-
1
-
-
0033964459
-
Incidence of erectile dysfunction in men 40 to 69 years old: Longitudinal results from the Massachusetts male aging study
-
CB Johannes AB Araujo HA Feldman CA Derby KP Kleinman JB McKinlay 2000 Incidence of erectile dysfunction in men 40-69 years old: longitudinal results from the Massachusetts Male Aging Study J Urol 163 460 3 10647654 1:STN:280:DC%2BD3c7ht1Wrsg%3D%3D 10.1016/S0022-5347(05)67900-1 (Pubitemid 30060493)
-
(2000)
Journal of Urology
, vol.163
, Issue.2
, pp. 460-463
-
-
Johannes, C.B.1
Araujo, A.B.2
Feldman, H.A.3
Derby, C.A.4
Kleinman, K.P.5
McKinlay, J.B.6
-
2
-
-
15844428954
-
Epidemiology/risk factors of sexual dysfunction
-
DOI 10.1111/j.1743-6109.2004.10106.x
-
RW Lewis KS Fugl-Meyer R Bosch, et al. 2004 Epidemiology/risk factors of sexual dysfunction J Sex Med 1 35 9 16422981 10.1111/j.1743-6109.2004.10106.x (Pubitemid 40424664)
-
(2004)
Journal of Sexual Medicine
, vol.1
, Issue.1
, pp. 35-39
-
-
Lewis, R.W.1
Fugl-Meyer, K.S.2
Bosch, R.3
Fugl-Meyer, A.R.4
Laumann, E.O.5
Lizza, E.6
Martin-Morales, A.7
-
3
-
-
77949382405
-
The POTENT II randomised trial: Efficacy and safety of an orodispersible vardenafil formulation for the treatment of erectile dysfunction
-
20456213 1:CAS:528:DC%2BC3cXksVertbs%3D 10.1111/j.1742-1241.2010.02358.x
-
M Gittelman CG McMahon JA Rodrigues-Rivera M Beneke E Ulbrich S Ewald 2010 The POTENT II randomised trial: efficacy and safety of an orodispersible vardenafil formulation for the treatment of erectile dysfunction Int J Clin Pract 64 594 603 20456213 1:CAS:528:DC%2BC3cXksVertbs%3D 10.1111/j.1742-1241. 2010.02358.x
-
(2010)
Int J Clin Pract
, vol.64
, pp. 594-603
-
-
Gittelman, M.1
McMahon, C.G.2
Rodrigues-Rivera, J.A.3
Beneke, M.4
Ulbrich, E.5
Ewald, S.6
-
4
-
-
75949087002
-
The role of testosterone in erectile dysfunction
-
19997070 1:CAS:528:DC%2BC3cXjtlaqsg%3D%3D 10.1038/nrurol.2009.235
-
C Corona M Maggi 2010 The role of testosterone in erectile dysfunction Nat Rev Urol 7 46 56 19997070 1:CAS:528:DC%2BC3cXjtlaqsg%3D%3D 10.1038/nrurol.2009.235
-
(2010)
Nat Rev Urol
, vol.7
, pp. 46-56
-
-
Corona, C.1
Maggi, M.2
-
5
-
-
11144355591
-
Androgens regulate phosphodiesterase type 5 expression and functional activity in corpora cavernosa
-
DOI 10.1210/en.2003-1699
-
A Morelli S Filippi R Mancina, et al. 2004 Androgens regulate phosphodiesterase type 5 expression and functional activity in corpora cavernosa Endocrinology 145 2253 63 14764637 1:CAS:528:DC%2BD2cXjsV2jsrw%3D 10.1210/en.2003-1699 (Pubitemid 38535054)
-
(2004)
Endocrinology
, vol.145
, Issue.5
, pp. 2253-2263
-
-
Morelli, A.1
Filippi, S.2
Mancina, R.3
Luconi, M.4
Vignozzi, L.5
Marini, M.6
Orlando, C.7
Vannelli, G.B.8
Aversa, A.9
Natali, A.10
Forti, G.11
Giorgi, M.12
Jannini, E.A.13
Ledda, F.14
Maggi, M.15
-
6
-
-
78549285356
-
An update of new oral PDE5 inhibitors for the treatment of erectile dysfunction
-
21068761 1:CAS:528:DC%2BC3cXhsVWms7nF 10.1038/nrurol.2010.165
-
V Palit I Eardley 2010 An update of new oral PDE5 inhibitors for the treatment of erectile dysfunction Nat Rev Urol 7 603 9 21068761 1:CAS:528:DC%2BC3cXhsVWms7nF 10.1038/nrurol.2010.165
-
(2010)
Nat Rev Urol
, vol.7
, pp. 603-9
-
-
Palit, V.1
Eardley, I.2
-
7
-
-
0034650714
-
Signal transduction by G-proteins, Rho-kinase and protein phosphatase to smooth muscle and non-muscle myosin II
-
AP Somlyo AV Somlyo 2000 Signal transduction by G-proteins, rho-kinase and protein phosphatise to smooth muscle and non-muscle myosin II J Physiol 15 177 85 10.1111/j.1469-7793.2000.t01-2-00177.x (Pubitemid 30068498)
-
(2000)
Journal of Physiology
, vol.522
, Issue.2
, pp. 177-185
-
-
Somlyo, A.P.1
Somlyo, A.V.2
-
8
-
-
0035724390
-
Rho-kinase as a potential target for the treatment of erectile dysfunction
-
K Chitaley RC Webb TM Mills 2001 Rho-kinase as a potential target for the treatment of erectile dysfunction Drugs News Prospect 14 601 6 1:CAS:528:DC%2BD38XisFOlsr0%3D (Pubitemid 34202600)
-
(2001)
Drug News and Perspectives
, vol.14
, Issue.10
, pp. 601-606
-
-
Chitaley, K.1
Webb, R.C.2
Mills, T.M.3
-
9
-
-
32644449489
-
RhoA/Rho-kinase in erectile tissue: Mechanisms of disease and therapeutic insights
-
DOI 10.1042/CS20050255
-
L Jin AL Burnett 2006 RhoA/Rho-kinase in erectile tissue: Mechanisms of disease and therapeutic insights Clin Sci 110 153 65 16411892 1:CAS:528:DC%2BD28XmtlOrtg%3D%3D 10.1042/CS20050255 (Pubitemid 43241477)
-
(2006)
Clinical Science
, vol.110
, Issue.2
, pp. 153-165
-
-
Jin, L.1
Burnett, A.L.2
-
10
-
-
34249065859
-
Testosterone regulates RhoA/Rho-kinase signaling in two distinct animal models of chemical diabetes
-
DOI 10.1111/j.1743-6109.2007.00440.x
-
L Vignozzi A Morelli S Filippi, et al. 2007 Testosterone regulates RhoA/Rho-kinase signaling in two distinct animal models of chemical diabetes J Sex Med 4 620 30 17498101 1:CAS:528:DC%2BD2sXmsFOhurY%3D 10.1111/j.1743-6109. 2007.00440.x discussion 631-32 (Pubitemid 46779298)
-
(2007)
Journal of Sexual Medicine
, vol.4
, Issue.3
, pp. 620-632
-
-
Vignozzi, L.1
Morelli, A.2
Filippi, S.3
Ambrosini, S.4
Mancina, R.5
Luconi, M.6
Mungai, S.7
Vannelli, G.B.8
Zhang, X.-H.9
Forti, G.10
Maggi, M.11
Traish, A.12
-
11
-
-
33750447627
-
Chronic administration of an oral Rho Kinase inhibitor prevents the development of vasculogenic erectile dysfunction in a rat model
-
DOI 10.1111/j.1743-6109.2006.00327.x
-
K Park SW Kim KS Rhu, et al. 2006 Chronic administration of an oral Rho-kinase inhibitor prevents the development of vasculogenic erectile dysfunction in a rat model J Sex Med 3 996 1003 17100932 1:CAS:528: DC%2BD28XhtlWmsLvO 10.1111/j.1743-6109.2006.00327.x (Pubitemid 44644711)
-
(2006)
Journal of Sexual Medicine
, vol.3
, Issue.6
, pp. 996-1003
-
-
Park, K.1
Kim, S.W.2
Rhu, K.S.3
Paick, J.-S.4
-
12
-
-
33646367872
-
Effect of Doxazosin With and Without Rho-Kinase Inhibitor on Human Corpus Cavernosum Smooth Muscle in the Presence of Bladder Outlet Obstruction
-
DOI 10.1016/S0022-5347(06)00281-3, PII S0022534706002813
-
O Demir N Murat G Aslan, et al. 2006 Effect of doxazosin with and without rho-kinase inhibitor on human corpus cavernosum smooth muscle in the presence of bladder outlet obstruction J Urol 175 2345 9 16697871 1:CAS:528: DC%2BD28XlsVehtbs%3D 10.1016/S0022-5347(06)00281-3 (Pubitemid 43668541)
-
(2006)
Journal of Urology
, vol.175
, Issue.6
, pp. 2345-2349
-
-
Demir, O.1
Murat, N.2
Aslan, G.3
Gidener, S.4
Esen, A.A.5
-
13
-
-
2442497286
-
Melanocortin receptors and erectile function
-
DOI 10.1016/j.eururo.2003.03.001, PII S0302283804000090
-
WJ Martin DE MacIntyre 2004 Melanocortin receptors and erectile function Eur Urol 45 706 13 15149741 1:CAS:528:DC%2BD2cXlsFCnsrs%3D 10.1016/j.eururo. 2003.03.001 (Pubitemid 38638389)
-
(2004)
European Urology
, vol.45
, Issue.6
, pp. 706-713
-
-
Martin, W.J.1
MacIntyre, D.E.2
-
14
-
-
0033779983
-
Melanocortin receptor agonists, penile erection, and sexual motivation: Human studies with Melanotan II
-
11035391 10.1038/sj.ijir.3900582
-
H Wessells N Levine ME Hardley R Dorr V Hruby 2000 Melanocortin receptor agonists, penile erection, and sexual motivation: Human studies with Melanotan II Int J Impot Res 12 s4 S74 9 11035391 10.1038/sj.ijir.3900582
-
(2000)
Int J Impot Res
, vol.12
, Issue.S4
, pp. 74-9
-
-
