Fabrication of dendrimers toward biological application

Progress in Molecular Biology and Translational Science

Volumn 104, Issue , 2011, Pages 101-140

  Tsai, Hsieh Chih ^a   Imae, Toyoko ^a  

^a NATIONAL TAIWAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Taiwan)

Author keywords

Biocompatibility; Boron neutron therapy; Cancer targeting; Chemical load; Dendrimer; Doping; Drug delivery; Fluorescence imaging; Gene therapy; Magnetic resonance imaging; Photodynamic therapy; Targeting delivery; Toxicity; X ray imaging

Indexed keywords

EID: 81255179303     PISSN: 18771173     EISSN: None     Source Type: Book Series    
DOI: 10.1016/B978-0-12-416020-0.00003-6     Document Type: Chapter

References (142)

1. J.J. Lundquist, and E.J. Toone The cluster glycoside effect Chem Rev 102 2002 555 578 (Pubitemid 35377623)
2. S. Andre, P.J.C. Ortega, M.A. Perez, R. Roy, and H.J. Gabius Lactose containing starbust dendrimers: influence of dendrimer generation and binding site orientation of receptor (plant/animal lectins and immunoglobulins) on binding properties Glycobiology 9 1999 1253 1261
3. H.T. Chen, M.F. Neerman, A.R. Parrish, and E.E. Simanek Cytotoxicity, hemolysis, and acute in vivo toxicity of dendrimers based on melamine, candidate vehicles for drug delivery J Am Chem Soc 126 2004 10044 10048 (Pubitemid 39079425)
4. K. Rittner, A. Benavente, A. Bompard-Sorlet, F. Heitz, G. Divita, and R. Brasseur New basic membrane-destabilizing peptides for plasmid-based gene delivery in vitro and in vivo Mol Ther 5 2002 104 114 (Pubitemid 34144826)
5. S.P. Hong, A.U. Bielinska, A. Mecke, B. Keszler, J.L. Beals, and X.Y. Shi Interaction of poly(amidoamine) dendrimers with supported lipid bilayers and cells: hole formation and the relation to transport Bioconjug Chem 15 2004 774 782 (Pubitemid 38981951)
6. N.A. Stasko, C.B. Johnson, M.H. Schoenfisch, T.A. Johnson, and E.L. Holmuhamedov Cytotoxicity of polypropylenimine dendrimer conjugates on cultured endothelial cells Biomacromolecules 8 2007 3853 3859
7. N. Malik, R. Wiwattanapatapee, R. Klopsch, K. Lorenz, H. Frey, and J.W. Weener Dendrimers: relationship between structure and biocompatibility in vitro, and preliminary studies on the biodistribution of I-125-labelled poly(amidoamine) dendrimers in vivo J Control Release 65 2000 133 148 (Pubitemid 30122922)
8. S. Parimi, T.J. Barnes, D.F. Callen, and C.A. Prestidge Mechanistic insight into cell growth, internalization, and cytotoxicity of PAMAM dendrimers Biomacromolecules 11 2010 382 389
9. R. Jevprasesphant, J. Penny, R. Jalal, D. Attwood, N.B. McKeown, and A. D'Emanuele The influence of surface modification on the cytotoxicity of PAMAM dendrimers Int J Pharm 252 2003 263 266 (Pubitemid 36126635)
10. M. El-Sayed, M. Ginski, C. Rhodes, and H. Ghandehari Transepithelial transport of poly(amidoamine) dendrimers across Caco-2 cell monolayers J Control Release 81 2002 355 365 (Pubitemid 34607155)
11. D. Fischer, Y. Li, B. Ahlemeyer, J. Krieglstein, and T. Kissel In vitro cytotoxicity testing of polycations: influence of polymer structure on cell viability and hemolysis Biomaterials 24 2003 1121 1131 (Pubitemid 36069121)
12. B.H. Zinselmeyer, S.P. Mackay, A.G. Schatzlein, and I.F. Uchegbu The lower-generation polypropylenimine dendrimers are effective gene-transfer agents Pharm Res 19 2002 960 967 (Pubitemid 34808705)
13. N. Bourne, L.R. Stanberry, E.R. Kern, G. Holan, B. Matthews, and D.I. Bernstein Dendrimers, a new class of candidate topical microbicides with activity against Herpes simplex virus infection Antimicrob Agents Chemother 44 2000 2471 2474 (Pubitemid 30650897)
14. J.C. Roberts, M.K. Bhalgat, and R.T. Zera Preliminary biological evaluation of poly(amidoamine) (PAMAM) starburst dendrimers J Biomed Mater Res 30 1996 53 65
