Boromycin abrogates bleomycin-induced G2 checkpoint

Journal of Antibiotics

Volumn 57, Issue 10, 2004, Pages 662-668

  Arai, Masayoshi ^a   Koizumi, Yukio ^a,b   Sato, Hitoshi ^a   Kawabe, Takumi ^c   Suganuma, Masashi ^c   Kobayashi, Hidetaka ^c   Tomoda, Hiroshi ^a,b   Omura, Satoshi ^a,b  

^a KITASATO UNIVERSITY   (Japan)

^b KITASATO INSTITUTE   (Japan)

^c CanBas Co Ltd   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BLEOMYCIN; BOROMYCIN; COLCHICINE; POLYETHER ANTIBIOTIC AGENT;

ACTINOBACTERIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CELL CYCLE; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CONTROLLED STUDY; DNA DAMAGE; DRUG POTENTIATION; DRUG SENSITIZATION; DRUG STRUCTURE; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; MICROTUBULE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SCID MOUSE; SIGNAL TRANSDUCTION; STREPTOMYCES;

EID: 8144230168     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.7164/antibiotics.57.662     Document Type: Article

References (28)

1. HARTWELL, L. H. & M. B. KASTAN: Cell cycle control and cancer. Science 266: 1821-1828, 1994
2. LEVINE, A. J.: p53, the cellular gatekeeper for growth and division. Cell 88: 323-331, 1997
3. CLIBY, W. A.; C. J. ROBERTS, K. A. CIMPRICH, C. M. STRINGER, J. R. LAMB, S. L. SCHREIBER & S. H. FRIEND: Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpoints. EMBO J. 17: 159-169, 1998
4. WRIGHT, J. A.; K. S. KEEGAN, D. R. HERENDEEN, N. J. BENTLEY, A. M. CARR, M. F. HOEKSTRA & P. CONCANNON: Protein kinase mutants of human ATR increase sensitivity to UV and ionizing radiation and abrogate cell cycle checkpoint control. Proc. Natl. Acad. Sci. U.S.A. 95: 7445-7450, 1998
5. SAVITSKY, K.; S. A. BAR, S. GILAD, G. ROTMAN, Y. ZIV, L. VANAGAITE, D. A. TAGLE, S. SMITH, T. UZIEL, S. SFEZ, M. ASHKENAZI, I. PECKER, M. FRYDMAN, R. HARNIK, S. R. PATANJALI, A. SIMMONS, G. A. CLINES, A. SARTIEL, R. A. GATTI, L. CHESSA, O. SANAL, M. F. LAVIN, N. G. J. JASPERS, A. M. R. TAYLOR, C. F. ARLETT, T. MIKI, S. M. WEISSMAN, M. LOVETT, F. S. COLLINS & Y. SHILOH: A single ataxia telangiectasia gene with a product similar to PI-3 kinase. Science 268: 1749-1753, 1995
6. MATSUOKA, S.; M. HUANG & S. J. ELLEDGE: Linkage of ATM to cell cycle regulation by the Chk2 protein kinase. Science 282: 1893-1897, 1998
7. SANCHEZ, Y.; C. WONG, R. S. THOMA, R. RICHMAN, Z. WU, H. PIWNICA-WORMS & S. J. ELLEDGE: Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25. Science 277: 1497-1501, 1997
8. CHATURVEDI, P.; W. K. ENG, Y. ZHU, M. R. MATTERN, R. MISHRA, M. R. HURLE, X. ZHANG, R. S. ANNAN, Q. LU, L. F. FAUCETTE, G. F. SCOTT, X. LI, S. A. CARR, R. K. JOHNSON, J. D. WINKLER & B. B. ZHOU: Mammalian Chk2 is a downstream effector of the ATM-dependent DNA damage checkpoint pathway. Oncogene 18: 4047-4054, 1999
9. BLASINA, A.; I. V. DE WEYER, M. C. LAUS, W. H. LUYTEN, A. E. PARKER & C. H. MCGOWAN: Human homologue of the checkpoint kinase Cds1 directly inhibits Cdc25 phosphatase. Curr. Biol. 9: 1-10, 1999
10. O'CONNELL, M. J.; J. M. RALEIGH, H. M. VERKADE & P. NURSE: Chk1 is a Weel kinase in the G2 DNA damage checkpoint inhibiting cdc2 by Y15 phosphorylation. EMBO J. 16: 545-554, 1997
11. RALEIGH, J. M. & M. J. O'CONNELL: The G(2) DNA damage checkpoint targets both Weel and Cdc25. J. Cell Sci. 113: 1727-1736, 2000
12. BUNCH, R. T. & A. EASTMAN: Enhancement of cisplatin-induced cytotoxicity by 7-hydroxystaurosporine (UCN-01), a new G2-checkpoint inhibitor. Clin. Cancer Res. 2: 791-797, 1996