Wessells, H.1
Levine, N.2
Hardley, M.E.3
Dorr, R.4
Hruby, V.5
-
15
-
-
17144389402
-
Co-administration of low doses of intranasal PT-141, a melanocortin receptor agonist, and sildenafil to men with erectile dysfunction results in an enhanced erectile response
-
DOI 10.1016/j.urology.2004.10.060
-
LE Diamond DC Earle WD Garcia C Spana 2005 Co-administration of low doses of intranasal PT-141, a melanocortin receptor agonist, and sildenafil to men with erectile dysfunction results in an enhanced erectile response Urology 65 4 755 9 15833522 1:STN:280:DC%2BD2M3gtVOkuw%3D%3D 10.1016/j.urology.2004.10.060 (Pubitemid 40523013)
-
(2005)
Urology
, vol.65
, Issue.4
, pp. 755-759
-
-
Diamond, L.E.1
Earle, D.C.2
Garcia, W.D.3
Spana, C.4
-
16
-
-
78549274673
-
Phase IIB study of bremelanotide in the treatment of ED in diabetic males (abstract 1177)
-
CP Steidle, et al. 2007 Phase IIB study of bremelanotide in the treatment of ED in diabetic males (abstract 1177) J Urol 177 s4 388
-
(2007)
J Urol
, vol.177
, Issue.S4
, pp. 388
-
-
Steidle, C.P.1
-
17
-
-
0032867797
-
Surgery for crural venous leakage
-
DOI 10.1016/S0090-4295(99)00244-7, PII S0090429599002447
-
TF Lue 1999 Surgery for crural venous leakage Urology 54 739 41 10510940 1:STN:280:DyaK1MvjvV2mug%3D%3D 10.1016/S0090-4295(99)00244-7 (Pubitemid 29449442)
-
(1999)
Urology
, vol.54
, Issue.4
, pp. 739-741
-
-
Lue, T.F.1
-
18
-
-
0028308597
-
Current status of penile revascularization for the treatment of male erectile dysfunction
-
M Sohn 1994 Current status of penile revascularization for the treatment of male erectile dysfunction J Androl 15 3 183 6 7928657 1:STN:280: DyaK2M%2FhtlKrtQ%3D%3D (Pubitemid 24218136)
-
(1994)
Journal of Andrology
, vol.15
, Issue.3
, pp. 183-186
-
-
Sohn, M.H.H.1
-
19
-
-
64549106971
-
Penile revascularization for erectile dysfunction: A systematic review and meta-analysis of effectiveness and complications
-
19241332
-
AR Babaei MR Safarinejad AA Kolahi 2009 Penile revascularization for erectile dysfunction: A systematic review and meta-analysis of effectiveness and complications Urol J 6 1 1 7 19241332
-
(2009)
Urol J
, vol.6
, Issue.1
, pp. 1-7
-
-
Babaei, A.R.1
Safarinejad, M.R.2
Kolahi, A.A.3
-
20
-
-
78649654364
-
Internal pudendal artery stenoses and erectile dysfunction: Correlation with angiographic coronary artery disease
-
This study represents the first angiographic report of coronary artery disease correlated with internal pudendal artery disease in patients with erectile dysfunction.
-
• Rogers JH, Karimi H, Kao J, Link D et al. Internal pudendal artery stenoses and erectile dysfunction: Correlation with angiographic coronary artery disease. Cath Cardiovasc Interv 2010;76(6):882-7. This study represents the first angiographic report of coronary artery disease correlated with internal pudendal artery disease in patients with erectile dysfunction.
-
(2010)
Cath Cardiovasc Interv
, vol.76
, Issue.6
, pp. 882-887
-
-
Rogers, J.H.1
Karimi, H.2
Kao, J.3
Link, D.4
-
21
-
-
0028300301
-
The emerging concept of vascular remodeling
-
DOI 10.1056/NEJM199405193302008
-
GH Gibbons VJ Dzau 1994 The emerging concept of vascular remodelling N Eng J Med 330 1431 8 1:STN:280:DyaK2c3htFantA%3D%3D 10.1056/NEJM199405193302008 (Pubitemid 24139238)
-
(1994)
New England Journal of Medicine
, vol.330
, Issue.20
, pp. 1431-1438
-
-
Gibbons, G.H.1
Dzau, V.J.2
-
22
-
-
0037699954
-
The biology of VEGF and its receptors
-
DOI 10.1038/nm0603-669
-
N Ferrara HP Gerber J LeCouter 2003 The biology of VEGF and its receptors Nat Med 9 669 76 12778165 1:CAS:528:DC%2BD3sXktFOnur4%3D 10.1038/nm0603-669 (Pubitemid 36749215)
-
(2003)
Nature Medicine
, vol.9
, Issue.6
, pp. 669-676
-
-
Ferrara, N.1
Gerber, H.-P.2
LeCouter, J.3
-
23
-
-
31744431907
-
Vascular endothelial growth factor restores erectile function through modulation of the insulin-like growth factor system and sex hormone receptors in diabetic rat
-
DOI 10.1016/j.bbrc.2005.12.226, PII S0006291X06000775
-
M Shirai M Yamanaka H Shiina, et al. 2006 vascular endothelial growth factor restores erectile function through modulation of the insulin-like growth factor system and sex hormone receptors in diabetic rat Biochem Biophys Res Commun 341 3 755 62 16455052 1:CAS:528:DC%2BD28XhtFaktb4%3D 10.1016/j.bbrc.2005. 12.226 (Pubitemid 43177554)
-
(2006)
Biochemical and Biophysical Research Communications
, vol.341
, Issue.3
, pp. 755-762
-
-
Shirai, M.1
Yamanaka, M.2
Shiina, H.3
Igawa, M.4
Kawakami, T.5
Ishii, N.6
Lue, T.F.7
Fujime, M.8
Dahiya, R.9
-
24
-
-
0031943236
-
VEGF upregulates eNOS message, protein, and NO production in human endothelial cells
-
9530221 1:CAS:528:DyaK1cXitVSjs7c%3D
-
JD Hood CJ Meininger M Ziche HJ Granger 1998 VEGF upregulates eNOS message, protein, and NO production in human endothelial cells Am J Physiol 274 H1054 8 9530221 1:CAS:528:DyaK1cXitVSjs7c%3D
-
(1998)
Am J Physiol
, vol.274
, pp. 1054-8
-
-
Hood, J.D.1
Meininger, C.J.2
Ziche, M.3
Granger, H.J.4
-
25
-
-
0032560844
-
VEGF/VPF overexpression in skin of transgenic mice induces angiogenesis, vascular hyperpermeability and accelerated tumor development
-
F Larcer R Murillas M Bolontrade CJ Conti JL Jorcano 1998 VEGF/VPP overexpression in skin of transgenic mice induces angiogenesis, vascular hyperpermeability and accelerated tumor development Oncogene 17 303 11 10.1038/sj.onc.1201928 (Pubitemid 28383007)
-
(1998)
Oncogene
, vol.17
, Issue.3
, pp. 303-311
-
-
Larcher, F.1
Murillas, R.2
Bolontrade, M.3
Conti, C.J.4
Jorcano, J.L.5
-
26
-
-
0038168385
-
Systemic basic fibroblast growth factor induces favorable histological changes in the corpus cavernosum of hypercholesterolemic rabbits
-
Q Dai AD Silverstein MG Davies, et al. 2003 Systemic basic fibroblast growth factor induces favourable histological changes in the corpus cavernosum of hypercholesterolemic rabbit J Urol 170 664 8 12853852 1:CAS:528: DC%2BD3sXlsVKgu7w%3D 10.1097/01.ju.0000065247.55066.ad (Pubitemid 36870280)
-
(2003)
Journal of Urology
, vol.170
, Issue.2
, pp. 664-668
-
-
Dai, Q.1
Silverstein, A.D.2
Davies, M.G.3
Hagen, P.-O.4
Donatucci, C.F.5
Annex, B.H.6
-
27
-
-
33744523020
-
Downregulation of angiogenic factors and their downstream target molecules affects the deterioration of erectile function in a rat model of hypercholesterolemia
-
DOI 10.1016/j.urology.2005.12.027, PII S0090429505017814
-
JK Ryu HY Shin SU Song, et al. 2006 Downregulation of angiogenic factors and their downstream target molecules affects the deterioration of erectile function in a rat model of hypercholesterolemia Urology 67 1329 34 16750245 10.1016/j.urology.2005.12.027 (Pubitemid 43818077)
-
(2006)
Urology
, vol.67
, Issue.6
, pp. 1329-1334
-
-
Ryu, J.-K.1
Shin, H.-Y.2
Song, S.U.3
Oh, S.-M.4
Piao, S.5
Han, J.-Y.6
Park, K.-W.7
Suh, J.-K.8
-
28
-
-
77955155084
-
Angiogenesis therapy for the treatment of erectile dysfunction
-
This article summarizes the results from all angiogenic therapies for the treatment of erectile dysfunction
-
•• Lysiak JJ, Kavoussi PK, Ellati RT, Steers WD, Annex BH. Angiogenesis therapy for the treatment of erectile dysfunction. J Sex Med 2010;7(7):2554-63. This article summarizes the results from all angiogenic therapies for the treatment of erectile dysfunction.
