Epidermal proteases in the pathogenesis of rosacea

Journal of Investigative Dermatology Symposium Proceedings

Volumn 15, Issue 1, 2011, Pages 16-23

  Meyer Hoffert, Ulf ^a   Schröder, Jens Michael ^a  

^a UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

APROTININ; ASPARTIC ACID; CATHEPSIN D; CYSTATIN; CYSTEINE; DIPEPTIDYL PEPTIDASE I; KALLIKREIN; MATRIPTASE; PROSTASIN; PROTEINASE; PROTEINASE INHIBITOR; SERINE PROTEINASE INHIBITOR;

CANDIDA ALBICANS; CELL DIFFERENTIATION; CONFERENCE PAPER; DERMATOPHAGOIDES FARINAE; DERMATOPHAGOIDES PTERONYSSINUS; DESQUAMATION; ENZYME ACTIVITY; ENZYME SUBSTRATE; HOST RESISTANCE; HUMAN; KERATINOCYTE; NEUTROPHIL; NONHUMAN; PATHOGENESIS; PROTEIN CLEAVAGE; PSEUDOMONAS AERUGINOSA; ROSACEA; SKIN DEFECT; STAPHYLOCOCCUS EPIDERMIDIS; STREPTOCOCCUS PYOGENES;

EID: 80955123583     PISSN: 10870024     EISSN: 15291774     Source Type: Journal    
DOI: 10.1038/jidsymp.2011.2     Document Type: Conference Paper

References (61)