15. O.L. Padilla De Jesús, H.R. Ihre, L. Gagne, J.M.J. Fréchet, and F.C. Szoka Jr. Polyester dendritic systems for drug delivery applications: in vitro and in vivo evaluation Bioconjug Chem 13 2002 453 461 (Pubitemid 34535938)
16. P. Agrawal, U. Gupta, and N.K. Jain Glycoconjugated peptide dendrimers-based nanoparticulate system for the delivery of chloroquine phosphate Biomaterials 28 2007 3349 3359 (Pubitemid 46693974)
17. A. Asthana, A.S. Chauhan, P. Diwan, and N.K. Jain Poly(amidoamine) (PAMAM) dendritic nanostructures for controlled site-specific delivery of acidic anti-inflammatory active ingredient AAPS Pharm Sci Technol 6 2005 E536 E542
18. D. Bhadra, S. Bhadra, S. Jain, and N.K. Jain A PEGylated dendritic nanoparticulate carrier of fluorouracil Int J Pharm 257 2003 111 124 (Pubitemid 36507038)
19. H.B. Agashe, T.D. Dutta, M. Garg, and N.K. Jain Investigations on the toxicological profile of functionalized fifth-generation poly (propylene imine) dendrimer J Pharm Pharmacol 58 2006 1491 1498 (Pubitemid 44785538)
20. M.A. Carnahan, and M.W. Grinstaff Synthesis and characterization of polyether-ester dendrimers from glycerol and lactic acid J Am Chem Soc 123 2001 2905 2906 (Pubitemid 32910726)
21. R.S. Dhanikula, and P. Hildgen Conformation and distribution of groups on the surface of amphiphilic polyether-co-polyester dendrimers: effect of molecular architecture J Colloid Interface Sci 311 2007 52 58 (Pubitemid 46671379)
22. Y. Hirayama, T. Nakamura, S. Uehara, Y. Sakamoto, K. Yamaguchi, and Y. Sei Synthesis and characterization of polyester dendrimers from acetoacetate and acrylate Org Lett 7 2005 525 528 (Pubitemid 40353433)
23. A. Agrawal, A. Asthana, U. Gupta, and N.K. Jain Tumor and dendrimers: a review on drug delivery aspects J Pharm Pharmacol 60 2008 671 688 (Pubitemid 351702440)
24. K.W. Wegmann, C.R. Wagner, R.H. Whitham, and D.J. Hinrichs Synthetic peptide dendrimers block the development and expression of experimental allergic encephalomyelitis J Immunol 181 2008 3301 3309
25. C. Cubillos, B.G. De la Torre, A. Jakab, G. Clementi, E. Borras, and J. Barcena Enhanced mucosal immunoglobulin A response and solid protection against foot-and-mouth disease virus challenge induced by a novel dendrimeric peptide J Virol 82 2008 7223 7230 (Pubitemid 351977739)
26. J. Shao, and J.P. Tam Unprotected peptides as building blocks for the synthesis of peptide dendrimers with oxime, hydrazone, and thiazolidine linkages J Am Chem Soc 117 1995 3893 3899
27. S.D. Konda, M. Aref, S. Wang, M. Brechbiel, and E.C. Wiener Specific targeting of folate dendrimer MRI contrast agents to the high affinity folate receptor expressed in ovarian tumor xenografts Magn Reson Mater Phys Biol Med 12 2001 104 113 (Pubitemid 32510128)
28. D. Bhadra, A.K. Yadav, S. Bhadra, and N.K. Jain Glycodendrimeric nanoparticulate carriers of primaquine phosphate for liver targeting Int J Pharm 295 2005 221 233 (Pubitemid 40558805)
29. V. Gajbhiye, P.V. Kumar, R.K. Tekade, and N.K. Jain PEGylated PPI dendritic architectures for sustained delivery of H2 receptor antagonist Eur J Med Chem 44 2009 1155 1166
30. A. Agrawal, U. Gupta, A. Asthana, and N.K. Jain Dextran conjugated dendritic nanoconstructs as potential vectors for anti-cancer agent Biomaterials 30 2009 3588 3596
31. J.F. Kukowska-Latallo, K.A. Candido, Z. Cao, S.S. Nigavekar, I.J. Majoros, and T.P. Thomas Nanoparticle targeting of anticancer drug improves therapeutic response in animal model of human epithelial cancer Cancer Res 65 2005 5317 5324 (Pubitemid 40827344)
32. R.B. Kolhatkar, K.M. Kitchens, P.W. Swaan, and H. Ghandehari Surface acetylation of polyamidoamine (PAMAM) dendrimers decreases cytotoxicity while maintaining membrane permeability Bioconjug Chem 18 2007 2054 2060 (Pubitemid 350220008)
