The effect of surface modification of adenovirus with an arginine-grafted bioreducible polymer on transduction efficiency and immunogenicity in cancer gene therapy

Biomaterials

Volumn 31, Issue 7, 2010, Pages 1865-1874

  Kim, Pyung Hwan ^a,b   Kim, Tae il ^c   Yockman, James W ^c   Kim, Sung Wan ^c,d   Yun, Chae Ok ^a,b  

^a Yonsei University   (South Korea)

^b Yonsei University College of Medicine   (South Korea)

^c UNIVERSITY OF UTAH   (United States)

^d Hanyang University   (South Korea)

Author keywords

Adenovirus; Arginine grafted bioreducible polymer; Cancer gene therapy; Electrostatic interaction; Hybrid vector

Indexed keywords

ADENOVIRAL VECTORS; BIOREDUCIBLE POLYMER; CANCER GENE THERAPY; CATIONIC POLYMERS; CLINICAL TRIAL; CYTOKINES; ELECTROSTATIC INTERACTIONS; GENE CARRIER; IMMUNOGENICITY; IN-CELL; INNATE IMMUNE RESPONSE; INTERLEUKIN-6; MACROPHAGE CELLS; NONVIRAL; PARTICLE RATIOS; SAFETY CONCERNS; SIDE EFFECT; SURFACE MODIFICATION; TRANSDUCTION EFFICIENCY; TRANSGENE EXPRESSION;

AMINO ACIDS; BACTERIOPHAGES; COMPLEXATION; ELECTROSTATIC SEPARATORS; ELECTROSTATICS; GENE THERAPY; GENE TRANSFER; GRAFTING (CHEMICAL); LIGHT TRANSMISSION; TRANSMISSION ELECTRON MICROSCOPY; VECTORS;

PLASTIC COATINGS;

ADENOVIRUS VECTOR; ARGININE; BIOPOLYMER; CATION; COXSACKIE VIRUS AND ADENOVIRUS RECEPTOR; CYTOKINE; INTERLEUKIN 6; POLYETHYLENEIMINE;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER GENE THERAPY; CANCER INHIBITION; CONTROLLED STUDY; CYTOKINE RELEASE; DRUG COATING; DRUG STRUCTURE; ELECTRICITY; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNOGENICITY; INNATE IMMUNITY; LIGHT SCATTERING; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ANALYSIS; SURFACE PROPERTY; TRANSGENE; TRANSMISSION ELECTRON MICROSCOPY; VIRAL GENE DELIVERY SYSTEM;

ADENOVIRIDAE; ANIMALS; ARGININE; CATIONS; CELL DEATH; CELL LINE; GENE THERAPY; HUMANS; IMMUNE EVASION; LIGHT; MICE; NEOPLASMS; POLYAMINES; POLYETHYLENEIMINE; RECEPTORS, VIRUS; REPRODUCIBILITY OF RESULTS; SCATTERING, RADIATION; SERUM; SURFACE PROPERTIES; TRANSDUCTION, GENETIC;

ADENOVIRIDAE; COXSACKIEVIRUS;

EID: 73249142676     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2009.11.043     Document Type: Article

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