Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex

Nature

Volumn 376, Issue 6538, 1995, Pages 313-320

  Jeffrey, Philip D ^a   Russo, Alicia A ^a   Polyak, Kornelia ^b   Gibbs, Emma ^c   Hurwitz, Jerard ^c   Massagué, Joan ^b   Pavletich, Nikola P ^a  

^a Howard Hughes Medical Institute Program ^*  (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^c MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; CYCLIN A; CYCLIN DEPENDENT KINASE;

ARTICLE; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME CONFORMATION; ENZYME SUBSTRATE COMPLEX; HUMAN; PRIORITY JOURNAL;

ADENOSINE TRIPHOSPHATE; ALLOSTERIC REGULATION; AMINO ACID SEQUENCE; BINDING SITES; COMPUTER GRAPHICS; CRYSTALLOGRAPHY, X-RAY; CYCLIC AMP-DEPENDENT PROTEIN KINASES; CYCLIN-DEPENDENT KINASES; CYCLINS; ENZYME ACTIVATION; ESCHERICHIA COLI; HUMAN; MOLECULAR SEQUENCE DATA; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN-SERINE-THREONINE KINASES; RECOMBINANT PROTEINS; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; THREONINE;

EID: 0029029617     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/376313a0     Document Type: Article

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