1. Alef T, Torres S, Hausser I et al. (2008) Ichthyosis, follicular atrophoderma, and hypotrichosis caused by mutations in ST14 is associated with impaired profilaggrin processing. J Invest Dermatol 129:862-9
2. Ashcroft GS, Lei K, Jin W et al. (2000) Secretory leukocyte protease inhibitor mediates non-redundant functions necessary for normal wound healing. Nat Med 6:1147-53
3. Borgono CA, Gavigan JA, Alves J et al. (2007) Defining the extended substrate specificity of kallikrein 1-related peptidases. Biol Chem 388:1215-25 (Pubitemid 350059617)
4. Brattsand M, Stefansson K, Hubiche T et al. (2009) SPINK9: a selective, skin-specific Kazal-type serine protease inhibitor. J Invest Dermatol 129:1656-65
5. Brinkmann V, Reichard U, Goosmann C et al. (2004) Neutrophil extracellular traps kill bacteria. Science 303:1532-5 (Pubitemid 38314426)
6. Bugge TH, List K, Szabo R (2007) Matriptase-dependent cell surface proteolysis in epithelial development and pathogenesis. Front Biosci 12:5060-70
7. Chavanas S, Bodemer C, Rochat A et al. (2000) Mutations in SPINK5, encoding a serine protease inhibitor, cause Netherton syndrome. Nat Genet 25:141-2 (Pubitemid 30394980)
8. Chen YW, Wang JK, Chou FP et al. (2010) Regulation of the matriptase-prostasin cell surface proteolytic cascade by hepatocyte growth factor activator inhibitor-1 during epidermal differentiation. J Biol Chem 285:31755-62
9. Crawford GH, Pelle MT, James WD (2004) Rosacea: I. Etiology, pathogenesis, and subtype classification. J Am Acad Dermatol 51:327-41 (Pubitemid 39178655)
10. Debela M, Goettig P, Magdolen V et al. (2007) Structural basis of the zinc inhibition of human tissue kallikrein 5. J Mol Biol 373:1017-31 (Pubitemid 47498441)
11. Demerjian M, Hachem JP, Tschachler E et al. (2008) Acute modulations in permeability barrier function regulate epidermal cornification: role of caspase-14 and the protease-activated receptor type 2. Am J Pathol 172:86-97 (Pubitemid 351186371)
12. Denecker G, Hoste E, Gilbert B et al. (2007) Caspase-14 protects against epidermal UVB photodamage and water loss. Nat Cell Biol 9:666-74 (Pubitemid 47214729)
13. Denecker G, Ovaere P, Vandenabeele P et al. (2008) Caspase-14 reveals its secrets. J Cell Biol 180:451-8 (Pubitemid 351240694)
14. Donnelly S, Dalton JP, Loukas A (2006) Proteases in helminth-and allergen-induced inflammatory responses. Chem Immunol Allergy 90:45-64 (Pubitemid 43265667)
15. Egberts F, Heinrich M, Jensen JM et al. (2004) Cathepsin D is involved in the regulation of transglutaminase 1 and epidermal differentiation. J Cell Sci 117:2295-307 (Pubitemid 38807497)
16. Eissa A, Amodeo V, Smith CR et al. (2011) Kallikrein-related peptidase-8 (KLK8) is an active serine protease in human epidermis and sweat and is involved in a skin barrier proteolytic cascade. J Biol Chem 286:687-706
17. Eissa A, Diamandis EP (2008) Human tissue kallikreins as promiscuous modulators of homeostatic skin barrier functions. Biol Chem 389:669-80 (Pubitemid 352009412)
18. Faurschou M, Borregaard N (2003) Neutrophil granules and secretory vesicles in inflammation. Microbes Infect 5:1317-27 (Pubitemid 37410245)
19. Hachem JP, Houben E, Crumrine D et al. (2006) Serine protease signaling of epidermal permeability barrier homeostasis. J Invest Dermatol 126:2074-86
20. Heilborn JD, Weber G, Gronberg A et al. (2010) Topical treatment with the vitamin D analogue calcipotriol enhances the upregulation of the antimicrobial protein hCAP18/LL-37 during wounding in human skin in vivo. Exp Dermatol 19:332-8
21. Horikoshi T, Igarashi S, Uchiwa H et al. (1999) Role of endogenous cathepsin D-like and chymotrypsin-like proteolysis in human epidermal desqua-mation. Br J Dermatol 141:453-9 (Pubitemid 29448405)
22. Ishida-Yamamoto A, Deraison C, Bonnart C et al. (2005) LEKTI is localized in lamellar granules, separated from KLK5 and KLK7, and is secreted in the extracellular spaces of the superficial stratum granulosum. J Invest Dermatol 124:360-6 (Pubitemid 40175883)
23. Ishida-Yamamoto A, Simon M, Kishibe M et al. (2004) Epidermal lamellar granules transport different cargoes as distinct aggregates. J Invest Dermatol 122:1137-44 (Pubitemid 38651088)
24. Kantyka T, Fischer J, Wu Z et al. (2011) Inhibition of kallikrein-related peptidases by the serine protease inhibitor of Kazal-type 6. Peptides 32:1187-92
25. Kato T, Takai T, Fujimura T et al. (2009) Mite serine protease activates protease-activated receptor-2 and induces cytokine release in human keratinocytes. Allergy 64:1366-74
26. Lee SE, Kim JM, Jeong SK et al. (2010) Protease-activated receptor-2 mediates the expression of inflammatory cytokines, antimicrobial peptides, and matrix metalloproteinases in keratinocytes in response to Propionibac-terium acnes. Arch Dermatol Res 302:745-56
27. Li C, Lasse S, Lee P et al. (2010) Development of atopic dermatitis-like skin disease from the chronic loss of epidermal caspase-8. Proc Natl Acad Sci USA 107:22249-54
28. Lundstrom A, Egelrud T (1988) Cell shedding from human plantar skin in vitro: evidence of its dependence on endogenous proteolysis. J Invest Dermatol 91:340-3
29. Lundwall A, Brattsand M (2008) Kallikrein-related peptidases. Cell Mol Life Sci 65:2019-38