-
(2010)
J Sex Med
, vol.7
, Issue.7
, pp. 2554-2563
-
-
Lysiak, J.J.1
Kavoussi, P.K.2
Ellati, R.T.3
Steers, W.D.4
Annex, B.H.5
-
29
-
-
0034980979
-
The effect of adeno-associated virus mediated brain derived neurotrophic factor in an animal model of neurogenic impotence
-
11371936 1:CAS:528:DC%2BD3MXkt1Cktb0%3D 10.1016/S0022-5347(05)66302-1
-
ME Bakircioglu CS Lin P Fan, et al. 2001 The effect of adeno-associated virus mediated brain derived neurotrophic factor in an animal model of neurogenic impotence J Urol 165 2103 9 11371936 1:CAS:528:DC%2BD3MXkt1Cktb0%3D 10.1016/S0022-5347(05)66302-1
-
(2001)
J Urol
, vol.165
, pp. 2103-9
-
-
Bakircioglu, M.E.1
Lin, C.S.2
Fan, P.3
-
30
-
-
34548451681
-
Herpes simplex virus vector-mediated delivery of glial cell line-derived neurotrophic factor rescues erectile dysfunction following cavernous nerve injury
-
DOI 10.1038/sj.gt.3302990, PII 3302990
-
R Kato D Wolfe CH Coyle, et al. 2007 Herpes simplex virus vector-mediated delivery of glial cell line-derived neurotrophic factor rescues erectile dysfunction following cavernous nerve injury Gene Ther 14 1344 52 17611585 1:CAS:528:DC%2BD2sXpvFWmtrg%3D (Pubitemid 47365620)
-
(2007)
Gene Therapy
, vol.14
, Issue.18
, pp. 1344-1352
-
-
Kato, R.1
Wolfe, D.2
Coyle, C.H.3
Huang, S.4
Wechuck, J.B.5
Goins, W.F.6
Krisky, D.M.7
Tsukamoto, T.8
Nelson, J.B.9
Glorioso, J.C.10
Chancellor, M.B.11
Yoshimura, N.12
-
31
-
-
33845764243
-
Regulation of cavernous nerve injury-induced apoptosis by sonic hedgehog
-
DOI 10.1095/biolreprod.106.053926
-
CA Podlasek CL Meroz Y Tang, et al. 2007 Regulation of cavernous nerve-injury apoptosis by sonic hedgehog Biol Reprod 76 1 19 28 16988214 1:CAS:528:DC%2BD2sXhs1Kquw%3D%3D 10.1095/biolreprod.106.053926 (Pubitemid 46013443)
-
(2007)
Biology of Reproduction
, vol.76
, Issue.1
, pp. 19-28
-
-
Podlasek, C.A.1
Meroz, C.L.2
Tang, Y.3
McKenna, K.E.4
McVary, K.T.5
-
32
-
-
78650765937
-
Peptide amphiphile nanofiber delivery of sonic hedgehog protein to reduce smooth muscle apoptosis in the penis after cavernous nerve resection
-
20807324 1:CAS:528:DC%2BC3MXisFajurY%3D 10.1111/j.1743-6109.2010.02001.x
-
CW Bond NL Angeloni DA Arrington, et al. 2011 Peptide amphiphile nanofiber delivery of sonic hedgehog protein to reduce smooth muscle apoptosis in the penis after cavernous nerve resection J Sex Med 8 1 78 89 20807324 1:CAS:528:DC%2BC3MXisFajurY%3D 10.1111/j.1743-6109.2010.02001.x
-
(2011)
J Sex Med
, vol.8
, Issue.1
, pp. 78-89
-
-
Bond, C.W.1
Angeloni, N.L.2
Arrington, D.A.3
-
33
-
-
61849095217
-
Role of immunophillins in recovery of erectile function after cavernous nerve injury
-
This article reviews the current understanding on immunophilin proteins and the neurotrophic effects in erectile recovery following CNI
-
• Sezen SF, Lagoda G, Burnett AL. Role of immunophillins in recovery of erectile function after cavernous nerve injury. J Sex Med. 2009;6(3):340-6. This article reviews the current understanding on immunophilin proteins and the neurotrophic effects in erectile recovery following CNI.
-
(2009)
J Sex Med
, vol.6
, Issue.3
, pp. 340-346
-
-
Sezen, S.F.1
Lagoda, G.2
Burnett, A.L.3
-
34
-
-
27544450744
-
Erythropoietin promotes the recovery of erectile function following cavernous nerve injury
-
DOI 10.1097/01.ju.0000176808.94610.dd
-
ME Allaf A Hoke AL Burnett 2005 Erythropoietin promotes the recovery of erectile function following cavernous nerve injury J Urol 174 2060 4 16217394 1:CAS:528:DC%2BD2MXhtV2rt7jL 10.1097/01.ju.0000176808.94610.dd (Pubitemid 41547024)
-
(2005)
Journal of Urology
, vol.174
, Issue.5
, pp. 2060-2064
-
-
Allaf, M.E.1
Hoke, A.2
Burnett, A.L.3
-
35
-
-
53549116168
-
Erythropoietin promotes erection recovery after nerve-sparing radical retropubic prostatectomy: A retrospective analysis
-
18778310 1:CAS:528:DC%2BD1cXhtlGit77P 10.1111/j.1743-6109.2008.00865.x
-
AL Burnett ME Allaf TJ Bivalacqua 2008 Erythropoietin promotes erection recovery after nerve-sparing radical retropubic prostatectomy: A retrospective analysis J Sex Med 5 2392 8 18778310 1:CAS:528:DC%2BD1cXhtlGit77P 10.1111/j.1743-6109.2008.00865.x
-
(2008)
J Sex Med
, vol.5
, pp. 2392-8
-
-
Burnett, A.L.1
Allaf, M.E.2
Bivalacqua, T.J.3
-
36
-
-
33845774784
-
HMaxi-K gene transfer in males with erectile dysfunction: Results of the first human trial
-
DOI 10.1089/hum.2006.17.1165
-
A Melman N Bar-Chama A McCullough, et al. 2006 hMaxi-K gene transfer in males with erectile dysfunction: Results of the first human trial Hum Gene Ther 17 1165 76 17134370 1:CAS:528:DC%2BD28XhtlGktLfJ 10.1089/hum.2006.17.1165 (Pubitemid 44975134)
-
(2006)
Human Gene Therapy
, vol.17
, Issue.12
, pp. 1165-1176
-
-
Melman, A.1
Bar-Chama, N.2
McCullough, A.3
Davies, K.4
Christ, G.5
-
37
-
-
0031834590
-
The application of gene therapy to the treatment of erectile dysfunction
-
GJ Christ A Melman 1998 The application of gene therapy to the treatment of erectile dysfunction Int J Impot Res 10 111 2 9647947 1:STN:280: DyaK1czhtFOmsQ%3D%3D 10.1038/sj.ijir.3900326 (Pubitemid 28286829)
-
(1998)
International Journal of Impotence Research
, vol.10
, Issue.2
, pp. 111-112
-
-
Christ, G.J.1
Melman, A.2
-
38
-
-
0034981758
-
Integrative erectile biology: The effects of age and disease on gap junctions and ion channels and their potential value to the treatment of erectile dysfunction
-
DOI 10.1016/S0094-0143(05)70133-6
-
A Melman GJ Christ 2001 Integrative erectile biology. The effects of age and disease on gap junctions and ion channels and their potential value to the treatment of erectile dysfunction Urol Clin North Am 28 217 31 11402576 1:STN:280:DC%2BD3MzjsFKguw%3D%3D 10.1016/S0094-0143(05)70133-6 (Pubitemid 32510465)
-
(2001)
Urologic Clinics of North America
, vol.28
, Issue.2
, pp. 217-231
-
-
Melman, A.1
Christ, G.J.2
-
39
-
-
0034522064
-
Adenoviral gene transfer of endothelial nitric oxide synthase (eNOS) to the penis improves age-related erectile dysfunction in the rat
-
11002394 10.1038/sj.ijir.3900556
-
TJ Bivalacqua HC Champion YS Mehta, et al. 2000 Adenoviral gene transfer of endothelial nitric oxide synthase (eNOS) to the penis improves age-related erectile dysfunction in the rat Int J Impot Res 12 suppl 3 S8 17 11002394 10.1038/sj.ijir.3900556
-
(2000)
Int J Impot Res
, vol.12
, Issue.SUPPL. 3
, pp. 8-17
-
-
Bivalacqua, T.J.1
Champion, H.C.2
Mehta, Y.S.3
-
40
-
-
0037404943
-