33. V. Gajbhiye, P.V. Kumar, R.K. Tekade, and N.K. Jain Pharmaceutical and biomedical potential of PEGylated dendrimers Curr Pharm Des 13 2007 415 429 (Pubitemid 46477762)
34. C. Dufes, I.F. Uchegbu, and A.G. Schatzlein Dendrimers in gene delivery Adv Drug Deliv Rev 57 2005 2177 2202 (Pubitemid 41759392)
35. T. Okuda, S. Kawakami, N. Akimoto, T. Niidome, F. Yamashita, and M. Hashida PEGylated lysine dendrimers for tumor-selective targeting after intravenous injection in tumor-bearing mice J Control Release 116 2006 330 336 (Pubitemid 44827409)
36. M.T. Morgan, Y. Nakanishi, D.J. Kroll, A.P. Griset, M.A. Carnahan, and M. Wathier Dendrimer encapsulated camptothecins: increased solubility, cellular uptake, and cellular retention afford enhanced anticancer activity in vitro Cancer Res 66 2006 11913 11921 (Pubitemid 46094204)
37. M.B. Steffensen, E. Hollink, F. Kuschel, M. Bauer, and E.E. Simanek Dendrimers based on [1,3,5]-triazines J Polym Sci A Polym Chem 44 2006 3411 3433 (Pubitemid 43836060)
38. A. Chouai, and E.E. Simanek Kilogram-scale synthesis of a second-generation dendrimer based on 1,3,5-triazine using green and industrially compatible methods with a single chromatographic step J Org Chem 73 2008 2357 2366 (Pubitemid 351497766)
39. L.J. Twyman, A.E. Beezer, R. Esfand, M.J. Hardy, and J.C. Mitchell The synthesis of water-soluble dendrimers, and their application as possible drug delivery systems Tetrahedron Lett 40 1999 1743 1746 (Pubitemid 29087289)
40. A.E. Beezer, A.S.H. King, I.K. Martin, J.C. Mitchel, L.J. Twyman, and C.F. Wain Dendrimers as potential drug carriers; encapsulation of acidic hydrophobes within water soluble PAMAM derivatives Tetrahedron 59 2003 3873 3880 (Pubitemid 36577607)
41. P. Kolhe, E. Misra, R.M. Kannan, S. Kannan, and M. Lieh-Lai Drug complexation, in vitro release and cellular entry of dendrimers and hyper-branched polymers Int J Pharm 259 2003 143 160 (Pubitemid 36638561)
42. Y. Cheng, and T. Xu Dendrimers as potential drug carriers. Part I. Solubilization of non-steroidal anti-inflammatory drugs in the presence of polyamidoamine dendrimers Eur J Med Chem 40 2005 1188 1192
43. S. Kannan, P. Kolhe, V. Raykova, M. Glibatec, R.M. Kannan, and M. Lieh-Lai Dynamics of cellular entry and drug delivery by dendritic polymers into human lung epithelial carcinoma cells J Biomater Sci Polym Ed 15 2004 311 330 (Pubitemid 38477061)
44. Y. Cheng, T. Xu, and R. Fu Polyamidoamine dendrimers used as solubility enhancers of ketoprofen Eur J Med Chem 40 2005 1390 1393
45. N. Man, Y. Cheng, T. Xu, Y. Ding, X. Wang, and Z. Li Dendrimers as potential drug carriers. Part II. Prolonged delivery of ketoprofen by in vitro and in vivo studies Eur J Med Chem 41 2006 670 674
46. J. Recker, D.J. Tomcik, and J.R. Parquette Folding dendrons: the development of solvent-, temperature-, and generation-dependent chiral conformational order in intramolecularly hydrogen-bonded dendrons J Am Chem Soc 122 2000 10298 10307
47. U. Boas, A.J. Karlsson, B.F.M. de Waal, and E.W. Meijer Synthesis and properties of new thiourea-functionalized poly(propylene imine) dendrimers and their role as hosts for urea functionalized guests J Org Chem 66 2001 2136 2145 (Pubitemid 32867347)
48. K. Funayama, T. Imae, K. Aoi, K. Tsutsumiuchi, M. Okada, and M. Furusaka Small-angle neutron scattering investigations of layer-block dendrimers in aqueous solutions J Phys Chem B 107 2003 1532 1539
49. K. Funayama, T. Imae, H. Seto, K. Aoi, K. Tsutsumiuchi, and M. Okada Fast and slow dynamics of water-soluble dendrimers consisting of amido-amine repeating units by neutron spin echo J Phys Chem B 107 2003 1353 1359
50. D. Kannaiyan, and T. Imae pH dependent encapsulation of pyrene in PPI-core: PAMAM-shell dendrimers Langmuir 25 2009 5282 5285