13. FUSE, E.; H. TANII, N. KURATA, H. KOBAYASHI, Y. SHIMADA, T. TAMURA, Y. SASAKI, Y. TANIGAWARA, R. D. LUSH, D. HEADLEE, W. D. FIGG, S. G. ARBUCK, A. M. SENDEROWICZ, E. A. SAUSVILLE, S. AKINAGA, T. KUWABARA & S. KOBAYASHI: Unpredicted clinical pharmacology of UCN-01 caused by specific binding to human alphal-acid glycoprotein. Cancer Res. 58: 3248-3253, 1998
14. WANG, Q.; P. J. WORLAND, J. L. CLARK, B. A. CARLSON & E. A. SAUSVILLE: Apoptosis in 7-hydroxystaurosporine-treated T lymphoblasts correlates with activation of cyclin-dependent kinases 1 and 2. Cell Growth Differ. 6: 927-936, 1995
15. SATO, S.; N. FUJITA & T. TSURUO: Interference with PDK1-Akt survival signaling pathway; by UCN-01 (7-hydroxystaurosporine). Oncogene 21: 1727-1738, 2002
16. JACKSON, J. R.; A. GILMARTIN, C. IMBURGIA, J. D. WINKLER, L. A. MARSHALL & A. ROSHAK: An indolocarbazole inhibitor of human checkpoint kinase (Chk1) abrogates cell cycle arrest caused by DNA damage. Cancer Res. 60: 566-572, 2000
17. KOHN, E. A.; C. J. YOO & A. EASTMAN: The protein kinase C inhibitor Go6976 is a potent inhibitor of DNA damage-induced S and G2 cell cycle checkpoints. Cancer Res. 63:31-35, 2003
18. CURMAN, D.; B. CINEL, D. E. WILLIAMS, N. RUNDLE, W. D. BLOCK, A. A. GOODARZI, J. R. HUTCHINS, P. R. CLARKE, B. B. ZHOU, S. P. LEES-MILLER, R. J. ANDERSEN & M. ROBERGE: Inhibition of the G2 DNA damage checkpoint and of protein kinases Chk1 and Chk2 by the marine sponge alkaloid debromohymenialdisine. J. Biol. Chem. 276: 17914-17919, 2001
19. YAO, S. L.; A. J. AKHTAR, K. A. MCKENNA, G. C. BEDI, D. SIDRANSKY, M. MABRY, R. RAVI, M. I. COLLECTOR, R. J. JONES, S. J. SHARKIS, E. J. FUCHS & A. BEDI: Selective radiosensitization of p53-deficient cells by caffeine-mediated activation of p34cdc2 kinase. Nat. Med. 2: 1140-1143, 1996
20. SARKARIA, J. N.; E. C. BUSBY, R. S. TIBBETTS, P. ROOS, Y. TAYA, L. M. KARNITZ & R. T. ABRAHAM: Inhibition of ATM and ATR kinase activities by the radiosensitizing agent, caffeine. Cancer Res. 59: 4375-4382, 1999
21. WANG, Y.; J. LI, R. N. BOOHER, A. KRAKER, T. LAWRENCE, W. R. LEOPOLD & Y. SUN: Radiosensitization of p53 mutant cells by PD0166285, a novel G(2) checkpoint abrogator. Cancer Res. 61: 8211-8217, 2001
22. SUGANUMA, M.; T. KAWABE, H. HORI, T. FUNABIKI & T. OKAMOTO: Sensitization of cancer cells to DNA damage-induced cell death by specific cell cycle G2 checkpoint abrogation. Cancer Res. 59: 5887-5891, 1999
23. HUTTER, R.; W. KELLER-SCHIERLEIN, F. KNUSEL, V. PRELOG, G. C. Jr. RODGERS, P. SUTER, G. VOGEL, W. VOSER & H. ZAHNER: The metabolic products of microorganisms. Boromycin. Helv. Chim. Acta 50: 1533-1539, 1967
24. KOHNO, J.; T. KAWAHATA, T. OTAKE, M. MORIMOTO, H. MORI, N. UEBA, M. NISHIO, A. KINUMAKI & S. KOMATSUBARA: Boromycin, an anti-HIV antibiotic. Biosci. Biotechnol. Biochem. 60: 1036-1037, 1996
25. LAEMMLI, U. K.: Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227: 680-685, 1970
26. MIURA, H.; H. TOMODA, K. MIURA, K. TAKISHIMA & S. OMURA: Lactacystin increases LDL receptor level on HepG2 cells. Biochem. Biophys. Res. Commun. 227: 684-687, 1996
27. PARK, W. H.; J. G. SEOL, E. S. KIM, W. K. KANG, Y. H. IM, C. W. JUNG, B. K. KIM & Y. Y. LEE: Monensin-mediated growth inhibition in human lymphoma cells through cell cycle arrest and apoptosis. Br. J. Haematol. 119: 400-407, 2002
28. 2+ homeostasis. Mol. Cell. Biochem. 231: 15-22, 2002