메뉴 건너뛰기




Volumn 6, Issue 11, 2011, Pages

CXCR4 antagonist AMD3100 modulates claudin expression and intestinal barrier function in experimental colitis

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CXCR4 ANTAGONIST; CLAUDIN; CLAUDIN 3; CLAUDIN 5; CLAUDIN 7; CLAUDIN 8; CYTOKINE; DEXTRAN SULFATE; GAMMA INTERFERON; INTERLEUKIN 6; PLERIXAFOR; TUMOR NECROSIS FACTOR ALPHA; CHEMOKINE RECEPTOR CXCR4; CXCR4 PROTEIN, MOUSE; HETEROCYCLIC COMPOUND; HUMAN IMMUNODEFICIENCY VIRUS FUSION INHIBITOR;

EID: 80455168387     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0027282     Document Type: Article
Times cited : (33)

References (49)
  • 1
    • 38149106730 scopus 로고    scopus 로고
    • Effect of n-3 polyunsaturated fatty acids on membrane microdomain localization of tight junction proteins in experimental colitis
    • Li QR, Zhang Q, Zhang M, Wang CY, Zhu ZX, et al. (2008) Effect of n-3 polyunsaturated fatty acids on membrane microdomain localization of tight junction proteins in experimental colitis. FEBS J 275: 411-20.
    • (2008) FEBS J , vol.275 , pp. 411-420
    • Li, Q.R.1    Zhang, Q.2    Zhang, M.3    Wang, C.Y.4    Zhu, Z.X.5
  • 2
    • 0037043658 scopus 로고    scopus 로고
    • Inflammatory bowel disease
    • Podolsky DK, (2002) Inflammatory bowel disease. N Engl J Med 347: 417-29.
    • (2002) N Engl J Med , vol.347 , pp. 417-429
    • Podolsky, D.K.1
  • 4
    • 0032958705 scopus 로고    scopus 로고
    • Altered tight junction structure contributes to the impaired epithelial barrier function in ulcerative colitis
    • Schmitz H, Barmeyer C, Fromm M, Runkel N, Foss HD, et al. (1999) Altered tight junction structure contributes to the impaired epithelial barrier function in ulcerative colitis. Gastroenterology 116: 301-9.
    • (1999) Gastroenterology , vol.116 , pp. 301-309
    • Schmitz, H.1    Barmeyer, C.2    Fromm, M.3    Runkel, N.4    Foss, H.D.5
  • 5
    • 0022748005 scopus 로고
    • The function of tight junctions in maintaining differences in lipid composition between the apical and the basolateral cell surface domains of MDCK cells
    • Van Meer G, Simons K, (1986) The function of tight junctions in maintaining differences in lipid composition between the apical and the basolateral cell surface domains of MDCK cells. EMBO J 5: 1455-64.
    • (1986) EMBO J , vol.5 , pp. 1455-1464
    • van Meer, G.1    Simons, K.2
  • 6
    • 3042856468 scopus 로고    scopus 로고
    • Barriers built on claudins
    • Turksen K, Troy TC, (2004) Barriers built on claudins. J Cell Sci 117: 2435-47.
    • (2004) J Cell Sci , vol.117 , pp. 2435-2447
    • Turksen, K.1    Troy, T.C.2
  • 7
    • 0032577975 scopus 로고    scopus 로고
    • Claudin-1 and -2: novel integral membrane proteins localizing at tight junctions with no sequence similarity to occludin
    • Furuse M, Fujita K, Hiiragi T, Fujimoto K, Tsukita S, (1998) Claudin-1 and-2: novel integral membrane proteins localizing at tight junctions with no sequence similarity to occludin. J Cell Biol 141: 1539-50.