51. R. Esfand, and D.A. Tomalia Poly(amidoamine) (PAMAM) dendrimers: from biomimicry to drug delivery and biomedical applications Drug Discov Today 6 2001 427 436 (Pubitemid 32328297)
52. T. Ooya, J. Lee, and K. Park Effects of ethylene glycol-based graft, star-shaped, and dendritic polymers on solubilization and controlled release of paclitaxel J Control Release 93 2003 121 127 (Pubitemid 37421354)
53. D. Leisner, and T. Imae Polyelectrolyte behavior of an interpolyelectrolyte complex formed in aqueous solution of a charged dendrimer and sodium poly(l-glutamate) J Phys Chem B 107 2003 13158 13167
54. K. Tamano, and T. Imae Investigation of luminescent poly(propylene imine) dendrimer J Nanosci Nanotechnol 9 2008 4329 4334
55. Q. Zheng, and C.Y. Pan Preparation and characterization of dendrimer- star PNIPAAM using dithiobenzoate-terminated PPI dendrimer via RAFT polymerization Eur Polym J 42 2006 807 814 (Pubitemid 43344422)
56. S. Gurdag, J. Khandare, S. Stapels, L.H. Matherly, and R.M. Kannan Activity of dendrimer-methotrexate conjugates on methotrexate-sensitive and -resistant cell lines Bioconjug Chem 17 2006 275 283
57. C.C. Lee, E.R. Gillies, M.E. Fox, S.J. Guillaudeu, J.M. Fréchet, and E.E. Dy A single dose of doxorubicin-functionalized bow-tie dendrimer cures mice bearing C-26 colon carcinomas Proc Natl Acad Sci USA 103 2006 16649 16654 (Pubitemid 44737307)
58. P. Kolhe, J. Khandare, O. Pillai, S. Kannan, M. Lieh-Lai, and R.M. Kannan Preparation, cellular transport, and activity of polyamidoamine based dendritic nanodevices with a high drug payload Biomaterials 27 2006 660 669 (Pubitemid 41464262)
59. K. Kono, C. Kojima, N. Hayashi, E. Nishisaka, K. Kiura, and S. Watarai Preparation and cytotoxic activity of poly(ethylene glycol)- modified poly(amidoamine) dendrimers bearing adriamycin Biomaterials 29 2008 1664 1675
60. M. Najlah, S. Freeman, D. Attwood, and A. D'Emanuele Synthesis, characterization and stability of dendrimer prodrugs Int J Pharm 308 2006 175 182 (Pubitemid 43097250)
61. M. Najlah, S. Freeman, D. Attwood, and A. D'Emanuele In vitro evaluation of dendrimer prodrugs for oral drug delivery Int J Pharm 336 2007 183 190 (Pubitemid 46551566)
62. Y.E. Kurtoglu, M.K. Mishra, S. Kannan, and R.M. Kannan Drug release characteristics of PAMAM dendrimer-drug conjugates with different linkers Int J Pharm 384 2010 189 194
63. R. Duncan The dawning era of polymer therapeutics Nat Rev Drug Discov 2 2003 347 360 (Pubitemid 37361705)
64. S. Hong, P.R. Leroueil, I.J. Majoros, B.G. Orr, J.R. Baker Jr., and M.M. Banaszak Holl The binding avidity of a nanoparticle-based multivalent targeted drug delivery platform Chem Biol 14 2007 107 115 (Pubitemid 46124068)
65. D. Chandrasekar, R. Sistla, F.J. Ahmad, R.K. Khar, and P.V. Diwan The development of folate-PAMAM dendrimer conjugates for targeted delivery of anti-arthritic drugs and their pharmacokinetics and biodistribution in arthritic rats Biomaterials 28 2007 504 512 (Pubitemid 44602223)
66. A.K. Patri, A. Myc, J. Beals, T.P. Thomas, N.H. Bander, and J.R. Baker Jr. Synthesis and in vitro testing of J591 antibody-dendrimer conjugates for targeted prostate cancer therapy Bioconjug Chem 15 2004 1174 1181 (Pubitemid 39552005)
67. R. Shukla, T.P. Thomas, J.L. Peters, A.M. Desai, J. Kukowska-Latallo, and A.K. Patri HER2 specific tumor targeting with dendrimer conjugated anti-HER2 mAb Bioconjug Chem 17 2006 1109 1115 (Pubitemid 44455317)
68. C. Wangler, G. Moldenhauer, M. Eisenhut, U. Haberkorn, and W. Mier Antibody-dendrimer conjugates: the number, not the size of the dendrimers, determines the immunoreactivity Bioconjug Chem 19 2008 813 820 (Pubitemid 351614537)
69. E.K. Woller, and M.J. Cloninger Mannose functionalization of a sixth generation dendrimer Biomacromolecules 2 2001 1052 1054 (Pubitemid 32894668)
