A convenient synthesis and molecular modeling study of novel purine and pyrimidine derivatives as CDK2/cyclin A3 inhibitors

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 21, 2010, Pages 7639-7650

  Hamad Elgazwy, Abdel Sattar S ^a   Ismail, Nasser S M ^b   Elzahabi, Heba S A ^c  

^a Ain Shams University   (Egypt)

^b Ain Shams University   (Egypt)

^c AL AZHAR UNIVERSITY   (Egypt)

Author keywords

Antitumor; Bioinformatics; CDK2; Diaminomaleonitrile (DAMN); Docking; Molecular modeling; Purine; Pyrimidine

Indexed keywords

2 METHYL 9 [(4 METHYLPHENYL)SULFONYL] 8 OXO 2 (2 OXOPROPYL) 2,7,8,9 TETRAHYDRO 1H PURINE 6 CARBOXAMIDE; 2,2 DIMETHYL 9 [(4 METHYLPHENYL)SULFONYL] 8 OXO 2,7,8,9 TETRAHYDRO 1H PURINE 6 CARBOXAMIDE; CYCLIN A3 INHIBITOR; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 2 INHIBITOR; N [[[1,2 DICYANO 2 [[(4 METHOXYPHENYL)METHYLENE]AMINO]VINYL]AMINO]CARBONYL] 4 METHYLBENZENESULFONAMIDE; PURINE DERIVATIVE; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; EHRLICH ASCITES TUMOR; ENZYME ACTIVE SITE; FEMALE; MOLECULAR DOCKING; MOLECULAR MODEL; MOUSE; NONHUMAN;

ANIMALS; ANTINEOPLASTIC AGENTS; BINDING SITES; CATALYTIC DOMAIN; CELL LINE, TUMOR; COMPUTER SIMULATION; CYCLIN-DEPENDENT KINASE 2; MICE; MODELS, MOLECULAR; PROTEIN KINASE INHIBITORS; PURINES; PYRIMIDINES; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES;

EID: 77957985488     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.08.033     Document Type: Article

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