Quantitative proteomic analysis of cellular protein modulation upon inhibition of the NEDD8-activating enzyme by MLN4924

Molecular and Cellular Proteomics

Volumn 10, Issue 11, 2011, Pages

  Liao, Hua ^a   Liu, Xiaozhen J ^a   Blank, Jonathan L ^a   Bouck, David C ^a   Bernard, Hugues ^a   Garcia, Khristofer ^a   Lightcap, Eric S ^a  

^a MILLENNIUM PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; BASIC HELIX LOOP HELIX LEUCINE ZIPPER TRANSCRIPTION FACTOR; CELL ANTIGEN; CYCLIN D1; CYCLIN DEPENDENT KINASE INHIBITOR 1A; CYCLIN DEPENDENT KINASE INHIBITOR 1B; CYCLIN E1; CYCLIN E2; ENDOTHELIAL PROTEIN C RECEPTOR; ENZYME INHIBITOR; F BOX PROTEIN; KRUPPEL LIKE FACTOR 5; MELANOMA ANTIGEN; MERLIN; MLN 4924; NEDD8 ACTIVATING ENZYME; ORIGIN RECOGNITION COMPLEX; PROTEIN EID1; PROTEIN MAGEA6; PROTEIN MLX; PROTEIN MORF4L1; PROTEIN MORF4L2; PROTEIN MRFAP1; PROTEIN ORC6L; PROTEIN P53; PROTEIN TAX1BP1; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR; UBIQUITIN; UBIQUITIN PROTEIN LIGASE; UNCLASSIFIED DRUG; ((1S,2S,4R) 4 (4 ((1S) 2,3 DIHYDRO 1H INDEN 1 YLAMINO) 7H PYRROLO(2,3 D)PYRIMIDIN 7 YL) 2 HYDROXYCYCLOPENTYL)METHYL SULPHAMATE; ((1S,2S,4R)-4-(4-((1S)-2,3-DIHYDRO-1H-INDEN-1-YLAMINO)-7H-PYRROLO(2,3-D)PYRIMIDIN-7-YL)-2-HYDROXYCYCLOPENTYL)METHYL SULPHAMATE; CYCLOPENTANE DERIVATIVE; PROTEASOME; PROTEOME; PYRIMIDINE DERIVATIVE;

ARTICLE; CELL CULTURE; CELL CYCLE; CELL DEATH; CYTOTOXICITY; DNA REPAIR; ISOTOPE LABELING; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN STABILITY; PROTEIN TRANSPORT; PROTEOMICS; QUANTITATIVE ANALYSIS; RNA INTERFERENCE; UPREGULATION; WESTERN BLOTTING; DRUG ANTAGONISM; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE SILENCING; GENETICS; HUMAN; KINETICS; METABOLISM; PHENOTYPE; PROTEIN DEGRADATION; TUMOR CELL LINE; UBIQUITINATION;

CELL LINE, TUMOR; CYCLOPENTANES; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE KNOCKDOWN TECHNIQUES; HUMANS; KINETICS; PHENOTYPE; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN STABILITY; PROTEOLYSIS; PROTEOME; PROTEOMICS; PYRIMIDINES; RNA INTERFERENCE; UBIQUITIN-ACTIVATING ENZYMES; UBIQUITINATION;

EID: 80555148876     PISSN: 15359476     EISSN: 15359484     Source Type: Journal    
DOI: 10.1074/mcp.M111.009183     Document Type: Article

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