Understanding the molecular mechanism of enzyme dynamics of ribonuclease a through protonation/deprotonation of HIS48

Journal of the American Chemical Society

Volumn 133, Issue 44, 2011, Pages 17727-17737

  Ji, Chang G ^a,b   Zhang, John Z H ^a,b,c  

^a EAST CHINA NORMAL UNIVERSITY   (China)

^b EAST CHINA NORMAL UNIVERSITY   (China)

^c NEW YORK UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYTIC PROCESS; CATALYTIC REACTIONS; CONFORMATIONAL STATE; DYNAMIC MOTIONS; EXPERIMENTAL OBSERVATION; HYDROGEN BOND NETWORKS; INTERACTION NETWORKS; MOLECULAR DYNAMICS SIMULATIONS; MOLECULAR MECHANISM; N-TERMINAL HELIX; N-TERMINALS; PARTIAL UNFOLDING; PROTONATED; RATE-LIMITING STEPS; REACTION CENTER; RIBONUCLEASE A; RNASE A; THEORETICAL STUDY;

CATALYSIS; DYNAMICS; HYDROGEN; HYDROGEN BONDS; MOLECULAR DYNAMICS; REACTION KINETICS;

ENZYME KINETICS;

HISTIDINE; HISTIDINE 48; RIBONUCLEASE A; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; ENZYME ACTIVE SITE; ENZYME ACTIVITY; HYDROGEN BOND; PROTEIN INTERACTION; PROTEIN STRUCTURE; PROTEIN UNFOLDING; PROTON TRANSPORT; RNA CONFORMATION; TITRIMETRY;

ENZYME ACTIVATION; HISTIDINE; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; PROTONS; RIBONUCLEASE, PANCREATIC;

EID: 80455123904     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja206212a     Document Type: Article

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