Gene transfer of endothelial nitric oxide synthase partially restores nitric oxide synthesis and erectile function in streptozotocin diabetic rats
-
DOI 10.1097/01.ju.0000051881.14239.4a
-
TJ Bivalacqua MF Usta HC Champion, et al. 2003 Gene transfer of endothelial nitric oxide synthase partially restores nitric oxide synthesis and erectile function in streptozocin diabetic rats J Urol 169 1911 17 12686872 1:CAS:528:DC%2BD3sXislKjsr0%3D 10.1097/01.ju.0000051881.14239.4a (Pubitemid 36443545)
-
(2003)
Journal of Urology
, vol.169
, Issue.5
, pp. 1911-1917
-
-
Bivalacqua, T.J.1
Usta, M.F.2
Champion, H.C.3
Adams, D.4
McNamara, D.B.5
Abdel-Mageed, A.B.6
Kadowitz, P.J.7
Hellstrom, W.J.G.8
-
41
-
-
1642524919
-
Effect of combination endothelial nitric oxide synthase gene therapy and sildenafil on erectile function in diabetic rats
-
DOI 10.1038/sj.ijir.3901054
-
TJ Bivalacqua MF Usta HC Champion, et al. 2004 Effect of combination endothelial nitric oxide synthase gene therapy and sildenafil on erectile function in diabetic rats Int J Impot Res 16 21 9 14963467 1:CAS:528: DC%2BD2cXhtlWksrY%3D 10.1038/sj.ijir.3901054 (Pubitemid 38401555)
-
(2004)
International Journal of Impotence Research
, vol.16
, Issue.1
, pp. 21-29
-
-
Bivalacqua, T.J.1
Usta, M.F.2
Champion, H.C.3
Leungwattanakij, S.4
Dabisch, P.A.5
McNamara, D.B.6
Kadowitz, P.J.7
Hellstrom, W.J.G.8
-
42
-
-
33847711835
-
Mesenchymal stem cells alone or ex vivo gene modified with endothelial nitric oxide synthase reverse age-associated erectile dysfunction
-
DOI 10.1152/ajpheart.00685.2006
-
TJ Bivalacqua W Deng M Kendirci, et al. 2007 Mesenchymal stem cells alone or ex vivo gene modified with endothelial nitric oxide synthase reverses age-associated erectile dysfunction Am J Physiol heart Circ Physiol 292 H1278 90 17071732 1:CAS:528:DC%2BD2sXjsVyls7o%3D 10.1152/ajpheart.00685.2006 (Pubitemid 46377115)
-
(2007)
American Journal of Physiology - Heart and Circulatory Physiology
, vol.292
, Issue.3
-
-
Bivalacqua, T.J.1
Deng, W.2
Kendirci, M.3
Usta, M.F.4
Robinson, C.5
Taylor, B.K.6
Murthy, S.N.7
Champion, H.C.8
Hellstrom, W.J.G.9
Kadowitz, P.J.10
-
43
-
-
0036085756
-
Gene therapy of erectile dysfunction in the rat with penile neuronal nitric oxide synthase
-
TR Magee M Ferrini HJ Garban, et al. 2002 Gene therapy of erectile dysfunction in the rat with penile neuronal nitric oxide synthase Biol Reprod 67 20 8 12079995 1:CAS:528:DC%2BD38XkvV2itrs%3D 10.1095/biolreprod67.3.1032 (Pubitemid 34680631)
-
(2002)
Biology of Reproduction
, vol.67
, Issue.1
, pp. 20-28
-
-
Magee, T.R.1
Ferrini, M.2
Garban, H.J.3
Vernet, D.4
Mitani, K.5
Rajfer, J.6
Gonzalez-Cacdavid, N.F.7
-
44
-
-
0030978643
-
Cloning of rat and human inducible penile nitric oxide synthase. Application for gene therapy of erectile dysfunction
-
DOI 10.1095/biolreprod56.4.954
-
H Garban, et al. 1997 Cloning of rat and human inducible penile nitric oxide synthase. Application for gene therapy of erectile dysfunction Biol Reprod 56 954 63 9096878 1:CAS:528:DyaK2sXitFKgsLs%3D 10.1095/biolreprod56.4.954 (Pubitemid 27150425)
-
(1997)
Biology of Reproduction
, vol.56
, Issue.4
, pp. 954-963
-
-
Garban, H.1
Marquez, D.2
Magee, T.3
Moody, J.4
Rajavashisth, T.5
Rodriguez, J.A.6
Hung, A.7
Vernet, D.8
Rajfer, J.9
Gonzalez-Cadavid, N.F.10
-
45
-
-
0037568492
-
Nitric oxide synthase gene transfer for erectile dysfunction in a rat model
-
DOI 10.1046/j.1464-410X.2003.04219.x
-
MB Chancellor S Tirney CE Mattes, et al. 2003 Nitric oxide synthase gene transfer for erectile dysfunction in a rat model BJU Int 91 691 6 12699487 1:CAS:528:DC%2BD3sXks1ynu7Y%3D 10.1046/j.1464-410X.2003.04219.x (Pubitemid 36583746)
-
(2003)
BJU International
, vol.91
, Issue.7
, pp. 691-696
-
-
Chancellor, M.B.1
Tirney, S.2
Mattes, C.E.3
Tzeng, E.4
Birder, L.A.5
Kanai, A.J.6
De Groat, W.C.7
Huard, J.8
Yoshimura, N.9
-
46
-
-
34249083476
-
Antisense and short hairpin RNA (shRNA) constructs targeting PIN (Protein Inhibitor of NOS) ameliorate aging-related erectile dysfunction in the rat
-
DOI 10.1111/j.1743-6109.2007.00459.x
-
TR Magee I Kovanecz HH Davila, et al. 2007 Antisense and short hairpin RNA (shRNA) constructs targeting PIN (Protein Inhibitor of NOS) ameliorate aging-related erectile dysfunction in rat J Sex Med 4 633 43 17433082 1:CAS:528:DC%2BD2sXmsFOhurc%3D 10.1111/j.1743-6109.2007.00459.x (Pubitemid 46779299)
-
(2007)
Journal of Sexual Medicine
, vol.4
, Issue.3
, pp. 633-643
-
-
Magee, T.R.1
Kovanecz, I.2
Davila, H.H.3
Ferrini, M.G.4
Cantini, L.5
Vernet, D.6
Zuniga, F.I.7
Rajfer, J.8
Gonzalez-Cadavid, N.F.9
-
47
-
-
33847700110
-
Overexpression of arginase in the aged mouse penis impairs erectile function and decreases eNOS activity:influence of in vivo gene therapy of anti-arginase
-
TJ Bivalacqua AL Burnett WJ Hellstrom HC Champion 2007 Overexpression of arginase in the aged mouse penis impairs erectile function and decreases eNOS activity:influence of in vivo gene therapy of anti-arginase Am J Physiol Heart Circ Physiol 292 H1320 51
-
(2007)
Am J Physiol Heart Circ Physiol
, vol.292
, pp. 1320-51
-
-
Bivalacqua, T.J.1
Burnett, A.L.2
Hellstrom, W.J.3
Champion, H.C.4
-
48
-
-
34447294864
-
Dysregulation of cGMP-dependent protein kinase 1 (PKG-1) impairs erectile function in diabetic rats: Influence of in vivo gene therapy of PKG1α
-
DOI 10.1111/j.1464-410X.2007.06794.x
-
TJ Bivalacqua M Kendirci HC Champion, et al. 2007 Dysregulation of cGMP-dependent protein kinase 1 (PKG-1) impairs erectile function in diabetic rats: influence of in vivo gene therapy of PKG 1 alpha BJU Int 99 1488 94 17355372 1:CAS:528:DC%2BD2sXotFansLY%3D 10.1111/j.1464-410X.2007.06794.x (Pubitemid 47164803)
-
(2007)
BJU International
, vol.99
, Issue.6
, pp. 1488-1494
-
-
Bivalacqua, T.J.1
Kendirci, M.2
Champion, H.C.3
Hellstrom, W.J.G.4
Andersson, K.-E.5
Hedlund, P.6
-
49
-
-
16344370756
-
Superoxide anion production in the rat penis impairs erectile function in diabetes: Influence of in vivo extracellular superoxide dismutase gene therapy
-
DOI 10.1111/j.1743-6109.2005.20228-1.x
-
TJ Bivalacqua, et al. 2005 Superoxide anion production in the rat penis impairs erectile function in diabetes: influence of in vivo extracellular superoxide dismutase gene therapy J Sex med 2 187 97 16422885 1:CAS:528:DC%2BD2MXjtlaltbY%3D 10.1111/j.1743-6109.2005.20228-1.x (Pubitemid 40468173)
-
(2005)
Journal of Sexual Medicine
, vol.2
, Issue.2
, pp. 187-197
-
-