70. R. Roy, and M.G. Baek Glycodendrimers: novel glycotope isosteres unmasking sugar coding. Case study with T-antigen markers from breast cancer MUC1 glycoprotein J Biotechnol 90 2002 291 309 (Pubitemid 34179578)
71. D. Lagnoux, T. Darbre, M.L. Schmitz, and J.L. Reymond Inhibition of mitosis by glycopeptide dendrimer conjugates of colchicines Chemistry 11 2005 3941 3950 (Pubitemid 40891173)
72. H.J. Gabius, C. Schroter, S. Gabius, U. Brinck, and L.F. Tietze Binding of T-antigen-bearing neoglycoprotein and peanut agglutinin to cultured tumor cells and breast carcinomas J Histochem Cytochem 38 1990 1625 1631 (Pubitemid 20346973)
73. A.H. Soloway, W. Tjarks, B.A. Barnum, F.G. Rong, R.F. Barth, and I.M. Codogni The chemistry of neutron capture therapy Chem Rev 98 1998 1515 1562 (Pubitemid 128635962)
74. M.F. Hawthorne, and A. Maderna Applications of radiolabeled boron clusters to the diagnosis and treatment of cancer Chem Rev 99 1999 3421 3434 (Pubitemid 129589124)
75. R.F. Barth, D.M. Adams, A.H. Soloway, F. Alam, and M.W. Darby Boronated starburst dendrimer-monoclonal antibody immunoconjugates: evaluation as a potential delivery system for neutron capture therapy Bioconjug Chem 5 1994 58 66 (Pubitemid 2043885)
76. J. Capala, R.F. Barth, M. Bendayan, M. Lauzon, D.M. Adams, and A.H. Soloway Boronated epidermal growth factor as a potential targeting agent for boron neutron capture therapy of brain tumors Bioconjug Chem 7 1996 7 15
77. G. Wu, R.F. Barth, W. Yang, M. Chatterjee, W. Tjarks, and M.J. Ciesielski Site-specific conjugation of boron-containing dendrimers to anti-EGF receptor monoclonal antibody cetuximab (IMC-C225) and its evaluation as a potential delivery agent for neutron capture therapy Bioconjug Chem 15 2004 185 194 (Pubitemid 38165994)
78. R.F. Barth, G. Wu, W. Yang, P.J. Binns, K.J. Reley, and H. Patel Neutron capture therapy of epidermal growth factor (+) gliomas using boronated cetuximab (IMC-C225) as a delivery agent Appl Radiat Isot 61 2004 899 903 (Pubitemid 39092637)
79. R. Ackroyd, C. Kelty, N. Brown, and M. Reed The history of photodetection and photodynamic therapy Photochem Photobiol 74 2001 656 669
80. M. Najlah, and A. D'Emanuele Synthesis of dendrimers and drug-dendrimer conjugates for drug delivery Curr Opin Drug Discov 10 2007 756 767 (Pubitemid 350076396)
81. S. Battah, C.E. Chee, H. Nakanishi, S. Gerscher, A.J. Macrobert, and C. Edwards Synthesis and biological studies of 5-aminolevulinic acid-containing dendrimers for photodynamic therapy Bioconjug Chem 12 2001 980 988 (Pubitemid 33136868)
82. G.M. Di Venosa, A.G. Casas, S. Battah, P. Dobbin, H. Fukuda, and A.J. Macrobert Investigation of a novel dendritic derivative of 5- aminolaevulinic acid for photodynamic therapy Int J Biochem Cell Biol 38 2006 82 91 (Pubitemid 41540719)
83. S. Battah, S. O'Neill, C. Edwards, S. Balaratnam, P. Dobbin, and A.J. MacRobert Enhanced porphyrin accumulation using dendritic derivatives of 5-aminolaevulinic acid for photodynamic therapy: an in vitro study Int J Biochem Cell Biol 38 2006 1382 1392 (Pubitemid 44287842)
84. S. Battah, S. Balaratnam, A. Casas, S. O'Neill, C. Edwards, and A. Batlle Macromolecular delivery of 5-aminolaevulinic acid for photodynamic therapy using dendrimer conjugates Mol Cancer Ther 6 2007 876 885 (Pubitemid 46554557)
85. S.A. Gerhardt, J.W. Lewis, D.S. Kliger, J.Z. Zhang, and U. Simonis Effect of micelles on oxygen-quenching processes of triplet-state parasubstituted tetraphenylporphyrin photosensitizers J Phys Chem A 107 2003 2763 2767
86. G.D. Zhang, A. Harada, N. Nishiyama, D.L. Jiang, H. Koyama, and T. Aida Polyion complex micelles entrapping cationic dendrimer porphyrin: effective photosensitizer for photodynamic therapy of cancer J Control Release 93 2003 141 150 (Pubitemid 37421356)
