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Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 24, 2011, Pages 7367-7372

2,6-Naphthyridines as potent and selective inhibitors of the novel protein kinase C isozymes

(14) Van Eis, Maurice J a Evenou, Jean Pierre a Floersheim, Philipp a Gaul, Christoph a Cowan Jacob, Sandra W a Monovich, Lauren b Rummel, Gabriele a Schuler, Walter a Stark, Wilhelm a Strauss, Andre a Matt, Anette Von a Vangrevelinghe, Eric a Wagner, Juergen a Soldermann, Nicolas a

a NOVARTIS PHARMA AG (Switzerland)

b NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH (United States)

Author keywords

2,6 Naphthyridines; Inhibitors; Isozyme specific; Protein Kinase C; T cell inhibition

Indexed keywords

2,6 NAPHTHYRIDINE DERIVATIVE; INTERLEUKIN 2; PROTEIN KINASE C DELTA; PROTEIN KINASE C EPSILON; PROTEIN KINASE C ETA; PROTEIN KINASE C INHIBITOR; PROTEIN KINASE C THETA; STAPHYLOCOCCUS ENTEROTOXIN B; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; ENZYME INHIBITION; IN VITRO STUDY; IN VIVO STUDY; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; RAT;

ADMINISTRATION, ORAL; ANIMALS; BINDING SITES; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; ENTEROTOXINS; INTERLEUKIN-2; ISOENZYMES; MICE; NAPHTHYRIDINES; PROTEIN KINASE C; PROTEIN KINASE INHIBITORS; PROTEIN STRUCTURE, TERTIARY; RATS; T-LYMPHOCYTES;

MUS; RATTUS; STAPHYLOCOCCUS AUREUS;

EID: 81255168493 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2011.10.025 Document Type: Article

Times cited : (26)

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