Bivalacqua, T.J.1
Usta, M.F.2
Kendirci, M.3
Pradhan, L.4
Alvarez, X.5
Champion, H.C.6
Kadowitz, P.J.7
Hellstrom, W.J.G.8
-
50
-
-
0036801934
-
Neurotrophic factors and axonal growth
-
DOI 10.1016/S0959-4388(02)00372-0
-
A Markus TD Patel WD Snider 2002 Neurotrophic factors and axonal growths Curr Opin Neurobiol 12 523 31 12367631 1:CAS:528:DC%2BD38XnsVagu7g%3D 10.1016/S0959-4388(02)00372-0 (Pubitemid 35284087)
-
(2002)
Current Opinion in Neurobiology
, vol.12
, Issue.5
, pp. 523-531
-
-
Markus, A.1
Patel, T.D.2
Snider, W.D.3
-
51
-
-
58149462239
-
Herpes simplex virus vector-mediated delivery of neurturin rescues erectile dysfunction of cavernous nerve injury
-
10.1038/gt.2008.132
-
R Kato D Wolfe CH Coyle, et al. 2009 Herpes simplex virus vector-mediated delivery of neurturin rescues erectile dysfunction of cavernous nerve injury Gene Ther 16 23 33 10.1038/gt.2008.132
-
(2009)
Gene Ther
, vol.16
, pp. 23-33
-
-
Kato, R.1
Wolfe, D.2
Coyle, C.H.3
-
52
-
-
0142060724
-
Neurotrophic effects of vascular endothelial growth factor and neurotrophins on cultured major pelvic ganglia
-
DOI 10.1046/j.1464-410X.2003.04439.x
-
G Lin KC Chen PS Hsieh, et al. 2003 Neurotrophic effects of vascular and endothelial growth factor and neurotrophins on cultured major pelvic ganglia BJU Int 952 631 5 10.1046/j.1464-410X.2003.04439.x (Pubitemid 37271746)
-
(2003)
BJU International
, vol.92
, Issue.6
, pp. 631-635
-
-
Lin, G.1
Chen, K.C.2
Hsieh, P.S.3
Yeh, C.H.4
Lue, T.F.5
Lin, C.S.6
-
53
-
-
20244367007
-
Improvement in erectile dysfunction after neurotrophic factor gene therapy in diabetic rats
-
DOI 10.1097/01.ju.0000158056.66236.1f
-
NE Bennett JH Kim DP Wolfe, et al. 2005 Improvement in erectile dysfunction after neurotrophic actor gene therapy in diabetic rats J Urol 173 1820 4 15821595 1:CAS:528:DC%2BD2MXjtFalsLs%3D 10.1097/01.ju.0000158056.66236.1f (Pubitemid 40524840)
-
(2005)
Journal of Urology
, vol.173
, Issue.5
, pp. 1820-1824
-
-
Bennett, N.E.1
Kim, J.H.2
Wolfe, D.P.3
Sasaki, K.4
Yoshimura, N.5
Goins, W.F.6
Huang, S.7
Nelson, J.B.8
De Groat, W.C.9
Glorioso, J.C.10
Chancellor, M.B.11
-
54
-
-
0037376430
-
The effect of vascular endothelial growth factor and adeno-associated virus mediated brain derived neurotrophic factor on neurogenic and vasculogenic erectile dysfunction induced by hyperlipidemia
-
DOI 10.1097/01.ju.0000055120.73261.76
-
SS Gholami R Rogers J Chang, et al. 2003 The effect of vascular endothelial growth factor and adeno-associated virus mediated brain derived neurotrophic factor on neurogenic and vasculogenic erectile dysfunction induced by hyperlipidemia J Urol 169 1577 81 12629419 1:CAS:528:DC%2BD3sXhvFahsLc%3D 10.1097/01.ju.0000055120.73261.76 (Pubitemid 36323848)
-
(2003)
Journal of Urology
, vol.169
, Issue.4
, pp. 1577-1581
-
-
Gholami, S.S.1
Rogers, R.2
Chang, J.3
Ho, H.-C.4
Grazziottin, T.5
Lin, C.-S.6
Lue, T.F.7
-
55
-
-
0037300192
-
Intracavernosal vascular endothelial growth factor (VEGF) injection and adeno-associated virus-mediated VEGF gene therapy prevent and reverse venogenic erectile dysfunction in rats
-
DOI 10.1038/sj.ijir.3900943
-
RS Rogers TM Graziottin CS Lin, et al. 2003 Intracavernosal vascular endothelial growth factor (VEGF) injection and adeno-associated virus-mediated VEGF gene therapy prevent and reverse venogenic erectile dysfunction in rats Int J Impot Res 15 26 37 12605238 1:CAS:528:DC%2BD3sXjt1ars7g%3D 10.1038/sj.ijir.3900943 (Pubitemid 36356356)
-
(2003)
International Journal of Impotence Research
, vol.15
, Issue.1
, pp. 26-37
-
-
Rogers, R.S.1
Graziottin, T.M.2
Lin, C.-S.3
Kan, Y.W.4
Lue, T.F.5
-
56
-
-
10344242040
-
Vascular endothelial growth factor restores erectile function through inhibition of apoptosis in diabetic rat penile crura
-
DOI 10.1097/01.ju.0000141586.46822.44
-
M Yamanaka M Shirai H Shiina, et al. 2005 Vascular endothelial growth factor restores erectile function through inhibition of apoptosis in diabetic rat penile crura J Urol 173 318 23 15592104 1:CAS:528:DC%2BD2cXhtVOhtrfN 10.1097/01.ju.0000141586.46822.44 (Pubitemid 39627742)
-
(2005)
Journal of Urology
, vol.173
, Issue.1
, pp. 318-323
-
-
Yamanaka, M.1
Shirai, M.2
Shiina, H.3
Tanaka, Y.4
Enokida, H.5
Tsujimura, A.6
Matsumiya, K.7
Okuyama, A.8
Dahiya, R.9
-
57
-
-
33645508745
-
Combined angiopoietin-1 and vascular endothelial growth factor gene transfer restores cavernous angiogenesis and erectile function in a rat model of hypercholesterolemia
-
16380295 1:CAS:528:DC%2BD28XjtFOktLs%3D 10.1016/j.ymthe.2005.10.016
-
JK Ryu CH Cho HY Skin, et al. 2006 Combined angiopoietin-1 and vascular endothelial growth factor gene transfer restores cavernous angiogenesis and erectile function in a rat model of hypercholesterolemia Mol Ther 13 705 15 16380295 1:CAS:528:DC%2BD28XjtFOktLs%3D 10.1016/j.ymthe.2005.10.016
-
(2006)
Mol Ther
, vol.13
, pp. 705-15
-
-
Ryu, J.K.1
Cho, C.H.2
Skin, H.Y.3
-
58
-
-
65349091922
-
Effect of HO-1 cDNA-liposome complex transfer on erectile signalling of aged rats
-
19400852 1:CAS:528:DC%2BD1MXmsVerurk%3D 10.1111/j.1439-0272.2008.00911.x
-
MT Abdel Aziz T Mostafa H Atta, et al. 2009 Effect of HO-1 cDNA-liposome complex transfer on erectile signalling of aged rats Andrologia 41 176 83 19400852 1:CAS:528:DC%2BD1MXmsVerurk%3D 10.1111/j.1439-0272.2008.00911.x
-
(2009)
Andrologia
, vol.41
, pp. 176-83
-
-
Abdel Aziz, M.T.1
Mostafa, T.2
Atta, H.3
-
59
-
-
16344370756
-
Superoxide anion production in the rat penis impairs erectile function in diabetes: Influence of in vivo extracellular superoxide dismutase gene therapy
-
DOI 10.1111/j.1743-6109.2005.20228-1.x
-
TJ Bivalacqua MF Usta M Kendirci, et al. 2005 Superoxide anion production in the rat penis impairs erectile function in diabetes: influence of in vivo extracellular superoxide dismutase gene therapy J Sex Med 2 2 187 97 16422885 1:CAS:528:DC%2BD2MXjtlaltbY%3D 10.1111/j.1743-6109.2005.20228-1.x discussion 197-8 (Pubitemid 40468173)
-
(2005)
Journal of Sexual Medicine
, vol.2
, Issue.2
, pp. 187-197
-
-
Bivalacqua, T.J.1
Usta, M.F.2
Kendirci, M.3
Pradhan, L.4
Alvarez, X.5
Champion, H.C.6
Kadowitz, P.J.7
Hellstrom, W.J.G.8
-
60
-
-
0028837352
-
Physiology of penile erection
-
KE Anderson G Wagner 1995 Physiology of penile erection Physiol Rev 75 191 236
-
(1995)
Physiol Rev
, vol.75
, pp. 191-236
-
-
Anderson, K.E.1
Wagner, G.2
-
61
-
-
0036093105
-