87. Y. Matsumura, and H. Maeda A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs Cancer Res 46 1986 6387 6392 (Pubitemid 17221789)
88. L.R. Hirsch, A.M. Gobin, A.R. Lowery, F. Tam, R.A. Drezek, and N.J. Halas Metal nanoshells Ann Biomed Eng 34 2006 15 22
89. X. Shi, S. Wang, S. Meshinchi, M.E. Van Antwerp, X. Bi, and I. Lee Dendrimer-entrapped gold nanoparticles as a platform for cancer-cell targeting and imaging Small 3 2007 1245 1252 (Pubitemid 47114383)
90. Y. Haba, C. Kojima, A. Harada, T. Ura, H. Horinaka, and K. Kono Preparation of poly(ethylene glycol)-modified poly(amido amine) dendrimers encapsulating gold nanoparticles and their heat-generating ability Langmuir 23 2007 5243 5246 (Pubitemid 46826461)
91. S.M. Elbashir, J. Harborth, W. Lendeckel, A. Yalcin, K. Weber, and T. Tuschl Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells Nature 411 2001 494 498 (Pubitemid 32494397)
92. A. Fire, S. Xu, M.K. Montgomery, S.A. Kostas, S.E. Driver, and C.C. Mello Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans Nature 391 1998 806 811 (Pubitemid 28099681)
93. R.J. Cristiano, B. Xu, D. Nguyen, G. Schumacher, M. Kataoka, and F.R. Spitz Viral and nonviral gene delivery vectors for cancer gene therapy Cancer Detect Prev 22 1998 445 454 (Pubitemid 28395562)
94. H. Ma, and S.L. Diamond Nonviral gene therapy and its delivery systems Curr Pharm Biotechnol 2 2001 1 17 (Pubitemid 32416443)
95. N.D. Sonawane, F.C. Szoka Jr., and A.S. Verkman Chloride accumulation and swelling in endosomes enhances DNA transfer by polyamine-DNA polyplexes J Biol Chem 278 2003 44826 44831 (Pubitemid 37377241)
96. A. Mitra, and T. Imae Nanogel formation consisting of dna and poly(amido amine) dendrimer studied by static light scattering and atomic force microscopy Biomacromolecules 5 2004 69 73 (Pubitemid 38181314)
97. C.S. Braun, J.A. Vetro, D.A. Tomalia, G.S. Koe, J.G. Koe, and C.R. Middaugh Structure/function relationships of polyamidoamine/DNA dendrimers as gene delivery vehicles J Pharm Sci 94 2005 423 436 (Pubitemid 40293337)
98. J.F. Kukowska-Latallo, A.U. Bielinska, J. Johnson, R. Spindler, D.A. Tomalia, and J.R. Baker Jr. Efficient transfer of genetic material into mammalian cells using Starburst polyamidoamine dendrimers Proc Natl Acad Sci USA 93 1996 4897 4902 (Pubitemid 26163501)
99. Y. Wang, W. Kong, Y. Song, Y. Duan, L. Wang, and G. Steinhoff Polyamidoamine dendrimers with a modified pentaerythritol core having high efficiency and low cytotoxicity as gene carriers Biomacromolecules 10 2009 617 622
100. D.M. Morgan, V.L. Larvin, and J.D. Pearson Biochemical characterisation of polycation-induced cytotoxicity to human vascular endothelial cells J Cell Sci 94 1989 553 559 (Pubitemid 20002853)
101. H. Arima, and K. Motoyama Recent findings concerning PAMAM dendrimer conjugates with cyclodextrins as carriers of DNA and RNA Sensor 29 2009 6346 6361
102. T. Tsutsumi, F. Hirayama, K. Uekama, and H. Arima Evaluation of polyamidoamine dendrimer/cyclodextrin conjugate (generation 3, G3) as a novel carrier for small interfering RNA (siRNA) J Control Release 119 2007 349 359 (Pubitemid 46770884)
103. T. Tsutsumi, F. Hirayama, K. Uekama, and H. Arima Potential use of polyamidoamine dendrimer/-cyclodextrin conjugate (generation 3, G3) as a novel carrier for short hairpin RNA expressing plasmid DNA J Pharm Sci 97 2008 3022 3034
104. J.S. Choi, K. Nam, J.-Y. Park, J.-B. Kim, J.-K. Lee, and J.-S. Park Enhanced transfection efficiency of PAMAM dendrimer by surface modification with L-arginine J Control Release 99 2004 445 456 (Pubitemid 39296913)
105. H.Y. Nam, K. Nam, H.J. Hahn, B.H. Kim, H.J. Lim, and H.J. Kim Biodegradable PAMAM ester for enhanced transfection efficiency with low cytotoxicity Biomaterials 30 2009 665 673
106. T.-I. Kim, C.Z. Bai, K. Nam, and J.-S. Park Comparison between arginine conjugated PAMAM dendrimers with structural diversity for gene delivery systems J Control Release 136 2009 132 139