30. Meyer-Hoffert U (2009a) Neutrophil-derived serine proteases modulate innate immune responses. Front Biosci 14:3409-18
31. Meyer-Hoffert U (2009b) Reddish, scaly, and itchy: how proteases and their inhibitors contribute to inflammatory skin diseases. Arch Immunol Ther Exp (Warsz) 57:345-54
32. Meyer-Hoffert U, Wiedow O (2011) Neutrophil serine proteases: mediators of innate immune responses. Curr Opin Hematol 18:19-24
33. Meyer-Hoffert U, Wu Z, Kantyka T et al. (2010) Isolation of SPINK6 in human skin: selective inhibitor of kallikrein-related peptidases. J Biol Chem 285:32174-81
34. Meyer-Hoffert U, Wu Z, Schroder JM (2009) Identification of lympho-epithelial Kazal-type inhibitor 2 in human skin as a kallikrein-related peptidase 5-specific protease inhibitor. PLoS One 4:e4372
35. Miller LS (2008) Toll-like receptors in skin. Adv Dermatol 24:71-87
36. Monk E, Shalita A, Siegel DM (2011) Clinical applications of non-antimicrobial tetracyclines in dermatology. Pharmacol Res 63:130-45
37. Naglik J, Albrecht A, Bader O et al. (2004) Candida albicans proteinases and host/pathogen interactions. Cell Microbiol 6:915-26 (Pubitemid 39255605)
38. Nakamura A, Mori Y, Hagiwara K et al. (2003) Increased susceptibility to LPS-induced endotoxin shock in secretory leukoprotease inhibitor (SLPI)-deficient mice. J Exp Med 197:669-74 (Pubitemid 36314661)
39. Netzel-Arnett S, Currie BM, Szabo R et al. (2006) Evidence for a matriptase-prostasin proteolytic cascade regulating terminal epidermal differentiation. J Biol Chem 281:32941-5 (Pubitemid 46036678)
40. Ovaere P, Lippens S, Vandenabeele P et al. (2009) The emerging roles of serine protease cascades in the epidermis. Trends Biochem Sci 34:453-63
41. Pham CT, Ivanovich JL, Raptis SZ et al. (2004) Papillon-Lefevre syndrome: correlating the molecular, cellular, and clinical consequences of cathepsin C/dipeptidyl peptidase I deficiency in humans. J Immunol 173:7277-81 (Pubitemid 39628164)
42. Pham CT, Ley TJ (1999) Dipeptidyl peptidase I is required for the processing and activation of granzymes A and B in vivo. Proc Natl Acad Sci USA 96:8627-32 (Pubitemid 29354842)
43. Potempa J, Pike RN (2009) Corruption of innate immunity by bacterial proteases. J Innate Immun 1:70-87
44. Rao NV, Rao GV, Hoidal JR (1997) Human dipeptidyl-peptidase I. Gene characterization, localization, and expression. J Biol Chem 272: 10260-5 (Pubitemid 27171707)
45. Sales KU, Masedunskas A, Bey AL et al. (2010) Matriptase initiates activation of epidermal pro-kallikrein and disease onset in a mouse model of Netherton syndrome. Nat Genet 42:676-83
46. Sandilands A, O'Regan GM, Liao H et al. (2006) Prevalent and rare mutations in the gene encoding filaggrin cause ichthyosis vulgaris and predispose individuals to atopic dermatitis. J Invest Dermatol 126:1770-5 (Pubitemid 44086511)
47. Schalkwijk J, Wiedow O, Hirose S (1999) The trappin gene family: proteins defined by an N-terminal transglutaminase substrate domain and a C-terminal four-disulphide core. Biochem J 340(Part 3):569-77 (Pubitemid 29312852)
48. Schroder JM (2010) Purification of antimicrobial peptides from human skin. Methods Mol Biol 618:15-30
49. Schroder JM (2011) Antimicrobial peptides in healthy skin and atopic dermatitis. Allergol Int 60:17-24
50. Steinhoff M, Buddenkotte J, Shpacovitch V et al. (2005) Proteinase-activated receptors: transducers of proteinase-mediated signaling in inflammation and immune response. Endocr Rev 26:1-43 (Pubitemid 40209385)
51. Steinhoff M, Corvera CU, Thoma MS et al. (1999) Proteinase-activated receptor-2 in human skin: tissue distribution and activation of keratinocytes by mast cell tryptase. Exp Dermatol 8:282-94 (Pubitemid 29370853)
52. Tseng IC, Xu H, Chou FP et al. (2010) Matriptase activation, an early cellular response to acidosis. J Biol Chem 285:3261-70
53. Voegeli R, Doppler S, Joller P et al. (2011) Increased mass levels of certain serine proteases in the stratum corneum in acute eczematous atopic skin. Int J Cosmet Sci (in press) doi:10.1111/j.1468-2494.2011.00671.x
54. Voegeli R, Rawlings AV, Breternitz M et al. (2009) Increased stratum corneum serine protease activity in acute eczematous atopic skin. Br J Dermatol 161:70-7
55. Wiedow O, Wiese F, Streit V et al. (1992) Lesional elastase activity in psoriasis, contact dermatitis, and atopic dermatitis. J Invest Dermatol 99:306-9
56. Wladyka B, Pustelny K (2008) Regulation of bacterial protease activity. Cell Mol Biol Lett 13:212-29
57. Yamasaki K, Di Nardo A, Bardan A et al. (2007) Increased serine protease activity and cathelicidin promotes skin inflammation in rosacea. Nat Med 13:975-80 (Pubitemid 47222043)
58. Yamasaki K, Gallo RL (2009) The molecular pathology of rosacea. J Dermatol Sci 55:77-81
59. Yamasaki K, Kanada K, Macleod DT et al. (2011) TLR2 expression is increased in rosacea and stimulates enhanced serine protease production by keratinocytes. J Invest Dermatol 131:688-97
60. Zeeuwen PL, Cheng T, Schalkwijk J (2009) The biology of cystatin M/E and its cognate target proteases. J Invest Dermatol 129:1327-38
61. Zhu J, Nathan C, Jin W et al. (2002) Conversion of proepithelin to epithelins: roles of SLPI and elastase in host defense and wound repair. Cell 111:867-78 (Pubitemid 36106407)