Potassium channels and human corporeal smooth muscle cell tone: Further evidence of the physiological relevance of the Maxi-K channel subtype to the regulation of human corporeal smooth muscle tone in vitro
-
M Spektor R Rodriguez RS Rosenbaum, et al. 2002 Potassium channels and human corporeal smooth muscle cell tone: further evidence of the physiological relevance of the Maxi-K channel subtype to the regulation of human corporeal smooth muscle tone in vitro J Urol 167 2628 35 11992099 1:CAS:528: DC%2BD38Xkt12qur0%3D 10.1016/S0022-5347(05)65049-5 (Pubitemid 34533192)
-
(2002)
Journal of Urology
, vol.167
, Issue.6
, pp. 2628-2635
-
-
Spektor, M.1
Rodriguez, R.2
Rosenbaum, R.S.3
Wang, H.-Z.4
Melman, A.5
Christ, G.J.6
-
62
-
-
0038340638
-
The successful long-term treatment of age related erectile dysfunction with hSlo CDNA in rats in vivo
-
DOI 10.1097/01.ju.0000063375.12512.6e
-
A Melman W Zhao KP Davies R Bakal GJ Christ 2003 The successful long-term treatment of age related erectile dysfunction with hSlo cDNA in rats in vivo J Urol 170 285 90 12796707 1:CAS:528:DC%2BD3sXks1yqs70%3D 10.1097/01.ju. 0000063375.12512.6e (Pubitemid 36734480)
-
(2003)
Journal of Urology
, vol.170
, Issue.1
, pp. 285-290
-
-
Melman, A.1
Zhao, W.2
Davies, K.P.3
Bakal, R.4
Christ, G.J.5
-
63
-
-
4744354628
-
Intracorporal injection of hSlo cDNA restores erectile capacity in STZ-diabetic F-344 rats in vivo
-
DOI 10.1152/ajpheart.00792.2003
-
GJ Christ N Day C Santizo, et al. 2004 Intracorporal injection of hSlo cDNA restores erectile capacity in STZ-diabetic F-344 rats in vivo Am J Physiol Heart Circ Physiol 287 H1544 53 15371262 1:CAS:528:DC%2BD2cXptFansbw%3D 10.1152/ajpheart.00792.2003 (Pubitemid 39313258)
-
(2004)
American Journal of Physiology - Heart and Circulatory Physiology
, vol.287
, Issue.4
-
-
Christ, G.J.1
Day, N.2
Santizo, C.3
Sato, Y.4
Zhao, W.5
Sclafani, T.6
Bakal, R.7
Salman, M.8
Davies, K.9
Melman, A.10
-
64
-
-
0031827271
-
Intracorporal injection of hSlo cDNA in rats produces physiologically relevant alterations in penile function
-
9683449 1:CAS:528:DyaK1cXlsVyjsL4%3D
-
GJ Christ J Rehman N Day, et al. 1998 Intracorporal injection of hSlo cDNA in rats produces physiologically relevant alterations in penile function Am J Physiol 275 H600 8 9683449 1:CAS:528:DyaK1cXlsVyjsL4%3D
-
(1998)
Am J Physiol
, vol.275
, pp. 600-8
-
-
Christ, G.J.1
Rehman, J.2
Day, N.3
-
65
-
-
39449121888
-
Gene transfer with a vector expressing Maxi-K from a smooth muscle-specific promoter restores erectile function in the aging rat
-
DOI 10.1038/sj.gt.3303093, PII 3303093
-
A Melman G Biggs K Davies, et al. 2008 Gene transfer with a vector expressing Maxi-K from a smooth muscle-specific promoter restores erectile function in the aging rat Gene Ther 15 364 70 18200069 1:CAS:528: DC%2BD1cXitVOls7w%3D 10.1038/sj.gt.3303093 (Pubitemid 351267378)
-
(2008)
Gene Therapy
, vol.15
, Issue.5
, pp. 364-370
-
-
Melman, A.1
Biggs, G.2
Davies, K.3
Zhao, W.4
Tar, M.T.5
Christ, G.J.6
-
66
-
-
70350571204
-
Smooth-muscle-specific gene transfer with the human Maxi-K channel improves erectile function and enhances sexual behaviour in atherosclerotic cynomolgus monkeys
-
This study shows dramatic changes in erectile function and sexual behavior following intracorporal Maxi-K gene transfer in primate species
-
• Christ GJ, Andersson KE, Williams K et al. Smooth-muscle-specific gene transfer with the human Maxi-K channel improves erectile function and enhances sexual behaviour in atherosclerotic cynomolgus monkeys. Eur Urol 2009;52:1055-66. This study shows dramatic changes in erectile function and sexual behavior following intracorporal Maxi-K gene transfer in primate species.
-
(2009)
Eur Urol
, vol.52
, pp. 1055-66
-
-
Christ, G.J.1
Andersson, K.E.2
Williams, K.3
-
67
-
-
70350066071
-
Gene transfer for erectile dysfunction: Will this novel therapy be accepted by urologist?
-
19741539 10.1097/MOU.0b013e3283314985
-
A Melman L Rojas G Christ 2009 Gene transfer for erectile dysfunction: will this novel therapy be accepted by urologist? Curr Opin Urol 19 595 600 19741539 10.1097/MOU.0b013e3283314985
-
(2009)
Curr Opin Urol
, vol.19
, pp. 595-600
-
-
Melman, A.1
Rojas, L.2
Christ, G.3
-
68
-
-
0036279709
-
Potassium channels and human corporeal smooth muscle cell tone: Diabetes and relaxation of human corpus cavernosum smooth muscle by adenosine triphosphate sensitive potassium channel openers
-
K Venkateswarlu A Giraldi W Zhao, et al. 2002 Potassium channels and human corporeal smooth muscle tone: diabetes and relaxation of human corpus cavernosum smooth muscle by adenosine triphosphate sensitive potassium channel openers J Urol 168 355 61 12050569 1:CAS:528:DC%2BD38Xlt1Cku7s%3D 10.1016/S0022-5347(05)64920-8 (Pubitemid 34640856)
-
(2002)
Journal of Urology
, vol.168
, Issue.1
, pp. 355-361
-
-
Venkateswarlu, K.1
Giraldi, A.2
Zhao, W.3
Wang, H.-Z.4
Melman, A.5
Spektor, M.6
Christ, G.J.7
-
69
-
-
35148834826
-
ATP channel restores age-related erectile dysfunction in rats
-
DOI 10.1111/j.1464-410X.2007.07050.x
-
I So MR Chae SW Lee 2007 Gene transfer of the K(ATP) channel restores age-related erectile dysfunction in rats BJU Int 100 1154 60 17645416 1:CAS:528:DC%2BD2sXhtlGgur%2FN (Pubitemid 47537641)
-
(2007)
BJU International
, vol.100
, Issue.5
, pp. 1154-1160
-
-
So, I.1
Chae, M.R.2
Lee, S.W.3
-
70
-
-
0027483448
-
Calcitonin gene-related peptide: Possibly neurotransmitter contributes to penile erection in monkeys
-
DOI 10.1016/0090-4295(93)90608-D
-
CG Stief F Benard R Bosch, et al. 1993 Calcitonin gene-related peptide: possibly neurotransmitter contributes to penile erection in monkeys Urology 41 397 401 8470332 1:STN:280:DyaK3s3islGitg%3D%3D 10.1016/0090-4295(93)90608-D (Pubitemid 23111579)
-
(1993)
Urology
, vol.41
, Issue.4
, pp. 397-401
-
-
Stief, C.G.1
Benard, F.2
Bosch, R.3
Aboseif, S.4
Wetterauer, U.5
Lue, T.E.6
Tanagho, E.A.7
-
71
-
-
0034762419
-
Gene transfer of prepro-calcitonin gene-related peptide restores erectile function in the aged rat
-
TJ Bivalacqua HC Champion AB Abdel-Mageed PJ Kadowitz WJ Hellstrom 2001 Gene transfer of prepro-calcitonin gene-related peptide restores erectile function in the aged rat Biol Reprod 65 1371 1377 11673252 1:CAS:528: DC%2BD3MXnvVersr0%3D 10.1095/biolreprod65.5.1371 (Pubitemid 33031494)
-
(2001)
Biology of Reproduction
, vol.65
, Issue.5
, pp. 1371-1377
-
-
Bivalacqua, T.J.1
Champion, H.C.2
