Introduction. Quantum catalysis in enzymes: Beyond the transition state theory paradigm

Philosophical Transactions of the Royal Society B: Biological Sciences

Volumn 361, Issue 1472, 2006, Pages 1293-1294

  Dutton, P Leslie ^a   Munro, Andrew W ^b,c   Scrutton, Nigel S ^b   Sutcliffe, Michael J ^b,c  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

^c UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSIS; ENZYME;

EID: 33748360130     PISSN: 09628436     EISSN: None     Source Type: Journal    
DOI: 10.1098/rstb.2006.1879     Document Type: Conference Paper

References (16)

1. Allemann, R. K., Evans, R. M., Tey, L.-h., Maglia, G., Pang, J., Rodriguez, R., Shrimpton, P. J. & Swanwick, R. S. 2006 Protein motions during catalysis by dihydrofolate reductases. Phil. Trans. R. Soc. B 361, 1317-1321. (doi:10.1098/rstb.2006.1865)
2. 12-dependent methylmalonyl-CoA mutase: experimental and computational insights. Phil. Trans. R. Soc. B 361, 1333-1339. (doi:10.1098/rstb.2006.1866)
3. DeVault, D. & Chance, B. 1966 Studies of photosynthesis using a pulsed laser. I. Temperature dependence of cytochrome oxidation rate in chromatium. Evidence for tunneling. Biophys. J. 6, 825-847.
4. Hammes-Schiffer, S. & Watney, J. B. 2006 Hydride transfer catalysed by Escherichia coli and Bacillus subtilis dihydrofolate reductase: coupled motions and distal mutations. Phil. Trans. R. Soc. B 361, 1365-1373. (doi:10.1098/rstb.2006.1869)
5. Klinman, J. P. 2006 Linking protein structure and dynamics to catalysis: the role of hydrogen tunnelling. Phil. Trans. R. Soc. B 361, 1323-1331. (doi:10.1098/rstb.2006.1870)
6. Limbach, H.-H., Lopez, J. M. & Kohen, A. 2006 Arrhenius curves of hydrogen transfers: tunnel effects, isotope effects and effects of pre-equilibria. Phil. Trans. R. Soc. B 361, 1399-1415. (doi:10.1098/rstb.2006. 1872)
7. Marcus, R. A. 2006 Summarizing lecture: factors influencing enzymatic H-transfers, analysis of nuclear tunnelling isotope effects and thermodynamic versus specific effects. Phil. Trans. R. Soc. B. 361, 1445-1455. (doi:10.1098/rstb.2006.1873)
8. Moser, C. C., Page, C. C. & Dutton, P. L. 2006 Darwin at the molecular scale: selection and variance in electron tunnelling proteins including cytochrome c oxidase. Phil. Trans. R. Soc. B. 361, 1295-1305. (doi:10.1098/rstb.2006.1868)
9. Northrop, D. B. 2006 Unusual origins of isotope effects in enzyme-catalysed reactions. Phil. Trans. R. Soc. B 361, 1341-1349. (doi:10.1098/rstb.2006.1875)
10. Nuñez, S., Tresadern, G., Hillier, I. H. & Burton, N. A. 2006 An analysis of reaction pathways for proton tunnelling in methylamine dehydrogenase. Phil. Trans. R. Soc. B 361, 1387-1398. (doi:10.1098/rstb.2006. 1867)
11. Olsson, M. H. M., Mavri, J. & Warshel, A. 2006 Transition state theory can be used in studies of enzyme catalysis: lessons from simulations of tunnelling and dynamical effects in lipoxygenase and other systems. Phil. Trans. R. Soc. B 361, 1417-1432. (doi:10.1098/rstb.2006.1880)
12. Onuchic, J. N., Kobayashi, C., Miyashita, O., Jennings, P. & Baldridge, K. K. 2006 Exploring biomolecular machines: energy landscape control of biological reactions. Phil. Trans. R. Soc. B 361, 1439-1443. (doi:10.1098/rstb.2006.1876)
13. Pineda, J. R. E. T. & Schwartz, S. D. 2006 Protein dynamics and catalysis: the problems of transition state theory and the subtlety of dynamic control. Phil. Trans. R. Soc. B 361, 1433-1438. (doi:10.1098/rstb.2006.1877)
14. Reece, S. Y., Hodgkiss, J. M., Stubbe, J. & Nocera, D. G. 2006 Proton-coupled electron transfer: the mechanistic underpinning for radical transport and catalysis in biology. Phil. Trans. R. Soc. B 361, 1351-1364. (doi:10.1098/rstb.2006.1874)
15. Sutcliffe, M. J. et al. 2006 Hydrogen tunnelling in enzyme-catalysed H-transfer reactions: flavoprotein and quino-protein systems. Phil. Trans. R. Soc. B 361, 1375-1386. (doi:10.1098/rstb.2006.1878)
16. Wang, L., Goodey, N. M., Benkovic, S. J. & Kohen, A. 2006 The role of enzyme dynamics in catalysing hydride transfer: studies of distal mutants of dihydrofolate reductase. Phil. Trans. R. Soc. B 361, 1307-1315. (doi:10.1098/rstb.2006.1871)