Human neural crest stem cells transplanted in rat penile corpus cavernosum to repair erectile dysfunction

BJU International

Volumn 102, Issue 2, 2008, Pages 220-224

  Song, Yun Seob ^c   Lee, Hong Jun ^d   Park, In Ho ^d   Lim, Ik Sung ^e   Ku, Ja Hyeon ^a   Kim, Seung U ^b  

^a Seoul National University Hospital   (South Korea)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^c Soonchunhyang University   (South Korea)

^d Gachon University College of Medicine   (South Korea)

^e Namseoul University   (South Korea)

Author keywords

Endothelial cell; Erectile dysfunction; Neural crest stem cell; Penis; Smooth muscle cell

Indexed keywords

ACTIN; CALPONIN; CD31 ANTIGEN; DESMIN; VON WILLEBRAND FACTOR;

ANIMAL EXPERIMENT; ARTICLE; CELL CULTURE; CELL DIFFERENTIATION; CONTROLLED STUDY; CORPUS CAVERNOSUM; ENDOTHELIUM CELL; ERECTILE DYSFUNCTION; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; NEURAL CREST CELL; NONHUMAN; PHASE CONTRAST MICROSCOPY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SMOOTH MUSCLE FIBER; STEM CELL TRANSPLANTATION;

ANIMALS; CELLS, CULTURED; ENDOTHELIAL CELLS; FEASIBILITY STUDIES; HUMANS; IMPOTENCE, VASCULOGENIC; MALE; MYOCYTES, SMOOTH MUSCLE; NEURAL CREST; PENILE ERECTION; PENIS; RATS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; STEM CELL TRANSPLANTATION;

EID: 45449113410     PISSN: 14644096     EISSN: 1464410X     Source Type: Journal    
DOI: 10.1111/j.1464-410X.2008.07469.x     Document Type: Article

References (19)

1. Lue TF. Erectile dysfunction. N Engl J Med 2000 342 : 1802 13
2. Miralles-Garcia JM, Garcia-Diez LC. Specific aspects of erectile dysfunction in endocrinology. Int J Impot Res 2004 16 (Suppl. 2 S10 2
3. Song YS, Lee HJ, Park IH et al. Potential differentiation of human mesenchymal stem cell transplanted in rat corpus cavernosum toward endothelial or smooth muscle cells. Int J Impot Res 2007 19 : 378 85
4. Trainor PA, Krumlauf R, Bronner-Fraser M. Neural crest cells. In Lanza R, Balu H, Douglas M, Handbook of Stem Cells. Burlington, MA : Elsevier Academic Press, 2004 : 205 18
5. Trentin A, Glavieux-Pardanaud C, Le Douarin NM et al. Self-renewal capacity is a widespread property of various types of neural crest precursor cells. Proc Natl Acad Sci USA 2004 101 : 4495 500
6. Maurer J, Fuchs S, Jager R et al. Establishment and controlled differentiation of neural crest stem cell lines using conditional transgenesis. Differentiation 2007 75 : 580 91
7. Kim SU, Nakagawa E, Hatori K et al. Production of immortalized human neural crest stem cells. Methods Mol Biol 2002 198 : 55 65
8. Youn YH, Feng J, Tessarollo L et al. Neural crest stem cell and cardiac endothelium defects in the TrkC null mouse. Mol Cell Neurosci 2003 23 : 160 70
9. Kim SU, Yong V, Watabe K et al. Human fetal Schwann cells in culture: phenotypic expressions and proliferative capability. J Neurosci Res 1989 22 : 50 9
10. Le Douarin NM, Creuzet S, Couly G et al. Neural crest cell plasticity and its limits. Development 2004 131 : 4637 50
11. Stemple DL, Anderson DJ. Isolation of a stem cell for neurons and glia from the mammalian neural crest. Cell 1992 71 : 973 85
12. Galli R, Borello U, Gritti A et al. Skeletal myogenic potential of human and mouse neural stem cells. Nat Neurosci 2000 3 : 986 91
13. Vittet D, Prandini MH, Berthier R et al. Embryonic stem cells differentiate in vitro to endothelial cells through successive maturation steps. Blood 1996 88 : 3424 31
14. Yamashita J, Itoh H, Hirashima M et al. Flk1-positive cells derived from embryonic stem cells serve as vascular progenitors. Nature 2000 408 : 92 6
15. Kim SU. Human neural stem cells genetically modified for brain repair in neurological disorders. Neuropathology 2004 24 : 159 71
16. Lee HJ, Kim KS, Park IH et al. Human neural stem cells over-expressing VEGF provide neuroprotection, angiogenesis and functional recovery in mouse stroke model. PLoS ONE 2007 2 : e156
17. Terada N, Hamazaki T, Oka M et al. Bone marrow cells adopt the phenotype of other cells by spontaneous cell fusion. Nature 2002 416 : 542 5
18. Ying QL, Nichols J, Evans EP et al. Changing potency by spontaneous fusion. Nature 2002 416 : 545 8
19. Pells S, Di Domenico AI, Gallagher EJ et al. Multipotentiality of neuronal cells after spontaneous fusion with embryonic stem cells and nuclear reprogramming in vitro. Cloning Stem Cells 2002 4 : 331 8