Potassium channels and human corporeal smooth muscle cell tone: Diabetes and relaxation of human corpus cavernosum smooth muscle by adenosine triphosphate sensitive potassium channel openers

Journal of Urology

Volumn 168, Issue 1, 2002, Pages 355-361

  Venkateswarlu, K ^a,b   Giraldi, A ^a,b   Zhao, W ^a,b   Wang, H Z ^a,b   Melman, A ^a,b   Spektor, M ^a,b   Christ, G J ^a,b  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b NONE

Author keywords

Diabetes mellitus; Impotence; Muscle, smooth; Penis; Potassium channels

Indexed keywords

4 AMINOPYRIDINE; ADENOSINE TRIPHOSPHATE; CHARYBDOTOXIN; GLIBENCLAMIDE; LEMAKALIM; PHENYLEPHRINE; PINACIDIL; POTASSIUM CHANNEL; POTASSIUM CHANNEL STIMULATING AGENT; POTASSIUM CHLORIDE; TETRYLAMMONIUM CHLORIDE;

ARTICLE; CALCIUM TRANSPORT; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORPUS CAVERNOSUM; DIABETES MELLITUS; ERECTILE DYSFUNCTION; HUMAN; HUMAN TISSUE; IMPOTENCE; MAJOR CLINICAL STUDY; MALE; MEASUREMENT; PATCH CLAMP; POTASSIUM CURRENT; PRIORITY JOURNAL; SMOOTH MUSCLE CONTRACTION; SMOOTH MUSCLE FIBER; SMOOTH MUSCLE FIBER MEMBRANE POTENTIAL; SMOOTH MUSCLE TONE;

EID: 0036279709     PISSN: 00225347     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-5347(05)64920-8     Document Type: Article

References (42)

1. Ion channels and vascular tone
2. Pharmacological and physiological significance of ion channels and factors that modulate them in vascular tissue
3. Interactions between membrane potential and intracellular calcium concentration in vascular smooth muscle
4. + channel modulation in arterial smooth muscle
5. Ca2+ channels, ryanodine receptors and Ca(2 +)-activated K+ channels: A functional unit for regulating arterial tone
6. Electrical and chemical control of smooth muscle activity of rabbit corpus cavernosum in vitro
7. Multiple types of ion channels in cavernous smooth muscle
8. Sympathetic control of arterial membrane potential by ATP-sensitive K(+)- channels
9. Potassium channel openers as potential therapeutic weapons in ion channel disease
10. 2+-activated potassium channels and ATP-sensitive potassium channels as modulators of vascular tone
11. Abnormal activation of K(+) channels in aortic smooth muscle of rats with endotoxic shock: Electrophysiological and functional evidence
12. + channels in mesenteric artery cells from hypertensive rats
13. Ion channels in vascular smooth muscle: Alterations in essential hypertension
14. Intracorporal injection of hSlo cDNA in rats produces physiologically relevant alterations in penile function
15. Role of K(ATP)(+) channels in regulation of systemic, pulmonary, and coronary vasomotor tone in exercising swine
16. ATP channels: Fact or artefact?
17. Toward understanding the assembly and structure of KATP channels
18. Structure and function of ATP-sensitive potassium channels
19. +-selective channels causing hyperpolarization and relaxation of noradrenaline contractions in rat mesenteric resistance vessels
20. Potassium channel activator drugs: Mechanism of action, pharmacological properties, and therapeutic potential
21. + currents in cerebral arterial smooth muscle: Pharmacological and hormonal modulation
22. Comparative studies of the maxi-K (K(Ca)) channel in freshly isolated myocytes of human and rat corpora
23. Ca channel in human corporal smooth muscle cells
24. Characterization of ATP-sensitive potassium channels in human corporal smooth muscle cells
25. Clinical pharmacology of potassium channel openers
26. Effects of pinacidil upon penile erectile tissue, in vitro and in vivo
27. ATP-channel opener as a potential treatment modality for erectile dysfunction
28. +-channel openers for relaxation of isolated penile erectile tissue from rabbit
29. The effect of intracavernous injection of potassium channel openers in monkeys and dogs
30. Relaxant effects of levcromakalim in isolated human small subcutaneous arteries
31. Effects of the potassium channel openers KRN4884 and levcromakalim on the contraction of rat aorta induced by A23187, compared with nifedipine
32. Pharmacological studies of human erectile tissue: Characteristics of spontaneous contractions and alterations in alpha-adrenoceptor responsiveness with age and disease in isolated tissues
33. 1-adrenergic contractions in human corpus cavernosum smooth muscle
34. Age-dependent alterations in the efficacy of phenylephrine-induced contractions in vascular smooth muscle isolated from the corpus cavernosum of impotent men
35. 1-adrenergic agonist on human corpus cavernosum smoth muscle
36. Potassium channel agonists cause penile erection in cats
37. Effect of diabetes mellitus on response of the basilar artery to activation of ATP-sensitive potassium channels
38. Functional changes in potassium channels in aortas from rats with streprozotocin-induced diabetes
39. Increased myogenic tone and diminished responsiveness to ATP-sensitive K+ channel openers in cerebral arteries from diabetic rats
40. Binding and effects of P1075, an opener of ATP-sensitive K+ channels, in the aorta from streptozotocin-treated diabetic rats
41. Characterization of nitroglycerine induced relaxation in human corpus cavernosum smooth muscle: Implications to erectile physiology and dysfunction