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Volumn 2, Issue 11, 2011, Pages 2232-2235

Synthesis of natural-product-like scaffolds in unprecedented efficiency via a 12-fold branching pathway

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Indexed keywords

TANDEM REACTION;

EID: 81355139618     PISSN: 20416520     EISSN: 20416539     Source Type: Journal    
DOI: 10.1039/c1sc00371b     Document Type: Article
Times cited : (56)

References (27)
  • 13
    • 37549020046 scopus 로고    scopus 로고
    • The phrase "Lead-Oriented Synthesis" was used by Drs Ian Churcher and Alan Nadin at the GSK Novel Synthetic Methods Symposium, GSK Stevenage, 24-25 May 2010. To the authors' knowledge, this is its first use
    • T. E. Nielsen S. L. Schreiber Angew. Chem., Int. Ed. 2008 47 48 56
    • (2008) Angew. Chem., Int. Ed. , vol.47 , pp. 48-56
    • Nielsen, T.E.1    Schreiber, S.L.2
  • 27
    • 0037136021 scopus 로고    scopus 로고
    • Itoh et al. 27 also found compounds with silyl groups gave the highest activity in their THP-1 assays. This may be down to better cell membrane permeation of these more lipophilic compounds, although the inactivity of 18 in the A549 cell lines rules out any generic cytotoxicity effect associated with lipophilic molecules
    • M. Itoh J. Kuwahara K. Itoh Y. Fukuka M. Kohya M. Shindo K. Shishido Bioorg. Med. Chem. Lett. 2002 12 2069
    • (2002) Bioorg. Med. Chem. Lett. , vol.12 , pp. 2069
    • Itoh, M.1    Kuwahara, J.2    Itoh, K.3    Fukuka, Y.4    Kohya, M.5    Shindo, M.6    Shishido, K.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.