    • (1998) J Cell Biol , vol.141 , pp. 1539-1550
    • Furuse, M.1    Fujita, K.2    Hiiragi, T.3    Fujimoto, K.4    Tsukita, S.5
  • 8
    • 0035013499 scopus 로고    scopus 로고
    • Regulated expression of claudin-4 decreases paracellular conductance through a selective decrease in sodium permeability
    • Van Itallie C, Rahner C, Anderson JM, (2001) Regulated expression of claudin-4 decreases paracellular conductance through a selective decrease in sodium permeability. J Clin Invest 107: 1319-27.
    • (2001) J Clin Invest , vol.107 , pp. 1319-1327
    • van Itallie, C.1    Rahner, C.2    Anderson, J.M.3
  • 9
    • 0038701734 scopus 로고    scopus 로고
    • Claudin extracellular domains determine paracellular charge selectivity and resistance but not tight junction fibril architecture
    • Colegio OR, Van Itallie C, Rahner C, Anderson JM, (2003) Claudin extracellular domains determine paracellular charge selectivity and resistance but not tight junction fibril architecture. Am J Physiol Cell Physiol 284: C1346-54.
    • (2003) Am J Physiol Cell Physiol , vol.284
    • Colegio, O.R.1    van Itallie, C.2    Rahner, C.3    Anderson, J.M.4
  • 10
    • 0242665742 scopus 로고    scopus 로고
    • Reversal of charge selectivity in cation or anion-selective epithelial lines by expression of different claudins
    • Van Itallie CM, Fanning AS, Anderson JM, (2003) Reversal of charge selectivity in cation or anion-selective epithelial lines by expression of different claudins. Am J Physiol Renal Physiol 285: F1078-84.
    • (2003) Am J Physiol Renal Physiol , vol.285
    • van Itallie, C.M.1    Fanning, A.S.2    Anderson, J.M.3
  • 11
    • 0035210487 scopus 로고    scopus 로고
    • Epithelial barrier defects in ulcerative colitis: characterization and quantification by electrophysiological imaging
    • Gitter AH, Wullstein F, Fromm M, Schulzke JD, (2001) Epithelial barrier defects in ulcerative colitis: characterization and quantification by electrophysiological imaging. Gastroenterology 121: 1320-28.
    • (2001) Gastroenterology , vol.121 , pp. 1320-1328
    • Gitter, A.H.1    Wullstein, F.2    Fromm, M.3    Schulzke, J.D.4
  • 12
    • 70350648021 scopus 로고    scopus 로고
    • Regulation of mucosal structure and barrier function in rat colon exposed to tumor necrosis factor alpha and interferon gamma in vitro: A novel model for studying the pathomechanisms of inflammatory bowel disease cytokines
    • Amasheh M, Grotjohann I, Amasheh S, Fromm A, Söderholm JD, et al. (2009) Regulation of mucosal structure and barrier function in rat colon exposed to tumor necrosis factor alpha and interferon gamma in vitro: A novel model for studying the pathomechanisms of inflammatory bowel disease cytokines. Scand J Gastroenterol 44: 1226-35.
    • (2009) Scand J Gastroenterol , vol.44 , pp. 1226-1235
    • Amasheh, M.1    Grotjohann, I.2    Amasheh, S.3    Fromm, A.4    Söderholm, J.D.5
  • 13
    • 57449095650 scopus 로고    scopus 로고
    • Changes in the expression of claudins in active ulcerative colitis
    • Oshima T, Miwa H, Joh T, (2008) Changes in the expression of claudins in active ulcerative colitis. J Gastroenterol Hepatol (Suppl 2): S146-50.
    • (2008) J Gastroenterol Hepatol , Issue.SUPPL. 2
    • Oshima, T.1    Miwa, H.2    Joh, T.3
  • 14
    • 66149090738 scopus 로고    scopus 로고
    • Probiotic mixture VSL#3 protects the epithelial barrier by maintaining tight junction protein expression and preventing apoptosis in a murine model of colitis
    • Mennigen R, Nolte K, Rijcken E, Utech M, Loeffler B, et al. (2009) Probiotic mixture VSL#3 protects the epithelial barrier by maintaining tight junction protein expression and preventing apoptosis in a murine model of colitis. Am J Physiol Gastrointest Liver Physiol 296: G1140-9.