Abdel-Mageed, A.B.3
Kadowitz, P.J.4
Hellstrom, W.J.G.5
-
72
-
-
17444373469
-
Gene transfer of vasoactive intestinal polypeptide into the penis improves erectile response in the diabetic rat
-
DOI 10.1111/j.1464-410X.2005.05422.x
-
ZJ Shen H Wang YL Lu, et al. 2005 Gene transfer of vasoactive intestinal polypeptide into the penis improves erectile response in the diabetic rat BJU Int 95 6 890 4 15794804 1:CAS:528:DC%2BD2MXktFGgtb8%3D 10.1111/j.1464-410X.2005. 05422.x (Pubitemid 40547228)
-
(2005)
BJU International
, vol.95
, Issue.6
, pp. 890-894
-
-
Shen, Z.-J.1
Wang, H.2
Lu, Y.-L.3
Zhou, X.-L.4
Chen, S.-W.5
Chen, Z.-D.6
-
73
-
-
0032721202
-
Endothelial cell transplantation into the corpus cavernosum: Moving towards cell-based gene therapy
-
10569612 1:STN:280:DC%2BD3c%2FjsV2jsg%3D%3D 10.1016/S0022-5347(05)68152-9
-
H Wessells SK Williams 1999 Endothelial cell transplantation into the corpus cavernosum: Moving towards cell-based gene therapy J Urol 162 2162 4 10569612 1:STN:280:DC%2BD3c%2FjsV2jsg%3D%3D 10.1016/S0022-5347(05)68152-9
-
(1999)
J Urol
, vol.162
, pp. 2162-4
-
-
Wessells, H.1
Williams, S.K.2
-
74
-
-
8144228785
-
The effect of neural embryonic stem cell therapy in a rat model of cavernosal nerve injury
-
DOI 10.1111/j.1464-410X.2003.05057.x
-
D Bochinski GT Lin L Nunes, et al. 2004 The effect of neural embryonic stem cell therapy in a rat model of cavernosal nerve injury BJU Int 94 904 9 15476533 10.1111/j.1464-410X.2003.05057.x (Pubitemid 39472495)
-
(2004)
BJU International
, vol.94
, Issue.6
, pp. 904-909
-
-
Bochinski, D.1
Lin, G.T.2
Nunes, L.3
Carrion, R.4
Rahman, N.5
Lin, C.S.6
Lue, T.F.7
-
75
-
-
45449113410
-
Human neural crest stem cells transplanted in rat penile corpus cavernosum to repair erectile dysfunction
-
DOI 10.1111/j.1464-410X.2008.07469.x
-
YS Song HJ Lee IH Park, et al. 2008 Human neural crest stem cells transplanted in rat penile corpus cavernosum to repair erectile dysfunction BJU Int 102 220 224 18284412 1:CAS:528:DC%2BD1cXps12ms78%3D 10.1111/j.1464-410X. 2008.07469.x discussion 224 (Pubitemid 351852582)
-
(2008)
BJU International
, vol.102
, Issue.2
, pp. 220-224
-
-
Song, Y.S.1
Lee, H.J.2
Park, I.H.3
Lim, I.S.4
Ku, J.H.5
Kim, S.U.6
-
76
-
-
34347397618
-
Potential differentiation of human mesenchymal stem cell transplanted in rat corpus cavernosum toward endothelial or smooth muscle cells
-
DOI 10.1038/sj.ijir.3901539, PII 3901539
-
YS Song HJ Lee IH Park, et al. 2007 Potential differentiation of human mesenchymal stem cell transplanted in rat corpus cavernosum toward endothelial or smooth muscle cells Int J Impot Res 19 378 85 17460699 1:CAS:528: DC%2BD2sXntFymsLw%3D 10.1038/sj.ijir.3901539 (Pubitemid 47026078)
-
(2007)
International Journal of Impotence Research
, vol.19
, Issue.4
, pp. 378-385
-
-
Song, Y.S.1
Lee, H.J.2
Park, I.H.3
Kim, W.K.4
Ku, J.H.5
Kim, S.U.6
-
77
-
-
41849111684
-
Effect of muscle-derived stem cells on the restoration of corpora cavernosa smooth muscle and erectile function in the aged rat
-
DOI 10.1111/j.1464-410X.2008.07507.x
-
G Nolazco I Kovanecz D Vernet, et al. 2008 Effect of muscle-derived stem cells on the restoration of corpora cavernosa smooth muscle and erectile function in the aged rat BJU Int 101 1156 64 18294308 1:CAS:528: DC%2BD1cXmtlSktb8%3D 10.1111/j.1464-410X.2008.07507.x (Pubitemid 351502662)
-
(2008)
BJU International
, vol.101
, Issue.9
, pp. 1156-1164
-
-
Nolazco, G.1
Kovanecz, I.2
Vernet, D.3
Gelfand, R.A.4
Tsao, J.5
Ferrini, M.G.6
Magee, T.7
Rajfer, J.8
Gonzalez-Cadavid, N.F.9
-
78
-
-
78650925587
-
Transplantation of nonhematopoietic adult bone marrow stem/progenitor cells isolated by p75 nerve growth factor receptor into the penis rescues erectile function in a rat model of cavernous nerve injury
-
This article highlights the role of p75-derived multipotent stromal cells harvested from adult bone marrow in recovery of erectile function following bilateral cavernous nerve crush injury.
-
• Kendirci M, Trost L, Bakondi B et al. Transplantation of nonhematopoietic adult bone marrow stem/progenitor cells isolated by p75 nerve growth factor receptor into the penis rescues erectile function in a rat model of cavernous nerve injury. J Urol. 2010;184(4):1560-6. This article highlights the role of p75-derived multipotent stromal cells harvested from adult bone marrow in recovery of erectile function following bilateral cavernous nerve crush injury.
-
(2010)
J Urol
, vol.184
, Issue.4
, pp. 1560-1566
-
-
Kendirci, M.1
Trost, L.2
Bakondi, B.3
-
79
-
-
77955242336
-
The effect of intracavernous injection of adipose tissue-derived stem cells on hyperlipidemia-associated erectile dysfunction in a rat model
-
YC Huang H Ning AW Shindel, et al. 2011 The effect of intracavernous injection of adipose tissue-derived stem cells on hyperlipidemia-associated erectile dysfunction in a rat model J Sex Med 7 4 Pt 1 1391 400
-
(2011)
J Sex Med
, vol.7
, Issue.4 PART 1
, pp. 1391-400
-
-
Huang, Y.C.1
Ning, H.2
Shindel, A.W.3
-
80
-
-
77957337960
-
Injections of adipose tissue-derived stem cells and stem cell lysate improve recovery of erectile function in a rat model of cavernous nerve injury
-
This article reports significant recovery in erectile function following ADSC and lysate treatments and that the underlying mechanism of recovery involved neuron preservation and cytoprotection by inhibition of cellular apoptosis.
-
• Albersen M, Fandel TM, Lin G et al. Injections of adipose tissue-derived stem cells and stem cell lysate improve recovery of erectile function in a rat model of cavernous nerve injury. J Sex Med 2010;7(10):3331-40. This article reports significant recovery in erectile function following ADSC and lysate treatments and that the underlying mechanism of recovery involved neuron preservation and cytoprotection by inhibition of cellular apoptosis.
-
(2010)
J Sex Med
, vol.7
, Issue.10
, pp. 3331-3340
-
-
Albersen, M.1
Fandel, T.M.2
Lin, G.3
-
81
-
-
77949424323
-
Emerging gene and stem cell therapies for the treatment of erectile dysfunction
-
This article provides a succinct summary on the pertinent studies relating to gene and stem-cell therapies
-
•• Harraz A, Shindel AW, Lue TF. Emerging gene and stem cell therapies for the treatment of erectile dysfunction. Nat Rev Urol. 2010:7:143-52. This article provides a succinct summary on the pertinent studies relating to gene and stem-cell therapies.