107. K.S. Kim, Y. Lei, D.B. Stolz, and D. Liu Bifunctional compounds for targeted hepatic gene delivery Gene Ther 14 2007 704 708 (Pubitemid 46585631)
108. O. Taratula, O.B. Garbuzenko, P. Kirkpatrick, I. Pandya, R. Savla, and V.P. Pozharov Surface-engineered targeted PPI dendrimer for efficient intracellular and intratumoral siRNA delivery J Control Release 140 2009 284 293
109. N. Nishiyama, A. Iriyama, W.D. Jang, K. Miyata, K. Itaka, and Y. Inoue Light-induced gene transfer from packaged DNA enveloped in a dendrimeric photosensitizer Nat Mater 4 2005 934 941
110. M.J. Shieh, C.L. Peng, P.J. Lou, C.H. Chiu, T.Y. Tsai, and C.Y. Hsu Non-toxic phototriggered gene transfection by PAMAM-porphyrin conjugates J Control Release 129 2008 200 206
111. M. Albrecht, R.A. Gossage, M. Lutz, A.L. Spek, and G. van Koten Diagnostic organometallic and metallodendritic materials for SO2 gas detection: reversible binding of sulfur dioxide to arylplatinum(II) complexes Chem Eur J 6 2000 1431 1445
112. M.C. Daniel, J. Ruiz, S. Nlate, J.C. Blais, and D. Astruc Nanoscopic assemblies between supramolecular redox active metallodendrons and gold nanoparticles: synthesis, characterization, and selective recognition of H2PO4-, HSO4-, and adenosine-5′-triphosphate (ATP2-) anions J Am Chem Soc 125 2003 2617 2628 (Pubitemid 36519110)
113. R.L. Stears, R.C. Getts, and S.R. Gullans A novel, sensitive detection system for high-density microarrays using dendrimer technology Physiol Genomics 3 2000 93 99
114. J. Wang, M. Jiang, T.W. Nilsen, and R.C. Getts Dendritic nucleic acid probes for DNA biosensors J Am Chem Soc 120 1998 8281 8282 (Pubitemid 28417656)
115. O. Finikova, A. Galkin, V. Rozhkov, M. Cordero, C. Haegerhaell, and S. Vino-gradov Porphyrin and tetrabenzoporphyrin dendrimers: tunable membrane-impermeable fluorescent pH nanosensors J Am Chem Soc 25 2003 4882 4893 (Pubitemid 36505381)
116. I.B. Rietveld, E. Kim, and S.A. Vinogradov Dendrimers with tetrabenzoporphyrin cores: near infrared phosphors for in vivo oxygen imaging Tetrahedron Lett 59 2003 3821 3831 (Pubitemid 36577603)
117. B. Alonso, P.G. Armada, J. Losada, I. Cuadrado, B. González, and C.M. Casado Amperometric enzyme electrodes for aerobic and anaerobic glucose monitoring prepared by glucose oxidase immobilized in mixed ferrocene- cobaltocenium dendrimers Biosens Bioelectron 19 2004 1617 1625 (Pubitemid 38655965)
118. M.P.G. Armada, J. Losada, M. Zamora, B. Alonso, I. Cuadrado, and C.M. Casado Electrocatalytical properties of polymethylferrocenyl den drimers and their applications in biosensing Bioelectrochemistry 69 2006 65 73 (Pubitemid 44287612)
119. B. Klajnert, M. Sadowska, and M. Bryszewska The effect of polyamidoamine dendrimers on human erythrocyte membrane acetylcholinesterase activity Bioelectrochemistry 65 2004 23 26 (Pubitemid 39452506)
120. D. Shcharbin, M. Jokiel, B. Klajnert, and M. Bryszewska Effect of dendrimers on pure acetylcholinesterase activity and structure Bioelectrochemistry 68 2006 56 59 (Pubitemid 43052800)
121. T. Imae, T. Hirota, K. Funayama, K. Aoi, and M. Okada Binding of poly(amido amine) dendrimer to sodium hyaluronate in aqueous NaCl solution J Colloid Interface Sci 263 2003 306 311 (Pubitemid 36692839)
122. S. Stiriba, H. Frey, and R. Haag Dendritic polymers in biomedical applications: from potential to clinical use in diagnostics and therapy Angew Chem Int Ed 41 2002 1329 1334 (Pubitemid 34437413)
123. E.C. Wiener, M.W. Brechbiel, H. Brothers, R.L. Magin, O.A. Gansow, and D.A. Tomalia Dendrimer-based metal chelates: a new class of magnetic resonance imaging contrast agents Magn Reson Med 31 1994 1 8 (Pubitemid 24016935)