    • (2009) Am J Physiol Gastrointest Liver Physiol , vol.296
    • Mennigen, R.1    Nolte, K.2    Rijcken, E.3    Utech, M.4    Loeffler, B.5
  • 15
    • 0029906582 scopus 로고    scopus 로고
    • Molecular cloning and characterization of a murine pre-B-cell growth-stimulating factor/stromal cell-derived factor 1 receptor, a murine homolog of the human immunodeficiency virus 1 entry coreceptor fusin
    • Nagasawa T, Nakajima T, Tachibana K, Iizasa H, Bleul CC, et al. (1996) Molecular cloning and characterization of a murine pre-B-cell growth-stimulating factor/stromal cell-derived factor 1 receptor, a murine homolog of the human immunodeficiency virus 1 entry coreceptor fusin. Proc Natl Acad Sci USA 93: 14726-9.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 14726-14729
    • Nagasawa, T.1    Nakajima, T.2    Tachibana, K.3    Iizasa, H.4    Bleul, C.C.5
  • 17
    • 34250165460 scopus 로고    scopus 로고
    • Pulmonary stromal-derived factor-1 expression and effect on neutrophil recruitment during acute lung injury
    • Petty JM, Sueblinvong V, Lenox CC, Jones CC, Cosgrove GP, et al. (2007) Pulmonary stromal-derived factor-1 expression and effect on neutrophil recruitment during acute lung injury. J Immunol 178: 8148-57.
    • (2007) J Immunol , vol.178 , pp. 8148-8157
    • Petty, J.M.1    Sueblinvong, V.2    Lenox, C.C.3    Jones, C.C.4    Cosgrove, G.P.5
  • 18
    • 0034235930 scopus 로고    scopus 로고
    • Critical involvement of the chemotactic axis CXCR4/stromal cell-derived factor-1 alpha in the inflammatory component of allergic airway disease
    • Gonzalo JA, Lloyd CM, Peled A, Delaney T, Coyle AJ, et al. (2000) Critical involvement of the chemotactic axis CXCR4/stromal cell-derived factor-1 alpha in the inflammatory component of allergic airway disease. J Immunol 165: 499-508.
    • (2000) J Immunol , vol.165 , pp. 499-508
    • Gonzalo, J.A.1    Lloyd, C.M.2    Peled, A.3    Delaney, T.4    Coyle, A.J.5
  • 19
    • 33751334789 scopus 로고    scopus 로고
    • Up-regulation of functional CXCR4 expression on human lymphocytes in sepsis
    • Ding Z, Jia SH, Marshall JC, Downey GP, Waddell TK, (2006) Up-regulation of functional CXCR4 expression on human lymphocytes in sepsis. Crit Care Med 34: 3011-7.
    • (2006) Crit Care Med , vol.34 , pp. 3011-3017
    • Ding, Z.1    Jia, S.H.2    Marshall, J.C.3    Downey, G.P.4    Waddell, T.K.5
  • 20
    • 69449096880 scopus 로고    scopus 로고
    • Alteration of CXCR4 Expression and Th1/Th2 Balance of Peripheral CD4-positive T Cells Can Be a Biomarker for Leukocytapheresis Therapy for Patients with Refractory Ulcerative Colitis
    • Nakase H, Mikami S, Chiba T, (2009) Alteration of CXCR4 Expression and Th1/Th2 Balance of Peripheral CD4-positive T Cells Can Be a Biomarker for Leukocytapheresis Therapy for Patients with Refractory Ulcerative Colitis. Inflamm Bowel Dis 15: 963-4.
