Enlightening the molecular basis of trypanothione specificity in trypanosomatids: Mutagenesis of Leishmania infantum glyoxalase II

Experimental Parasitology

Volumn 129, Issue 4, 2011, Pages 402-408

  Barata, Lídia ^a,b   Sousa Silva, Marta ^a,c   Schuldt, Linda ^b   Ferreira, António E N ^a   Gomes, Ricardo A ^a   Tomás, Ana M ^c,d   Weiss, Manfred S ^b   Ponces Freire, Ana ^a   Cordeiro, Carlos ^a  

^a UNIVERSITY OF LISBON   (Portugal)

^b EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

^c UNIVERSITY OF PORTO   (Portugal)

^d UNIVERSITY OF PORTO   (Portugal)

Author keywords

Enzyme kinetics; Enzyme specificity shift; Glyoxalase II; Leishmania infantum; Trypanothione

Indexed keywords

HYDROXYACYLGLUTATHIONE HYDROLASE; TRYPANOTHIONE;

AMINO ACID SUBSTITUTION; ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG DETERMINATION; DRUG MECHANISM; DRUG PROTEIN BINDING; DRUG SPECIFICITY; DRUG STRUCTURE; ENZYME SPECIFICITY; ENZYME SUBSTRATE COMPLEX; GENE OVEREXPRESSION; LEISHMANIA INFANTUM; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; STRUCTURAL HOMOLOGY; TRYPANOSOMA; X RAY CRYSTALLOGRAPHY;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; CLONING, MOLECULAR; CRYSTALLOGRAPHY, X-RAY; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GLUTATHIONE; LEISHMANIA INFANTUM; MASS SPECTROMETRY; MODELS, STRUCTURAL; MOLECULAR SEQUENCE DATA; MUTAGENESIS; PROTEIN CONFORMATION; SPERMIDINE; SUBSTRATE SPECIFICITY; THIOLESTER HYDROLASES;

LEISHMANIA INFANTUM; TRYPANOSOMATIDAE;

EID: 80455122647     PISSN: 00144894     EISSN: 10902449     Source Type: Journal    
DOI: 10.1016/j.exppara.2011.08.008     Document Type: Article

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