-
(2010)
Nat Rev Urol
, vol.7
, pp. 143-152
-
-
Harraz, A.1
Shindel, A.W.2
Lue, T.F.3
-
82
-
-
55149123945
-
Current status of tissue engineering in urology
-
18832940 10.1097/MOU.0b013e32830f9402
-
D Wood J Southgate 2008 Current status of tissue engineering in urology Curr Opin Urol 18 564 9 18832940 10.1097/MOU.0b013e32830f9402
-
(2008)
Curr Opin Urol
, vol.18
, pp. 564-9
-
-
Wood, D.1
Southgate, J.2
-
83
-
-
0032726785
-
Tissue engineering applications for erectile dysfunction
-
10554929 10.1038/sj.ijir.3900483
-
A Atala 1999 Tissue engineering applications for erectile dysfunction Int J Impot Res 11 s1 s41 10554929 10.1038/sj.ijir.3900483
-
(1999)
Int J Impot Res
, vol.11
, Issue.S1
, pp. 41
-
-
Atala, A.1
-
84
-
-
77649258697
-
Bioengineered corporal tissue for structural and functional restoration of the penis
-
This study shows that neo-corpora engineered from cavernosal collagen matrices could replaced the entire pendular penile corporal bodies in a rabbit model and also demonstrated structural and functional parameters similar to native tissue
-
• Chen KL, Eberli D, Yoo JJ, Atala A. Bioengineered corporal tissue for structural and functional restoration of the penis. Proc Natl Acad Sci USA. 2010;107(8):3346-50. This study shows that neo-corpora engineered from cavernosal collagen matrices could replaced the entire pendular penile corporal bodies in a rabbit model and also demonstrated structural and functional parameters similar to native tissue.
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, Issue.8
, pp. 3346-50
-
-
Chen, K.L.1
Eberli, D.2
Yoo, J.J.3
Atala, A.4
-
85
-
-
0142062593
-
Formation of Corporal Tissue Architecture in Vivo Using Human Cavernosal Muscle and Endothelial Cells Seeded on Collagen Matrices
-
DOI 10.1089/107632703322495529
-
G Falke JJ Yoo MG Machado R Moreland A Atala 2003 Formation of corporal tissue architecture in vivo using human cavernosal muscle and endothelial cells seeded on collagen matrices Tissue Eng 9 871 79 14633372 1:CAS:528: DC%2BD3sXotlejtb8%3D 10.1089/107632703322495529 (Pubitemid 37296819)
-
(2003)
Tissue Engineering
, vol.9
, Issue.5
, pp. 871-879
-
-
Falke, G.1
Yoo, J.J.2
Kwon, T.G.3
Moreland, R.4
Atala, A.5
-
86
-
-
53049109051
-
A method to improve cellular content for corporal tissue engineering
-
18433315 10.1089/ten.tea.2007.0249
-
D Eberli R Susaeta JJ Yoo A Atala 2008 A method to improve cellular content for corporal tissue engineering Tissue Eng Part A 14 10 1581 9 18433315 10.1089/ten.tea.2007.0249
-
(2008)
Tissue Eng Part A
, vol.14
, Issue.10
, pp. 1581-9
-
-
Eberli, D.1
Susaeta, R.2
Yoo, J.J.3
Atala, A.4
-
87
-
-
50249150758
-
Cavernous nerve regeneration using acellular nerve grafts
-
18594832 10.1007/s00345-008-0283-y
-
SS Connolly JJ Yoo M Abouheba, et al. 2008 Cavernous nerve regeneration using acellular nerve grafts World J Urol 26 4 333 9 18594832 10.1007/s00345-008-0283-y
-
(2008)
World J Urol
, vol.26
, Issue.4
, pp. 333-9
-
-
Connolly, S.S.1
Yoo, J.J.2
Abouheba, M.3
-
88
-
-
38349157091
-
Shock wave activate in vitro cultured progenitors and precursors of cardiac cell lineages from the human heart
-
17913335 10.1016/j.ultrasmedbio.2007.07.017
-
D Nurzynska F Di Meglio C Castaldo, et al. 2008 Shock wave activate in vitro cultured progenitors and precursors of cardiac cell lineages from the human heart Ultrasound Med Biol 34 334 42 17913335 10.1016/j.ultrasmedbio.2007. 07.017
-
(2008)
Ultrasound Med Biol
, vol.34
, pp. 334-42
-
-
Nurzynska, D.1
Di Meglio, F.2
Castaldo, C.3
-
89
-
-
77649217983
-
Double-blind and placebo-controlled study of the effectiveness and safety of extracorporal cardiac shock wave therapy for severe angina pectoris
-
20134096 10.1253/circj.CJ-09-1028
-
Y Kikuchi K Ito Y Ito, et al. 2010 Double-blind and placebo-controlled study of the effectiveness and safety of extracorporal cardiac shock wave therapy for severe angina pectoris Circ J 74 589 91 20134096 10.1253/circj.CJ-09-1028
-
(2010)
Circ J
, vol.74
, pp. 589-91
-
-
Kikuchi, Y.1
Ito, K.2
Ito, Y.3
-
90
-
-
63049090751
-
Extracorporeal shockwave treatment for chronic diabetic foot ulcers
-
18619622 10.1016/j.jss.2008.01.026
-
CJ Wang YR Kuo RW Wu, et al. 2009 Extracorporeal shockwave treatment for chronic diabetic foot ulcers J Surg Res 152 96 103 18619622 10.1016/j.jss.2008. 01.026
-
(2009)
J Surg Res
, vol.152
, pp. 96-103
-
-
Wang, C.J.1
Kuo, Y.R.2
Wu, R.W.3
-
91
-
-
0037024381
-
Short-time non-enzymatic nitric oxide synthesis from L-arginine and hydrogen peroxide induced by shock waves treatment
-
DOI 10.1016/S0014-5793(02)02807-7, PII S0014579302028077
-
G Gotte E Amelio S Russo, et al. 2002 Short-time non-enzymatic nitric oxide synthesis from L-arginine and hydrogen peroxide induced by shock waves treatment FEBS Lett 520 153 5 12044888 1:CAS:528:DC%2BD38XktFOgtLs%3D 10.1016/S0014-5793(02)02807-7 (Pubitemid 34607291)
-
(2002)
FEBS Letters
, vol.520
, Issue.1-3
, pp. 153-155
-
-
Gotte, G.1
Amelio, E.2
Russo, S.3
Marlinghaus, E.4
Musci, G.5
Suzuki, H.6
-
92
-
-
0008474064
-
Revascularization with extracorporeal shock wave therapy: First clinical results
-
GH Caspari R Erbel 1999 Revascularization with extracorporeal shock wave therapy: first clinical results Circulation 100 84 9
-
(1999)
Circulation
, vol.100
, pp. 84-9
-
-
Caspari, G.H.1
Erbel, R.2
-
93
-
-
28844498493
-
Nitric oxide mediates anti-inflammatory action of extracorporeal shock waves
-
DOI 10.1016/j.febslet.2005.11.023, PII S0014579305013839
-
AR Ciampa 2005 Carcereri de Pratti A, Amelio E et al. Nitric oxide mediates anti-inflammatory action of extracorporeal shock waves FEBS Lett 579 6839 45 16325181 1:CAS:528:DC%2BD2MXht12qurzM 10.1016/j.febslet.2005.11.023 (Pubitemid 41773696)
-
(2005)
FEBS Letters
, vol.579
, Issue.30
, pp. 6839-6845
-
-
Ciampa, A.R.1
De Prati, A.C.2
Amelio, E.3
Cavalieri, E.4
Persichini, T.5
Colasanti, M.6
Musci, G.7
Marlinghaus, E.8
Suzuki, H.9
Mariotto, S.10
-
94
-
-
77955307447
-
Can low-intensity extracorporeal shockwave therapy improve erectile function? A 6-month follow-up pilot study in patients with organic erectile dysfunction
-
This study provides proof-of-concept that low-intensity extracorporeal shock wave therapy is effective and tolerable for the treatment of vasculogenic ED. Furthermore, it improves endothelial function and has the potential to play an important role in penile rehabilitation without pharmacotherapy.
-
• Vardi Y, Appel B, Jacob G et al. Can low-intensity extracorporeal shockwave therapy improve erectile function? A 6-month follow-up pilot study in patients with organic erectile dysfunction. Eur Urol 2010;58(2):243-8. This study provides proof-of-concept that low-intensity extracorporeal shock wave therapy is effective and tolerable for the treatment of vasculogenic ED. Furthermore, it improves endothelial function and has the potential to play an important role in penile rehabilitation without pharmacotherapy.
-
(2010)
Eur Urol
, vol.58
, Issue.2
, pp. 243-248
-
-
Vardi, Y.1
Appel, B.2
Jacob, G.3
-
95
-
-
38749133768
-
The Impact of Shock Wave Therapy at Varied Energy and Dose Levels on Functional and Structural Changes in Erectile Tissue
-
DOI 10.1016/j.eururo.2007.06.032, PII S0302283807008664
-
A Müller Y Akin-Olugbade S Deveci, et al. 2008 The impact of shock wave therapy at varied energy and dose levels on functional and structural changes in erectile tissue Eur Urol 53 635 43 17618733 10.1016/j.eururo.2007.06. 032 (Pubitemid 351178985)
-
(2008)
European Urology
, vol.53
, Issue.3
, pp. 635-643
-
-
Muller, A.1
Akin-Olugbade, Y.2
Deveci, S.3
Donohue, J.F.4
Tal, R.5
Kobylarz, K.A.6
Palese, M.7
Mulhall, J.P.8
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