    • (2009) Inflamm Bowel Dis , vol.15 , pp. 963-964
    • Nakase, H.1    Mikami, S.2    Chiba, T.3
  • 21
    • 77949514514 scopus 로고    scopus 로고
    • CXCL12 is a constitutive and inflammatory chemokine in the intestinal immune system
    • Dotan I, Werner L, Vigodman S, Weiss S, Brazowski E, et al. (2010) CXCL12 is a constitutive and inflammatory chemokine in the intestinal immune system. Inflamm Bowel Dis 16: 583-92.
    • (2010) Inflamm Bowel Dis , vol.16 , pp. 583-592
    • Dotan, I.1    Werner, L.2    Vigodman, S.3    Weiss, S.4    Brazowski, E.5
  • 23
    • 33947622744 scopus 로고    scopus 로고
    • Infection with a helminth parasite prevents experimental colitis via a macrophage-mediated mechanism
    • Smith P, Mangan NE, Walsh CM, Fallon RE, McKenzie AN, et al. (2007) Infection with a helminth parasite prevents experimental colitis via a macrophage-mediated mechanism. J Immunol 178: 4557-66.
    • (2007) J Immunol , vol.178 , pp. 4557-4566
    • Smith, P.1    Mangan, N.E.2    Walsh, C.M.3    Fallon, R.E.4    McKenzie, A.N.5
  • 24
    • 77149133137 scopus 로고    scopus 로고
    • Granulocyte-macrophage colony-stimulating factor elicits bone marrow-derived cells that promote efficient colonic mucosal healing
    • Bernasconi E, Favre L, Maillard MH, Bachmann D, Pythoud C, et al. (2010) Granulocyte-macrophage colony-stimulating factor elicits bone marrow-derived cells that promote efficient colonic mucosal healing. Inflamm Bowel Dis 16: 428-41.
    • (2010) Inflamm Bowel Dis , vol.16 , pp. 428-441
    • Bernasconi, E.1    Favre, L.2    Maillard, M.H.3    Bachmann, D.4    Pythoud, C.5
  • 25
    • 34547698923 scopus 로고    scopus 로고
    • Absence of functional peroxisome proliferator-activated receptor-alpha enhanced ileum permeability during experimental colitis
    • Mazzon E, Cuzzocrea S, (2007) Absence of functional peroxisome proliferator-activated receptor-alpha enhanced ileum permeability during experimental colitis. Shock 28: 192-201.
    • (2007) Shock , vol.28 , pp. 192-201
    • Mazzon, E.1    Cuzzocrea, S.2
  • 27
    • 39449129981 scopus 로고    scopus 로고
    • Hydrophobicity of mucosal surface and its relationship to gut barrier function
    • Qin XF, Caputo FJ, Xu DZ, Deitch EA, (2008) Hydrophobicity of mucosal surface and its relationship to gut barrier function. Shock 29: 372-6.
    • (2008) Shock , vol.29 , pp. 372-376
    • Qin, X.F.1    Caputo, F.J.2    Xu, D.Z.3    Deitch, E.A.4
  • 28
    • 0026006055 scopus 로고
    • Cl- secretion in epithelial monolayers of mucus-forming human colon cells (HT-29/B6)
    • Kreusel KM, Fromm M, Schulzke JD, Hegel U, (1991) Cl- secretion in epithelial monolayers of mucus-forming human colon cells (HT-29/B6). Am J Physiol 261: C574-82.
    • (1991) Am J Physiol , vol.261
    • Kreusel, K.M.1    Fromm, M.2    Schulzke, J.D.3    Hegel, U.4
  • 29
    • 77955970294 scopus 로고    scopus 로고
    • Anti-proliferative and pro-apoptotic effects of tectorigenin on hepatic stellate cells
    • Wu JH, Wang YR, Huang WY, Tan RX, (2010) Anti-proliferative and pro-apoptotic effects of tectorigenin on hepatic stellate cells. World J Gastroenterol 16 (31): 3911-8.
