoxicity in mice is ameliorated by PPAR deficiency despite increases in fatty acid oxidation The Journal of Clinical Investigation 2010 120 10 3443 3454
9. Finck B. N., Lehman J. J., Leone T. C., Welch M. J., Bennett M. J., Kovacs A., Han X., Gross R. W., Kozak R., Lopaschuk G. D., Kelly D. P., The cardiac phenotype induced by PPAR overexpression mimics that caused by diabetes mellitus The Journal of Clinical Investigation 2002 109 1 121 130 (Pubitemid 34052548)
10. Gilde A. J., van der Lee K. A., Willemsen P. H., Chinetti G., Van der Leij F. R., Van der Vusse G. J., Staels B., Van Bilsen M., Peroxisome proliferator-activated receptor (PPAR) and PPAR /, but not PPAR, modulate the expression of genes involved in cardiac lipid metabolism Circulation Research 2003 92 5 518 524 (Pubitemid 36368664)
11. Cheng L., Ding G., Qin Q., Peroxisome proliferator-activated receptor delta activates fatty acid oxidation in cultured neonatal and adult cardiomyocytes Biochemical and Biophysical Research Communications 2004 313 2 277 286 (Pubitemid 37543582)
12. Cheng L., Ding G., Qin Q., Huang Y., Lewis W., He N., Evans R. M., Schneider M. D., Brako F. A., Xiao Y., Chen Y. E., Yang Q., Cardiomyocyte- restricted peroxisome proliferator-activated receptor- deletion perturbs myocardial fatty acid oxidation and leads to cardiomyopathy Nature Medicine 2004 10 11 1245 1250 (Pubitemid 39540443)
13. Burkart E. M., Sambandam N., Han X., Gross R. W., Courtois M., Gierasch C. M., Shoghi K., Welch M. J., Kelly D. P., Nuclear receptors PPAR / and PPAR direct distinct metabolic regulatory programs in the mouse heart The Journal of Clinical Investigation 2007 117 12 3930 3939 (Pubitemid 350224102)
14. Lee J., Hu Q., Nakamura Y., Wang X., Zhang X., Zhu X., Chen W., Yang Q., Zhang J., Open-chest 31 P magnetic resonance spectroscopy of mouse heart at 4.7Tesla Journal of Magnetic Resonance Imaging 2006 24 6 1269 1276 (Pubitemid 44871870)
15. Li Y., Yin R., Liu J., Wang P., Wu S., Luo J., Zhelyabovska O., Yang Q., Peroxisome proliferator-activated receptor regulates mitofusin 2 expression in the heart Journal of Molecular and Cellular Cardiology 2009 46 6 876 882
16. Liu J., Wang P., Luo J., Peroxisome proliferator-activated receptor / activation in adult hearts facilitates mitochondrial function and cardiac performance under pressure-overload condition Hypertension 2011 57 2 223 230
17. Yang Q., Cheng L., Molecular regulation of lipotoxicity in the heart Drug Discovery Today 2005 2 1 101 107
18. Li Y., Cheng L., Qin Q., Liu J., Lo W. K., Brako L. A., Yang Q., High-fat feeding in cardiomyocyte-restricted PPAR knockout mice leads to cardiac overexpression of lipid metabolic genes but fails to rescue cardiac phenotypes Journal of Molecular and Cellular Cardiology 2009 47 4 536 543
19. Duncan J. G., Fong J. L., Medeiros D. M., Finck B. N., Kelly D. P., Insulin-resistant heart exhibits a mitochondrial biogenic response driven by the peroxisome proliferator-activated receptor- /PGC-1 gene regulatory pathway Circulation 2007 115 7 909 917 (Pubitemid 46294731)
20. Barak Y., Liao D., He W., Ong E. S., Nelson M. C., Olefsky J. M., Boland R., Evans R. M., Effects of peroxisome proliferator-activated receptor on placentation, adiposity, and colorectal cancer Proceedings of the National Academy of Sciences of the United States of America 2002 99 1 303 308 (Pubitemid 34060358)
21. Agah R., Frenkel P. A., French B. A., Michael L. H., Overbeek P. A., Schneider M. D., Gene recombination in postmitotic cells: targeted expression of Cre recombinase provokes cardiac-restricted, site-specific rearrangement in adult ventricular muscle in vivo The Journal of Clinical Investigation 1997 100 1 169 179 (Pubitemid 27311255)
22. Wang P., Liu J., Li Y., Wu S., Luo J., Yang H., Subbiah R., Chatham J., Zhelyabovska O., Yang Q., Peroxisome proliferator-activated receptor is an essential transcriptional regulator for mitochondrial protection and biogenesis in adult heart Circulation Research 2010 106 5 911 919
23. Sohal D. S., Nghiem M., Crackower M. A., Witt S. A., Kimball T. R., Tymitz K. M., Penninger J. M., Molkentin J. D., Temporally regulated and tissue-specific gene manipulations in the adult and embryonic heart using a tamoxifen-inducible Cre protein Circulation Research 2001 89 1 20 25 (Pubitemid 34135487)
24. Lee S. S., Pineau T., Drago J., Lee E. J., Owens J. W., Kroetz D. L., Fernandez- Salguero P. M., Westphal H., Gonzalez F. J., Targeted disruption of the isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators Molecular Cellular Biology 1995 15 6 3012 3022
25. Naya F. J., Black B. L., Wu H., Bassel-Duby R., Richardson J. A., Hill J. A., Olson E. N., Mitochondrial deficiency and cardiac sudden death in mice lacking the MEF2A transcription factor Nature Medicine 2002 8 11 1303 1309 (Pubitemid 35373564)
26. Luo J., Wu S., Liu J., Conditional PPAR knockout from cardiomyocytes of adult mice impairs myocardial fatty acid utilization and cardiac function American Journal of Translational Research 2011 3 1 61 72
27. Sambandam N., Morabito D., Wagg C., Finck B. N., Kelly D. P., Lopaschuk G. D., Chronic activation of PPAR is detrimental to cardiac recovery after ischemia American Journal of Physiology 2006 290 1 H87 H95
28. Lopaschuk G. D., Barr R. L., Measurements of fatty acid and carbohydrate metabolism in the isolated working rat heart Molecular and Cellular Biochemistry 1997 172 1-2 137 147 (Pubitemid 27374583)
29. Gulick T., Cresci S., Caira T., Moore D. D., Kelly D. P., The peroxisome proliferator-activated receptor regulates mitochondrial fatty acid oxidative enzyme gene expression Proceedings of the National Academy of Sciences of the United States of America 1994 91 23 11012 11016 (Pubitemid 24349615)
30. Duan S. Z., Ivashchenko C. Y., Russell M. W., Milstone D. S., Mortensen R. M., Cardiomyocyte-specffic knockout and agonist of peroxisome proliferator-activated receptor- both induce cardiac hypertrophy in mice Circulation Research 2005 97 4 372 379 (Pubitemid 41216142)
31. Ding G., Fu M., Qin Q., Lewis W., Kim H. W., Fukai T., Bacanamwo M., Chen Y. E., Schneider M. D., Mangelsdorf D. J., Evans R. M., Yang Q., Cardiac peroxisome proliferator-activated receptor is essential in protecting cardiomyocytes from oxidative damage Cardiovascular Research 2007 76 2 269 279 (Pubitemid 350198591)
32. Luo J., Wu S., Liu J., Li Y., Conditional PPARg knockout from cardiomyocytes of adult mice disturbs myocardial fatty acid utilization American Journal of Translational Research 2011 1 59 70