Hydrophobicity of mucosal surface and its relationship to gut barrier function

Shock

Volumn 29, Issue 3, 2008, Pages 372-376

  Qin, Xiaofa ^a   Caputo, Francis J ^a   Xu, Da Zhong ^a   Deitch, Edwin A ^a  

^a RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

Author keywords

Contact angle; I R; Intestinal permeability; Mucolytic agent

Indexed keywords

ACETYLCYSTEINE; FLUORESCEIN DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; DUODENUM; GONIOMETRY; HYDROPHOBICITY; ILEUM; IN VIVO STUDY; INTESTINE FUNCTION; INTESTINE ISCHEMIA; INTESTINE MUCOSA; MALE; MESENTERIC ARTERY OCCLUSION; NONHUMAN; RAT;

ACETYLCYSTEINE; ANIMALS; EXPECTORANTS; HYDROPHOBICITY; INTESTINAL MUCOSA; ISCHEMIA; MALE; MUCUS; PERMEABILITY; RATS; RATS, SPRAGUE-DAWLEY;

EID: 39449129981     PISSN: 10732322     EISSN: None     Source Type: Journal    
DOI: 10.1097/SHK.0b013e3181453f4e     Document Type: Article

References (29)

1. Guarner F, Malagelada JR: Gut flora in health and disease. Lancet 361:512-519, 2003.
2. Magnotti LJ, Deitch EA: Burns, bacterial translocation, gut barrier function, and failure. J Burn Care Rehabil 26:383-391, 2005.
3. Hills BA, Butler BD, Lichtenberger LM: Gastric mucosal barrier: hydrophobic lining to the lumen of the stomach. Am J Physiol 244:G561-G568, 1983.
4. Goddard PJ, Kao YC, Lichtenberger LM: Luminal surface hydrophobicity of canine gastric mucosa is dependent on a surface mucous gel. Gastroenterology 98:361-370, 1990.
5. Specian RD, Oliver MG: Functional biology of intestinal goblet cells. Am J Physiol 260:C183-C193, 1991.
6. Rupani B, Caputo FJ, Watkins AC, Vega D, Magnotti LJ, Lu Q, Xu da Z, Deitch EA: Relationship between disruption of the unstirred mucus layer and intestinal restitution in loss of gut barrier function after trauma hemorrhagic shock. Surgery 141:481-489, 2007.
7. Atuma C, Strugala V, Allen A, Holm L: The adherent gastrointestinal mucus gel layer: thickness and physical state in vivo. Am J Physiol 280:G922-G929, 2001.
8. Allen A, Flemstrom G: Gastroduodenal mucus bicarbonate barrier: protection against acid and pepsin. Am J Physiol Cell Physiol 288:C1-C19, 2005.
9. Lichtenberger LM: The hydrophobic barrier properties of gastrointestinal mucus. Annu Rev Physiol 57:565-583, 1995.
10. Mack DR, Neumann AW, Policova Z, Sherman PM: Surface hydrophobicity of the intestinal tract. Am J Physiol 262:G171-G177, 1992.
11. Lugea A, Salas A, Casalot J, Guarner F, Malagelada JR: Surface hydrophobicity of the rat colonic mucosa is a defensive barrier against macromolecules and toxins. Gut 46:515-521, 2000.
12. Ethell MT, Hodgson DR, Hills BA: Evidence for surfactant contributing to the gastric mucosal barrier of the horse. Equine Vet J 32:470-474, 2000.
13. Lugea A, Antolin M, Mourelle M, Guarner F, Malagelada JR: Deranged hydrophobic barrier of the rat gastroduodenal mucosa after parenteral nonsteroidal anti-inflammatory drugs. Gastroenterology 112:1931-1939, 1997.
14. Tatsumi Y, Lichtenberger LM: Molecular association of trinitrobenzenesulfonic acid and surface phospholipids in the development of colitis in rats. Gastroenterology 110:780-789, 1996.
15. Dial EJ, Romero JJ, Villa X, Mercer DW, Lichtenberger LM: Lipopolysaccharide-induced gastrointestinal injury in rats: role of surface hydrophobicity and bile salts. Shock 17:77-80, 2002.
16. Lichtenberger LM, Romero JJ: Effect of ammonium ion on the hydrophobic and barrier properties of the gastric mucus gel layer: implications on the role of ammonium in H. pylori-induced gastritis. J Gastroenterol Hepatol 9(suppl 1):13-19, 1994.
17. Goggin PM, Northfield TC, Spychal RT: Factors affecting gastric mucosal hydrophobicity in man. Scand J Gastroenterol 181:65-73, 1991.
18. Spychal RT, Goggin PM, Marrero JM, Saverymuttu SH, Yu CW, Corbishley CM, Maxwell JD, Northfield TC: Surface hydrophobicity of gastric mucosa in peptic ulcer disease. Relationship to gastritis and Campylobacter pylori infection. Gastroenterology 98:1250-1254, 1990.
19. Hackelsberger A, Platzer U, Nilius M, Schultze V, Gunther T, Dominguez-Munoz JE, Malfertheiner P: Age and Helicobacter pylori decrease gastric mucosal surface hydrophobicity independently. Gut 43:465-469, 1998.
20. Goggin PM, Marrero JM, Spychal RT, Jackson PA, Corbishley CM, Northfield TC: Surface hydrophobicity of gastric mucosa in Helicobacter pylori infection: effect of clearance and eradication. Gastroenterology 103:1486-1490, 1992.
21. Spychal RT, Marrero JM, Saverymuttu SH, Northfield TC: Measurement of the surface hydrophobicity of human gastrointestinal mucosa. Gastroenterology 97:104-111, 1989.
22. Grotz MR, Deitch EA, Ding J, Xu D, Huang Q, Regel G: Intestinal cytokine response after gut ischemia: role of gut barrier failure. Ann Surg 229:478-486, 1999.
23. Mosenthal AC, Xu D, Deitch EA: Elemental and intravenous total parenteral nutrition diet-induced gut barrier failure is intestinal site specific and can be prevented by feeding nonfermentable fiber. Crit Care Med 30:396-402, 2002.
24. Deitch EA, Specian RD, Berg RD: Endotoxin-induced bacterial translocation and mucosal permeability: role of xanthine oxidase, complement activation, and macrophage products. Crit Care Med 19:785-791, 1991.
25. Mojzis J, Hegedusova R, Mirossay L: Role of mucus in ischemia/ reperfusion-induced gastric mucosal injury in rats. Physiol Res 49:441-446, 2000.
26. Seno K, Joh T, Yokoyama Y, Itoh M: Role of mucus in gastric mucosal injury induced by local ischemia/reperfusion. J Lab Clin Med 126:287-293, 1995.
27. Iiboshi Y, Nezu R, Cui L, Chen K, Khan J, Yoshida H, Sando K, Kamata S, Takagi Y, Okada A: Adhesive mucous gel layer and mucus release as intestinal barrier in rats. JPEN J Parenter Enteral Nutr 20:98-104, 1996.
28. Einerhand AW, Renes IB, Makkink MK, van der Sluis M, Buller HA, Dekker J: Role of mucins in inflammatory bowel disease: important lessons from experimental models. Eur J Gastroenterol Hepatol 14:757-765, 2002.
29. Corfield AP, Myerscough N, Longman R, Sylvester P, Arul S, Pignatelli M: Mucins and mucosal protection in the gastrointestinal tract: new prospects for mucins in the pathology of gastrointestinal disease. Gut 47:589-594, 2000.