    • (2010) World J Gastroenterol , vol.16 , Issue.31 , pp. 3911-3918
    • Wu, J.H.1    Wang, Y.R.2    Huang, W.Y.3    Tan, R.X.4
  • 30
    • 0030950581 scopus 로고    scopus 로고
    • Acidosis induces hyperpermeability in Caco-2BBe cultured intestinal epithelial monolayers
    • Menconi MJ, Salzman AL, Unno N, Ezzell RM, Casey DM, et al. (1997) Acidosis induces hyperpermeability in Caco-2BBe cultured intestinal epithelial monolayers. Am J Physiol 272: G1007-21.
    • (1997) Am J Physiol , vol.272
    • Menconi, M.J.1    Salzman, A.L.2    Unno, N.3    Ezzell, R.M.4    Casey, D.M.5
  • 31
    • 0036724929 scopus 로고    scopus 로고
    • HMGB1 B box increases the permeability of Caco-2 enterocytic monolayers and impairs intestinal barrier function in mice
    • Sappington PL, Yang R, Yang H, Tracey KJ, Delude RL, et al. (2002) HMGB1 B box increases the permeability of Caco-2 enterocytic monolayers and impairs intestinal barrier function in mice. Gastroenterology 123: 790-802.
    • (2002) Gastroenterology , vol.123 , pp. 790-802
    • Sappington, P.L.1    Yang, R.2    Yang, H.3    Tracey, K.J.4    Delude, R.L.5
  • 32
    • 0141957168 scopus 로고    scopus 로고
    • Proinflammatory cytokines cause NO*-dependent and independent changes in expression and localization of tight junction proteins in intestinal epithelial cells
    • Han X, Fink MP, Delude RL, (2003) Proinflammatory cytokines cause NO*-dependent and independent changes in expression and localization of tight junction proteins in intestinal epithelial cells. Shock 19: 229-37.
    • (2003) Shock , vol.19 , pp. 229-237
    • Han, X.1    Fink, M.P.2    Delude, R.L.3
  • 33
    • 34347218991 scopus 로고    scopus 로고
    • In vitro scratch assay: a convenient and inexpensive method for analysis of cell migration in vitro
    • Liang CC, Park AY, Guan JL, (2007) In vitro scratch assay: a convenient and inexpensive method for analysis of cell migration in vitro. Nat Protoc 2: 329-33.
    • (2007) Nat Protoc , vol.2 , pp. 329-333
    • Liang, C.C.1    Park, A.Y.2    Guan, J.L.3
  • 34
    • 55949133234 scopus 로고    scopus 로고
    • Rho kinases regulate corneal epithelial wound healing
    • Yin J, Yu FS, (2008) Rho kinases regulate corneal epithelial wound healing. Am J Physiol Cell Physiol 295 (2): C378-87.
    • (2008) Am J Physiol Cell Physiol , vol.295 , Issue.2
    • Yin, J.1    Yu, F.S.2
  • 35
    • 34547176642 scopus 로고    scopus 로고
    • Unravelling the pathogenesis of inflammatory bowel disease
    • Xavier RJ, Podolsky DK, (2007) Unravelling the pathogenesis of inflammatory bowel disease. Nature 448: 427-34.
    • (2007) Nature , vol.448 , pp. 427-434
    • Xavier, R.J.1    Podolsky, D.K.2
  • 37
    • 54349114505 scopus 로고    scopus 로고
    • Epithelial apoptosis is a prominent feature of the epithelial barrier disturbance in intestinal inflammation: effect of pro-inflammatory interleukin-13 on epithelial cell function
    • Heller F, Fromm A, Gitter AH, Mankertz J, Schulzke JD, (2008) Epithelial apoptosis is a prominent feature of the epithelial barrier disturbance in intestinal inflammation: effect of pro-inflammatory interleukin-13 on epithelial cell function. Mucosal Immunol Suppl 1: S58-61.