124. D.A. Tomalia, L.A. Reyna, and S. Svenson Dendrimers as multi-purpose nanodevices for oncology drug delivery and diagnostic imaging Biochem Soc Trans 35 2007 61 67
125. E.C. Wiener, F.P. Auteri, J.W. Chen, M.W. Brechbiel, O.A. Gansow, and D.S. Schneider Molecular dynamics of ion-chelate complexes attached to dendrimers J Am Chem Soc 118 1996 7774 7782 (Pubitemid 26285129)
126. H. Kobayashi, S. Kawamoto, S.-K. Jo, H.L. Bryant Jr., M.W. Brechbiel, and R.A. Star Macromolecular MRI contrast agents with small dendrimers: pharmacokinetic differences between sizes and cores Bioconjug Chem 14 2003 388 394 (Pubitemid 36348662)
127. S. Langereis, Q.G. de Lussanet, M.H.P. van Genderen, W.H. Backes, and E.W. Meijer Multivalent contrast agents based on gadolinium- diethylenetriaminepentaacetic acid-terminated poly(propylene imine) dendrimers for magnetic resonance imaging Macromolecules 37 2004 3084 3091
128. C.U. Herborn, J. Barkhausen, I. Paetsch, P. Hunold, M. Mahler, and K. Shamsi Coronary arteries: contrast-enhanced MR imaging with SH L 643A - experience in 12 volunteers Radiology 229 2003 217 223 (Pubitemid 37152127)
129. G.M. Nicolle, E. Toth, H. Schmitt-Willich, B. Raduchel, and A.E. Merbach The impact of rigidity and water exchange on the relaxivity of a dendritic MRI contrast agent Chem Eur J 8 2002 1040 1048 (Pubitemid 34250981)
130. H. Schumann, B.C. Wassermann, S. Schutte, J. Velder, J. Velder, and Y. Aksu Synthesis and characterization of water-soluble tin-based metallodendrimers Organometallics 22 2003 2034 2041
131. W. Krause, N. Hackmann-Schlichter, F.K. Maier, and R. Muller Dendrimers in diagnostics Top Curr Chem 210 2000 261 308
132. Y. Fu, D.E. Nitecki, D. Maltby, G.H. Simon, K. Berejnoi, and H.J. Raatschen Dendritic iodinated contrast agents with PEG-cores for CT imaging: synthesis and preliminary characterization Bioconjug Chem 17 2006 1043 1056 (Pubitemid 44162625)
133. J.F. Hainfeld, D.N. Slatkin, T.M. Focella, and H.M. Smilowitz Gold nanoparticles: a new X-ray contrast agent Br J Radiol 79 2006 248 253
134. D. Kim, S. Park, J. Lee, Y. Jeong, and S. Jon Antibiofouling polymer-coated gold nanoparticles as a contrast agent for in vivo x-ray computed tomography imaging J Am Chem Soc 129 2007 7661 7665 (Pubitemid 46981930)
135. Q.Y. Cai, S.H. Kim, K.S. Choi, S.Y. Kim, S.J. Byun, and K.W. Kim Colloidal gold nanoparticles as a blood-pool contrast agent for X-ray computed tomography in mice Invest Radiol 42 2007 797 806 (Pubitemid 350126561)
136. C. Xu, G.A. Tung, and S. Sun Size and concentration effect of gold nanoparticles on X-ray attenuation as measured on computed tomography Chem Mater 20 2008 4167 4169
137. P.A. Jackson, W.N. Rahman, C.J. Wong, T. Ackerly, and M. Geso Potential dependent superiority of gold nanoparticles in comparison to iodinated contrast agents Eur J Radiol 75 2010 104 109
138. C. Kojima, U. Yasuhito, O. Mikako, A. Harada, M. Yasuhiro, and K. Kono X-ray computed tomography contrast agents prepared by seeded growth of gold nanoparticles in PEGylated dendrimer Nanotechnology 21 2010 1 6
139. R. Guo, H. Wang, C. Peng, M. Shen, L. Zheng, and G. Zhang Enhanced X-ray attenuation property of dendrimer-entrapped gold nanoparticles complexed with diatrizoic acid J Mater Chem 21 2011 5120 5127
140. M.C. Parrott, S.R. Benhabbour, C. Saab, J.A. Lemon, S. Parker, and J.F. Valliant Synthesis, radiolabeling, and bio-imaging of high-generation polyester dendrimers J Am Chem Soc 131 2009 2906 2916
141. A. Myc, I.J. Majoros, T.P. Thomas, and J.R. Baker Jr. Dendrimer-based targeted delivery of an apoptotic sensor in cancer cells Biomacromolecules 8 2007 13 18 (Pubitemid 46140467)
142. T.P. Thomas, M.T. Myaing, J.Y. Ye, K. Candido, A. Kotlyar, and J. Beals Detection and analysis of tumor fluorescence using a two-photon optical fiber probe Biophys J 86 2004 3959 3965 (Pubitemid 38780272)