    • (2008) Mucosal Immunol Suppl , vol.1
    • Heller, F.1    Fromm, A.2    Gitter, A.H.3    Mankertz, J.4    Schulzke, J.D.5
  • 38
    • 34548663087 scopus 로고    scopus 로고
    • Chronic alcohol ingestion alters claudin expression in the alveolar epithelium of rats
    • Fernandez AL, Koval M, Fan X, Guidot DM, (2007) Chronic alcohol ingestion alters claudin expression in the alveolar epithelium of rats. Alcohol 41: 371-9.
    • (2007) Alcohol , vol.41 , pp. 371-379
    • Fernandez, A.L.1    Koval, M.2    Fan, X.3    Guidot, D.M.4
  • 39
    • 67651215624 scopus 로고    scopus 로고
    • Claudin-4 augments alveolar epithelial barrier function and is induced in acute lung injury
    • Wray C, Mao Y, Pan J, Chandrasena A, Piasta F, et al. (2009) Claudin-4 augments alveolar epithelial barrier function and is induced in acute lung injury. Am J Physiol Lung Cell Mol Physiol 297: L219-27.
    • (2009) Am J Physiol Lung Cell Mol Physiol , vol.297
    • Wray, C.1    Mao, Y.2    Pan, J.3    Chandrasena, A.4    Piasta, F.5
  • 40
    • 60649108674 scopus 로고    scopus 로고
    • VEGF-mediated disruption of endothelial CLN-5 promotes blood-brain barrier breakdown
    • Argaw AT, Gurfein BT, Zhang Y, Zameer A, John GR, (2009) VEGF-mediated disruption of endothelial CLN-5 promotes blood-brain barrier breakdown. Proc Natl Acad Sci USA 106: 1977-82.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 1977-1982
    • Argaw, A.T.1    Gurfein, B.T.2    Zhang, Y.3    Zameer, A.4    John, G.R.5
  • 41
    • 77954561025 scopus 로고    scopus 로고
    • Emodin enhances alveolar epithelial barrier function in rats with experimental acute pancreatitis
    • Xia XM, Wang FY, Wang ZK, Wan HJ, Xu WA, et al. (2010) Emodin enhances alveolar epithelial barrier function in rats with experimental acute pancreatitis. World J Gastroenterol 16: 2994-3001.
    • (2010) World J Gastroenterol , vol.16 , pp. 2994-3001
    • Xia, X.M.1    Wang, F.Y.2    Wang, Z.K.3    Wan, H.J.4    Xu, W.A.5
  • 42
    • 48249101929 scopus 로고    scopus 로고
    • Neutrophil chemokines GCP-2 and GRO-alpha in patients with inflammatory bowel disease
    • Alzoghaibi MA, Al-Mofleh IA, Al-Jebreen AM, (2008) Neutrophil chemokines GCP-2 and GRO-alpha in patients with inflammatory bowel disease. J Dig Dis 9: 144-8.
    • (2008) J Dig Dis , vol.9 , pp. 144-148
    • Alzoghaibi, M.A.1    Al-Mofleh, I.A.2    Al-Jebreen, A.M.3
  • 43
    • 34250810989 scopus 로고    scopus 로고
    • Blockade of interferon-γ-inducible protein-10 attenuates chronic experimental colitis by blocking cellular trafficking and protecting intestinal epithelial cells
    • Suzuki K, Kawauchi Y, Palaniyandi SS, Veeraveedu PT, Fujii M, et al. (2007) Blockade of interferon-γ-inducible protein-10 attenuates chronic experimental colitis by blocking cellular trafficking and protecting intestinal epithelial cells. Pathol Int 57: 413-20.
    • (2007) Pathol Int , vol.57 , pp. 413-420
    • Suzuki, K.1    Kawauchi, Y.2    Palaniyandi, S.S.3    Veeraveedu, P.T.4    Fujii, M.5
  • 44
    • 27744551342 scopus 로고    scopus 로고
    • Inlfammatory processes have differential effects on claudins 2, 3 and 4 in colonic epithelial cells
    • Prasad S, Mingrino R, Kaukinen K, Hayes KL, Powell RM, et al. (2005) Inlfammatory processes have differential effects on claudins 2, 3 and 4 in colonic epithelial cells. Lab Invest 85: 1139-62.
    • (2005) Lab Invest , vol.85 , pp. 1139-1162
    • Prasad, S.1    Mingrino, R.2    Kaukinen, K.3    Hayes, K.L.4    Powell, R.M.5
  • 45
    • 45849127579 scopus 로고    scopus 로고
    • Role of TNF-alpha in ileum tight junction alteration in mouse model of restraint stress
    • Mazzon E, Cuzzocrea S, (2008) Role of TNF-alpha in ileum tight junction alteration in mouse model of restraint stress. Am J Physiol Gastrointest Liver Physiol 294: G1268-80.
    • (2008) Am J Physiol Gastrointest Liver Physiol , vol.294
    • Mazzon, E.1    Cuzzocrea, S.2
  • 46
    • 38149087653 scopus 로고    scopus 로고
    • Role of TNF-α in lung tight junction alteration in mouse model of acute lung inflammation
    • doi:10.1186/1465-9921-8-75
    • Mazzon E, Cuzzocrea S, (2007) Role of TNF-α in lung tight junction alteration in mouse model of acute lung inflammation. Respiratory Research 8: 75 doi:10.1186/1465-9921-8-75.
    • (2007) Respiratory Research , vol.8 , pp. 75
    • Mazzon, E.1    Cuzzocrea, S.2
  • 47
    • 77954255645 scopus 로고    scopus 로고
    • CXCR4 antagonist AMD3100 attenuates colonic damage in mice with experimental colitis
    • Xia XM, Wang FY, Xu WA, Wang ZK, Liu J, et al. (2010) CXCR4 antagonist AMD3100 attenuates colonic damage in mice with experimental colitis. World J Gastroenterol 16 (23): 2873-80.
    • (2010) World J Gastroenterol , vol.16 , Issue.23 , pp. 2873-2880
    • Xia, X.M.1    Wang, F.Y.2    Xu, W.A.3    Wang, Z.K.4    Liu, J.5
  • 48
    • 54349114505 scopus 로고    scopus 로고
    • Epithelial apoptosis is a prominent feature of the epithelial barrier disturbance in intestinal inflammation: effect of proinflammatory interleukin-13 on epithelial cell function
    • Heller F, Fromm A, Gitter AH, Mankertz J, Schulzke JD, (2008) Epithelial apoptosis is a prominent feature of the epithelial barrier disturbance in intestinal inflammation: effect of proinflammatory interleukin-13 on epithelial cell function. Mucosal Immunol 1 (Suppl 1): S58-61.
    • (2008) Mucosal Immunol , vol.1 , Issue.SUPPL. 1
    • Heller, F.1    Fromm, A.2    Gitter, A.H.3    Mankertz, J.4    Schulzke, J.D.5
  • 49
    • 50249102756 scopus 로고    scopus 로고
    • Expression of apoptotic epithelial cells within lamina propria beneath the basement membrane triggers dextran sulfate sodium-induced colitis
    • Shichijo K, Ihara M, Razzaque MS, Matsuu-Matsuyama M, Nakayama T, et al. (2008) Expression of apoptotic epithelial cells within lamina propria beneath the basement membrane triggers dextran sulfate sodium-induced colitis. Dig Dis Sci 53: 2443-51.
    • (2008) Dig Dis Sci , vol.53 , pp. 2443-2451
    • Shichijo, K.1    Ihara, M.2    Razzaque, M.S.3    Matsuu-Matsuyama, M.4    Nakayama, T.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.